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1.发明授权CMOS-process compatible high-DC surface coating for capacitive detection and stimulation of biological tissues 有权CMOS工艺兼容的高直流表面涂层，用于电容检测和刺激生物组织公开(公告)号：US07379766B2
公开(公告)日：2008-05-27
申请号：US10931482
申请日：2004-09-01
申请人： Reinhard Gabl , Tamara Birkenmaier , Bjorn-Oliver Eversmann , Peter Fromherz , Martin Jenkner , Matthias Schreiter , Roland Thewes , Wolfram Wersing
发明人： Reinhard Gabl , Tamara Birkenmaier , Bjorn-Oliver Eversmann , Peter Fromherz , Martin Jenkner , Matthias Schreiter , Roland Thewes , Wolfram Wersing
CPC分类号： C12N5/0619 , G01N33/4833
摘要： Biochip for capacitive stimulation and/or detection of biological tissues. The biochip has a carrier structure, at least one stimulation and/or sensor device, which is arranged in or at the carrier structure, and at least one dielectric layer, one layer area of which is arranged at the stimulation and/or sensor device and the opposite layer area of which forms a stimulation and/or sensor area for capacitive simulation and/or detection of biological tissues, wherein the dielectric layer comprises TiO2.
摘要翻译： 用于电容刺激和/或检测生物组织的生物芯片。 生物芯片具有载体结构，布置在载体结构中或载体结构中的至少一个刺激和/或传感器装置，以及至少一个电介质层，其一个区域布置在刺激和/或传感器装置处， 其相对层区域形成用于电容模拟和/或检测生物组织的刺激和/或传感器区域，其中该介电层包含TiO 2。
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2.发明申请CMOS-process compatible high-DC surface coating for capacitive detection and stimulation of biological tissues 有权CMOS工艺兼容的高直流表面涂层，用于电容检测和刺激生物组织公开(公告)号：US20050187454A1
公开(公告)日：2005-08-25
申请号：US10931482
申请日：2004-09-01
申请人： Reinhard Gabl , Tamara Birkenmaier , Bjorn-Oliver Eversmann , Peter Fromherz , Martin Jenkner , Matthias Schreiter , Roland Thewes , Wolfram Wersing
发明人： Reinhard Gabl , Tamara Birkenmaier , Bjorn-Oliver Eversmann , Peter Fromherz , Martin Jenkner , Matthias Schreiter , Roland Thewes , Wolfram Wersing
IPC分类号： C12N5/0793 , G01N27/414 , G01N33/487 , A61B17/24 , A61B17/26
CPC分类号： C12N5/0619 , G01N33/4833
摘要： Biochip for capacitive stimulation and/or detection of biological tissues. The biochip has a carrier structure, at least one stimulation and/or sensor device, which is arranged in or at the carrier structure, and at least one dielectric layer, one layer area of which is arranged at the stimulation and/or sensor device and the opposite layer area of which forms a stimulation and/or sensor area for capacitive simulation and/or detection of biological tissues, wherein the dielectric layer comprises TiO2.
摘要翻译： 用于电容刺激和/或检测生物组织的生物芯片。 生物芯片具有载体结构，布置在载体结构中或载体结构中的至少一个刺激和/或传感器装置，以及至少一个电介质层，其一个区域布置在刺激和/或传感器装置处， 其相对层区域形成用于电容模拟和/或检测生物组织的刺激和/或传感器区域，其中该介电层包含TiO 2。
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3.发明申请Event detection - apparatus and method for measuring the activity of neural netwoks 有权事件检测 - 用于测量神经网络活动的装置和方法公开(公告)号：US20050107893A1
公开(公告)日：2005-05-19
申请号：US10964560
申请日：2004-10-12
CPC分类号： A61B5/7264 , A61B5/04001 , A61B5/7203 , A61B5/7232 , A61B5/7282 , A61B2562/0209 , A61B2562/046 , G06N3/061
摘要： Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.
摘要翻译： 用纹理化半导体衬底测量神经网络活动的装置。 传感器元件在基板表面上具有检测电极，用于检测神经网络信号，检测到的神经信号是经由各个传感器元件输出输出电传感器输出信号的基础。 每个放大器元件都有一个输入和一个输出。 每个传感器元件都具有一个放大器元件，其输入端连接到相应传感器元件的传感器输出端。 放大的传感器输出信号作为放大器输出信号输出放大器输出。 活动评估器具有连接到至少一个放大器输出的输入和输出。 活动评估装置基于放大器输出信号产生作为神经网络的活动度量的活动信号，并通过评估输出输出放大器输出信号。
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4.发明授权Event detection—apparatus and method for measuring the activity of neural networks 有权事件检测装置和测量神经网络活动的方法公开(公告)号：US07809432B2
公开(公告)日：2010-10-05
申请号：US10964560
申请日：2004-10-12
IPC分类号： A61B5/00
CPC分类号： A61B5/7264 , A61B5/04001 , A61B5/7203 , A61B5/7232 , A61B5/7282 , A61B2562/0209 , A61B2562/046 , G06N3/061
摘要： Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.
