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公开(公告)号：US08409510B2
公开(公告)日：2013-04-02
申请号：US11542453
申请日：2006-10-02
申请人： Robert Andrew McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Stanley Vincent Stepnowski , Viet Nguyen
发明人： Robert Andrew McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Stanley Vincent Stepnowski , Viet Nguyen
CPC分类号： B01L7/00 , B01L3/502753 , B01L2200/10 , B01L2300/069 , B01L2300/1827 , B82Y30/00 , G01N1/02 , G01N1/2214 , G01N1/2273 , G01N1/40 , G01N1/405 , G01N30/08 , G01N33/0011 , G01N2001/022 , G01N2030/062 , G01N2030/121 , Y10T436/25 , Y10T436/255
摘要： In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.
摘要翻译： 在本发明中，收集装置包括布置成收集分析物的流过微尺度板。 该板包括孔和在板的接触表面上的吸附剂涂层。 这些孔通过分析物流体流动，例如分析物蒸汽，使得用于收集的流体流可以大致垂直于吸附剂板。 优选的实施例板包括集成加热器迹线。 在优选实施例中，高的基本上垂直的流被用于收集和浓缩，并且在解吸和输送期间使用低的基本上平行的流动。 选择低流量以满足检测器系统的约束。
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公开(公告)号：US20100120167A1
公开(公告)日：2010-05-13
申请号：US11542453
申请日：2006-10-02
申请人： Robert Andrew McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Stanley Vincent Stepnowski
发明人： Robert Andrew McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Stanley Vincent Stepnowski
CPC分类号： B01L7/00 , B01L3/502753 , B01L2200/10 , B01L2300/069 , B01L2300/1827 , B82Y30/00 , G01N1/02 , G01N1/2214 , G01N1/2273 , G01N1/40 , G01N1/405 , G01N30/08 , G01N33/0011 , G01N2001/022 , G01N2030/062 , G01N2030/121 , Y10T436/25 , Y10T436/255
摘要： In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.
摘要翻译： 在本发明中，收集装置包括布置成收集分析物的流过微尺度板。 该板包括孔和在板的接触表面上的吸附剂涂层。 这些孔通过分析物流体流动，例如分析物蒸汽，使得用于收集的流体流可以大致垂直于吸附剂板。 优选的实施例板包括集成加热器迹线。 在优选实施例中，高的基本上垂直的流被用于收集和浓缩，并且在解吸和输送期间使用低的基本上平行的流动。 选择低流量以满足检测器系统的约束。
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公开(公告)号：US20050095722A1
公开(公告)日：2005-05-05
申请号：US10865685
申请日：2004-06-10
申请人： Robert McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Viet Nguyen
发明人： Robert McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Viet Nguyen
IPC分类号： B01L3/00 , G01N1/02 , G01N1/22 , G01N1/40 , G01N30/06 , G01N30/08 , G01N30/12 , G01N33/00 , G01N1/00
CPC分类号： B01L7/00 , B01L3/502753 , B01L2200/10 , B01L2300/069 , B01L2300/1827 , B82Y30/00 , G01N1/02 , G01N1/2214 , G01N1/2273 , G01N1/40 , G01N1/405 , G01N30/08 , G01N33/0011 , G01N2001/022 , G01N2030/062 , G01N2030/121 , Y10T436/25 , Y10T436/255
摘要： In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.
摘要翻译： 在本发明中，收集装置包括布置成收集分析物的流过微尺度板。 该板包括孔和在板的接触表面上的吸附剂涂层。 这些孔通过分析物流体流动，例如分析物蒸汽，使得用于收集的流体流可以大致垂直于吸附剂板。 优选的实施例板包括集成加热器迹线。 在优选实施例中，高的基本上垂直的流被用于收集和浓缩，并且在解吸和输送期间使用低的基本上平行的流动。 选择低流量以满足检测器系统的约束。
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公开(公告)号：US20100236341A1
公开(公告)日：2010-09-23
申请号：US12406756
申请日：2009-03-18
CPC分类号： G01N1/405 , G01N2001/022
摘要： An analyte collection system device includes an active area that includes a plurality of perforations extending therethrough. The plurality of perforations are arranged to permit passage of an analyte fluid flow through the microscale plate. A heating element is provided for heating the active area, and a thermal distribution layer is disposed over at least a portion of the active area. For cooling the active area at or below an ambient temperature, an active cooler is provided.
