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公开(公告)号：US08304195B2
公开(公告)日：2012-11-06
申请号：US12047131
申请日：2008-03-12
IPC分类号： G01N33/53
摘要： The present invention provides labeling reagents and methods for labeling primary antibodies and for detecting a target in a sample using an immuno-labeled complex that comprises a target-binding antibody and one or more labeling reagents. The labeling reagents comprise monovalent antibody fragments or non-antibody monomeric proteins whereby the labeling proteins have affinity for a specific region of the target-binding antibody and are covalently attached to a label. Typically, the labeling reagent is an anti-Fc Fab or Fab′ fragment that was generated by immunizing a goat or rabbit with the Fc fragment of an antibody. The present invention provides for discrete subsets of labeling reagent and immuno-labeled complexes that facilitate the simultaneous detection of multiple targets in a sample wherein the immuno-labeled complexes are distinguished by i) a ratio of label to labeling reagent, or ii) a physical property of said label, or iii) a ratio of labeling reagent to said target-binding antibody, or iv) by said target-binding antibody. This is particularly useful for fluorophore labels that can be attached to labeling reagents and subsequently immuno-labeled complexes in ratios for the detection of multiple targets.
摘要翻译： 本发明提供标记试剂和用于标记一抗的标记试剂和使用包含靶结合抗体和一种或多种标记试剂的免疫标记复合物检测样品中靶标的方法。 标记试剂包括单价抗体片段或非抗体单体蛋白质，由此标记的蛋白质对靶标结合抗体的特定区域具有亲和力，并且共价连接到标记物上。 通常，标记试剂是通过用抗体的Fc片段免疫山羊或兔而产生的抗Fc Fab或Fab'片段。 本发明提供标记试剂和免疫标记的复合物的离散子集，其有助于同时检测样品中的多个靶标，其中通过i）标记物与标记试剂的比率来区分免疫标记的复合物，或ii）物理 或iii）标记试剂与所述靶结合抗体的比例，或iv）所述靶结合抗体。 这对于可以连接到标记试剂和随后的用于检测多个靶的比例的免疫标记的复合物的荧光团标记物特别有用。
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公开(公告)号：US08535894B2
公开(公告)日：2013-09-17
申请号：US13610009
申请日：2012-09-11
IPC分类号： G01N33/53
摘要： Provided are labeling reagents and methods for labeling primary antibodies and for detecting a target in a sample using an immuno-labeled complex that comprises a target-binding antibody and one or more labeling reagents. The labeling reagents comprise monovalent antibody fragments or non-antibody monomeric proteins whereby the labeling proteins have affinity for a specific region of the target-binding antibody and are covalently attached to a label. Discrete subsets of labeling reagent and immune-labeled complexes are provided that facilitate the simultaneous detection of multiple targets in a sample-complexes are distinguished by i) a ratio of label to labeling reagent, or ii) a physical property of said label, or iii) a ratio of labeling reagent to said target-binding antibody, or iv) by said target-binding antibody. This is particularly useful for fluorophore labels that can be attached to labeling reagents and subsequently immuno-labeled complexes in ratios for the detection of multiple targets.
