公开(公告)号：US20140054651A1

公开(公告)日：2014-02-27

申请号：US13992217

申请日：2011-11-18

申请人： Rashid Bashir ,  Bobby Reddy ,  Brian Ross Dorvel

发明人： Rashid Bashir ,  Bobby Reddy ,  Brian Ross Dorvel

IPC分类号： G01N27/414

CPC分类号： G01N27/4145

摘要： Provided are semiconductor field effect sensors including a high-k thin film gate dielectric. The semiconductor field effect sensors described herein exhibit high detection sensitivity and enhanced reliability when placed in contact with liquids. Also disclosed are semiconductor field effect sensors having optimized fluid gate electrode voltages and/or back gate electrode voltages for improved detection sensitivity.

摘要翻译： 提供了包括高k薄膜栅极电介质的半导体场效应传感器。 当与液体接触时，本文所述的半导体场效应传感器表现出高检测灵敏度和增强的可靠性。 还公开了具有优化的流体栅电极电压和/或背栅电极电压的半导体场效应传感器，以提高检测灵敏度。

公开(公告)号：US20120021918A1

公开(公告)日：2012-01-26

申请号：US13120710

申请日：2009-09-29

申请人： Rashid Bashir ,  Ashraf Alam ,  Demir Akin ,  Oguz Hasan Elibol ,  Bobby Reddy ,  Donald E. Bergstrom ,  Yi-Shao Liu

发明人： Rashid Bashir ,  Ashraf Alam ,  Demir Akin ,  Oguz Hasan Elibol ,  Bobby Reddy ,  Donald E. Bergstrom ,  Yi-Shao Liu

IPC分类号： C40B20/00 ,  G01R27/28 ,  G01N27/414 ,  C12P19/34 ,  C40B60/10

CPC分类号： G01N27/414 ,  B82Y15/00 ,  B82Y35/00 ,  G01N27/4145 ,  G01N27/4148

摘要： In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR.

摘要翻译： 在一个方面，本文描述了可用于化学和/或生物化学感测的场效应化学传感器装置。 本文还提供了用于单分子检测的方法。 在另一方面，本文所述是通过PCR扩增靶分子的方法。

公开(公告)号：US09835634B2

公开(公告)日：2017-12-05

申请号：US14075557

申请日：2013-11-08

申请人： Rashid Bashir ,  Bobby Reddy ,  Muhammad A Alam ,  Pradeep R Nair ,  Jonghyun Go

发明人： Rashid Bashir ,  Bobby Reddy ,  Muhammad A Alam ,  Pradeep R Nair ,  Jonghyun Go

IPC分类号： G01R19/00 ,  G01N33/84 ,  C12Q1/25 ,  G01N33/50 ,  G01N33/543 ,  G01N33/573 ,  G01N33/574 ,  G01N33/94 ,  G01N27/414

CPC分类号： G01N33/84 ,  C12Q1/25 ,  G01N27/414 ,  G01N33/5091 ,  G01N33/5438 ,  G01N33/573 ,  G01N33/574 ,  G01N33/94 ,  G01N2800/709

摘要： Provided herein are methods and devices for measuring pH and for amplifying a pH signal to obtain ultrasensitive detection of changes in pH. This is achieved by providing a sensor and a transducer, wherein the sensor transconductance is sensitive to changes in pH and the transducer transconductance is not affected by pH change. The transducer instead compensates for changes in the sensor transconductance arising from pH change. The unique configuration of the sensor and transducer with respect to each other provides substantial increases in a pH amplification factor, thereby providing pH sensing devices with a giant Nernst response and, therefore, effectively increased pH sensitivity.

公开(公告)号：US08945912B2

公开(公告)日：2015-02-03

申请号：US13120710

申请日：2009-09-29

申请人： Rashid Bashir ,  Ashraf Alam ,  Demir Akin ,  Oguz Hasan Elibol ,  Bobby Reddy ,  Donald E. Bergstrom ,  Yi-Shao Liu

发明人： Rashid Bashir ,  Ashraf Alam ,  Demir Akin ,  Oguz Hasan Elibol ,  Bobby Reddy ,  Donald E. Bergstrom ,  Yi-Shao Liu

IPC分类号： C12M1/36 ,  C12P19/34 ,  G01N27/414 ,  C40B20/00 ,  B82Y15/00 ,  B82Y35/00

CPC分类号： G01N27/414 ,  B82Y15/00 ,  B82Y35/00 ,  G01N27/4145 ,  G01N27/4148

摘要： In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR.

摘要翻译： 在一个方面，本文描述了可用于化学和/或生物化学感测的场效应化学传感器装置。 本文还提供了用于单分子检测的方法。 在另一方面，本文所述是通过PCR扩增靶分子的方法。