摘要翻译： 分析物收集系统装置包括有效区域，其包括穿过其中延伸的多个穿孔。 多个穿孔布置成允许分析物流体流通过微尺度板。 提供加热元件以加热有源区域，并且热分布层设置在有源区域的至少一部分上。 为了在环境温度或低于环境温度下冷却有源区域，提供有源冷却器。
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公开(公告)号：US20090249958A1
公开(公告)日：2009-10-08
申请号：US12337449
申请日：2008-12-17
申请人： Scott Cambron , Thomas Roussel , Robert Keynton , Michael Martin , Kevin Walsh , Doug Jackson , John Naber
发明人： Scott Cambron , Thomas Roussel , Robert Keynton , Michael Martin , Kevin Walsh , Doug Jackson , John Naber
IPC分类号： B01D50/00
CPC分类号： G01N1/405 , G01N30/08 , G01N35/1095
摘要： An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urging member is at least partially retracted, a space is defined between the urging member and the surface of the inner housing for accommodating at least one preconcentrator chip. A continuous fluid flow path is defined through the outer housing and through the space. The interchangeable preconcentrator assembly may further comprise at least one modular preconcentrator carriage.
摘要翻译： 可互换的预浓缩器组件包括外壳体和限定腔室的内壳体。 偏压推动构件至少部分地保持在外壳体内并且可滑动地偏压到内壳体的表面。 当偏压推动构件至少部分地缩回时，在推动构件和内壳体的表面之间限定一个空间，用于容纳至少一个预浓缩器芯片。 连续的流体流动路径通过外部壳体并通过该空间来限定。 可互换的预浓缩器组件还可以包括至少一个模块化预浓缩器托架。
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公开(公告)号：US08178045B2
公开(公告)日：2012-05-15
申请号：US12337449
申请日：2008-12-17
申请人： Scott Cambron , Thomas Roussel , Robert Keynton , Michael Martin , Kevin Walsh , Doug Jackson , John Naber
发明人： Scott Cambron , Thomas Roussel , Robert Keynton , Michael Martin , Kevin Walsh , Doug Jackson , John Naber
CPC分类号： G01N1/405 , G01N30/08 , G01N35/1095
摘要： An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urging member is at least partially retracted, a space is defined between the urging member and the surface of the inner housing for accommodating at least one preconcentrator chip. A continuous fluid flow path is defined through the outer housing and through the space. The interchangeable preconcentrator assembly may further comprise at least one modular preconcentrator carriage.
摘要翻译： 可互换的预浓缩器组件包括外壳体和限定腔室的内壳体。 偏压推动构件至少部分地保持在外壳体内并且可滑动地偏压到内壳体的表面。 当偏压推动构件至少部分地缩回时，在推动构件和内壳体的表面之间限定一个空间，用于容纳至少一个预浓缩器芯片。 连续的流体流动路径通过外部壳体并通过该空间来限定。 可互换的预浓缩器组件还可以包括至少一个模块化预浓缩器托架。
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公开(公告)号：US08448532B2
公开(公告)日：2013-05-28
申请号：US12406756
申请日：2009-03-18
IPC分类号： G01N1/22
CPC分类号： G01N1/405 , G01N2001/022
摘要： An analyte collection system device includes an active area that includes a plurality of perforations extending therethrough. The plurality of perforations are arranged to permit passage of an analyte fluid flow through the microscale plate. A heating element is provided for heating the active area, and a thermal distribution layer is disposed over at least a portion of the active area. For cooling the active area at or below an ambient temperature, an active cooler is provided.