摘要翻译： 提供标记试剂和用于标记一抗的标记试剂和用于使用包含靶结合抗体和一种或多种标记试剂的免疫标记复合物检测样品中的靶标的方法。 标记试剂包括单价抗体片段或非抗体单体蛋白质，由此标记的蛋白质对靶标结合抗体的特定区域具有亲和力，并且共价连接到标记物上。 提供标记试剂和免疫标记复合物的离散子集，其有利于同时检测样品中多个靶标的复合物，其特征在于i）标记与标记试剂的比例，或ii）所述标记的物理性质，或iii ）标记试剂与所述靶结合抗体的比例，或iv）所述靶结合抗体。 这对于可以连接到标记试剂和随后的用于检测多个靶的比例的免疫标记的复合物的荧光团标记物特别有用。
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公开(公告)号：US20050069962A1
公开(公告)日：2005-03-31
申请号：US10467550
申请日：2002-10-02
IPC分类号： G01N33/53
摘要： The present invention provides labeling reagents and methods for labeling primary antibodies and for detecting a target in a sample using an immuno-labeled complex that comprises a target-binding antibody and one or more labeling reagents. The labeling reagents comprise monovalent antibody fragments or non-antibody monomeric proteins whereby the labeling proteins have affinity for a specific region of the target-binding antibody and are covalently attached to a label. Typically, the labeling reagent is an anti-Fc Fab or Fab′ fragment that was generated by immunizing a goat or rabbit with the Fc fragment of an antibody. The present invention provides for discrete subsets of labeling reagent and immuno-labeled complexes that facilitate the simultaneous detection of multiple targets in a sample wherein the immuno-labeled complexes are distinguished by i) a ratio of label to labeling reagent, or ii) a physical property of said label, or iii) a ratio of labeling reagent to said target-binding antibody, or iv) by said target-binding antibody. This is particularly useful for fluorophore labels that can be attached to labeling reagents and subsequently immuno-labeled complexes in ratios for the detection of multiple targets.
摘要翻译： 本发明提供标记试剂和用于标记一抗的标记试剂和使用包含靶结合抗体和一种或多种标记试剂的免疫标记复合物检测样品中靶标的方法。 标记试剂包括单价抗体片段或非抗体单体蛋白质，由此标记的蛋白质对靶标结合抗体的特定区域具有亲和力，并且共价连接到标记物上。 通常，标记试剂是通过用抗体的Fc片段免疫山羊或兔而产生的抗Fc Fab或Fab'片段。 本发明提供标记试剂和免疫标记的复合物的离散子集，其有助于同时检测样品中的多个靶标，其中通过i）标记物与标记试剂的比率来区分免疫标记的复合物，或ii）物理 或iii）标记试剂与所述靶结合抗体的比例，或iv）所述靶结合抗体。 这对于可以连接到标记试剂和随后的用于检测多个靶的比例的免疫标记的复合物的荧光团标记物特别有用。
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4.发明申请公开(公告)号：US20070061698A1
公开(公告)日：2007-03-15
申请号：US11223180
申请日：2005-09-09
申请人： Eran Megiddo , Daniel Parish , Daniel Battagin , Robert Archer , Amarinder Grewal , Justin Rockwood , Sean Boon
发明人： Eran Megiddo , Daniel Parish , Daniel Battagin , Robert Archer , Amarinder Grewal , Justin Rockwood , Sean Boon
IPC分类号： G06F17/00
CPC分类号： G06F17/246 , G06F17/2247
摘要： For standalone spreadsheet applications and/or Web-based spreadsheet services, the ability to designate, discover and set parameters for spreadsheet documents is provided. When creating a spreadsheet document, the ability to designate certain cells or ranges of cells as parameters to a spreadsheet is enabled. Furthermore, whether viewed in a standalone spreadsheet application or via a Web service, the ability to discover these parameters through the user interface or object model is provided. The ability to set or change these parameters one at a time or in bulk and drive the changes into the calculation model is also provided. Accordingly, whether viewed in a standalone spreadsheet application or via a Web rendering service, the effect of the parameters entered by the user can be calculated and viewed at once. The ability to suspend recalculation of a workbook until all relevant values, such as a current set of parameters, are obtained is also enabled.
