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1.发明授权Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use 失效取代二苯并氮杂化合物的氨基甲酸衍生物，药物组合物和使用方法
公开(公告)号：US5677296A
公开(公告)日：1997-10-14
申请号：US446193
申请日：1995-05-19
申请人： Robert Alan Chrusciel , Timothy Joseph Hagen , E. Ann Hallinan , Jinglin Li , Sofya Tsymbalov , David B. Reitz
发明人： Robert Alan Chrusciel , Timothy Joseph Hagen , E. Ann Hallinan , Jinglin Li , Sofya Tsymbalov , David B. Reitz
IPC分类号： C07D498/04 , C07D498/06 , C07D498/10 , A61K31/55 , C07D513/04
CPC分类号： C07D498/04 , C07D498/06 , C07D498/10
摘要： The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E.sub.2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
摘要翻译： 本发明提供了可用作治疗疼痛的止痛剂和作为用于治疗前列腺素-E2介导的疾病的前列腺素E2拮抗剂的式I的取代二苯并氮杂化合物：其可用作治疗有效量的药物组合物 的式I化合物与药学上可接受的载体的组合，消除或改善动物疼痛的方法，以及在动物中治疗前列腺素-E2介导的疾病的方法，包括给予治疗有效量的化合物 的I型动物。
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公开(公告)号：US06265583B1
公开(公告)日：2001-07-24
申请号：US09177100
申请日：1998-10-22
申请人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号： C07D28506
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号：US5849784A
公开(公告)日：1998-12-15
申请号：US556883
申请日：1995-11-02
申请人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号：US06960664B2
公开(公告)日：2005-11-01
申请号：US10152601
申请日：2002-05-22
IPC分类号： C07D277/20 , A61K31/166 , A61K31/18 , A61K31/426 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07C243/28 , C07C243/32 , C07C311/16 , C07C311/49 , C07D277/56
CPC分类号： C07C243/32 , C07C243/28 , C07C311/16 , C07C311/49
摘要： Disclosed are compounds of formula: and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, R2 and R20 are defined herein. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要翻译： 公开了可用于治疗和/或预防阿尔茨海默病和其它类似疾病的式的化合物及其药学上可接受的盐和酯，其中R N，R C，R 本文定义了R 1，R 2和R 20。 这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。 本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。
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公开(公告)号：US06906104B2
公开(公告)日：2005-06-14
申请号：US10171343
申请日：2002-06-13
IPC分类号： C07D277/20 , A61K31/166 , A61K31/421 , A61K31/426 , A61K31/4409 , A61K31/4439 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07C215/28 , C07C231/02 , C07C233/73 , C07C235/84 , C07C255/44 , C07C319/20 , C07C323/42 , C07D213/40 , C07D263/48 , C07D277/52 , C07D277/56 , C07D413/12 , C07D417/12 , A61K31/164 , A61K31/133 , C07D235/26 , C07D235/70
CPC分类号： C07D413/12 , C07C215/28 , C07C235/84 , C07C255/44 , C07C323/42 , C07D263/48 , C07D277/52 , C07D417/12
摘要： The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要翻译： 本发明涉及式（I）化合物：可用于治疗阿尔茨海默氏病和其他类似疾病。 这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。 本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。
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公开(公告)号：US06552203B2
公开(公告)日：2003-04-22
申请号：US09973991
申请日：2001-10-11
申请人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号： C07D49500
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号：US07354943B2
公开(公告)日：2008-04-08
申请号：US11076161
申请日：2005-03-08
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D213/82 , C07C237/22 , C07C255/13 , C07C271/22 , C07C317/50 , C07C323/59 , C07D277/56
摘要： The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
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公开(公告)号：US07358264B2
公开(公告)日：2008-04-15
申请号：US11075161
申请日：2005-03-08
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D213/82 , C07C237/22 , C07C255/13 , C07C271/22 , C07C317/50 , C07C323/59 , C07D277/56
摘要： The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要翻译： 本发明涉及式（I）化合物：可用于治疗阿尔茨海默氏病和其他类似疾病。 这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。 本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。
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公开(公告)号：US07053109B2
公开(公告)日：2006-05-30
申请号：US10192543
申请日：2002-07-10
IPC分类号： A61K31/34 , A61K31/35 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , C07D209/30 , C07D213/44 , C07D215/16 , C07D233/00 , C07D239/00 , C07D265/00 , C07D281/00 , C07D291/00 , C07D307/18 , C07D309/08 , C07D313/02 , C07D327/00 , C07D333/26
CPC分类号： C07D213/82 , C07C237/22 , C07D263/06 , C07D263/34 , C07D277/56 , C07D295/26 , C07D317/30
摘要： The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
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公开(公告)号：US06875790B2
公开(公告)日：2005-04-05
申请号：US10369197
申请日：2003-02-20
申请人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人： Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00 , A61K31/335 , C07D215/16 , C07D337/00
CPC分类号： C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要： The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
摘要翻译： 本发明涉及含环状砜部分的羟乙基胺蛋白酶抑制剂化合物及其用途的药物或方法，特别是作为HIV蛋白酶的抑制剂。
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