摘要:
[Problems to be Solved]To provide an effective process for total synthesis of pladienolide B and pladienolide D having excellent anti-tumor activity and to provide useful intermediates in the above-described process. [Measure for Solving the Problem]A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined below, characterized by including reacting a compound represented by Formula (12): wherein P7 means a hydrogen atom or a protecting group for hydroxy group; R1 means a hydrogen atom or a hydroxy group, with a compound represented by Formula (13): wherein P1 means a hydrogen atom or a protecting group for hydroxy group; P8 means a hydrogen atom, an acetyl group or a protecting group for hydroxy group; P9 means a hydrogen atom or a protecting group for hydroxy group; or P8 and P9 may form together a group represented by a formula: wherein R5 means a phenyl group which may have a substituent, in the presence of a catalyst.
摘要:
A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined herein, characterized by including reacting a compound represented by Formula (12): with a compound represented by Formula (13): in the presence of a catalyst.
摘要:
Process for producing compound of Formula: wherein P2, P3 and R2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7): wherein P3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8): wherein P2 means a protecting group for hydroxy group; and R2 means a phenyl group which may be substituted, in the presence of a base.
摘要:
Process for producing compound of Formula: wherein P2, P3 and R2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7): wherein P3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8): wherein P2 means a protecting group for hydroxy group; and R2 means a phenyl group which may be substituted, in the presence of a base.
摘要:
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要:
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要:
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it
摘要:
A method for examining Alzheimer's disease comprising (1) the measurement step of measuring an amount of lidocaine or a metabolite thereof in a cerebrospinal fluid derived from a lidocaine-administered test subject, and (2) the determination step of determining whether the test subject has Alzheimer's disease or not on the basis of the measured amount.
摘要:
Printing to aNd MICR code reading from a cut-sheet form imprinted with an MICR code, such as personal checks, are continuously accomplished by a single apparatus, thereby simplifying processing and reducing the required installation space. A magnetic head and a magnet for reading the MICR code are disposed on the slope of a paper path provided in a printer housing. A personal check in paper path is held by cut-sheet form loading rollers and/or transportation rollers which operate at a synchronized speed, and is passed over the magnetic head for MICR code reading. Thereafter, the personal check is held by the loading rollers and/or the transportation rollers for endorsement printing by the print head.
摘要:
A winding shaft, for use in a printer allows a wound recording paper to be easily removed therefrom. The winding shaft includes a shaft main body, a winding portion and a support-removing member. The winding portion, which sandwiches the shaft main body, winds the recording paper therearound. The shaft main body includes a pair of support-removing members, which respectively project from the shaft main body. The two support-removing members are respectively supported on the two side portions of the shaft main body in such a manner that they can be freely rotated about their respective support shafts. A tension-coiled spring is bridgingly disposed between the two support-removing members, so that the two support-removing members remain in standing positions when no external force is applied to them. If the recording paper is lightly rotated in a direction opposite to the winding direction of the recording paper, then the two support-removing members are brought down in the same direction due to an external force applied thereto from the innermost peripheral recording paper. As a result, the innermost peripheral recording paper is loosened, that is, is caused to float loosely from the outer peripheral surface of the shaft main body, thereby enabling the removal of the recording paper from the winding shaft.