公开(公告)号：US20060078999A1

公开(公告)日：2006-04-13

申请号：US11149632

申请日：2005-06-10

申请人： Alan Bell ,  Richard Bruce ,  Scott Elrod ,  Eric Peeters ,  Francisco Torres

发明人： Alan Bell ,  Richard Bruce ,  Scott Elrod ,  Eric Peeters ,  Francisco Torres

IPC分类号： G01K17/02

CPC分类号： B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.

摘要翻译： 用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米尺度计。 热测量设备连接到检测电子设备。 该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。 这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。 然后用检测电子元件测量在合并溶液中发生的热变化。

公开(公告)号：US20060159585A1

公开(公告)日：2006-07-20

申请号：US11037666

申请日：2005-01-18

申请人： Francisco Torres ,  Michael Chabinyc ,  Scott Elrod ,  Eric Peeters ,  Gregory Anderson ,  Alan Bell ,  Richard Bruce

发明人： Francisco Torres ,  Michael Chabinyc ,  Scott Elrod ,  Eric Peeters ,  Gregory Anderson ,  Alan Bell ,  Richard Bruce

IPC分类号： G01N25/20

CPC分类号： G01N25/482 ,  G01K17/006

摘要： A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.

摘要翻译： 检测系统包括检测装置和防蒸发装置。 检测装置包括被配置为合并至少两个小液滴并且检测由液滴的合并产生的潜在瞬态信号的区域。 防蒸发被配置为包围该区域并限制该区域的蒸发。 一种用于检测信号的方法包括以下步骤：在滴合并区域内的检测装置上沉积潜在的反应性化学溶液滴; 将防蒸发装置放置在熔融合并区域上以形成围绕滴合并区域的密封; 合并潜在的活性化学溶液滴; 并且测量在合并的溶液中发生的信号下降。

公开(公告)号：US20050254994A1

公开(公告)日：2005-11-17

申请号：US11167612

申请日：2005-06-27

申请人： Alan Bell ,  Richard Bruce ,  Eric Peeters ,  Michal Wolkin ,  Dirk Bruyker

发明人： Alan Bell ,  Richard Bruce ,  Eric Peeters ,  Michal Wolkin ,  Dirk Bruyker

IPC分类号： G01F1/68 ,  G01K1/00 ,  G01K7/30 ,  G01K17/00 ,  G01N25/20 ,  G01N25/48 ,  G01N27/00

CPC分类号： G01K7/30 ,  G01K17/00 ,  G01N25/482

摘要： Thermal sensing devices can include two subsets of thermal sensors connected in a bridge by circuitry on the same support layer or surface with the sensors. Each thermal sensor can be formed in a patterned layer of semiconductor material, and the bridge circuitry can include leads formed in a patterned layer of conductive material, over or under the semiconductor layer. In one implementation, the bridge circuitry includes conductive portions that extend across and electrically contact the lower surface of each sensor's semiconductor slab. The bridge circuitry can also include pads that can be electrically contacted, such as by pogo pins. The device's reaction surface can be spaced apart from or over the thermal sensors. The device's components can be shaped and positioned so that the bridge's offset voltage is below the sensitivity level required for an application, such as by left-right symmetry about an axis.

摘要翻译： 热感测装置可以包括通过与传感器相同的支撑层或表面上的电路在桥中连接的两个热传感器子集。 每个热传感器可以形成在半导体材料的图案化层中，并且桥接电路可以包括形成在导电材料的图案化层中的引线，在半导体层之上或之下。 在一个实施方式中，桥接电路包括导电部分，其延伸并且电接触每个传感器的半导体板的下表面。 桥接电路还可以包括可以电接触的焊盘，例如通过弹簧销。 设备的反应表面可以与热传感器间隔开或超过热传感器。 该装置的部件可以被成形和定位，使得桥的偏移电压低于应用所需的灵敏度水平，例如通过关于轴的左右对称。

公开(公告)号：US20050265898A1

公开(公告)日：2005-12-01

申请号：US11167635

申请日：2005-06-27

申请人： Alan Bell ,  Richard Bruce ,  Eric Peeters

发明人： Alan Bell ,  Richard Bruce ,  Eric Peeters

IPC分类号： G01F1/68 ,  G01K1/00 ,  G01K7/30 ,  G01K17/00 ,  G01N25/20 ,  G01N25/48 ,  G01N27/00

CPC分类号： G01K7/30 ,  B82Y15/00 ,  G01K17/00 ,  G01N25/482 ,  G01N25/4846 ,  G01N25/4866

摘要： Thermal detectors and thermal sensing cells can include a region of a support layer or support structure. Within the region can be reaction surfaces or other reaction regions, as well as contact pads and circuitry connecting the contact pads to other components. Also, a cell region can include a structure with reaction regions, contact pads, and control/detection circuitry connected to the contact pads; the control/detection circuitry controls occurrence of reactions in response to control signals, such as by drop merging, and also allows electrical detection of thermal signals from the reaction regions. The control/detection circuitry can include reaction control components such as drop merger electrodes and also thermal sensors such as thermistors, or it can include control/sensor elements such as semiconductor slabs that perform both functions. Each cell in an array can have control/detection circuitry that does not extend or connect outside the cell except through contact pads.

