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1.发明授权Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair 有权将人间充质干细胞分化为促进心脏修复的心脏祖细胞公开(公告)号：US08431397B2
公开(公告)日：2013-04-30
申请号：US11227533
申请日：2005-09-14
申请人： Richard B Robinson , Michael R Rosen , Ira S. Cohen , Peter R. Brink , Glenn Gaudette , Irina Potapova
发明人： Richard B Robinson , Michael R Rosen , Ira S. Cohen , Peter R. Brink , Glenn Gaudette , Irina Potapova
CPC分类号： C12N5/0657
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
摘要翻译： 在体内治疗患有心脏病症的受试者的方法包括（i）诱导祖细胞在体外对心源性细胞的分化; 和（ii）向受试者施用治疗有效量的步骤（i）的心源性细胞，从而治疗受试者的心脏疾病。 本发明还提供了相关的制造和方法。
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2.发明授权公开(公告)号：US07968126B2
公开(公告)日：2011-06-28
申请号：US10584303
申请日：2004-12-22
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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3.发明授权Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA 有权通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统公开(公告)号：US07842673B2
公开(公告)日：2010-11-30
申请号：US10583369
申请日：2004-12-17
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译： 将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触 与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。
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4.发明授权公开(公告)号：US08435509B2
公开(公告)日：2013-05-07
申请号：US13109804
申请日：2011-05-17
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： The invention provides a method of creating an atrioventricular bypass tract for a heart comprising growing mesenchymal stem cells into a strip with two ends, and attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart. By this attachment, a tract is created that connects the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 本发明提供了一种创建心脏的房室旁路的方法，包括将间充质干细胞生长成具有两端的条带，并将条带的一端附接到心脏的心房上，并将带的另一端附接到 心脏心室。 通过该附件，产生将心房连接到心室的管道，以提供由窦房结产生的电信号通过管道传播并激励心室的路径。
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5.发明授权Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart 有权具有钠通道，钙通道和/或钾通道的生物旁路桥以补偿心脏中的传导阻滞公开(公告)号：US08236296B2
公开(公告)日：2012-08-07
申请号：US11490760
申请日：2006-07-21
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
摘要翻译： 本发明提供了一种旁路桥，其包括一段具有第一端和第二端的间隙连接耦合的电池，两端能够连接到心脏中的两个选定位置，以允许起搏器和/或电气 在两个位点之间的通道之间的信号/电流，其中细胞在功能上表达钠通道。 本发明还提供了制造旁路桥的相关方法，在心脏中植入其的方法，以及治疗与受试者心脏中的传导受损有关的障碍的方法。
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6.发明授权公开(公告)号：US08097650B2
公开(公告)日：2012-01-17
申请号：US11498343
申请日：2006-08-02
CPC分类号： G01N33/502 , A61K31/195 , A61K31/202 , A61K31/277 , A61K31/41 , G01N33/5061
摘要： This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of the invention the agent is a TREK-1 agonist.
摘要翻译： 本发明提供用于治疗与受试者中TASK-1的磷酸化相关的病症的方法和组合物，其包括向受试者施用一定量的有效克服由TASK-1功能引起的磷酸化依赖性损失从而由此治疗该病症的药剂。 在本发明的具体实施方案中，所述试剂是TREK-1激动剂。
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