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    Alanine 2,3-aminomutases and related polynucleotides
    2.
    发明授权
    Alanine 2,3-aminomutases and related polynucleotides 有权
    丙氨酸2,3-氨基变位酶和相关多核苷酸

    公开(公告)号：US07790432B2

    公开(公告)日：2010-09-07

    申请号：US11919271

    申请日：2005-10-25

    申请人： Ranjini Chatterjee ,  Kenneth W. Mitchell ,  Susan Y. Louie ,  Richard J. Fox ,  Michelle Chen

    发明人： Ranjini Chatterjee ,  Kenneth W. Mitchell ,  Susan Y. Louie ,  Richard J. Fox ,  Michelle Chen

    IPC分类号： C12N9/88 ,  C12N1/20 ,  C12N1/00 ,  C12N15/00 ,  C07H21/02

    CPC分类号： C12N9/90

    摘要： The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.

    摘要翻译： 本发明涉及相对于具有与丙氨酸交叉反应性的结果具有附带的AAM活性的野生型酶具有增强的丙氨酸2,3-氨基变位酶（AAM）活性和/或热稳定性的多肽。 此外，本发明涉及编码本发明的AAM多肽的多核苷酸，包含多核苷酸的核酸序列与包含与启动子可操作连接的多核苷酸的表达载体，转染以表达AAM的宿主细胞 多肽，以及用于制备本发明的AAM多肽的方法。