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1.发明授权Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases 有权使用核苷化合物进行无意义抑制和遗传性疾病的治疗公开(公告)号：US07449570B2
公开(公告)日：2008-11-11
申请号：US11048659
申请日：2005-01-21
IPC分类号： A61K31/7008 , A61K31/7028 , C07H5/04 , C07H7/06
CPC分类号： A61K31/506 , A61K31/7072 , C07H19/00
摘要： The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括核苷化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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2.发明授权Use of Acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease 失效使用乙酰氨基苯甲酸化合物进行无味抑制和治疗疾病公开(公告)号：US07763656B2
公开(公告)日：2010-07-27
申请号：US11789625
申请日：2007-04-24
申请人： Richard G. Wilde , Ellen M. Welch , James Jan Takasugi , Neil G. Almstead , Steven Marc Rubenstein , Holger Beckmann
发明人： Richard G. Wilde , Ellen M. Welch , James Jan Takasugi , Neil G. Almstead , Steven Marc Rubenstein , Holger Beckmann
IPC分类号： A61K31/19
CPC分类号： C07C235/24 , C07C235/74 , C07C323/60 , C07C327/42 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D207/273 , C07D209/48 , C07D213/74 , C07D239/38 , C07D257/04 , C07D271/10 , C07D317/64
摘要： Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型乙酰氨基苯甲酸化合物，使用方法和包含乙酰氨基苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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3.发明授权Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权乙酰氨基苯甲酸化合物及其用于无意义抑制和治疗疾病公开(公告)号：US07247741B2
公开(公告)日：2007-07-24
申请号：US11048657
申请日：2005-01-21
申请人： Richard G. Wilde , Ellen M. Welch , James Jan Takasugi , Neil G. Almstead , Steven Marc Rubenstein , Holger Beckmann
发明人： Richard G. Wilde , Ellen M. Welch , James Jan Takasugi , Neil G. Almstead , Steven Marc Rubenstein , Holger Beckmann
IPC分类号： C07C229/00 , C07C205/00
CPC分类号： C07C235/24 , C07C235/74 , C07C323/60 , C07C327/42 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D207/273 , C07D209/48 , C07D213/74 , C07D239/38 , C07D257/04 , C07D271/10 , C07D317/64
摘要： Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型乙酰氨基苯甲酸化合物，使用方法和包含乙酰氨基苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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4.发明申请METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH 有权从具有非扩散性突变的DNA生产功能性蛋白质的方法和与之相关的疾病的治疗方法公开(公告)号：US20110046136A1
公开(公告)日：2011-02-24
申请号：US12294952
申请日：2007-03-29
申请人： Neil G. Almstead , Guangming Chen , Hirawat Samit , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
发明人： Neil G. Almstead , Guangming Chen , Hirawat Samit , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
IPC分类号： A61K31/4245 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/4439 , A61K31/519 , A61K31/498 , A61K31/53 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/433 , A61K31/421 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/42 , A61K31/4164 , A61K31/34 , A61K31/381 , A61K31/4196 , A61P21/00 , A61P11/00 , A61P7/00 , A61P25/00 , A61P13/12 , A61P27/02
CPC分类号： A61K31/4245 , A61K31/00 , A61K31/40 , A61K31/41 , A61K31/4162 , A61K31/44 , A61K31/46
摘要： The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
摘要翻译： 本发明涉及由包含无义突变的核酸序列编码的功能性蛋白质。 本发明还涉及用于产生由包含无义突变的核酸序列编码的功能性蛋白质的方法以及用于预防，管理和/或治疗与基因中的无义突变有关的疾病的这些蛋白质的用途。
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5.发明授权Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations 有权核苷化合物及其用于治疗与体细胞突变相关的癌症和疾病的用途公开(公告)号：US07291603B2
公开(公告)日：2007-11-06
申请号：US10625059
申请日：2003-07-22
申请人： Richard G. Wilde , Paul D. Kennedy , Neil G. Almstead , Ellen M. Welch , James J. Takasugi , Westley J. Friesen
发明人： Richard G. Wilde , Paul D. Kennedy , Neil G. Almstead , Ellen M. Welch , James J. Takasugi , Westley J. Friesen
IPC分类号： A61K31/706
CPC分类号： C07H19/00
摘要： The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括核苷化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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6.发明申请HYDROXYLATED 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS, COMPOSITIONS THEREOF AND THEIR USE IN BIOASSAYS 有权羟基苯氧基-1,2,4-氧杂二苯甲酸化合物，其组合物及其在生物利用中的应用公开(公告)号：US20120087896A1
公开(公告)日：2012-04-12
申请号：US13327816
申请日：2011-12-16
IPC分类号： A61K35/76 , A61K35/12 , A61K35/74 , A61P3/10 , A61P35/00 , A61P11/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P25/00 , A61P3/04 , C12Q1/68 , A61P9/00
CPC分类号： A61K31/4245 , C07D271/06
摘要： Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型羟基化的1,2,4-恶二唑苯甲酸化合物，使用方法和包含羟基化的1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变改善的疾病或改善与其相关的一种或多种症状的方法。
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7.发明申请Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression 有权羟基化的1,2,4-恶二唑苯甲酸化合物及其组合物，以及废物抑制的用途公开(公告)号：US20080139632A1
公开(公告)日：2008-06-12
申请号：US11904001
申请日：2007-09-24
IPC分类号： A61K31/4245 , C12N5/06 , C12N5/08 , A61P35/00 , C07D271/06
CPC分类号： A61K31/4245 , C07D271/06
摘要： Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型羟基化的1,2,4-恶二唑苯甲酸化合物，使用方法和包含羟基化的1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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8.发明授权Hydroxylated 1,2,4-oxadiazole benzoic acid compounds and compositions thereof 有权羟基化的1,2,4-恶二唑苯甲酸化合物及其组合物公开(公告)号：US08101641B2
公开(公告)日：2012-01-24
申请号：US11904001
申请日：2007-09-24
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： A61K31/4245 , C07D271/06
摘要： Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型羟基化的1,2,4-恶二唑苯甲酸化合物，使用方法和包含羟基化的1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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9.发明授权Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and their use in bioassays 有权羟基化的1,2,4-恶二唑苯甲酸化合物，其组合物及其在生物测定中的用途公开(公告)号：US08691511B2
公开(公告)日：2014-04-08
申请号：US13327816
申请日：2011-12-16
IPC分类号： C12Q1/68 , C07D271/06 , A61K31/41 , C12P21/04
CPC分类号： A61K31/4245 , C07D271/06
摘要： Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型羟基化的1,2,4-恶二唑苯甲酸化合物，使用方法和包含羟基化的1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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10.发明申请UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE 有权UREIDO替代苯甲酸化合物及其用于非感染抑制和疾病治疗的用途公开(公告)号：US20080275233A1
公开(公告)日：2008-11-06
申请号：US12140641
申请日：2008-06-17
IPC分类号： C07D295/00 , C07D233/02 , C07D403/02
CPC分类号： C07D285/16 , A61K31/17 , A61K31/4166 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/426 , C07C275/42 , C07D233/32 , C07D233/42 , C07D233/72 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/06 , C07D409/04
摘要： The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括脲基取代的苯甲酸化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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