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    MICRO SCALE FLOW THROUGH SORBENT PLATE COLLECTION DEVICE
    3.
    发明申请
    MICRO SCALE FLOW THROUGH SORBENT PLATE COLLECTION DEVICE 审中-公开
    通过同步板收集装置的微尺度流动

    公开(公告)号：US20100034703A1

    公开(公告)日：2010-02-11

    申请号：US12572807

    申请日：2009-10-02

    申请人： Eric J. Houser ,  Robert Andrew McGill ,  David J. Nagel ,  Stanley Vincent Stepnowski

    发明人： Eric J. Houser ,  Robert Andrew McGill ,  David J. Nagel ,  Stanley Vincent Stepnowski

    IPC分类号： B01L3/00

    CPC分类号： B01L7/00 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2300/069 ,  B01L2300/1827 ,  B82Y30/00 ,  G01N1/02 ,  G01N1/2214 ,  G01N1/2273 ,  G01N1/40 ,  G01N1/405 ,  G01N30/08 ,  G01N33/0011 ,  G01N2001/022 ,  G01N2030/062 ,  G01N2030/121 ,  Y10T436/25 ,  Y10T436/255

    摘要： In the invention, a collection device includes a first micro scale plate having a sorbent surface and a through hole. The through hole provides for the passage of an analyte fluid flow through the plate and it has a volume and geometry to provide contact between the fluid and the sorbent surface in an amount effective to absorb a sufficient amount of analyte for subsequent detection of the analyte. The sorbent surface can be provided by a sorbent coating such as an active sensing film, e.g. a conducting or optically active material, examples of which include conducting polymers, polymer/carbon composites, carbon nanotubes. and dye-containing materials. The analyte collection device preferably includes a heating source, e.g. a heating element formed from a resistive trace, or a plurality of resistive traces on or within the first microscale plate, for effecting a thermal release of collected analyte from the plate.

    摘要翻译： 在本发明中，收集装置包括具有吸附剂表面和通孔的第一微尺度板。 通孔提供了分析物流体通过板的通道，并且其具有体积和几何形状以提供流体和吸附剂表面之间的接触，其量有效地吸收足够量的分析物以便随后检测分析物。 吸附剂表面可以由吸附剂涂层提供，例如主动感测膜，例如， 导电或光学活性材料，其实例包括导电聚合物，聚合物/碳复合材料，碳纳米管。 和含染料的材料。 分析物收集装置优选地包括加热源，例如， 由电阻迹线形成的加热元件或在第一微米板上或第一微米板上的多个电阻迹线，用于实现从板上热收集分析物的释放。

    Method of producing a film coating by matrix assisted pulsed laser deposition
    5.
    发明授权
    Method of producing a film coating by matrix assisted pulsed laser deposition 失效
    通过基质辅助脉冲激光沉积制备薄膜涂层的方法

    公开(公告)号：US6025036A

    公开(公告)日：2000-02-15

    申请号：US864320

    申请日：1997-05-28

    申请人： Robert Andrew McGill ,  Douglas Brian Chrisey

    发明人： Robert Andrew McGill ,  Douglas Brian Chrisey

    IPC分类号： A61F2/28 ,  B05D3/06 ,  B05D7/24 ,  C08F2/46 ,  C23C14/12 ,  C23C14/28

    CPC分类号： B05D1/60 ,  C23C14/12 ,  C23C14/28

    摘要： A film of a coating material is produced on a substrate by a pulsed laser deposition method in which the material that forms the coating material is first combined with a matrix material to form a target. The target is then exposed to a source of laser energy to desorb the matrix material from the target and lift the coating material from the surface of the target. The target and the substrate are oriented with respect to each other so that the lifted coating material is deposited as a film upon said substrate. The matrix material is selected to have the property of being more volatile than the coating material and less likely than the coating material to adhere to the substrate. The matrix material is further selected as having the property such that when the target is exposed to a source of laser energy, the matrix material desorbs from the target and lifts the coating material from the surface of the target. In another aspect of the invention, a method of making an improved chemical or biochemical sensing device that includes a chemoselective or bioselective coating on a substrate is carried out by coating the substrate by pulsed laser deposition.

    摘要翻译： 通过脉冲激光沉积方法在基板上制造涂料的膜，其中形成涂料的材料首先与基质材料组合以形成靶。 然后将靶暴露于激光能量源以从靶上解吸基质材料并从靶的表面提起涂层材料。 靶和基底相对于彼此定向，使得提起的涂层材料作为膜沉积在所述基底上。 选择基质材料具有比涂层材料更易挥发的性质，并且不太可能比涂覆材料粘附到基底上。 基质材料被进一步选择为具有这样的特性，使得当靶暴露于激光能量源时，基质材料从目标解吸并从涂层表面提起涂层材料。 在本发明的另一方面，通过用脉冲激光沉积涂覆基底来进行制造包括化学选择性或生物选择性涂层在内的改进的化学或生化检测装置的方法。

    Linear chemoselective carbosilane polymers and methods for use in analytical and purification applications
    6.
    发明授权
    Linear chemoselective carbosilane polymers and methods for use in analytical and purification applications 有权
    线性化学选择性碳硅烷聚合物和用于分析和纯化应用的方法