摘要翻译： 对于独立的电子表格应用程序和/或基于Web的电子表格服务，提供了指定，发现和设置电子表格文档参数的功能。 创建电子表格文档时，可以将某些单元格或单元格范围指定为电子表格的参数。 此外，无论是在独立电子表格应用程序中查看还是通过Web服务查看，都提供了通过用户界面或对象模型发现这些参数的能力。 还提供了一次一次或批量设置或更改这些参数的能力，并将更改驱动到计算模型中。 因此，无论是在独立电子表格应用程序中查看还是通过Web呈现服务查看，都可以一次性计算和查看用户输入的参数的影响。 能够暂停重新计算工作簿直到获得所有相关值（如当前参数集）的能力。
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公开(公告)号：US20060154384A1
公开(公告)日：2006-07-13
申请号：US10526804
申请日：2003-09-03
申请人： Craig Murphy , Salvatore Cina , Timothy Butler , Matthew Roberts , Nalinkumar Patel , Clare Foden , Mark Leadbeater , Daniel Forsythe , Robert Archer , Nicholas Baynes , Nathan Philips , Anil Duggal , Jie Liu
发明人： Craig Murphy , Salvatore Cina , Timothy Butler , Matthew Roberts , Nalinkumar Patel , Clare Foden , Mark Leadbeater , Daniel Forsythe , Robert Archer , Nicholas Baynes , Nathan Philips , Anil Duggal , Jie Liu
IPC分类号： H01L21/00
CPC分类号： H01L51/0043 , H01L51/0003 , H01L51/0035 , H01L51/0037 , H01L51/0039 , H01L51/0059 , H01L51/5012 , H01L51/5048 , H01L51/56
摘要： A method of forming an optical device comprising the steps of: providing a substrate comprising a first electrode capable of injecting or accepting charge carriers of a first type; forming over the first electrode a first layer that is at least partially insoluble in a solvent by depositing a first semiconducting material that is free of cross-linkable vinyl or ethynyl groups and is, at the time of deposition, soluble in the solvent; forming a second layer in contact with the first layer and comprising a second semiconducting material by depositing a second semiconducting material from a solution in the solvent; and forming over the second layer a second electrode capable of injecting or accepting charge carriers of a second type wherein the first layer is rendered at least partially insoluble by one or more of heat, vacuum and ambient drying treatment following deposition of the first semiconducting material.
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公开(公告)号：US07019759B1
公开(公告)日：2006-03-28
申请号：US09567185
申请日：2000-05-09
申请人： David Moore , Sara Warner-Phillips , Jason Mark , Robert Archer , Ryan Moore
发明人： David Moore , Sara Warner-Phillips , Jason Mark , Robert Archer , Ryan Moore
CPC分类号： G06T11/00 , G06Q30/0621
摘要： A method enables online purchase of customizable home construction plans. The method includes accessing a web based software package, customizing the home, and ordering the construction plans. The software package is a second aspect. The software allows the consumer to select different predefined features and add them to a stock floor plan. The selection of different features enables the customization of the home plan. The features selected are displayed to the consumer through a series of layers. The layers are superimposed on each other according to a predefined logic so that the consumer views what the home actually will look like rather an amalgamation of pieces. When the consumer is satisfied with the customized plan, the consumer orders formal plans and construction plans are sent to the consumer.
摘要翻译： 一种方法可以在线购买可定制的家庭建筑计划。 该方法包括访问基于Web的软件包，定制家庭和订购施工计划。 软件包是第二个方面。 该软件允许消费者选择不同的预定义功能并将其添加到库存平面图。 选择不同的功能可以自定义家庭计划。 所选的功能通过一系列图层显示给消费者。 这些层根据预定义的逻辑叠加在一起，使得消费者观察家庭实际上将看起来像什么，而不是合并的片段。 当消费者对定制计划感到满意时，消费者将正式的计划和施工计划送达消费者。
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公开(公告)号：US4998774A
公开(公告)日：1991-03-12
申请号：US407636
申请日：1989-09-15
申请人： George L. Huff , Robert Archer , James P. Haynes
发明人： George L. Huff , Robert Archer , James P. Haynes
IPC分类号： A47C4/54
CPC分类号： A47C9/007 , Y10S297/08
摘要： A stool seat includes an impermeable top wall having an upper surface upon which a user sits and a peripheral edge. The top wall is sealingly joined along its peripheral edge to an impermeable bottom wall and is adapted to support itself in spaced relation above the bottom wall so that the top wall is suspended above the bottom wall from its peripheral edge to provide a single sealed cavity containing a fluid at a predetermined pressure between the top and bottom walls. The top wall is further adapted to resiliently deflect toward the bottom wall under the weight of the user so that the pressure of the fluid in the sealed cavity is increased when the user sits upon the upper surface.
