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    Prosthetic ligament
    2.
    发明授权
    Prosthetic ligament 失效
    假肢韧带

    公开(公告)号：US4932972A

    公开(公告)日：1990-06-12

    申请号：US186330

    申请日：1988-04-26

    申请人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  James A. Davidson ,  Neil B. Beals ,  Yancy L. Gill

    发明人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  James A. Davidson ,  Neil B. Beals ,  Yancy L. Gill

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  D04C1/12 ,  D10B2509/00

    摘要： A prosthetic ligament assembly includes a nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia, and a bone screw adapted for tensioning the prosthetic ligament during implantation. The prosthetic ligament includes a load bearing member intertwined into a plain braid from a plurality of biocompatible, high strength, ultra high molecular weight polyethylene yarns. Each yarn includes at least fifty fibers and has a tensile strength greater than or equal to about 100,000 psi. The load bearing member has a gage section and a loop at each end thereof for anchoring the load bearing member to the body members. The load bearing member is preloaded to remove slack therefrom. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to permit radiographic visualization of the prosthetic ligament. A sheath may be friction fit or molded onto the exterior of the gage section. The assembly also includes one or two bone screws for complimentary engagement with the loops of the load bearing member. The bone screws have a tapered section extending beneath the head of the screw to the shank for tensioning the prosthetic ligament during implantation.

    摘要翻译： 假肢韧带组件包括用于永久地替换跨越第一和第二身体构件（例如股骨和胫骨）的天然韧带的修饰韧带，以及适于在植入期间张紧假体韧带的骨螺钉。 假体韧带包括从多个生物相容的高强度超高分子量聚乙烯纱线缠绕成平纹编织物的承载构件。 每个纱线包括至少五十根纤维，并且具有大于或等于约100,000psi的拉伸强度。 承载构件在其每个端部具有一定量部分和一个环，用于将承载构件锚固到主体构件上。 承载构件被预加载以从其中移除松弛。 承载构件可以单独使用或者可以形成为具有设置在编织物的中空部分内的芯的中空编织物，以允许假体韧带的放射线显影。 护套可以摩擦配合或模制到计量部分的外部。 组件还包括一个或两个骨螺钉，用于与承载构件的环互补接合。 骨螺钉具有在螺钉头部下方延伸到柄部的锥形部分，用于在植入期间张紧假体韧带。

    Phosthetic ligament
    3.
    发明授权
    Phosthetic ligament 失效
    假韧带

    公开(公告)号：US4790850A

    公开(公告)日：1988-12-13

    申请号：US64634

    申请日：1987-06-22

    申请人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  James A. Davidson ,  Neil B. Beals ,  Yancy L. Gill

    发明人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  James A. Davidson ,  Neil B. Beals ,  Yancy L. Gill

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  D04C1/12 ,  D10B2509/00

    摘要： A prosthetic ligament assembly includes a nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia, and a bone screw adapted for tensioning the prosthetic ligament during implantation. The prosthetic ligament includes a load bearing member intertwined into a plain braid from a plurality of biocompatible, high strength, ultra high molecular weight polyethylene yarns. Each yarn includes at least fifty fibers and has a tensile strength greater than or equal to about 100,000 psi. The load bearing member has a gage section and a loop at each end thereof for anchoring the load bearing member to the body members. The load bearing member is preloaded to remove slack therefrom. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to permit radiographic visualization of the prosthetic ligament. A sheath may be friction fit or molded onto the exterior of the gage section. The assembly also includes one or two bone screws for complimentary engagement with the loops of the load bearing member. The bone screws have a tapered section extending beneath the head of the screw to the shank for tensioning the prosthetic ligament during implantation.

