公开(公告)号：US07611897B2

公开(公告)日：2009-11-03

申请号：US10872750

申请日：2004-06-21

Applicant: Ranjini Chatterjee ,  Jonathan P. Duvick ,  James English

Inventor： Ranjini Chatterjee ,  Jonathan P. Duvick ,  James English

IPC: C12N5/10 ,  C12N15/00 ,  C12N15/82 ,  C07H21/04

CPC classification number: C12N9/16 ,  C12N9/18 ,  C12N15/8209 ,  C12N15/8242 ,  C12N15/8282

Abstract: New fumonisin detoxifying or fumonisin-derivative detoxifying homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, antibodies to the new homologues, and methods of using the homologues are also provided.

Abstract translation: 提供新的伏马毒素解毒或伏马毒素衍生物解毒同系物（核酸和蛋白质）。 还提供了包括这些新蛋白质，重组细胞，新同系物的抗体以及使用同源物的方法的组合物。

公开(公告)号：US20120202257A1

公开(公告)日：2012-08-09

申请号：US13220616

申请日：2011-08-29

Applicant: Ranjini Chatterjee ,  Kenneth Zahn ,  Kenneth Mitchell ,  Yaoquan Liu

Inventor： Ranjini Chatterjee ,  Kenneth Zahn ,  Kenneth Mitchell ,  Yaoquan Liu

IPC: C12N9/10 ,  C12P7/42 ,  C12P13/00 ,  C12P7/22 ,  C12P7/24

CPC classification number: C12N9/1088 ,  C12N9/88 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12Y205/01018

Abstract: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.

Abstract translation: 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。

公开(公告)号：US20120196335A1

公开(公告)日：2012-08-02

申请号：US13220652

申请日：2011-08-29

Applicant: RANJINI CHATTERJEE ,  KENNETH ZAHN ,  KENNETH MITCHELL ,  YAOQUAN LIU

Inventor： RANJINI CHATTERJEE ,  KENNETH ZAHN ,  KENNETH MITCHELL ,  YAOQUAN LIU

IPC: C12N1/21 ,  C12N15/63 ,  C12P7/42 ,  C12P7/24 ,  C12P13/00 ,  C12N15/54 ,  C12P7/22

CPC classification number: C12N9/1088 ,  C12N9/88 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12Y205/01018

Abstract: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.

Abstract translation: 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。

公开(公告)号：US20100248312A1

公开(公告)日：2010-09-30

申请号：US11581946

申请日：2006-10-16

Applicant: Svetlana Balatskaya ,  Birthe Borup ,  Ranjini Chatterjee ,  Ish Dhawan ,  Richard J. Fox ,  Kenneth W. Mitchell ,  Emily C. Mundorff ,  Les Partridge ,  Matthew Tobin

Inventor： Svetlana Balatskaya ,  Birthe Borup ,  Ranjini Chatterjee ,  Ish Dhawan ,  Richard J. Fox ,  Kenneth W. Mitchell ,  Emily C. Mundorff ,  Les Partridge ,  Matthew Tobin

IPC: C12P13/06 ,  C12N9/90 ,  C07H21/04 ,  C12N15/63 ,  C12N1/20

CPC classification number: C12N9/90 ,  C12P13/06

Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.

Abstract translation: 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。

公开(公告)号：US20130143304A9

公开(公告)日：2013-06-06

申请号：US13220662

申请日：2011-08-29

Applicant: RANJINI CHATTERJEE ,  KENNETH ZAHN ,  KENNETH MITCHELL ,  YAOQUAN LIU

Inventor： RANJINI CHATTERJEE ,  KENNETH ZAHN ,  KENNETH MITCHELL ,  YAOQUAN LIU

IPC: C12N1/21

CPC classification number: C12N9/1088 ,  C12N9/88 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12Y205/01018

Abstract: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.