摘要翻译： 粪便座包括具有用户所在的上表面和外围边缘的不透水顶壁。 顶壁沿着其周边边缘密封地连接到不可渗透的底壁，并且适于在自身的底壁上方以间隔的关系支撑自身，使得顶壁从其外围边缘悬挂在底壁上方，以提供包含 在顶壁和底壁之间的预定压力下的流体。 顶壁还适于在使用者的重量下朝向底壁弹性偏转，使得当使用者坐在上表面上时，密封空腔中的流体的压力增加。
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公开(公告)号：US08396317B1
公开(公告)日：2013-03-12
申请号：US12613415
申请日：2009-11-05
CPC分类号： G06T5/008 , G06T2207/20012
摘要： An analysis module accesses an input image, identifies an algorithm to be used to generate an output image from the input image, analyzes the algorithm, and determines a pixel offset of the algorithm. A generation module identifies a region of the output image in which output pixels are to be generated without an edge-checking operation. The generation module generates a modified version of the algorithm that omits the edge-checking operation and generates the output image by using the modified version to generate output pixels in the identified region.
摘要翻译： 分析模块访问输入图像，识别用于从输入图像生成输出图像的算法，分析算法，并确定算法的像素偏移。 生成模块识别输出图像的区域，其中将生成输出像素而不进行边缘检查操作。 生成模块生成省略边缘检查操作的算法的修改版本，并通过使用修改版本来生成输出图像，以在识别的区域中生成输出像素。
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公开(公告)号：US20110168987A1
公开(公告)日：2011-07-14
申请号：US13001587
申请日：2009-06-30
申请人： Ilaria Grizzi , Richard Wilson , Robert Archer , Matthew Roberts
发明人： Ilaria Grizzi , Richard Wilson , Robert Archer , Matthew Roberts
CPC分类号： H01L51/5088 , C08G2261/141 , C08G2261/212 , C08G2261/3223 , C08G2261/512 , H01L51/0036 , H01L51/0037 , H01L51/5092
摘要： An organic electronic device comprising: an anode; a hole injecting layer; a cathode; and organic semiconductive material disposed between the hole injecting layer and the cathode, wherein the cathode comprises an electron-injecting material having a higher electron-injection efficiency than BaO/Al, and wherein the hole injecting layer comprises a hole injecting material which has a lower workfunction than PEDOT:PSS (1:6).
摘要翻译： 一种有机电子器件，包括：阳极; 空穴注入层; 阴极 以及设置在所述空穴注入层和所述阴极之间的有机半导体材料，其中所述阴极包含电子注入效率高于BaO / Al的电子注入材料，并且其中所述空穴注入层包含具有较低 功能比PEDOT：PSS（1：6）。
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公开(公告)号：US5159917A
公开(公告)日：1992-11-03
申请号：US801228
申请日：1991-12-03
申请人： Robert Archer , Harold O. Duggin
发明人： Robert Archer , Harold O. Duggin
IPC分类号： A47J37/07
CPC分类号： A47J37/0763
摘要： Barbecue grills, particularly small-size portable grills adapted for picnics, stadium parking lot cooking and the like. The portable grill comprises a hemispherical cooking bowl and a hemispherical hood removably supported upon the top rim of the cooking bowl. A pair of locking brackets is inserted within the cooking bowl rim, so as to engage the hood such, that the hood and cooking bowl are locked together during carrying.
摘要翻译： 烧烤架，特别是适合野餐，体育馆停车场烹饪的小型便携式烤架等。 便携式格栅包括半球形烹饪碗和可移除地支撑在烹饪碗的顶部边缘上的半球形罩。 一对锁定支架插入烹饪碗边缘内，以便与罩相接合，使得罩和烹饪碗在携带期间被锁定在一起。
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