摘要翻译： 用纹理化半导体衬底测量神经网络活动的装置。 传感器元件在基板表面上具有检测电极，用于检测神经网络信号，检测到的神经信号是经由各个传感器元件输出输出电传感器输出信号的基础。 每个放大器元件都有一个输入和一个输出。 每个传感器元件都具有一个放大器元件，其输入端连接到相应传感器元件的传感器输出端。 放大的传感器输出信号作为放大器输出信号输出放大器输出。 活动评估器具有连接到至少一个放大器输出的输入和输出。 活动评估装置基于放大器输出信号产生作为神经网络的活动度量的活动信号，并通过评估输出输出放大器输出信号。
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5.发明授权Biosensor circuit and sensor array consisting of a plurality of said biosensor circuits and biosensor array 有权由多个所述生物传感器电路和生物传感器阵列组成的生物传感器电路和传感器阵列公开(公告)号：US07019305B2
公开(公告)日：2006-03-28
申请号：US10821803
申请日：2004-04-08
IPC分类号： G01N27/416
CPC分类号： H03F3/45188 , G01N27/4145 , G01N33/4836 , H03F2203/45352
摘要： Biosensor circuit arrangement including a substrate, a sensor element formed in or on a surface region of the substrate with a physical parameter, which is coupled to a substance to be examined, the type of coupling having a resistive component, the sensor element having an electrically conductive sensor electrode that is coupled to the substance to be examined, the sensor element having a measuring transistor the gate terminal of which is coupled to the electrically conductive sensor electrode, and the physical parameter being the threshold voltage of the measuring transistor, and a calibration device formed in or on the substrate, the calibration device being set up such that it is used to at least partly compensate for an alteration of the value of the physical parameter of the sensor element.
摘要翻译： 生物传感器电路装置，其包括衬底，形成在衬底的表面区域中或其上的具有物理参数的传感器元件，该物理参数耦合到待检查物质，具有电阻部件的耦合类型，所述传感器元件具有电 导电传感器电极，其耦合到待检查的物质，传感器元件具有测量晶体管，栅极端子耦合到导电传感器电极，物理参数是测量晶体管的阈值电压，并且校准 所述校准装置设置成使得其被用于至少部分地补偿所述传感器元件的物理参数的值的变化。
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6.发明申请Biosensor circuit and sensor array consisting of a plurality of said biosensor circuits and biosensor array 有权由多个所述生物传感器电路和生物传感器阵列组成的生物传感器电路和传感器阵列公开(公告)号：US20050017190A1
公开(公告)日：2005-01-27
申请号：US10821803
申请日：2004-04-08
IPC分类号： G01N27/414 , G01N33/487 , H03F3/45
CPC分类号： H03F3/45188 , G01N27/4145 , G01N33/4836 , H03F2203/45352
摘要： Biosensor circuit arrangement including a substrate, a sensor element formed in or on a surface region of the substrate with a physical parameter, which is coupled to a substance to be examined, the type of coupling having a resistive component, the sensor element having an electrically conductive sensor electrode that is coupled to the substance to be examined, the sensor element having a measuring transistor the gate terminal of which is coupled to the electrically conductive sensor electrode, and the physical parameter being the threshold voltage of the measuring transistor, and a calibration device formed in or on the substrate, the calibration device being set up such that it is used to at least partly compensate for an alteration of the value of the physical parameter of the sensor element.
摘要翻译： 生物传感器电路装置，其包括衬底，形成在衬底的表面区域中或其上的具有物理参数的传感器元件，该物理参数耦合到待检查物质，具有电阻部件的耦合类型，所述传感器元件具有电 导电传感器电极，其耦合到待检查的物质，传感器元件具有测量晶体管，栅极端子耦合到导电传感器电极，物理参数是测量晶体管的阈值电压，并且校准 所述校准装置设置成使得其被用于至少部分地补偿所述传感器元件的物理参数的值的变化。
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7.发明授权Measuring cell and measuring field comprising measuring cells of this type, use of a measuring and use of a measuring field 有权测量电池和测量领域包括测量这种类型的电池，使用测量和使用测量领域公开(公告)号：US07084641B2
公开(公告)日：2006-08-01
申请号：US10754909
申请日：2004-01-09
CPC分类号： G11C27/024 , G01N27/4148 , G01N33/48728
摘要： A measuring cell for recording an electrical potential of an analyte situated on the measuring cell. The measuring cell has a sensor, a layer arranged above the sensor and electrically insulating the analyte from the sensor, and an amplifier circuit connected to the sensor on a substrate and having an input stage containing a field-effect transistor or a bipolar transistor, the sensor being at least indirectly connected to a control terminal of the field-effect transistor or of the bipolar transistor. An operating point of the amplifier circuit is set by means of a voltage or a current applied at the control terminal of the field-effect transistor or of the bipolar transistor of the input stage of the amplifier circuit.
