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公开(公告)号：US08338498B2
公开(公告)日：2012-12-25
申请号：US12708019
申请日：2010-02-18
IPC分类号： C08L75/04
摘要： A bone defect filler for implantation in a bone defect of a patient includes a particulate polymer distributed within a polymeric binder. The particulate polymer includes a plurality of particles, which may have substantially the same material composition as the polymeric binder. The particles of the particulate polymer may be formed in a variety of shapes and/or sizes to provide the bone defect filler with improved pore interconnectivity, material expansion and contamination characteristics, while maintaining sufficient mechanical strength and handling characteristics for bone repair applications. The bone defect filler also provides the flexibility to be molded or shaped in situ to fill the bone defect.
摘要翻译： 用于植入患者骨缺损的骨缺损填料包括分布在聚合物粘合剂内的颗粒聚合物。 颗粒聚合物包括多个颗粒，其可以具有与聚合物粘合剂基本相同的材料组成。 颗粒状聚合物的颗粒可以以各种形状和/或尺寸形成，以提供具有改善的孔互连性，材料膨胀和污染特性的骨缺损填料，同时保持骨修复应用的足够的机械强度和处理特性。 骨缺损填料还提供在原位成型或成形以填充骨缺损的柔性。
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公开(公告)号：US20110201704A1
公开(公告)日：2011-08-18
申请号：US12962161
申请日：2010-12-07
IPC分类号： C08J9/00 , C09J175/04
CPC分类号： C08G18/10 , A61L27/48 , A61L27/56 , A61L2430/02 , C08G18/7664 , C08J9/0085 , C08J9/24 , C08J9/33 , C08J2375/04 , C08J2475/04 , C08L75/04 , C08G18/36
摘要： A bone defect filler for implantation in a bone defect of a patient includes a particulate polymer distributed within a polymeric binder. The particulate polymer includes a plurality of particles, which may have substantially the same material composition as the polymeric binder. The particles of the particulate polymer may be formed in a variety of shapes and/or sizes to provide the bone defect filler with improved pore interconnectivity, material expansion and contamination characteristics, while maintaining sufficient mechanical strength and handling characteristics for bone repair applications. The bone defect filler also provides the flexibility to be molded or shaped in situ to fill the bone defect.
摘要翻译： 用于植入患者骨缺损的骨缺损填料包括分布在聚合物粘合剂内的颗粒聚合物。 颗粒聚合物包括多个颗粒，其可以具有与聚合物粘合剂基本相同的材料组成。 颗粒状聚合物的颗粒可以以各种形状和/或尺寸形成，以提供具有改善的孔互连性，材料膨胀和污染特性的骨缺损填料，同时保持骨修复应用的足够的机械强度和处理特性。 骨缺损填料还提供在原位成型或成形以填充骨缺损的柔性。
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公开(公告)号：US20110201711A1
公开(公告)日：2011-08-18
申请号：US12708019
申请日：2010-02-18
IPC分类号： C08L75/12
摘要： A bone defect filler for implantation in a bone defect of a patient includes a particulate polymer distributed within a polymeric binder. The particulate polymer includes a plurality of particles, which may have substantially the same material composition as the polymeric binder. The particles of the particulate polymer may be formed in a variety of shapes and/or sizes to provide the bone defect filler with improved pore interconnectivity, material expansion and contamination characteristics, while maintaining sufficient mechanical strength and handling characteristics for bone repair applications. The bone defect filler also provides the flexibility to be molded or shaped in situ to fill the bone defect.