    公开(公告)号：US06660230B2

    公开(公告)日：2003-12-09

    申请号：US09895292

    申请日：2001-07-02

    申请人： Robert Andrew McGill ,  Eric J. Houser

    发明人： Robert Andrew McGill ,  Eric J. Houser

    IPC分类号： G01N700

    CPC分类号： C08G77/24 ,  B01J20/285 ,  C08G77/60 ,  C08L83/16 ,  Y10T428/31663 ,  Y10T436/163333 ,  Y10T436/17

    摘要： This invention relates generally to a new class of chemoselective polymer materials. In particular, the invention relates to linear polycarbosilane compounds for use in various analytical applications involving sorbent polymer materials, including chromatoghraphy, chemical trapping, analyte collection, and chemical sensor applications. These polymers have pendant and terminal aryl, alkyl, alkenyl, and alkynyl groups that are functionalized with halogen substituted alcohol or phenol groups, having the general structure: wherein n is an integer greater than 1; wherein at least one of R1 and R2 is a linear or branched arm having at least one group independently selected from the group consisting of alkyl, alkenyl, alkynyl, and aryl groups, or combinations thereof, and having at least one halogen substituted alcohol or phenol groups attached thereto; wherein any said R1 and R2 aryl groups are attached to said [Si—X—]n either directly or through a short hydrocarbon chain; wherein any remaining said R1 or R2 group is a hydrocarbon or carbosilane group; wherein X is a polymer component selected from the group consisting of alkylene, alkenylene, alkynylene, arylene groups, and combinations thereof; and wherein Z1 and Z2 are end groups independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkyl silanes, aryl silanes, hydroxyl, silicon hydride, alkoxides, halogen substituted alcohol, halogen substituted phenol, organosilyl, and combinations thereof. These polymeric materials are primarily designed to sorb hydrogen bond basic analytes such as organophosphonate esters (nerve agents and precursors) and nitro-substituted compounds (explosives).

    摘要翻译： 本发明一般涉及一类新的化学选择性聚合物材料。 特别地，本发明涉及用于涉及吸收剂聚合物材料的各种分析应用中的线性聚碳硅烷化合物，包括色谱法，化学捕获，分析物收集和化学传感器应用。 这些聚合物具有侧链和末端芳基，被卤素取代的醇或酚基官能化的烷基，链烯基和炔基，其具有以下通式结构：其中n是大于1的整数;其中R 1和 R 2是具有至少一个独立地选自烷基，烯基，炔基和芳基的基团或其组合的至少一个基团并且具有至少一个连接到其上的卤素取代的醇或苯酚基团的直链或支链臂; 其中任何所述R 1和R 2芳基直接或通过短的烃链连接到所述[Si-X] n;其中任何剩余的所述R 1或R 2基团是 烃或碳硅烷基;其中X是选自亚烷基，亚烯基，亚炔基，亚芳基及其组合的聚合物组分; 并且其中Z 1和Z 2均为独立地选自烷基，烯基，炔基，芳基，烷基硅烷，芳基硅烷，羟基，氢化硅，烷氧基化物，卤素取代的醇，卤素取代的苯酚，有机甲硅烷基 ，以及它们的组合。这些聚合物材料主要设计用于吸附氢键碱性分析物如有机膦酸酯（神经试剂和前体）和硝基取代的化合物（爆炸物）。

    Method and apparatus for energy efficient tacking of resonant devices
    7.
    发明授权
    Method and apparatus for energy efficient tacking of resonant devices 失效
    谐振装置的能量效率的方法和装置

    公开(公告)号：US06336368B1

    公开(公告)日：2002-01-08

    申请号：US09404720

    申请日：1999-09-10

    申请人： Russell Chung ,  Robert Andrew McGill

    发明人： Russell Chung ,  Robert Andrew McGill

    IPC分类号： G01L100

    CPC分类号： B06B1/0648 ,  G01H11/08 ,  G10K9/125 ,  G10K11/36

    摘要： A method and apparatus for interrogating a resonator to monitor its resonance characteristics (e.g. resonant frequency) in an especially energy efficient manner, particularly changes to the characteristics over time. The resonator is pulsed and the response thereto sampled. By comparison of samples of the response to sequential pulses, sampled at the same times after pulse initiation, one can infer phase changes between the responses, and hence infer changes in resonance characteristics. Preferably, one calibrates the resonator's time response initially as a reference, which permits subsequent determination of the resonance state with only one digital sample per pulse. In one embodiment, the invention this detection scheme is used as a chemical detector. The resonator is an electo-acoustic device, having plural Bragg gratings, with a different adsorptive material atop each grating which adsorbs one selected chemical particularly well. Absorption causes the weight of material to increase, changing the resonance characteristics of the gratings. A single pulse launched into the SAW will cause reflections from each of the Bragg cells which are staggered in time, and hence separately detectable. The resonance of each grating is then tracked as above described, and changes thereto over time indicates the amount of material adsorbed.

