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公开(公告)号：US20120188258A1
公开(公告)日：2012-07-26
申请号：US13289304
申请日：2011-11-04
申请人： Rex MCCRARY , Michael Houston , Philip J. Rogers , Gongxian Jeffrey Cheng , Mark Hummel , Paul Blinzer
发明人： Rex MCCRARY , Michael Houston , Philip J. Rogers , Gongxian Jeffrey Cheng , Mark Hummel , Paul Blinzer
IPC分类号： G06F15/16
摘要： A method, system, and computer program product are disclosed for providing improved access to accelerated processing device compute resources to user mode applications. The functionality disclosed allows user mode applications to provide commands to an accelerated processing device without the need for kernel mode transitions in order to access a unified ring buffer. Instead, applications are each provided with their own buffers, which the accelerated processing device hardware can access to process commands. With full operating system support, user mode applications are able to utilize the accelerated processing device in much the same way as a CPU.
摘要翻译： 公开了一种方法，系统和计算机程序产品，用于提供对用户模式应用的加速处理设备计算资源的改进访问。 所公开的功能允许用户模式应用程序向加速处理设备提供命令，而不需要内核模式转换以便访问统一的环形缓冲区。 相反，应用程序各自提供有自己的缓冲区，加速处理设备硬件可以访问进程命令。 通过完整的操作系统支持，用户模式应用程序能够以与CPU相同的方式利用加速处理设备。
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公开(公告)号：US09176795B2
公开(公告)日：2015-11-03
申请号：US13289304
申请日：2011-11-04
申请人： Rex McCrary , Michael Houston , Philip J. Rogers , Gongxian Jeffrey Cheng , Mark Hummel , Paul Blinzer
发明人： Rex McCrary , Michael Houston , Philip J. Rogers , Gongxian Jeffrey Cheng , Mark Hummel , Paul Blinzer
摘要： A method, system, and computer program product are disclosed for providing improved access to accelerated processing device compute resources to user mode applications. The functionality disclosed allows user mode applications to provide commands to an accelerated processing device without the need for kernel mode transitions in order to access a unified ring buffer. Instead, applications are each provided with their own buffers, which the accelerated processing device hardware can access to process commands. With full operating system support, user mode applications are able to utilize the accelerated processing device in much the same way as a CPU.
摘要翻译： 公开了一种方法，系统和计算机程序产品，用于提供对用户模式应用的加速处理设备计算资源的改进访问。 所公开的功能允许用户模式应用程序向加速处理设备提供命令，而不需要内核模式转换以便访问统一的环形缓冲区。 相反，应用程序各自提供有自己的缓冲区，加速处理设备硬件可以访问进程命令。 通过完整的操作系统支持，用户模式应用程序能够以与CPU相同的方式利用加速处理设备。
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3.发明授权System and method for synchronizing threads using shared memory having different buffer portions for local and remote cores in a multi-processor system 有权用于在多处理器系统中使用具有用于本地和远程核的不同缓冲器部分的共享存储器来同步线程的系统和方法公开(公告)号：US08832712B2
公开(公告)日：2014-09-09
申请号：US12846222
申请日：2010-07-29
CPC分类号： G06F9/522
摘要： A method of processing threads is provided. The method includes receiving a first thread that accesses a memory resource in a current state, holding the first thread, and releasing the first thread based responsive to a final thread that accesses the memory resource in the current state has been received.
摘要翻译： 提供一种处理线程的方法。 该方法包括接收当前状态的存储资源的第一线程，保持第一线程，并且响应于在当前状态访问存储器资源的最终线程已经接收到释放第一线程。
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4.发明申请Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs 审中-公开用于鼻内给予PTH或PTH或PTH类似物的灭活制剂的非活性类似物的组合物和方法公开(公告)号：US20060069021A1
公开(公告)日：2006-03-30
申请号：US11205255
申请日：2005-08-15
IPC分类号： A61K38/29
CPC分类号： C07K14/635 , A61K38/00
摘要： Pharmaceutical compositions and methods are described comprising at inactive forms or parathyroid hormone peptide (PTH) or PTH analogs wherein the inactive forms are activated upon administration into the systemic circulation. Also described is a method of preventing local reaction to a biologically active agent, preparing a formulation comprising said biologically active agent, a solubilizing agent and a surfactant, and administering such formulation by contacting said formulation with a mucosal surface.
摘要翻译： 描述了包含无活性形式或甲状旁腺激素肽（PTH）或PTH类似物的药物组合物和方法，其中所述非活性形式在施用于全身循环中时被活化。 还描述了防止对生物活性剂的局部反应，制备包含所述生物活性剂，增溶剂和表面活性剂的制剂，以及通过使所述制剂与粘膜表面接触来施用这种制剂的方法。
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公开(公告)号：US09645854B2
公开(公告)日：2017-05-09
申请号：US13287418
申请日：2011-11-02
CPC分类号： G06F9/5044 , G06T1/20
摘要： A method, system and article of manufacture for balancing a workload on heterogeneous processing devices. The method comprising accessing a memory storage of a processor of one type by a dequeuing entity associated with a processor of a different type, identifying a task from a plurality of tasks within the memory that can be processed by the processor of the different type, synchronizing a plurality of dequeuing entities capable of accessing the memory storage, and dequeuing the task form the memory storage.