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公开(公告)号：US20120065641A1
公开(公告)日：2012-03-15
申请号：US12881626
申请日：2010-09-14
IPC分类号： A61B17/58 , A61K31/765 , A61P19/08 , A61K31/74
CPC分类号： A61K31/74 , A61B17/68 , A61B17/823 , A61K31/765
摘要： A bone repair apparatus includes a partially polymerized biocompatible adhesive provided in a state wherein polymerization of the biocompatible adhesive is substantially suspended. A method for repairing a bone defect includes preparing the biocompatible adhesive, suspending polymerization of the biocompatible adhesive prior to full cure, delivering the biocompatible adhesive to the bone defect while polymerization is substantially suspended and accelerating polymerization of the biocompatible adhesive to achieve full cure. The method provides an implanted biocompatible adhesive with a malleable osteoconductive structure without compromising the physical characteristics of the biocompatible adhesive, thereby improving handling and delivery of the bone adhesive.
摘要翻译： 骨修复装置包括在生物相容性粘合剂的聚合基本上悬浮的状态下提供的部分聚合的生物相容性粘合剂。 修复骨缺损的方法包括制备生物相容性粘合剂，在完全固化之前悬浮生物相容性粘合剂的聚合，将生物相容性粘合剂递送至骨缺损，同时聚合基本上悬浮并促进生物相容性粘合剂的聚合以实现完全固化。 该方法提供了具有可延展的骨传导结构的植入的生物相容性粘合剂，而不损害生物相容性粘合剂的物理特性，从而改善骨粘合剂的处理和递送。
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公开(公告)号：US08337497B2
公开(公告)日：2012-12-25
申请号：US12575060
申请日：2009-10-07
申请人： Richard J. Deslauriers , Eric Kolb
发明人： Richard J. Deslauriers , Eric Kolb
CPC分类号： A61B17/00491 , A61B17/68 , A61B17/8076 , A61B17/823 , A61B17/8805
摘要： A method for sternal closure of a separated sternum includes applying an adhesive to a portion of an incision between at least a first sternum portion and at least a second sternum portion and maintaining the first sternum portion proximate to the second sternum portion until the adhesive has bonded with the first sternum portion and the second sternum portion. The adhesive may be applied over substantially the entire length of the incision or may be applied in intervals. The method for sternal closure may also include compressing the first sternum portion and the second sternum portion together using one or more compression devices and introducing adhesive to contact regions where the compressive devices contact the sternum. The method may also include cutting an interface feature in the first and second sternum portions or spanning the incision between the first and second interface portions with a structural support.
摘要翻译： 分离胸骨的胸骨封闭的方法包括在至少第一胸骨部分和至少第二胸骨部分之间的切口部分上施加粘合剂，并且将第一胸骨部分保持靠近第二胸骨部分直到粘合剂粘合 具有第一胸骨部分和第二胸骨部分。 粘合剂可以在切口的基本上整个长度上施用，或者可以间隔地施用。 用于胸骨闭合的方法还可以包括使用一个或多个压缩装置将第一胸骨部分和第二胸骨部分压缩在一起，并将粘合剂引入压缩装置接触胸骨的接触区域。 该方法还可以包括切割第一和第二胸骨部分中的界面特征，或者用结构支撑物跨越第一和第二界面部分之间的切口。
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公开(公告)号：US20110012280A1
公开(公告)日：2011-01-20
申请号：US12502635
申请日：2009-07-14
IPC分类号： B29C67/20
CPC分类号： B29C44/04 , A61B5/064 , A61B90/39 , A61B2090/3945 , A61B2090/3983 , A61B2090/3987 , A61B2090/3991 , A61B2090/3995 , A61F2/442 , A61F2/4465 , A61F2/447 , A61F9/0136 , A61F2002/30006 , A61F2002/30011 , A61F2002/30056 , A61F2002/3008 , A61F2002/30448 , A61F2002/30594 , A61F2002/30617 , A61F2002/30619 , A61F2002/30772 , A61F2002/30774 , A61F2002/30795 , A61F2002/30797 , A61F2002/30904 , A61F2002/3093 , A61F2002/30957 , A61F2002/30971 , A61F2002/3266 , A61F2002/4629 , A61F2220/005 , A61F2250/0015 , A61F2250/0023 , A61F2250/0032 , A61F2250/0096 , A61F2250/0097 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , B29C44/1214 , B29C44/3403
摘要： A multi-density polymeric interbody spacer formed from biocompatible material for osteoconductivity includes multiple density regions of different porosity to provide both strength and osteoconductivity. An interface region is formed between the density regions to provide both direct adhesion and mechanical interlocking between the different density regions to increase the strength of the multi-density polymeric interbody spacer. A method for forming the multi-density polymeric interbody spacer includes curing a first density region to achieve a first target porosity. A second density region may then be molded to the first density region to achieve a second target porosity. A portion of the second density region partially flows into pores of the first density region, providing direct adhesion and mechanical interlocking between the first and second density regions.
