公开(公告)号：US08043078B2

公开(公告)日：2011-10-25

申请号：US12207051

申请日：2008-09-09

申请人： Robert C. Stover ,  Huaming Guo ,  Minghau Yan ,  Jun You ,  Yong Cao

发明人： Robert C. Stover ,  Huaming Guo ,  Minghau Yan ,  Jun You ,  Yong Cao

IPC分类号： F03C4/00 ,  F04C18/00 ,  F04C2/00

CPC分类号： F04C18/0215 ,  F04C23/008 ,  F04C27/005

摘要： A compressor may include a shell, first and second scroll members, a partition and a first annular seal. The partition may be fixed to the shell and may overly the first scroll member. The partition may include first and second sides having a second discharge opening passing therethrough and being in communication with the first discharge opening. The first side may include a protrusion extending toward the first scroll member and generally surrounding the second discharge opening. The first annular seal may sealingly engage the partition and may be displaceable radially inward to a position abutting the protrusion to limit a radially inward travel of the first annular seal.

摘要翻译： 压缩机可以包括壳体，第一和第二涡旋构件，隔板和第一环形密封件。 分隔件可以固定到壳体并且可以过度地覆盖第一涡旋构件。 分隔件可以包括具有穿过其中并与第一排出口连通的第二排放口的第一和第二侧。 第一侧可以包括朝向第一涡旋构件延伸并且大致围绕第二排出口的突起。 第一环形密封件可以密封地接合隔板，并且可以径向向内移动到与突起抵接的位置以限制第一环形密封件的径向向内的行进。

公开(公告)号：US20090068048A1

公开(公告)日：2009-03-12

申请号：US12207051

申请日：2008-09-09

申请人： Robert C. Stover ,  Huaming Guo ,  Minghau Yan ,  Jun You ,  Yong Cao

发明人： Robert C. Stover ,  Huaming Guo ,  Minghau Yan ,  Jun You ,  Yong Cao

IPC分类号： F04C27/00 ,  F04C18/04

CPC分类号： F04C18/0215 ,  F04C23/008 ,  F04C27/005

摘要： A compressor may include a shell, first and second scroll members, a partition and a first annular seal. The partition may be fixed to the shell and may overly the first scroll member. The partition may include first and second sides having a second discharge opening passing therethrough and being in communication with the first discharge opening. The first side may include a protrusion extending toward the first scroll member and generally surrounding the second discharge opening. The first annular seal may sealingly engage the partition and may be displaceable radially inward to a position abutting the protrusion to limit a radially inward travel of the first annular seal.

摘要翻译： 压缩机可以包括壳体，第一和第二涡旋构件，隔板和第一环形密封件。 分隔件可以固定到壳体并且可以过度地覆盖第一涡旋构件。 分隔件可以包括具有穿过其中并与第一排出口连通的第二排放口的第一和第二侧。 第一侧可以包括朝向第一涡旋构件延伸并且大致围绕第二排出口的突起。 第一环形密封件可以密封地接合隔板，并且可以径向向内移动到与突起抵接的位置，以限制第一环形密封件的径向向内行进。

公开(公告)号：US08356987B2

公开(公告)日：2013-01-22

申请号：US12207072

申请日：2008-09-09

申请人： Huaming Guo ,  Jun You ,  Yong Cao

发明人： Huaming Guo ,  Jun You ,  Yong Cao

IPC分类号： F04C18/00 ,  F04C2/00

CPC分类号： F04C23/008 ,  F01C21/10 ,  F04C18/0215 ,  F04C2230/603 ,  F04C2240/30 ,  F16C2360/42 ,  Y10T29/49229 ,  Y10T29/49236 ,  Y10T29/4924 ,  Y10T137/7857 ,  Y10T137/7891 ,  Y10T137/7892 ,  Y10T137/85978

摘要： A compressor may include a shell and a housing fixed within the shell. A compression mechanism may be supported by the housing and may include an orbiting scroll member and a non-orbiting scroll member that are meshingly engaged to form a series of compression pockets. A retaining assembly may include an axial retention member and a rotational retention member, each of which is engaged with the non-orbiting scroll member to limit axial translation and rotation of the non-orbiting scroll member relative to the housing.