摘要翻译： 热检测器和热感测单元可以包括支撑层或支撑结构的区域。 该区域内可以是反应表面或其它反应区域，以及接触焊盘和将接触焊盘连接到其它部件的电路。 此外，电池区域可以包括具有反应区域，接触焊盘和连接到接触焊盘的控制/检测电路的结构; 控制/检测电路控制响应于控制信号的反应的发生，例如通过下降合并，并且还允许来自反应区域的热信号的电检测。 控制/检测电路可以包括反应控制部件，例如液滴合并电极和热敏传感器，例如热敏电阻，或者它可以包括执行这两个功能的控制/传感器元件，例如半导体板。 阵列中的每个单元都可以具有控制/检测电路，除了通过接触焊盘之外，它们不会扩展或连接到电池外部。

公开(公告)号：US20050112766A1

公开(公告)日：2005-05-26

申请号：US10719961

申请日：2003-11-21

申请人： Richard Bruce ,  Francisco Torres ,  Alan Bell ,  Eric Peeters

发明人： Richard Bruce ,  Francisco Torres ,  Alan Bell ,  Eric Peeters

IPC分类号： B01J19/00 ,  C40B50/08 ,  G01N25/48 ,  G01N37/00 ,  G01N31/10

CPC分类号： G01N25/4866 ,  B01J2219/00599 ,  B01J2219/00702 ,  C40B50/08 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

摘要： A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.

摘要翻译： 公开了用于高通量筛选测定样品制备和用于鉴定药物靶标和文库化合物之间的结合的测试的方法，用于测量结合反应焓的量热器件。 该方法包括将文库化合物与指定溶剂混合，并将目标化合物溶液与第二指定溶剂混合在量热装置上。 文库化合物/溶剂与目标化合物/溶剂溶液合并，文库化合物/溶剂溶液也与量热装置上的第三溶剂溶液合并。 对于两个合并的溶液检测反应热，并进行比较。

公开(公告)号：US5442467A

公开(公告)日：1995-08-15

申请号：US215454

申请日：1994-03-21

申请人： Louis D. Silverstein ,  Thomas G. Fiske ,  Richard Bruce ,  Robert A. Sprague

发明人： Louis D. Silverstein ,  Thomas G. Fiske ,  Richard Bruce ,  Robert A. Sprague

IPC分类号： G02B6/00 ,  G02B6/08 ,  G02F1/1335 ,  G02F1/13357

CPC分类号： G02B6/08 ,  G02F1/133514 ,  G02F1/133524 ,  G02F1/133604 ,  Y10S385/901

摘要： A transmissive, backlit color twisted-nematic or super-twisted-nematic liquid crystal display employing a front fiber-optic faceplate as a front retaining element of a liquid crystal cell that increases viewing angle between the display and a viewer while minimizing or eliminating undesirable variations in luminance, contrast ratio and chromaticity is described. This novel configuration effectively decouples the liquid crystal cell and other optical elements behind the front fiber optic faceplate from the angular orientation of the viewer with respect to the display. The liquid crystal display described in this invention further provides a high quality color display, without viewing parallax, using a color selection filter mosaic outside of the liquid crystal cell. The display also increases luminous efficiency and improves color saturation by concentrating the transmission of available backlight illumination through the use of a rear fiber-optic faceplate and a second rear-mounted mosaic of color interference filters.

摘要翻译： 使用前光纤面板作为液晶单元的前保持元件的透射式背光彩色扭曲向列或超扭曲向列型液晶显示器，其在最小化或消除不期望的变化的同时增加显示器和观看者之间的视角 描述了亮度，对比度和色度。 这种新颖的配置有效地将液晶单元和前光纤面板后面的其它光学元件与观看者相对于显示器的角度定向分离。 在本发明中描述的液晶显示器还使用液晶单元外部的选色滤光片马赛克，提供了不观看视差的高质量彩色显示器。 该显示器还通过使用后部光纤面板和第二个后置安装的彩色干涉滤光片马赛克集中可用背光照明的透射来提高发光效率并提高色彩饱和度。

公开(公告)号：US5196652A

公开(公告)日：1993-03-23

申请号：US633923

申请日：1990-12-26

申请人： James C. Mikkelsen, Jr. ,  William Meuli ,  Richard Bruce ,  Jackson Ho

发明人： James C. Mikkelsen, Jr. ,  William Meuli ,  Richard Bruce ,  Jackson Ho

IPC分类号： G09F9/00 ,  G09F9/35 ,  G09F9/40 ,  H01R4/02 ,  H01R4/04 ,  H01R12/52 ,  H05K1/11 ,  H05K1/14 ,  H05K3/32 ,  H05K3/34 ,  H05K3/36

CPC分类号： H05K1/142 ,  G09F9/35 ,  H01R12/52 ,  H05K3/3405 ,  H05K3/36 ,  H01R4/02 ,  H05K1/117 ,  H05K2201/09154 ,  H05K2203/049 ,  H05K3/321 ,  H05K3/328 ,  Y10T29/49149

