公开(公告)号：US20070224683A1

公开(公告)日：2007-09-27

申请号：US11698084

申请日：2007-01-26

申请人： Richard Clarke ,  M. Womble

发明人： Richard Clarke ,  M. Womble

IPC分类号： G01N35/10 ,  G01J3/44

CPC分类号： G01N21/65 ,  G01N21/658 ,  G01N21/8483 ,  Y10T436/112499

摘要： The invention provides diagnostic apparatuses that are advantageously adapted for the Raman spectroscopic analysis of fluid samples, such as biological fluid samples, deposited on test strip substrates. The tests strips may be include a surface-enhanced Raman spectroscopy (SERS) surface for deposition and analysis of a sample and/or may be lateral flow binding assay type test strips.

摘要翻译： 本发明提供了有利地适用于沉积在测试条基材上的流体样品（例如生物流体样品）的拉曼光谱分析的诊断装置。 测试条可以包括用于样品沉积和分析的表面增强拉曼光谱（SERS）表面和/或可以是侧向流动结合测定型测试条。

公开(公告)号：US20060176478A1

公开(公告)日：2006-08-10

申请号：US11054379

申请日：2005-02-09

申请人： Richard Clarke ,  M. Womble

发明人： Richard Clarke ,  M. Womble

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/10 ,  G01N21/65 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2021/8528 ,  G01N2201/08

摘要： Methods and apparatus for analysis of a sample using Raman spectroscopy, which employs a multi-mode radiation source and a spectral filter, are disclosed. The source radiation produces a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The resulting spectroscopic data has higher resolution and stability than conventional low-resolution Raman systems.

摘要翻译： 公开了采用多模式辐射源和光谱滤波器的拉曼光谱分析样品的方法和装置。 源辐射产生由散射电磁辐射组成的拉曼光谱，其通过分散元件分离成不同的波长分量。 检测阵列检测散射光的至少一些波长分量，并向处理器提供数据以处理数据。 所得到的光谱数据具有比常规低分辨率拉曼系统更高的分辨率和稳定性。

公开(公告)号：US20080064120A1

公开(公告)日：2008-03-13

申请号：US11698083

申请日：2007-01-26

申请人： Richard Clarke ,  M. Womble

发明人： Richard Clarke ,  M. Womble

IPC分类号： G01N33/558 ,  G01N21/65

CPC分类号： G01N33/558 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/585

摘要： The invention provides improved Raman spectroscopy-based methods and systems for the quantitative analysis of selected analytes using lateral flow binding assay test strips.

摘要翻译： 本发明提供了改进的基于拉曼光谱的方法和系统，用于使用侧向流动结合测定试片对所选分析物进行定量分析。

公开(公告)号：US20060240401A1

公开(公告)日：2006-10-26

申请号：US11340712

申请日：2006-01-27

申请人： Richard Clarke ,  M. Womble

发明人： Richard Clarke ,  M. Womble

IPC分类号： C12Q1/00 ,  C12M1/34 ,  A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2562/0295 ,  G01N21/65 ,  G01N21/658 ,  G01N21/8483 ,  G01N33/52 ,  G01N2021/656

摘要： Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects at least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the body fluid sample.

摘要翻译： 公开了使用低分辨率拉曼光谱法体外检测体液样品中分析物的方法和装置。 体液分析仪包括用于接收目标区域上的体液样本的一次性条，所述目标区域包括金溶胶 - 凝胶以提供表面增强的拉曼散射。 光源照射目标区域以产生由分散元件分离成不同波长分量的散射电磁辐射组成的拉曼光谱。 检测阵列检测散射光的至少一些波长分量，并向处理器提供数据以处理数据。 处理数据的结果显示在屏幕上以通知用户体液样品内的分析物。

公开(公告)号：US20060166302A1

公开(公告)日：2006-07-27

申请号：US10905956

申请日：2005-01-27

申请人： Richard Clarke ,  M. Womble

发明人： Richard Clarke ,  M. Womble

IPC分类号： G06F19/00 ,  C12Q1/26

CPC分类号： G01N21/65 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2562/0295 ,  G01N21/658 ,  G01N21/8483 ,  G01N2021/656

摘要： Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the blood sample.

公开(公告)号：US20050171436A1

公开(公告)日：2005-08-04

申请号：US10754158

申请日：2004-01-09

申请人： Richard Clarke ,  M. Womble

发明人： Richard Clarke ,  M. Womble

IPC分类号： A61B5/00 ,  A61B6/00 ,  A61B5/05

CPC分类号： A61B5/0084 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/4839

摘要： The present invention provides low-resolution Raman spectroscopic systems and methods for in situ monitoring of drug-eluting devices in a lumen of a subject. A preferred system can employ multi-mode radiation in making in situ Raman spectroscopic measurements of the lumen and/or device. For example, a system can include a light source such as a multi-mode laser, and a light detector to measure spectral patterns and differentiates spectral features of drugs released in a target region. Drug-release curves can be extrapolated or otherwise predicted using the Raman spectrum taken during or subsequent to device insertion and/or activation.

摘要翻译： 本发明提供了低分辨率拉曼光谱系统和用于在受试者的管腔中原位监测药物洗脱装置的方法。 优选的系统可以采用多模辐射来进行管腔和/或器件的原位拉曼光谱测量。 例如，系统可以包括诸如多模式激光器的光源和用于测量光谱图案的光检测器并且区分在目标区域中释放的药物的光谱特征。 可以使用在装置插入和/或激活期间或之后进行的拉曼光谱推断或预测药物释放曲线。