摘要翻译： 压缩机可以包括壳体和固定在壳体内的壳体。 压缩机构可以由壳体支撑，并且可以包括绕动涡旋构件和非绕动涡旋构件，其啮合地接合以形成一系列压缩腔。 保持组件可以包括轴向保持构件和旋转保持构件，每个构件与非绕动涡旋构件接合以限制非绕动涡旋构件相对于壳体的轴向平移和旋转。

公开(公告)号：US20090068044A1

公开(公告)日：2009-03-12

申请号：US12207072

申请日：2008-09-09

申请人： Huaming Guo ,  Jun You ,  Yong Cao

发明人： Huaming Guo ,  Jun You ,  Yong Cao

IPC分类号： F01C1/02

CPC分类号： F04C23/008 ,  F01C21/10 ,  F04C18/0215 ,  F04C2230/603 ,  F04C2240/30 ,  F16C2360/42 ,  Y10T29/49229 ,  Y10T29/49236 ,  Y10T29/4924 ,  Y10T137/7857 ,  Y10T137/7891 ,  Y10T137/7892 ,  Y10T137/85978

摘要： A compressor may include a shell and a housing fixed within the shell. A compression mechanism may be supported by the housing and may include an orbiting scroll member and a non-orbiting scroll member that are meshingly engaged to form a series of compression pockets. A retaining assembly may include an axial retention member and a rotational retention member, each of which is engaged with the non-orbiting scroll member to limit axial translation and rotation of the non-orbiting scroll member relative to the housing.

摘要翻译： 压缩机可以包括壳体和固定在壳体内的壳体。 压缩机构可以由壳体支撑，并且可以包括绕动涡旋构件和非绕动涡旋构件，其啮合地接合以形成一系列压缩腔。 保持组件可以包括轴向保持构件和旋转保持构件，每个构件与非绕动涡旋构件接合以限制非绕动涡旋构件相对于壳体的轴向平移和旋转。

公开(公告)号：US20140208456A1

公开(公告)日：2014-07-24

申请号：US14009373

申请日：2012-04-01

申请人： Lizhong Xiong ,  Jun You

发明人： Lizhong Xiong ,  Jun You

IPC分类号： C12N15/82

CPC分类号： C12N15/8273 ,  C07K14/415

摘要： Rice OsSRO1C gene conferring enhanced drought resistance of a plant is provided, wherein the said gene encodes an amino acid sequences as set forth in SEQ ID NO: 2. DNA constructs, transgenic plants or cells comprising the OsSRO1C gene and the uses of the OsSRO1C gene in improving though resistance of a plant are also provided. The OsSRO1C gene controlling rice drought resistance is cloned by screening a rice T-DNA insertion mutant database and determination of expression level and identification of drought stress phenotype, which shows that the mutant is co-segregated with the drought susceptible phenotype.

摘要翻译： 提供赋予植物抗旱性的水稻OsSRO1C基因，其中所述基因编码如SEQ ID NO：2所示的氨基酸序列.DNA构建体，转基因植物或包含OsSRO1C基因的细胞和OsSRO1C基因的用途 在提高植物抗药性方面也有提高。 通过筛选水稻T-DNA插入突变体数据库，测定表达水平和鉴定干旱胁迫表型，克隆了耐旱稻田OsSRO1C基因，表明突变体与干旱易感基因表型共分离。

公开(公告)号：US20120088819A1

公开(公告)日：2012-04-12

申请号：US13126355

申请日：2009-10-30

申请人： Makoto Inoue ,  Koichi Saeki ,  Jun You ,  Toshiaki Tabata ,  Hitoshi Iwasaki ,  Tsugumine Shu ,  Mamoru Hasegawa

发明人： Makoto Inoue ,  Koichi Saeki ,  Jun You ,  Toshiaki Tabata ,  Hitoshi Iwasaki ,  Tsugumine Shu ,  Mamoru Hasegawa

IPC分类号： A61K31/7088 ,  C12N5/10 ,  C12P21/00 ,  C12N15/63

CPC分类号： C12N15/67 ,  A61K2039/53 ,  C07K2319/55 ,  C12N15/86 ,  C12N2760/18843

摘要： The present invention provides methods for enhancing protein expression from an RNA viral vector and RNA viral vectors with enhanced protein expression capacity. The present inventors successfully increased the level of protein expression significantly by expressing the proteins fused with an AB5B protein from RNA viral vectors. Effective gene therapy, gene vaccination, monoclonal antibody preparation, or such can be achieved by using a gene transfer RNA viral vector of the present invention.

