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公开(公告)号：US5025010A
公开(公告)日：1991-06-18
申请号：US423714
申请日：1989-10-17
IPC分类号： A61K31/54 , A61K31/5415 , A61P3/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , C07D279/16 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D279/16
摘要： A description is given of compounds I ##STR1## with R(1) equal to H, alkyl, alkoxy, Hal, NO.sub.2, OH, acetamido or amino; R(2) equal to H, alk(en)yl or phenylalkyl; R(3) equal to H, (cyclo)alk(en)yl(alkyl), phenyl or phenylalkyl; R(4) equal to H, alkyl, alkoxy, Hal CF.sub.3, NO.sub.2, OH, acetamido or amino; A equal to --C.tbd.C-- or --CH.dbd.CH--; R(5) equal to various amines; m and n equal to 1-3; and their salts. Preparation processes are also described. Compounds I are excellent calcium agonists or calcium antagonists. They also act to regulate the blood glucose.
摘要翻译： 化合物I（I）与R（1）等于H，烷基，烷氧基，卤素，NO 2，OH，乙酰氨基或氨基的化合物的描述; R（2）等于H，alk（en）或苯基烷基; R（3）等于H，（环）烷（烯）基（烷基），苯基或苯基烷基; R（4）等于H，烷基，烷氧基，Hal CF3，NO2，OH，乙酰氨基或氨基; A等于-C 3 C或-CH = CH-; R（5）等于各种胺; m和n等于1-3; 和它们的盐。 还描述了制备方法。 化合物I是优异的钙激动剂或钙拮抗剂。 它们也起到调节血糖的作用。
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2.发明授权Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia 失效治疗心脏病和血管性高血压和高血压的方法
公开(公告)号：US5236943A
公开(公告)日：1993-08-17
申请号：US791501
申请日：1991-11-14
IPC分类号： A61K31/41 , A61K31/415 , A61K31/495 , A61K31/675 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P43/00 , C07D233/64 , C07D233/68 , C07D233/90 , C07D249/04 , C07D249/08 , C07D257/04 , C07D403/10
CPC分类号： A61K31/415 , A61K31/41
摘要： The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetrazole type.
摘要翻译： 本发明涉及通过施用优选咪唑，吡咯，吡唑，三唑或四唑类型的血管紧张素II受体阻断剂来治疗心脏和血管肥大和/或增生的方法。
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3.发明授权Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia 失效治疗心脏病和血管性高血压和高血压的方法
公开(公告)号：US5231083A
公开(公告)日：1993-07-27
申请号：US564618
申请日：1990-08-09
申请人： Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz , Gabriele Wiemer , Hansjorg Urbach , Rainer Henning , Volker Teetz
发明人： Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz , Gabriele Wiemer , Hansjorg Urbach , Rainer Henning , Volker Teetz
CPC分类号： A61K38/556
摘要： The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is hydrogen or an organic radical, and R.sup.4 and R.sup.5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.
摘要翻译： 本发明涉及通过施用血管紧张素转换酶抑制剂治疗心脏和血管肥大和增生的方法。 给予其中n为1或2，R 1，R 2和R 3的式I化合物（I）相同或不同，各自为氢或有机基团，并且R 4和R 5与 携带它们的原子，单环，双环或三环杂环体系是优选的。 本发明还涉及血管紧张素转换酶抑制剂和含有这些用于治疗上述疾病的药剂。
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公开(公告)号：US5360791A
公开(公告)日：1994-11-01
申请号：US1221
申请日：1993-01-06
CPC分类号： C07D401/12 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/06078 , A61K38/00
摘要： The invention relates to compounds of the formula I ##STR1## in which A denotes a radical of the formula II ##STR2## in which E denotes a CH.sub.2 group or an NR.sup.9 radical,G denotes a radical from the group comprising S, SO, SO.sub.2, O, CO, CS or a direct bond,B denotes an amino acid,D denotes a heterocycle andR.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.9 are defined in the description, and their salts.The invention in addition relates to a process for the preparation of the compounds of the formula I and their use as pharmaceuticals.