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公开(公告)号：US20120192201A1
公开(公告)日：2012-07-26
申请号：US13287418
申请日：2011-11-02
IPC分类号： G06F9/52
CPC分类号： G06F9/5044 , G06T1/20
摘要： A method, system and article of manufacture for balancing a workload on heterogeneous processing devices. The method comprising accessing a memory storage of a processor of one type by a dequeuing entity associated with a processor of a different type, identifying a task from a plurality of tasks within the memory that can be processed by the processor of the different type, synchronizing a plurality of dequeuing entities capable of accessing the memory storage, and dequeuing the task form the memory storage
摘要翻译： 用于平衡异构处理设备上的工作负载的方法，系统和制品。 该方法包括通过与不同类型的处理器相关联的出队实体访问一种类型的处理器的存储器存储器，从存储器内可由不同类型的处理器处理的多个任务识别任务，同步 能够访问存储器存储器的多个出队实体，以及从该存储器存储器出来的任务
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7.发明申请Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells 审中-公开用于增强双链RNA或双链杂交核酸的转运以调节哺乳动物细胞中的基因表达的方法和组合物公开(公告)号：US20060014289A1
公开(公告)日：2006-01-19
申请号：US11107371
申请日：2005-04-15
申请人： Mohammad Ahmadian , Kunyuan Cui , Lishan Chen , Shu-Chih Chen , Michael Houston
发明人： Mohammad Ahmadian , Kunyuan Cui , Lishan Chen , Shu-Chih Chen , Michael Houston
CPC分类号： A61K45/06 , A61K31/713 , A61K38/00 , A61K47/554 , A61K48/005 , C07K14/00 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12Y302/01023
摘要： Cholesterol moieties are linked to specific ends of double-stranded RNA, preferably a small, interfering (si)RNA or to a dsHybrid. The dsHybrid has one strand comprised of DNA and one strand comprised of RNA. Preferably the sense strand is the DNA strand and the antisense strand is the RNA strand of the dsHybrid. The present invention is based upon the discovery that a cholesterol moiety, if linked to a specific end or ends of the sense or antisense strands of a siRNA, can enhance the delivery and silencing efficiency of the siRNA directed against its target message, in comparison with a corresponding, non-conjugated siRNA. Conjugated siRNAs and dsHybrids of the invention are optionally formulated with, or coordinately administered with, a secondary delivery-enhancing agent, such as a delivery-enhancing peptide, to enhance intracellular delivery and uptake of the conjugated siRNAs or dsHybrid.
摘要翻译： 胆固醇部分连接到双链RNA的特异性末端，优选小的干扰（si）RNA或dsHybrid。 dsHybrid具有由DNA组成的一条链和由RNA组成的一条链。 优选地，有义链是DNA链，反义链是dsHybrid的RNA链。 本发明基于以下发现：与siRNA的有义链或反义链的特定末端或末端连接的胆固醇部分可以提高针对其目标信息的siRNA的递送和沉默效率，与 相应的非共轭siRNA。 本发明的共轭siRNA和dsHybrids任选地与二次递送增强剂（例如递送增强肽）一起配制或配位施用，以增强缀合siRNA或dsHybrid的细胞内递送和摄取。
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公开(公告)号：US08752064B2
公开(公告)日：2014-06-10
申请号：US13307505
申请日：2011-11-30
IPC分类号： G06F13/00
CPC分类号： G06F9/544 , G06F9/522 , G06F9/546 , G06F2209/509 , G06T1/20
摘要： Provided herein is a method for optimizing communication for system calls. The method includes storing a system call for each work item in a wavefront and transmitting said stored system calls to a processor for execution. The method also includes receiving a result to each work item in the wavefront responsive to said transmitting.
摘要翻译： 这里提供了一种用于优化用于系统呼叫的通信的方法。 该方法包括将波形中的每个工作项的系统调用存储起来，并将所存储的系统调用发送到处理器进行执行。 该方法还包括响应于所述发送，将波形中的每个工作项接收结果。
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公开(公告)号：US20080096769A1
公开(公告)日：2008-04-24
申请号：US11955207
申请日：2007-12-12
申请人： Steven Quay , Douglas Badders , Richard Herman , Michael Houston , Paul Johnson
发明人： Steven Quay , Douglas Badders , Richard Herman , Michael Houston , Paul Johnson
IPC分类号： C40B30/04 , C07H21/04 , C07K14/00 , C12N1/21 , C12N7/00 , C40B40/02 , C12N7/02 , C12P21/00 , C12Q1/68
CPC分类号： C12N15/1037 , A61K38/00
摘要： Trp cage binding domains polypeptides are disclosed. The Trp cage binding domains have the generic formulae of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage display technology.
摘要翻译： 公开了Trp结构域结合域多肽。 Trp结构域具有SEQ ID NO：2，7，10或11的通式。它们可以使用噬菌体展示技术有效地生产和筛选。
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公开(公告)号：US09614784B1
公开(公告)日：2017-04-04
申请号：US14862819
申请日：2015-09-23
申请人： Michael Houston , Gabriel Perez
发明人： Michael Houston , Gabriel Perez
CPC分类号： H04L47/822 , G06F9/4887 , G06F9/50 , G06F9/5055 , G06Q10/06 , H04L43/0817 , H04L47/821 , H04L47/823 , H04L67/1008 , H04L67/1012
摘要： Techniques relate to facilitating assignments of tasks to promote efficient resource timetables. A first communication from a client device is received that corresponds to an electronic request to sue a resource to complete a task. A task type of the task and a client corresponding to the electronic request are identified. Usage data corresponding to the task type and client are identified. A task-assignment duration is defined based on the usage data and a buffer time period. An availability in a timetable of a resource that is of a duration that is at least as long as the task-assignment duration is identified. A second communication identifying a start time of the availability is transmitted to the client device. A third communication is received that accepts the start time, and a fourth communication is transmitted to a device controlling use of the resource that identifies the client, task and availability.
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