摘要翻译： 用于记录位于测量池上的分析物的电位的测量单元。 测量单元具有传感器，布置在传感器上方并将分析物与传感器电绝缘的层，以及连接到衬底上的传感器并具有包含场效应晶体管或双极晶体管的输入级的放大器电路， 传感器至少间接连接到场效应晶体管或双极晶体管的控制端子。 放大器电路的工作点通过施加在场效应晶体管的控制端或放大器电路的输入级的双极晶体管的电压或电流来设定。
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公开(公告)号：US20060057025A1
公开(公告)日：2006-03-16
申请号：US10530882
申请日：2003-10-14
IPC分类号： G01N27/00
CPC分类号： G01N27/4145 , G01N33/48728
摘要： A sensor arrangement and method of operating the sensor arrangement are described. The sensor arrangement has sensor devices formed on or in a substrate and a calibration device for calibrating a respective sensor device. Each sensor device has an electrical signal converter which is a field-effect transistor (FET) having a gate terminal coupled to a sensor element that is coupled to the signal converter, a device that keeps constant the electrical voltage between source and drain terminals of the FET, and a device for detecting the value of the electric current flowing through the signal converter. The sensor element characteristically influences the electrical conductivity of the signal converter on account of a sensor event on the sensor element. The calibration device brings the gate region of the FET to an electrical calibration potential such that the electric current is independent of parameter fluctuations of the FET.
摘要翻译： 描述了传感器装置和操作传感器装置的方法。 传感器装置具有形成在基板上或基板中的传感器装置和用于校准相应传感器装置的校准装置。 每个传感器装置具有电信号转换器，该电信号转换器是具有耦合到耦合到信号转换器的传感器元件的栅极端子的场效应晶体管（FET），保持恒定的源极和漏极端子之间的电压的装置 FET和用于检测流过信号转换器的电流值的装置。 传感器元件由于传感器元件上的传感器事件而特征地影响信号转换器的电导率。 校准装置使FET的栅极区域达到电校准电位，使得电流与FET的参数波动无关。
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公开(公告)号：US07470352B2
公开(公告)日：2008-12-30
申请号：US10826881
申请日：2004-04-16
IPC分类号： G01N27/403 , G01N27/327 , G01N27/414 , G01D18/00 , C12Q1/68 , G11C11/36
CPC分类号： G06K9/0002 , G01N27/4145 , G01N33/4836
摘要： Sensor arrangement having row and column lines arranged in first and second directions, respectively, sensor arrays arranged in crossover regions of the row and column lines, a detector, and a decoding device. The sensor arrays have a coupling device for electrically coupling respective row and column lines, and a sensor element to influence electric current flow through the coupling device. The detector is electrically coupled to a respective end section of at least a portion of the row and column lines, and detects a respective accumulative current flow from the individual electrical current flows provided by the sensor arrays of the respective lines. The decoding device is coupled to the row and column lines, and evaluates at least a portion of the accumulative electric current flows fed to the decoding device via the row and column lines to determine at which of the sensor elements a sensor signal is present.
摘要翻译： 分别具有沿第一和第二方向布置的行和列线的传感器布置，布置在行和列线的交叉区域中的传感器阵列，检测器和解码装置。 传感器阵列具有用于电耦合相应的行和列线的耦合装置和用于影响通过耦合装置的电流的传感器元件。 检测器电耦合到行和列线的至少一部分的相应端部，并且检测来自各线的传感器阵列提供的各个电流的相应的累积电流。 解码装置耦合到行和列线，并且通过行和列线评估馈送到解码装置的累积电流的至少一部分，以确定在哪个传感器元件处存在传感器信号。
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公开(公告)号：US20050029099A1
公开(公告)日：2005-02-10
申请号：US10826881
申请日：2004-04-16
IPC分类号： G01N27/414 , G01N33/487 , G06K9/00 , G01N27/26
CPC分类号： G06K9/0002 , G01N27/4145 , G01N33/4836
摘要： Sensor arrangement having row and column lines arranged in first and second directions, respectively, sensor arrays arranged in crossover regions of the row and column lines, a detector, and a decoding device. The sensor arrays have a coupling device for electrically coupling respective row and column lines, and a sensor element to influence electric current flow through the coupling device. The detector is electrically coupled to a respective end section of at least a portion of the row and column lines, and detects a respective accumulative current flow from the individual electrical current flows provided by the sensor arrays of the respective lines. The decoding device is coupled to the row and column lines, and evaluates at least a portion of the accumulative electric current flows fed to the decoding device via the row and column lines to determine at which of the sensor elements a sensor signal is present.
摘要翻译： 分别具有沿第一和第二方向布置的行和列线的传感器布置，布置在行和列线的交叉区域中的传感器阵列，检测器和解码装置。 传感器阵列具有用于电耦合相应的行和列线的耦合装置和用于影响通过耦合装置的电流的传感器元件。 检测器电耦合到行和列线的至少一部分的相应端部，并且检测来自各线的传感器阵列提供的各个电流的相应的累积电流。 解码装置耦合到行和列线，并且通过行和列线评估馈送到解码装置的累积电流的至少一部分，以确定在哪个传感器元件处存在传感器信号。
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