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公开(公告)号：US08048151B2
公开(公告)日：2011-11-01
申请号：US12603973
申请日：2009-10-22
IPC分类号： A61F2/06
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/108 , Y10T29/49885
摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
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2.发明授权Connection for a coiled lead to an electrical contact for an implantable medical device 有权将线圈引线连接到可植入医疗设备的电接点公开(公告)号：US07715923B2
公开(公告)日：2010-05-11
申请号：US11682400
申请日：2007-03-06
IPC分类号： A61N1/04
CPC分类号： H01R4/5033 , A61N1/05 , A61N1/0553 , A61N1/056 , H01R4/183 , H01R13/5224
摘要： High reliability electrical connections between a helical strand and flat electrodes, such us strip electrodes found in implantable neurostimulator system, are described. The connection consists of a crimp joint in which an inside diameter mandrel is used to provided the coil with sufficient radial rigidity to ensure structural integrity of the crimp. The mandrel is made of a relatively soft biocompatible material that deforms rather than damages the fine wires of the helical strand during crimping. The crimping is accomplished by radial deformation of an annular or semi-annular crimping member that receives the helical strand/mandrel assembly.
摘要翻译： 描述了螺旋线和扁平电极之间的高可靠性电连接，例如我们在可植入神经刺激器系统中发现的带状电极。 连接件包括一个卷边接头，其中使用内径心轴来使线圈具有足够的径向刚度，以确保卷曲的结构完整性。 心轴由相对柔软的生物相容材料制成，其在卷曲期间变形而不损坏螺旋股线的细线。 卷边通过容纳螺旋股/心轴组件的环形或半环形压接构件的径向变形来实现。
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公开(公告)号：US20100189879A1
公开(公告)日：2010-07-29
申请号：US12756516
申请日：2010-04-08
申请人： Robert C. O'Brien
发明人： Robert C. O'Brien
CPC分类号： A61N1/056 , A61N1/0551 , C23C14/562 , Y10T428/2913
摘要： Implantable electrical lead wires, such as cobalt-chromium-molybdenum alloy wires, are coated with a metal, ceramic, or carbon to a thickness of about 100 nm or less to provide a non-reactive interface to polyurethane sheathing materials. Preferred is sputter coating an amorphous carbon intermediate the alloy wire and the polyurethane sheath.
摘要翻译： 诸如钴 - 铬 - 钼合金线的可植入电引线被涂覆有约100nm或更小的厚度的金属，陶瓷或碳，以提供与聚氨酯护套材料的非反应性界面。 优选在合金丝和聚氨酯护套之间溅射涂覆无定形碳。
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4.发明授权Connection for a coiled lead to an electrical contact for an implantable medical device 失效将线圈引线连接到可植入医疗设备的电接点公开(公告)号：US07383090B2
公开(公告)日：2008-06-03
申请号：US10968310
申请日：2004-10-19
IPC分类号： A61N1/04
CPC分类号： H01R4/5033 , A61N1/05 , A61N1/0553 , A61N1/056 , H01R4/183 , H01R13/5224
摘要： High reliability electrical connections between a helical strand and flat electrodes, such as strip electrodes found in implantable neurostimulator systems, are described. The connection consists of a crimp joint in which an inside diameter mandrel is used to provided the coil with sufficient radial rigidity to ensure structural integrity of the crimp. The mandrel is made of a relatively soft biocompatible material that deforms rather than damages the fine wires of the helical strand during crimping. The crimp is accomplished by radial deformation of an annular or semi-annular crimping member that receives the helical strand/mandrel assembly.
摘要翻译： 描述了在可植入的神经刺激器系统中发现的螺旋线和扁平电极之间的高可靠性电连接，例如条形电极。 连接件包括一个卷边接头，其中使用内径心轴来使线圈具有足够的径向刚度，以确保卷曲的结构完整性。 心轴由相对柔软的生物相容性材料制成，其在卷曲期间变形而不损坏螺旋股线的细线。 卷曲是通过接收螺旋股/心轴组件的环形或半环形压接构件的径向变形实现的。
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公开(公告)号：US07162308B2
公开(公告)日：2007-01-09
申请号：US10719632
申请日：2003-11-21
申请人： Robert C. O'Brien , Christine Frysz
发明人： Robert C. O'Brien , Christine Frysz
IPC分类号： A61N1/00
CPC分类号： B21C37/00 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36017 , A61N1/3605 , B82Y30/00
摘要： Coatings for implantable electrodes consisting of single- or multi-walled nanotubes, nanotube ropes, carbon whiskers, and a combination of these are described. The nanotubes can be carbon or other conductive nanotube-forming materials such as a carbon-doped boron nitride. The nanotube coatings are grown “in situ” on a catalytic substrate surface from thermal decomposition, or they are bonded to the substrate using a metal or conductive metal oxide thin film binder deposited by means of a metal compound precursor in liquid form. In the latter case, the precursor/nanotube coating is then converted to a pure metal or conductive metal oxide, resulting in the desired surface coating with imbedded nanotubes.
摘要翻译： 描述了由单壁或多壁纳米管，纳米管绳索，碳晶须及其组合组成的可植入电极的涂层。 纳米管可以是碳或其它导电纳米管形成材料，例如碳掺杂的氮化硼。 纳米管涂层在热分解的催化底物表面上“原地”生长，或者使用通过液体形式的金属化合物前体沉积的金属或导电金属氧化物薄膜粘合剂将其结合到基底上。 在后一种情况下，将前体/纳米管涂层转化为纯金属或导电金属氧化物，从而形成嵌入的纳米管所需的表面涂层。
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公开(公告)号：US08367151B2
公开(公告)日：2013-02-05
申请号：US12755777
申请日：2010-04-07
IPC分类号： A61L33/00
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/108 , Y10T29/49885
摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
摘要翻译： 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架，每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层，同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除，暴露所有表面，并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性，而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。
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公开(公告)号：US08057543B2
公开(公告)日：2011-11-15
申请号：US11307226
申请日：2006-01-27
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/108 , Y10T29/49885
摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
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公开(公告)号：US20100100172A1
公开(公告)日：2010-04-22
申请号：US12646096
申请日：2009-12-23
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/108 , Y10T29/49885
摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
摘要翻译： 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架，每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层，同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除，暴露所有表面，并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性，而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。
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公开(公告)号：US08066764B2
公开(公告)日：2011-11-29
申请号：US12646096
申请日：2009-12-23
IPC分类号： A61F2/06
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/108 , Y10T29/49885
摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
摘要翻译： 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架，每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层，同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除，暴露所有表面，并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性，而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。
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公开(公告)号：US20100198335A1
公开(公告)日：2010-08-05
申请号：US12755777
申请日：2010-04-07
CPC分类号： A61L31/084 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/108 , Y10T29/49885
摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
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