公开(公告)号：US08386010B2

公开(公告)日：2013-02-26

申请号：US12572156

申请日：2009-10-01

申请人： Robert Beetel ,  Frank Viola

发明人： Robert Beetel ,  Frank Viola

IPC分类号： A61B5/04 ,  A61B5/0404 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/05 ,  A61B5/053

CPC分类号： A61B5/0538 ,  A61B1/00082 ,  A61B5/053 ,  A61B5/4255 ,  A61B5/6853

摘要： A tissue monitoring system includes an introducer having an inflatable section and a plurality of electrodes disposed thereon. The electrodes are alternatively connected to an electrode contact system which includes at least one signal line and at least one measurement line for taking readings about a circumferential segment of tissue encompassed by the electrodes.

摘要翻译： 组织监测系统包括具有可膨胀部分和设置在其上的多个电极的导引器。 电极交替地连接到电极接触系统，该电极接触系统包括至少一条信号线和至少一条测量线，用于读取围绕电极包围的组织周向段的读数。

公开(公告)号：US09066720B2

公开(公告)日：2015-06-30

申请号：US13281269

申请日：2011-10-25

申请人： Sowmya Ballakur ,  Robert Beetel ,  Paul Friedrichs ,  Andrew Wu ,  Denise Zarins ,  David Herzfeld ,  Mark S. Leung

发明人： Sowmya Ballakur ,  Robert Beetel ,  Paul Friedrichs ,  Andrew Wu ,  Denise Zarins ,  David Herzfeld ,  Mark S. Leung

IPC分类号： A61B18/10 ,  A61B18/12 ,  A61B18/14 ,  A61B17/00 ,  A61B18/00

CPC分类号： A61B18/1206 ,  A61B18/10 ,  A61B18/1492 ,  A61B2017/00075 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61F7/12 ,  A61F2007/0093 ,  A61F2007/126

摘要： The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.

摘要翻译： 本公开涉及用于评估应用于患者组织的治疗成功的装置，系统和方法，例如用于神经调节与肾动脉相关的神经的射频消融治疗。 系统监视在治疗过程中产生的参数或值。 提供给运营商的反馈是基于监测值，并且涉及对完成的处理在技术上成功的可能性的评估。 在其他实施例中，可以评估在不完全处理过程中产生的参数或值（例如由于高温或高阻抗条件），以向操作者提供额外的指令或反馈。

公开(公告)号：US20120143293A1

公开(公告)日：2012-06-07

申请号：US13281395

申请日：2011-10-25

申请人： Kevin Mauch ,  Mario Alvarado ,  Robert Beetel ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Sukyoung Shin ,  Michele Silver ,  Sina Som ,  Andrew Wu ,  Denise Zarins ,  Juanita Sanchez-Cole ,  Maria G. Aboytes

发明人： Kevin Mauch ,  Mario Alvarado ,  Robert Beetel ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Sukyoung Shin ,  Michele Silver ,  Sina Som ,  Andrew Wu ,  Denise Zarins ,  Juanita Sanchez-Cole ,  Maria G. Aboytes

IPC分类号： A61N1/18 ,  A61F7/12

CPC分类号： A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

公开(公告)号：US20060273135A1

公开(公告)日：2006-12-07

申请号：US11444548

申请日：2006-05-31

申请人： Robert Beetel

发明人： Robert Beetel

IPC分类号： A61B17/10

CPC分类号： A61B17/07207 ,  A61B17/068 ,  A61B17/0686 ,  A61B17/072 ,  A61B17/115 ,  A61B17/1155 ,  A61B17/128 ,  A61B17/29 ,  A61B34/10 ,  A61B90/06 ,  A61B2017/00022 ,  A61B2017/00039 ,  A61B2017/00106 ,  A61B2017/00119 ,  A61B2017/07214 ,  A61B2090/061 ,  A61B2090/065 ,  A61B2090/0811

摘要： According to an aspect of the present disclosure, a surgical instrument for operating on tissue is provided. The surgical instrument includes an end effector including a first tissue engaging member and a second tissue engaging member in juxtaposed relation to the first tissue engaging member; a gap determination element operatively associated with each of the first tissue engaging member and the second tissue engaging member for measuring a gap distance between the first tissue engaging member and the second tissue engaging member; and a tissue contact determining element operatively associated with a respective tissue contacting surface of at least one of the first tissue engaging member and the second tissue engaging member. The present disclosure also relates to methods of using the surgical instrument.

公开(公告)号：US08956352B2

公开(公告)日：2015-02-17

申请号：US13281395

申请日：2011-10-25

申请人： Kevin Mauch ,  Mario Alvarado ,  Robert Beetel ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Sukyoung Shin ,  Michele Silver ,  Sina Som ,  Andrew Wu ,  Denise Zarins ,  Juanita Sanchez-Cole ,  Maria G. Aboytes

发明人： Kevin Mauch ,  Mario Alvarado ,  Robert Beetel ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Sukyoung Shin ,  Michele Silver ,  Sina Som ,  Andrew Wu ,  Denise Zarins ,  Juanita Sanchez-Cole ,  Maria G. Aboytes

IPC分类号： A61B18/14 ,  A61B18/04 ,  A61B18/18 ,  A61B18/00 ,  A61M25/00 ,  A61M25/01

CPC分类号： A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

摘要翻译： 本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。 例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。 阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。 多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。 电极或能量输送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

