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公开(公告)号：US20100099143A1
公开(公告)日：2010-04-22
申请号：US11919271
申请日：2005-10-25
CPC分类号： C12N9/90
摘要： The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.
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公开(公告)号：US07790432B2
公开(公告)日：2010-09-07
申请号：US11919271
申请日：2005-10-25
CPC分类号： C12N9/90
摘要： The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.
摘要翻译： 本发明涉及相对于具有与丙氨酸交叉反应性的结果具有附带的AAM活性的野生型酶具有增强的丙氨酸2,3-氨基变位酶（AAM）活性和/或热稳定性的多肽。 此外，本发明涉及编码本发明的AAM多肽的多核苷酸，包含多核苷酸的核酸序列与包含与启动子可操作连接的多核苷酸的表达载体，转染以表达AAM的宿主细胞 多肽，以及用于制备本发明的AAM多肽的方法。
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公开(公告)号：US20100248312A1
公开(公告)日：2010-09-30
申请号：US11581946
申请日：2006-10-16
申请人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
发明人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
摘要： The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
摘要翻译： 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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公开(公告)号：US20120040437A1
公开(公告)日：2012-02-16
申请号：US13223604
申请日：2011-09-01
申请人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
发明人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
IPC分类号： C12N9/90
摘要： The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
摘要翻译： 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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公开(公告)号：US08030051B2
公开(公告)日：2011-10-04
申请号：US11581946
申请日：2006-10-16
申请人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
发明人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
摘要： The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
摘要翻译： 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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公开(公告)号：US07611897B2
公开(公告)日：2009-11-03
申请号：US10872750
申请日：2004-06-21
CPC分类号： C12N9/16 , C12N9/18 , C12N15/8209 , C12N15/8242 , C12N15/8282
摘要： New fumonisin detoxifying or fumonisin-derivative detoxifying homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, antibodies to the new homologues, and methods of using the homologues are also provided.
摘要翻译： 提供新的伏马毒素解毒或伏马毒素衍生物解毒同系物（核酸和蛋白质）。 还提供了包括这些新蛋白质，重组细胞，新同系物的抗体以及使用同源物的方法的组合物。
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公开(公告)号：US20120202257A1
公开(公告)日：2012-08-09
申请号：US13220616
申请日：2011-08-29
CPC分类号： C12N9/1088 , C12N9/88 , C12P7/22 , C12P7/26 , C12P7/42 , C12Y205/01018
摘要： The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.
摘要翻译： 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。
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公开(公告)号：US20050050586A1
公开(公告)日：2005-03-03
申请号：US10872750
申请日：2004-06-21
CPC分类号： C12N9/16 , C12N9/18 , C12N15/8209 , C12N15/8242 , C12N15/8282
摘要： New fumonisin detoxifying or fumonisin-derivative detoxifying homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, antibodies to the new homologues, and methods of using the homologues are also provided.
摘要翻译： 提供新的伏马毒素解毒或伏马毒素衍生物解毒同系物（核酸和蛋白质）。 还提供了包括这些新蛋白质，重组细胞，新同系物的抗体以及使用同源物的方法的组合物。
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公开(公告)号：US20120196334A1
公开(公告)日：2012-08-02
申请号：US13220629
申请日：2011-08-29
CPC分类号： C12N9/1088 , C12N9/88 , C12P7/22 , C12P7/26 , C12P7/42 , C12Y205/01018
摘要： The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.
摘要翻译： 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。
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公开(公告)号：US20120202272A1
公开(公告)日：2012-08-09
申请号：US13220658
申请日：2011-08-29
IPC分类号： C12N1/21
CPC分类号： C12N9/1088 , C12N9/88 , C12P7/22 , C12P7/26 , C12P7/42 , C12Y205/01018
摘要： The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.
摘要翻译： 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。
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