Abstract translation: 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。

公开(公告)号：US20120196353A1

公开(公告)日：2012-08-02

申请号：US13220662

申请日：2011-08-29

Applicant: RANJINI CHATTERJEE ,  KENNETH ZAHN ,  KENNETH MITCHELL ,  YAOQUAN LIU

Inventor： RANJINI CHATTERJEE ,  KENNETH ZAHN ,  KENNETH MITCHELL ,  YAOQUAN LIU

IPC: C12N1/21

CPC classification number: C12N9/1088 ,  C12N9/88 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12Y205/01018

Abstract: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.

Abstract translation: 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。

公开(公告)号：US20100099143A1

公开(公告)日：2010-04-22

申请号：US11919271

申请日：2005-10-25

Applicant: Ranjini Chatterjee ,  Kenneth W. Mitchell ,  Susan Y. Louie ,  Richard J. Fox ,  Michelle Chen

Inventor： Ranjini Chatterjee ,  Kenneth W. Mitchell ,  Susan Y. Louie ,  Richard J. Fox ,  Michelle Chen

IPC: C12P21/02 ,  C12N9/10 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21

CPC classification number: C12N9/90

Abstract: The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.

公开(公告)号：US20090162895A1

公开(公告)日：2009-06-25

申请号：US12049839

申请日：2008-03-17

Applicant: Ranjini CHATTERJEE ,  Michelle M. Chen ,  Ranjan Patnaik ,  Stephen L. Schmidt

Inventor： Ranjini CHATTERJEE ,  Michelle M. Chen ,  Ranjan Patnaik ,  Stephen L. Schmidt

IPC: C12P21/02

CPC classification number: C12N9/88

Abstract: The present invention relates to novel ribulose-1,5-bisphosphate carboxylase/oxygenase polypeptides and the polynucleotides that encode them. The invention also provides related host cells and methods.

Abstract translation: 本发明涉及新的核酮糖-1,5-二磷酸羧化酶/加氧酶多肽和编码它们的多核苷酸。 本发明还提供相关的宿主细胞和方法。

公开(公告)号：US20050050586A1

公开(公告)日：2005-03-03

申请号：US10872750

申请日：2004-06-21

Applicant: Ranjini Chatterjee ,  Jonathan Duvick ,  James English

Inventor： Ranjini Chatterjee ,  Jonathan Duvick ,  James English

IPC: A01H1/00 ,  C07H21/04 ,  C12N5/04 ,  C12N9/18 ,  C12N15/82

CPC classification number: C12N9/16 ,  C12N9/18 ,  C12N15/8209 ,  C12N15/8242 ,  C12N15/8282

Abstract: New fumonisin detoxifying or fumonisin-derivative detoxifying homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, antibodies to the new homologues, and methods of using the homologues are also provided.

Abstract translation: 提供新的伏马毒素解毒或伏马毒素衍生物解毒同系物（核酸和蛋白质）。 还提供了包括这些新蛋白质，重组细胞，新同系物的抗体以及使用同源物的方法的组合物。

公开(公告)号：US20120196334A1

公开(公告)日：2012-08-02

申请号：US13220629

申请日：2011-08-29

Applicant: Ranjini Chatterjee ,  Kenneth Zahn ,  Kenneth Mitchell ,  Yaoquan Liu

Inventor： Ranjini Chatterjee ,  Kenneth Zahn ,  Kenneth Mitchell ,  Yaoquan Liu

IPC: C12N9/10 ,  C12P7/42 ,  C12P13/00 ,  C12P7/22 ,  C12P7/24

CPC classification number: C12N9/1088 ,  C12N9/88 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12Y205/01018

Abstract: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.

Abstract translation: 本文提供的教导通常涉及使用酶促生物转化过程将木质素衍生的化合物转化为有价值的芳族化学品的方法。 该教导提供（i）对木质素部分中存在的有毒化合物具有耐受性的宿主细胞的选择; （ii）在木质素部分生物转化成芳族化学产品时可用作酶的多肽; （iii）可用于转化宿主细胞以表达多肽选择的多核苷酸，作为木质素级分的生物转化中的酶; 和（iv）表达酶的转化体。