公开(公告)号：US20060282084A1

公开(公告)日：2006-12-14

申请号：US11444547

申请日：2006-05-31

申请人： Ken Blier ,  Frank Viola ,  Robert Beetel ,  Russell Heinrich ,  Michael Soltz

发明人： Ken Blier ,  Frank Viola ,  Robert Beetel ,  Russell Heinrich ,  Michael Soltz

IPC分类号： A61B17/56

CPC分类号： A61B17/0643 ,  A61B17/0644 ,  A61B2017/0408 ,  A61B2017/042 ,  A61B2017/0647

摘要： A medical fastener for securing tissue and creating hemostatis thereon is disclosed. The fastener includes a shaft having a proximal and distal ends and a head disposed at a proximal end and a tip disposed at a distal end. The tip is configured to penetrate the tissue and to form a mushroomed tip or a modified B-formation tip to secure the fastener to the tissue.

摘要翻译： 公开了一种用于固定组织并在其上产生血栓的医疗紧固件。 紧固件包括具有近端和远端的轴，以及设置在近端的头部和设置在远端的尖端。 尖端构造成穿透组织并形成蘑菇状尖端或修改的B形结构顶端以将紧固件固定到组织上。

公开(公告)号：US20120101538A1

公开(公告)日：2012-04-26

申请号：US13281269

申请日：2011-10-25

申请人： Sowmya Ballakur ,  Robert Beetel ,  Paul Friedrichs ,  David Herzfeld ,  Andrew Wu ,  Denise Zarins ,  Mark S. Leung

发明人： Sowmya Ballakur ,  Robert Beetel ,  Paul Friedrichs ,  David Herzfeld ,  Andrew Wu ,  Denise Zarins ,  Mark S. Leung

IPC分类号： A61N1/36 ,  A61F7/12

CPC分类号： A61B18/1206 ,  A61B18/10 ,  A61B18/1492 ,  A61B2017/00075 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61F7/12 ,  A61F2007/0093 ,  A61F2007/126

摘要： The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.

摘要翻译： 本公开涉及用于评估应用于患者组织的治疗成功的装置，系统和方法，例如用于神经调节与肾动脉相关的神经的射频消融治疗。 系统监视在治疗过程中产生的参数或值。 提供给运营商的反馈是基于监测值，并且涉及对完成的处理在技术上成功的可能性的评估。 在其他实施例中，可以评估在不完全处理过程中产生的参数或值（例如由于高温或高阻抗条件），以向操作者提供额外的指令或反馈。

公开(公告)号：US20120116382A1

公开(公告)日：2012-05-10

申请号：US13281360

申请日：2011-10-25

申请人： Vincent Ku ,  Robert Beetel ,  Andrew Wu ,  Denise Zarins ,  Maria G. Aboytes

发明人： Vincent Ku ,  Robert Beetel ,  Andrew Wu ,  Denise Zarins ,  Maria G. Aboytes

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

公开(公告)号：US20100137738A1

公开(公告)日：2010-06-03

申请号：US12572156

申请日：2009-10-01

申请人： Robert Beetel ,  Frank Viola

发明人： Robert Beetel ,  Frank Viola

IPC分类号： A61B5/053

CPC分类号： A61B5/0538 ,  A61B1/00082 ,  A61B5/053 ,  A61B5/4255 ,  A61B5/6853

摘要： A tissue monitoring system includes an introducer having an inflatable section and a plurality of electrodes disposed thereon. The electrodes are alternatively connected to an electrode contact system which includes at least one signal line and at least one measurement line for taking readings about a circumferential segment of tissue encompassed by the electrodes.

摘要翻译： 组织监测系统包括具有可膨胀部分和设置在其上的多个电极的导引器。 电极交替地连接到电极接触系统，该电极接触系统包括至少一条信号线和至少一条测量线，用于读取围绕电极包围的组织周向段的读数。

公开(公告)号：US20070012728A1

公开(公告)日：2007-01-18

申请号：US11388176

申请日：2006-03-24

申请人： Frank Viola ,  Michael Soltz ,  Robert Beetel ,  Katherine Jordan ,  Alicia Farrell ,  Emily Gumkowski

发明人： Frank Viola ,  Michael Soltz ,  Robert Beetel ,  Katherine Jordan ,  Alicia Farrell ,  Emily Gumkowski

IPC分类号： B67D5/64 ,  C12Q1/00

CPC分类号： G01N33/48764

摘要： A media-dispensing apparatus for testing body fluids and a method of using the same are disclosed. The apparatus includes a housing having a lower portion and an upper portion, and an elongated tubular member having a distal opening adjacent a distal end thereof. The elongated tubular member includes a first lumen within the elongated tubular member extending from the lower portion of the housing to the distal opening and includes a second lumen within the elongated tubular member extending from the upper portion of the housing to the distal opening. A media strip is dispensable from the lower portion of the housing, through the first lumen, out the distal opening of the elongated tubular member, through the second lumen and into the upper portion of the housing.

摘要翻译： 公开了一种用于测试体液的介质分配装置及其使用方法。 该装置包括具有下部和上部的壳体，以及具有邻近其远端的远端开口的细长管状构件。 所述细长管状构件包括在所述细长管状构件内从所述壳体的下部延伸到所述远端开口的第一腔，并且包括所述细长管状构件中的从所述壳体的上部延伸到所述远端开口的第二腔。 介质条从壳体的下部经由第一内腔排出，从细长管状构件的远端开口穿过第二内腔并进入壳体的上部是不必要的。