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1.发明申请PROCESS FOR THE PREPARATION OF 7-AMINO SYN 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, INTERMEDIATES THEREOF AND METHODS FOR THEIR PREPARATION 失效制备7-氨基-3,5-二羟基丙酸衍生物的方法，其中间体及其制备方法公开(公告)号：US20080125601A1
公开(公告)日：2008-05-29
申请号：US11941347
申请日：2007-11-16
申请人： Reinhold Ohrlein , Gabriele Baisch , Hans Jorg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
发明人： Reinhold Ohrlein , Gabriele Baisch , Hans Jorg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
IPC分类号： C07C233/08
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra′ and Rc′ are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Rb is a carboxy-protecting group.
摘要翻译： 制备适于制备他汀类衍生物的中间体的合成方法，特别是其中R a和R c的中间体的合成方法 各自独立地为氢或羟基保护基，或者一起是桥羟基保护基; R b是羧基保护基。
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2.发明申请Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US20070142662A1
公开(公告)日：2007-06-21
申请号：US11657808
申请日：2007-01-24
申请人： Reinhold Ohrlein , Gabriele Baisch , Hans Jurg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
发明人： Reinhold Ohrlein , Gabriele Baisch , Hans Jurg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC分类号： C07C227/04
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
摘要翻译： 本发明涉及用于制备适于制备他汀类衍生物的中间体的新型合成方法，特别涉及式VI中间体的新型合成方法，其中R a a， C 1各自独立地为另一个氢或羟基保护基团，或者一起是桥接羟基保护基团，并且R b是羧基保护基团，该方法进行 通过其中R a a和R c C分别独立于另一个氢或羟基保护基的式XIX的中间体的转化，并且R b' SUB>是羧基保护基。
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3.发明申请Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US20050033086A1
公开(公告)日：2005-02-10
申请号：US10481704
申请日：2002-07-02
申请人： Reinhold Ohrlein , Gabriele Baisch , Hans Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
发明人： Reinhold Ohrlein , Gabriele Baisch , Hans Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC分类号： C07C67/307 , C07B53/00 , C07B61/00 , C07C67/30 , C07C67/31 , C07C69/67 , C07C69/675 , C07C69/708 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/06 , C07C227/16 , C07C227/32 , C07C229/22 , C07C231/02 , C07C235/06 , C07C235/74 , C07C247/12 , C07C253/30 , C07D207/34 , C12P7/62
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
摘要翻译： 本发明涉及适用于制备他汀类衍生物的中间体的新型合成方法，特别是式VI中间体的新合成方法，其中R a和R c各自独立地为氢或羟基 - 保护基或一起是桥接羟基保护基，Rb是羧基保护基，该方法通过式XIX的中间体转化而进行，其中R a和R c各自独立地为氢或羟基保护基 基团，Rb是羧基保护基。
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4.发明授权Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation 失效7-氨基顺式3,5-二羟基庚酸衍生物的制备方法，其中间体及其制备方法公开(公告)号：US07504532B2
公开(公告)日：2009-03-17
申请号：US11941347
申请日：2007-11-16
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
IPC分类号： C07C229/00 , C07C291/00 , C07C59/10
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra′ and Rc′ are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Rb is a carboxy-protecting group.
摘要翻译： 用于制备适于制备他汀类衍生物的中间体的合成方法，特别是其中R a'和R c'各自独立于其它氢或羟基保护基的式（Ⅵ）中间体的合成方法，或 一起是桥接羟基保护基团; 并且Rb是羧基保护基。
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5.发明授权Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US07692034B2
公开(公告)日：2010-04-06
申请号：US11657808
申请日：2007-01-24
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC分类号： C07C229/00
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
摘要翻译： 本发明涉及适用于制备他汀类衍生物的中间体的新型合成方法，特别是式VI中间体的新合成方法，其中R a和R c各自独立地为氢或羟基 - 保护基或一起是桥接羟基保护基，Rb是羧基保护基，该方法通过式XIX的中间体转化而进行，其中R a和R c各自独立地为氢或羟基保护基 基团，Rb是羧基保护基。
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6.发明授权Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation 失效7-氨基顺式3,5-二羟基庚酸衍生物的制备方法，其中间体及其制备方法公开(公告)号：US07317123B2
公开(公告)日：2008-01-08
申请号：US10482946
申请日：2002-07-02
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
IPC分类号： C07C229/00 , C07C233/00
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra′ and Rc′ are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein Ra′ and Rc′ are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation
摘要翻译： 本发明涉及用于制备适于制备他汀类衍生物的中间体的新型合成方法，特别涉及式VI中间体的新型合成方法，其中R a'和R“ > C独立地是氢或羟基保护基，或者一起是桥接羟基保护基，R b是羧基保护基，这些方法是 通过式XVI的中间体的转化而进行，其中R a a和R c'各自独立地是氢或羟基保护基，R *和R **各自独立地为另一个氢或酰胺保护基团，并且R b为羧基保护基团; 哪些方法进行进一步的新中间体及其制备方法
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7.发明授权Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US07199261B2
公开(公告)日：2007-04-03
申请号：US10481704
申请日：2002-07-02
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC分类号： C07C229/00
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group
摘要翻译： 本发明涉及用于制备适于制备他汀类衍生物的中间体的新型合成方法，特别涉及式VI中间体的新型合成方法，其中R a a， C 1各自独立地为另一个氢或羟基保护基团，或者一起是桥接羟基保护基团，并且R b是羧基保护基团，该方法进行 通过其中R a a和R c C分别独立于另一个氢或羟基保护基的式XIX的中间体的转化，并且R b' SUB>是羧基保护基
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公开(公告)号：US07141697B2
公开(公告)日：2006-11-28
申请号：US10130196
申请日：2001-12-12
申请人： Niranjan Paingankar , Vilas N. Mumbaikar , Vadiraj S. Ekkundi , Hans-Peter Jalett , Urs Siegrist , Paul Adriaan Van Der Schaaf , Frank Bienewald , Martin Studer , Stefan Burkhardt
发明人： Niranjan Paingankar , Vilas N. Mumbaikar , Vadiraj S. Ekkundi , Hans-Peter Jalett , Urs Siegrist , Paul Adriaan Van Der Schaaf , Frank Bienewald , Martin Studer , Stefan Burkhardt
IPC分类号： C07C211/00
CPC分类号： C07C213/02 , C07C217/74 , C07C2601/14
摘要： Disclosed is a process for the preparation of a compound of formula wherein R1 is hydrogen, hydroxyl, or unsubstituted or substituted alkyl or alkoxy, R2 is hydrogen or a substituent which can be converted to hydrogen, and n is 0, 1 or 2, comprising hydrogenating a compound of formula wherein R1, R2 and n are as defined above, in the presence of a nickel or cobalt catalyst.