摘要翻译： 本发明涉及式I的化合物，其中A表示式II的基团，其中E表示CH 2基团或NR 9基团，G表示包括S，SO的基团 ，SO 2，O，CO，CS或直接键，B表示氨基酸，D表示杂环，R 1，R 2，R 3，R 4，R 5，R 6和R 9在说明书中定义，及其盐。 本发明还涉及制备式I化合物及其作为药物的用途的方法。
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公开(公告)号：US5684016A
公开(公告)日：1997-11-04
申请号：US445543
申请日：1995-05-22
IPC分类号： A61K38/00 , A61K38/55 , C07K5/02 , A61K31/47 , C07D217/26
CPC分类号： C07K5/0222 , A61K38/556
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
摘要翻译： 本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团 并且R4和R5与携带它们的原子一起形成单环，双环或三环杂环体系。 本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。
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6.发明授权Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors 失效使用血管紧张素转换酶抑制剂治疗心功能不全的方法
公开(公告)号：US5403856A
公开(公告)日：1995-04-04
申请号：US188745
申请日：1994-01-31
IPC分类号： C07K14/81 , A61K38/00 , A61K38/55 , A61P9/00 , A61P9/12 , A61P43/00 , C07K5/02 , C07K5/06 , C12N9/99 , A61K31/40
CPC分类号： A61K38/556 , C07K5/0222 , Y10S514/913
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
摘要翻译： 本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团 和R4 R5与携带它们的原子一起形成单环，双环或三环杂环体系。 本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。
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公开(公告)号：US5158959A
公开(公告)日：1992-10-27
申请号：US565900
申请日：1983-12-27
IPC分类号： A61K38/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61P9/12 , C07D209/42 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81
CPC分类号： C07K5/0222 , C07D217/26 , A61K38/00
摘要： What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.
摘要翻译： 所公开的是下式的氨基酸化合物，其中n为0或1，及其盐，所述化合物和具有降血压性质的盐; 制备化合物的方法; 含有该化合物或盐的药物组合物; 以及使用化合物和盐治疗高血压。
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公开(公告)号：US5440046A
公开(公告)日：1995-08-08
申请号：US250491
申请日：1994-05-27
申请人： Adalbert Wagner , Rainer Henning , Hermann Gerhards , Bernward Scholkens , Jean-Paul Vevert , Jean-Claude Caille
发明人： Adalbert Wagner , Rainer Henning , Hermann Gerhards , Bernward Scholkens , Jean-Paul Vevert , Jean-Claude Caille
IPC分类号： A61K31/415 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/4155 , A61K31/4164 , A61K31/423 , A61K31/437 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/495 , A61K31/505 , A61K31/519 , A61P9/12 , A61P29/00 , A61P43/00 , C07D233/64 , C07D233/84 , C07D233/90 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D471/04 , C07D487/04 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.
摘要翻译： 本发明涉及其中X，Y和Z相同或不同且为N或CR2的式“IMAGE”的化合物，L为亚烷基，q为0或1，A为稠合杂双环化合物的基团 。 本发明还涉及制备所述化合物的方法，含有它们的药剂及其用于血管紧张素II受体的方法。
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公开(公告)号：US5747504A
公开(公告)日：1998-05-05
申请号：US709286
申请日：1996-09-06
CPC分类号： C07K5/0222 , A61K38/556
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
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10.发明授权Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof 失效氨基酸衍生物，其制备方法，含有这些化合物的试剂及其用途
公开(公告)号：US5401766A
公开(公告)日：1995-03-28
申请号：US208443
申请日：1994-03-09
IPC分类号： A61K38/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61P9/12 , C07D209/42 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81 , C07D209/34 , A61K31/405
CPC分类号： C07K5/0222 , C07D217/26 , A61K38/00
摘要： Aminoacid derivatives of the formula I ##STR1## A , n, R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these compounds, and their use as medicaments.
摘要翻译： 式I的氨基酸衍生物A，n，R 1，R 2和R 3具有给定的含义及其盐，其制备方法，基于这些化合物的药物制剂及其作为药物的用途。
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