摘要翻译： 分析物收集系统装置包括有效区域，其包括穿过其中延伸的多个穿孔。 多个穿孔布置成允许分析物流体流通过微尺度板。 提供加热元件以加热有源区域，并且热分布层设置在有源区域的至少一部分上。 为了在环境温度或低于环境温度下冷却有源区域，提供有源冷却器。
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8.发明授权Methods and compositions related to regulation of cytokine production by glycogen synthase kinase 3 (GSK-3) 失效与糖原合酶激酶3（GSK-3）细胞因子产生调节有关的方法和组成公开(公告)号：US08048454B2
公开(公告)日：2011-11-01
申请号：US10598671
申请日：2005-03-09
申请人： Michael Martin
发明人： Michael Martin
CPC分类号： A61K33/14 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y10S514/921
摘要： This invention relates generally to a method of treating inflammation and associated diseases and disorders by administering an agent that inhibits glycogen synthase kinase 3 activity.
摘要翻译： 本发明一般涉及通过施用抑制糖原合酶激酶3活性的药物来治疗炎症和相关疾病和病症的方法。
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公开(公告)号：US20100322698A1
公开(公告)日：2010-12-23
申请号：US12486562
申请日：2009-06-17
申请人： Michael Martin
发明人： Michael Martin
IPC分类号： B43K23/02
摘要： The writing instrument mountable to a ferrous surface includes an ink barrel of a non-ferrous material and first and second ends, an interior ink receiving space defined by an interior surface thereof, and a longitudinally extending axis. An agitator is positioned within the interior ink receiving space and is freely slidable therein for reciprocation along the longitudinally extending axis. The agitator includes a continuously open passage extending therethrough and generally in a direction from the first end towards the second end of the ink barrel. The agitator is a permanent magnet, whereby the writing instrument is detachably mountable to a surface of a ferrous material by a magnetic attraction between the surface of a ferrous material and the agitator when the ink barrel is positioned against the surface of a ferrous material.
摘要翻译： 可安装到黑色金属表面的书写工具包括有色金属材料的墨桶和第一和第二端，由其内表面限定的内部墨水容纳空间和纵向延伸的轴线。 搅拌器定位在内部油墨接收空间内并且可自由地在其中滑动以沿着纵向延伸的轴线往复运动。 搅拌器包括一个连续打开的通道，其通过其延伸，并且大致在从墨桶的第一端到第二端的方向上。 搅拌器是永久磁铁，借此当墨水筒靠着铁质材料的表面定位时，书写工具可以通过铁质材料表面和搅拌器之间的磁吸引力而可拆卸地安装到铁质材料的表面上。
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公开(公告)号：US20070169342A1
公开(公告)日：2007-07-26
申请号：US11690595
申请日：2007-03-23
申请人： Noah Lassar , Mohammad Akhavain , Michael Martin
发明人： Noah Lassar , Mohammad Akhavain , Michael Martin
IPC分类号： H05K3/00
CPC分类号： H05K1/111 , H01L2924/00013 , H05K1/0306 , H05K2201/09418 , H05K2201/09427 , H05K2201/09709 , H05K2201/10674 , Y02P70/611 , Y10T29/49147 , Y10T29/49149 , Y10T29/49165 , H01L2224/29099
摘要： In an implementation of connection pad layouts, a connection assembly includes a substrate assembly and connection pads disposed thereon. The connection pads form a configuration such that each connection pad is configured to align with a different terminal of an interconnect that is warped or otherwise has a non-linear alignment of terminals.
摘要翻译： 在连接焊盘布局的实现中，连接组件包括衬底组件和设置在其上的连接焊盘。 连接焊盘形成这样的配置，使得每个连接焊盘被配置成与被弯曲的互连的不同端子对齐或者具有端子的非线性对准。
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