摘要翻译： 公开了一种制备下式化合物的方法，其中R 1是氢，羟基或未取代或取代的烷基或烷氧基，R 2是氢或取代基， 可以转化为氢，并且n为0,1或2，包括将下式化合物其中R 1，R 2，N和n如上定义的氢化， 存在镍或钴催化剂。
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公开(公告)号：US08404864B2
公开(公告)日：2013-03-26
申请号：US12680904
申请日：2008-09-22
申请人： Zhimin Hao , Beat Schmidhalter , Jean-Luc Budry , Margherita Fontana , Mathieu Turbiez , Frank Bienewald , Mathias Düggeli , Oliver Frédéric Aebischer , Pascal Hayoz , Marta Fonrodona Turon
发明人： Zhimin Hao , Beat Schmidhalter , Jean-Luc Budry , Margherita Fontana , Mathieu Turbiez , Frank Bienewald , Mathias Düggeli , Oliver Frédéric Aebischer , Pascal Hayoz , Marta Fonrodona Turon
IPC分类号： C07D487/02
CPC分类号： H01L51/0071 , C07D487/04 , C09B57/004 , H01L51/0053 , H01L51/0058 , H01L51/0068 , H01L51/0095 , Y02E10/549
摘要： The present invention relates to compounds of the formula (I) wherein the substituents are as defined in claim 1, and their use as organic semiconductor in organic devices, like diodes, organic field effect transistors and/or a solar cells. The compounds of the formula I have excellent solubility in organic solvents. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when said compounds are used in semiconductor devices or organic photovoltaic (PV) devices (solar cells).
摘要翻译： 本发明涉及式（I）化合物，其中取代基如权利要求1中所定义，及其作为有机半导体在有机器件中的用途，如二极管，有机场效应晶体管和/或太阳能电池。 式I的化合物在有机溶剂中具有优异的溶解性。 当所述化合物用于半导体器件或有机光伏（PV）器件（太阳能电池））时，可以观察到高效率的能量转换，优异的场效应迁移率，良好的导通/截止电流比和/或优异的稳定性。
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公开(公告)号：US20090101890A1
公开(公告)日：2009-04-23
申请号：US11919605
申请日：2006-05-03
IPC分类号： H01L51/00 , C07D471/04 , H01L51/40 , C07D409/14
CPC分类号： C09B5/028 , C07D471/06 , H01L51/0067 , H01L51/0069 , H01L51/0071 , H01L51/0072 , H01L51/0512 , H01L51/0541 , H01L51/5012 , Y10S428/93
摘要： A novel semiconductor device comprises an azaperylene organic semiconductor of the formula I (I) wherein each of R1, R2, R3 and R4 independently is selected from H, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl, halogen, Si(RH)3, XR6; or one or more of R1 and R2, R2 and R3, R3 and R4, together with the carbon atoms they are bonding to, form a saturated or unsaturated, unsubstituted or substituted carbocyclic or heterocyclic ring; R5 is OR7, SR7, NR7R8, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, or unsubstituted or substituted aryl; R6 is Si(R11)3, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl; R7 is H, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl; X is O, S, NR8; Rδ is H, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl, R11 being C1-C20-alkyl or -alkoxy.
摘要翻译： 一种新颖的半导体器件包括式I（I）的氮杂伯有机半导体，其中R1，R2，R3和R4各自独立地选自H，未取代或取代的烷基，未取代或取代的烯基，未取代或取代的炔基，未取代或取代的 芳基，卤素，Si（RH）3，XR6; 或R 1和R 2，R 2和R 3，R 3和R 4中的一个或多个与它们键合的碳原子一起形成饱和或不饱和的未取代或取代的碳环或杂环; R5是OR7，SR7，NR7R8，未取代或取代的烷基，未取代或取代的烯基，未取代或取代的炔基，或未取代或取代的芳基; R6是Si（R11）3，未取代或取代的烷基，未取代或取代的烯基，未取代或取代的炔基，未取代或取代的芳基; R 7为H，未取代或取代的烷基，未取代或取代的烯基，未取代或取代的炔基，未取代或取代的芳基; X是O，S，NR8; Rdelta是H，未取代或取代的烷基，未取代或取代的烯基，未取代或取代的炔基，未取代或取代的芳基，R11为C1-C20烷基或 - 烷氧基。
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