    摘要翻译： 假肢韧带组件包括用于永久地替换跨越第一和第二身体构件（例如股骨和胫骨）的天然韧带的修饰韧带，以及适于在植入期间张紧假体韧带的骨螺钉。 假体韧带包括从多个生物相容的高强度超高分子量聚乙烯纱线缠绕成平纹编织物的承载构件。 每个纱线包括至少五十根纤维，并且具有大于或等于约100,000psi的拉伸强度。 承载构件在其每个端部具有一定量部分和一个环，用于将承载构件锚固到主体构件上。 承载构件被预加载以从其中移除松弛。 承载构件可以单独使用或者可以形成为具有设置在编织物的中空部分内的芯的中空编织物，以允许假体韧带的放射线显影。 护套可以摩擦配合或模制到计量部分的外部。 组件还包括一个或两个骨螺钉，用于与承载构件的环互补接合。 骨螺钉具有在螺钉头部下方延伸到柄部的锥形部分，用于在植入期间张紧假体韧带。

    Prosthetic ligament
    4.
    发明授权
    Prosthetic ligament 失效
    假肢韧带

    公开(公告)号：US4731084A

    公开(公告)日：1988-03-15

    申请号：US840298

    申请日：1986-03-14

    申请人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  Richard W. Treharne, III

    发明人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  Richard W. Treharne, III

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  D04C1/12 ,  D10B2509/00

    摘要： A nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia includes a load bearing member formed from a plurality of biocompatible polyolefin fibers positioned at angles of from 0.degree. to 55.degree. relative to the longitudinal axis of the load bearing member. Each fiber is less than 100 microns in diameter and has a tensile strength greater than or equal to about 50,000 psi. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to provide shape for the load bearing member. A sheath may be friction fit or molded onto the exterior of the load bearing member to prevent abrasion of the fibers.

    摘要翻译： 用于永久性地替换跨越第一和第二身体构件（例如股骨和胫骨）的天然韧带的未修复的假体韧带包括由多个生物相容性聚烯烃纤维形成的承载构件，所述承载构件相对于纵向方向以0°至55°的角度定位 承载构件的轴线。 每个纤维的直径小于100微米，并且具有大于或等于约50,000psi的拉伸强度。 承载构件可以单独使用或者可以形成为具有设置在编织物的中空部分内的芯的中空编织物，以为承载构件提供形状。 护套可以摩擦配合或模制在承载构件的外部上以防止纤维的磨损。

    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    7.
    发明授权
    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent 有权
    制备含有生物活性剂的可生物降解的生物相容性微粒

    公开(公告)号：US06403114B1

    公开(公告)日：2002-06-11

    申请号：US09920862

    申请日：2001-08-03

    申请人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    发明人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    IPC分类号： A61F200

    CPC分类号： B01J13/04 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  Y10T428/2985

    摘要： A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.

    摘要翻译： 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物，活性剂和溶剂的第一相。 准备第二阶段 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 不连续的第一相与连续的第二相分离。 不连续第一相中溶剂的残留量减少到小于约2重量％。

    Microencapsulation process
    10.
    发明授权
    Microencapsulation process 失效
    微胶囊化方法

    公开(公告)号：US4389330A

    公开(公告)日：1983-06-21

    申请号：US194127

    申请日：1980-10-06

    申请人： Thomas R. Tice ,  Danny H. Lewis

    发明人： Thomas R. Tice ,  Danny H. Lewis

    IPC分类号： A61K9/50 ,  A61K9/16 ,  B01J13/12 ,  B01J13/14 ,  B01J13/02

    CPC分类号： B01J13/125 ,  A61K9/1694 ,  Y10S424/14

    摘要： Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microcapsules containing said active agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

    摘要翻译： 通过包括以下方法制备负载有活性剂的微胶囊：（a）将活性剂溶解或分散在溶剂中并将壁形成材料溶解在所述溶剂中; （b）将含有所述活性剂和壁形成材料的所述溶剂分散在连续相处理介质中; （c）从步骤（b）的所述分散体中蒸发掉一部分所述溶剂，从而在悬浮液中形成含有所述活性剂的微胶囊; 和（d）从所述微胶囊中提取剩余的溶剂。