摘要： A method for electrically connecting planar element substrates (12) to form an array (10) by forming conductive bridges (16) between metal pads (14) located on the surface of array elements (12). These bridges (16) are designed to transmit or receive visual, acoustical or other electromagnetic data and power. The conductive bridges (16) are formed to be nearly coplanar with the planar elements (12) and are made to connect the edges (14b) of pads (14) which are fused to the planar substrate (12). Metal wire (16a), solder (16b-c), a conductive polymer (16d), or a suspension of conductive particles in paste (16e) are used to bridge and electrically connect the pads (14) located on the array elements (12). The bridges (16) have a low profile, occupy a very small area and reduce the need for highly accurate alignment of adjacent substrates (12) within the tiled array (10) before electrical connections are formed. These low profile bridges (16) are especially advantageous in that they allow a protective plastic or similar cover sheet, or a liquid crystal laminate to be surface mounted on the composite array (10) without causing detrimental surface blemishes or ridges. The small area of the bridges (16) greatly reduces the non-transmitting area of the visual display. The bridges (16), being substantially narrower than the pads (14) which they connect, are more likely to connect the intended pads (14) and less likely to "short" pads (14) which are not in accurate alignment.

公开(公告)号：US20060123462A1

公开(公告)日：2006-06-08

申请号：US11004748

申请日：2004-12-02

申请人： Teresa Lunt ,  Daniel Greene ,  Philippe Golle ,  Richard Bruce ,  Jessica Staddon

发明人： Teresa Lunt ,  Daniel Greene ,  Philippe Golle ,  Richard Bruce ,  Jessica Staddon

IPC分类号： H04L9/00

CPC分类号： H04L63/0421 ,  H04L63/102

摘要： Techniques for protecting non-public information in a mobile environment are provided. A request for non-public information about users in a mobile environment is received. Privacy policies, non-public and optional public information about the users affected by the request are determined. An optional privacy impact indicator is determined based on how satisfying the request increases the current public information about the users. Crowds of users having similar attribute name/values are optionally determined. User and optional requestor privacy policies which associate threshold release criteria such minimum crowd size, minimum consideration with the non-public information are determined. A privacy agreement is reached for the disclosure of the requested non-public information based on the compatibility of the requester and user privacy policies. Privacy protecting transformations are optionally determined and applied to create crowds or groups associated with the requested attribute.

摘要翻译： 提供了在移动环境中保护非公开信息的技术。 接收到关于用户在移动环境中的非公开信息的请求。 确定关于受请求影响的用户的隐私政策，非公开和可选的公开信息。 可选的隐私影响指标是根据请求如何满足当前有关用户的公开信息来确定的。 具有相似属性名称/值的用户群可以任选地确定。 用户和可选择的请求者隐私策略，其将阈值释放标准与最小人群大小，最小考虑与非公开信息相关联。 根据请求者和用户隐私政策的兼容性，达成了所要求的非公开信息披露的隐私协议。 可选地确定并应用隐私保护转换以创建与所请求的属性相关联的人群或组。

公开(公告)号：US20060038120A1

公开(公告)日：2006-02-23

申请号：US10921556

申请日：2004-08-19

申请人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

发明人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

IPC分类号： H01J49/00

CPC分类号： B03C1/253

摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.

摘要翻译： 公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。 样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。 还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

公开(公告)号：US20050254552A1

公开(公告)日：2005-11-17

申请号：US11167746

申请日：2005-06-27

申请人： Richard Bruce ,  Dirk De Bruyker ,  Francisco Torres ,  Michal Wolkin

发明人： Richard Bruce ,  Dirk De Bruyker ,  Francisco Torres ,  Michal Wolkin

IPC分类号： G01F1/68 ,  G01K1/00 ,  G01K7/30 ,  G01K17/00 ,  G01N25/20 ,  G01N25/48 ,  G01N27/00

CPC分类号： G01K7/30 ,  G01K17/00 ,  G01K17/006 ,  G01N25/482

摘要： In thermal sensing devices, such as for calorimetry, a support layer or central layer can have a thermometer element or other thermal sensor on one side and a thermally conductive structure or component on the other. The thermally conductive structure can conduct temperature or other thermal input signals laterally across the support layer or central layer. The temperature or signals can then be provided to the thermometer element, such as by thermal contact through the support layer. An electrically conducting, thermally isolating anti-coupling layer, such as of gold or chromium, can reduce capacitive coupling between the thermally conductive structure and the thermometer element or other thermal sensor.

摘要翻译： 在诸如用于量热法的热感测装置中，支撑层或中心层可以在一侧具有温度计元件或其它热传感器，而在另一侧可以具有导热结构或部件。 导热结构可以横跨支撑层或中心层横向传导温度或其他热输入信号。 然后可以将温度或信号提供给温度计元件，例如通过通过支撑层的热接触。 导电的，热隔离的抗耦合层（例如金或铬）可以减少导热结构和温度计元件或其它热传感器之间的电容耦合。