摘要翻译： 由用于骨传导性的生物相容性材料形成的多密度聚合物体间间隔物包括具有不同孔隙率的多个密度区域以提供强度和骨传导性。 在密度区域之间形成界面区域，以提供不同密度区域之间的直接粘合和机械互锁，以增加多密度聚合物体间间隔物的强度。 用于形成多密度聚合物体间间隔物的方法包括固化第一密度区域以实现第一目标孔隙度。 然后可以将第二密度区域模制到第一密度区域以实现第二目标孔隙度。 第二密度区域的一部分部分地流入第一密度区域的孔，从而提供第一和第二密度区域之间的直接粘合和机械互锁。
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公开(公告)号：US20110082498A1
公开(公告)日：2011-04-07
申请号：US12575060
申请日：2009-10-07
申请人： Richard J. Deslauriers , Eric Kolb
发明人： Richard J. Deslauriers , Eric Kolb
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/68 , A61B17/8076 , A61B17/823 , A61B17/8805
摘要： A method for sternal closure of a separated sternum includes applying an adhesive to a portion of an incision between at least a first sternum portion and at least a second sternum portion and maintaining the first sternum portion proximate to the second sternum portion until the adhesive has bonded with the first sternum portion and the second sternum portion. The adhesive may be applied over substantially the entire length of the incision or may be applied in intervals. The method for sternal closure may also include compressing the first sternum portion and the second sternum portion together using one or more compression devices and introducing adhesive to contact regions where the compressive devices contact the sternum. The method may also include cutting an interface feature in the first and second sternum portions or spanning the incision between the first and second interface portions with a structural support.
摘要翻译： 分离胸骨的胸骨封闭的方法包括在至少第一胸骨部分和至少第二胸骨部分之间的切口部分上施加粘合剂，并且将第一胸骨部分保持靠近第二胸骨部分直到粘合剂粘合 具有第一胸骨部分和第二胸骨部分。 粘合剂可以在切口的基本上整个长度上施用，或者可以间隔地施用。 用于胸骨闭合的方法还可以包括使用一个或多个压缩装置将第一胸骨部分和第二胸骨部分压缩在一起，并将粘合剂引入压缩装置接触胸骨的接触区域。 该方法还可以包括切割第一和第二胸骨部分中的界面特征，或者用结构支撑物跨越第一和第二界面部分之间的切口。
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公开(公告)号：US20110082497A1
公开(公告)日：2011-04-07
申请号：US12862191
申请日：2010-08-24
申请人： Richard J. Deslauriers , Eric Kolb
发明人： Richard J. Deslauriers , Eric Kolb
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/68 , A61B17/8076 , A61B17/823 , A61B17/8805 , A61B17/8811
摘要： A method for closing a sternum separated into at least a first sternum portion and a second sternum portion includes preparing at least one cut surface of at least one of the first or second sternum portions to have an adhesive applied thereon. The adhesive is applied to at least a portion of the at least one cut surface. The at least one cut surface is approximated to a second cut surface of the other of the first sternum portion or second sternum portion. As the adhesive cures, it bonds with the first cut surface and the second cut surface. Preparing the at least one cut surface may remove contaminants that could inhibit adhesion of the adhesive. The adhesive may be applied through adhesive injection holes formed along an incision separating the first and second sternum portions. Devices for preparing the cut surfaces and applying the adhesive are also provided.