    摘要翻译： 一种用于询问谐振器以以特别高效的方式监测其谐振特性（例如谐振频率）的方法和装置，特别是随时间的特性的变化。 谐振器是脉冲的并且其响应被采样。 通过比较脉冲启动后相同时间采样的顺序脉冲的响应样本，可以推断出响应之间的相位变化，从而推断出共振特性的变化。 优选地，首先校准谐振器的时间响应作为参考，其允许随后每个脉冲仅使用一个数字样本来确定谐振状态。在一个实施例中，本发明将该检测方案用作化学检测器。 谐振器是具有多个布拉格光栅的电声装置，在每个光栅顶上具有不同的吸附材料，其特别好地吸附一个所选择的化学物质。 吸收会导致材料的重量增加，改变光栅的共振特性。 发射到SAW中的单个脉冲将引起每个布拉格细胞的反射，其随时间交错，因此可以单独检测。 然后如上所述跟踪每个光栅的共振，随着时间的推移，其变化表示吸附材料的量。

    Detection of chemicals with infrared light
    9.
    发明授权
    Detection of chemicals with infrared light 有权
    用红外线检测化学品

    公开(公告)号：US08421018B2

    公开(公告)日：2013-04-16

    申请号：US13488593

    申请日：2012-06-05

    申请人： Robert Andrew McGill ,  Chris Kendziora ,  Robert Furstenberg ,  Michael Papantonakis ,  James S Horwitz ,  Graham K Hubler

    发明人： Robert Andrew McGill ,  Chris Kendziora ,  Robert Furstenberg ,  Michael Papantonakis ,  James S Horwitz ,  Graham K Hubler

    IPC分类号： G01N21/00

    CPC分类号： G01N21/71 ,  G01N21/718

    摘要： The present invention is directed to a method for non-contact or stand off chemical detection by selectively exciting one or more analytes of interest using an IR source tuned to at least one specific absorption band without significantly decomposing the analyte and determining if the analyte is present by comparing emitted photons with an IR detector signal made before and during or shortly after exciting the analyte. Another embodiment provides a method for non-contact or stand off chemical detection by selectively exciting one or more analytes of interest using an IR source tuned to at least one specific absorption band without significantly decomposing the analyte, wherein the analyte is excited sufficiently to generate a vapor plume, and wherein the plume is examined to detect the presence of the analyte. Additionally, the present invention provides for a system for non-contact or stand off chemical detection.

    摘要翻译： 本发明涉及一种用于非接触或脱离化学检测的方法，其通过使用调谐到至少一个特定吸收带的IR源选择性地激发一种或多种目的分析物而不显着分解分析物并确定分析物是否存在 通过将发射的光子与在激发分析物之前和之后或之后不久的IR检测器信号进行比较。 另一个实施方案提供了通过使用调节至少一个特定吸收带的IR源选择性地激发一种或多种感兴趣的分析物而不显着分解分析物的方法，用于非接触或脱离化学检测的方法，其中分析物被充分激发以产生 蒸气羽流，并且其中检查羽流以检测分析物的存在。 另外，本发明提供了用于非接触或脱离化学检测的系统。

    Hyperbranched chemoselective silicon-based polymers for chemical sensor applications
    10.
    发明授权
    Hyperbranched chemoselective silicon-based polymers for chemical sensor applications 有权
    用于化学传感器应用的超支化化学选择性硅基聚合物

    公开(公告)号：US07153582B2

    公开(公告)日：2006-12-26

    申请号：US10672272

    申请日：2003-09-26

    申请人： Eric J Houser ,  Robert Andrew McGill

    发明人： Eric J Houser ,  Robert Andrew McGill

    IPC分类号： G01N30/00

    CPC分类号： G01N29/036 ,  C08G77/50 ,  C08G77/60 ,  G01N2291/0257 ,  Y10T428/31663 ,  Y10T436/163333 ,  Y10T436/17

    摘要： The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a hyperbranched compound having: (1) a polymer backbone portion that is at least partly randomly branched; (2) at least one pendant group extending from the polymer backbone portion; and (3) at least one halogen substituted alcohol or phenol group substituted at the pendant group(s) of the polymer backbone portion. The compound of the invention preferably has the general formula: wherein A is the hyperbranched backbone portion of the polymer; L and M are independently selected pendant groups of said polymer backbone; X and Y are independently selected halogen substituted alcohol or phenol groups; q and r are independently selected and at least 1; and n is at least 3.

    摘要翻译： 本发明提供了一种用于选择性分子识别的装置，该装置包括感测部分，其中所述感测部分包括其上涂覆有包含超支化化合物的层的基底，其具有：（1）至少部分地随机分支的聚合物主链部分; （2）至少一个从聚合物主链部分延伸的侧基; 和（3）在聚合物主链部分的侧基取代的至少一个卤素取代的醇或苯酚基团。 本发明的化合物优选具有以下通式：其中A是聚合物的超支化骨架部分; L和M独立地选自所述聚合物骨架的侧基; X和Y独立地选择卤素取代的醇或苯酚基团; q和r独立地选择并且至少为1; n为3以上。