摘要翻译： 用于封闭分为至少第一胸骨部分和第二胸骨部分的胸骨的方法包括制备第一或第二胸骨部分中的至少一个的至少一个切割表面以在其上施加粘合剂。 将粘合剂施加到至少一个切割表面的至少一部分。 至少一个切割表面近似于第一胸骨部分或第二胸骨部分中另一个的第二切割表面。 当粘合剂固化时，它与第一切割表面和第二切割表面结合。 制备至少一个切割表面可以去除可能抑制粘合剂粘附的污染物。 可以通过沿着分开第一和第二胸骨部分的切口形成的粘合剂注入孔来施加粘合剂。 还提供了用于制备切割表面和施加粘合剂的装置。
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公开(公告)号：US08852199B2
公开(公告)日：2014-10-07
申请号：US12852260
申请日：2010-08-06
CPC分类号： A61B17/00491 , A61B42/20
摘要： A bone adhesive application device has a pliable structure with an application surface upon which a bone adhesive may be applied. The application surface has a surface energy substantially equal to or less than a surface energy of the bone adhesive to reduce adhesion between the bone adhesive and the bone adhesive application device. The bone adhesive application device may be included in a kit for repairing bone defects having a bone adhesive formed from a reactive biocompatible polyurethane material. The bone adhesive may be applied to a bone defect by positioning the pliable structure over at least a portion of the bone defect, delivering the bone adhesive to the bone defect and removing the pliable structure from the bone adhesive.
摘要翻译： 骨粘合剂施用装置具有柔韧的结构，其上具有施用表面，可以在其上施用骨粘合剂。 施用表面具有基本上等于或小于骨粘合剂的表面能的表面能，以减少骨粘合剂和骨粘合剂施加装置之间的粘合。 骨粘合剂施加装置可以包括在用于修复具有由反应性生物相容性聚氨酯材料形成的骨粘合剂的骨缺损的试剂盒中。 通过将柔韧结构定位在骨缺损的至少一部分上，将骨粘合剂施加到骨缺损，将骨粘合剂输送到骨缺损并从骨粘合剂去除柔韧结构。
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公开(公告)号：US08668697B2
公开(公告)日：2014-03-11
申请号：US12862191
申请日：2010-08-24
申请人： Richard J. Deslauriers , Eric Kolb
发明人： Richard J. Deslauriers , Eric Kolb
CPC分类号： A61B17/00491 , A61B17/68 , A61B17/8076 , A61B17/823 , A61B17/8805 , A61B17/8811
摘要： A method for closing a sternum separated into at least a first sternum portion and a second sternum portion includes preparing at least one cut surface of at least one of the first or second sternum portions to have an adhesive applied thereon. The adhesive is applied to at least a portion of the at least one cut surface. The at least one cut surface is approximated to a second cut surface of the other of the first sternum portion or second sternum portion. As the adhesive cures, it bonds with the first cut surface and the second cut surface. Preparing the at least one cut surface may remove contaminants that could inhibit adhesion of the adhesive. The adhesive may be applied through adhesive injection holes formed along an incision separating the first and second sternum portions. Devices for preparing the cut surfaces and applying the adhesive are also provided.
摘要翻译： 用于封闭分为至少第一胸骨部分和第二胸骨部分的胸骨的方法包括制备第一或第二胸骨部分中的至少一个的至少一个切割表面以在其上施加粘合剂。 将粘合剂施加到至少一个切割表面的至少一部分。 至少一个切割表面近似于第一胸骨部分或第二胸骨部分中另一个的第二切割表面。 当粘合剂固化时，它与第一切割表面和第二切割表面结合。 制备至少一个切割表面可以去除可能抑制粘合剂粘附的污染物。 可以通过沿着分开第一和第二胸骨部分的切口形成的粘合剂注入孔来施加粘合剂。 还提供了用于制备切割表面和施加粘合剂的装置。
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