摘要翻译： 本发明提供了从具有增强的蛋白质表达能力的RNA病毒载体和RNA病毒载体增强蛋白质表达的方法。 通过从RNA病毒载体表达与AB5B蛋白质融合的蛋白质，本发明人通过显着地成功地提高了蛋白质表达水平。 有效的基因治疗，基因疫苗接种，单克隆抗体制备等可以通过使用本发明的基因转移RNA病毒载体来实现。

公开(公告)号：US20100209974A1

公开(公告)日：2010-08-19

申请号：US12373684

申请日：2007-07-03

申请人： Jun You ,  Makoto Inoue ,  Mamoru Hasegawa

发明人： Jun You ,  Makoto Inoue ,  Mamoru Hasegawa

IPC分类号： C12N15/86 ,  C12N15/33 ,  C12N15/64

CPC分类号： C12N15/86 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2820/00

摘要： The present inventors succeeded in producing non-replicating SeV vectors whose genomic RNAs lack all genes for the NP, P, and L proteins, which are RNP-constituting proteins. The present inventors confirmed that the NP/P/L-deficient SeV vectors carrying a marker gene such as GFP provide high productivity, and high transfer and expression efficiencies of foreign genes (high MOI infection is essential for achieving high expression levels). By lacking the L gene or two or more of the NP, P, and L genes, the vectors of the present invention enable lowering the level of virus-derived proteins expressed in host cells, thereby reducing the immunogenicity upon in vivo administration.

摘要翻译： 本发明人成功地生产了非复制型SeV载体，其基因组RNA缺乏作为构成RNP的蛋白质的NP，P和L蛋白的所有基因。 本发明人确认携带GFP等标记基因的NP / P / L-缺陷型SeV载体提供高生产率，外源基因的高转移和表达效率（高MOI感染对于获得高表达水平至关重要）。 通过缺乏L基因或两个以上的NP，P和L基因，本发明的载体能够降低在宿主细胞中表达的病毒衍生的蛋白质的水平，从而降低体内给药时的免疫原性。

公开(公告)号：US09568243B2

公开(公告)日：2017-02-14

申请号：US13990767

申请日：2011-06-15

申请人： Chaohui Liu ,  Chuan Zhou ,  Yi Liu ,  Qi Kang ,  Jun You ,  Kun Zhou

发明人： Chaohui Liu ,  Chuan Zhou ,  Yi Liu ,  Qi Kang ,  Jun You ,  Kun Zhou

IPC分类号： F26B3/347 ,  F26B5/06 ,  F26B5/04

CPC分类号： F26B3/347 ,  F26B5/042 ,  F26B5/048 ,  F26B5/06

摘要： A continuous microwave freeze-drying device comprises a vacuum water-trapping system (1), a microwave shield plate (2), a microwave bin (6) and a freeze-drying bin (5) located in the microwave bin (6), wherein the freeze-drying bin (5) comprises an upper bin opening, a left bin wall, a right bin wall and a bottom bin wall, and the left, right and bottom bin walls are all made from nonmetal wave transmitting materials, such as polyfluortetraethylene, polyethylene, polypropylene or quartz glass. The device solves the technical problem of freeze-drying failure caused by glow discharge of microwave under freeze-drying environment.

摘要翻译： 连续的微波冷冻干燥装置包括位于微波炉（6）中的真空吸水系统（1），微波屏蔽板（2），微波炉（6）和冷冻干燥箱（5） 其特征在于，所述冷冻干燥箱（5）包括上部箱体开口，左侧箱壁，右侧箱壁和底部箱体壁，左侧和右侧箱体壁全部由非金属波浪传输材料制成，例如 聚四氟乙烯，聚乙烯，聚丙烯或石英玻璃。 该装置解决了冷冻干燥环境下微波辉光放电引起的冷冻干燥故障的技术问题。

公开(公告)号：US20130333237A1

公开(公告)日：2013-12-19

申请号：US13990767

申请日：2011-06-15

申请人： Chaohui Liu ,  Chuan Zhou ,  Yi Liu ,  Qi Kang ,  Jun You ,  Kun Zhou

发明人： Chaohui Liu ,  Chuan Zhou ,  Yi Liu ,  Qi Kang ,  Jun You ,  Kun Zhou

IPC分类号： F26B3/347

CPC分类号： F26B3/347 ,  F26B5/042 ,  F26B5/048 ,  F26B5/06

摘要： A continuous microwave freeze-drying device comprises a vacuum water-trapping system (1), a microwave shield plate (2), a microwave bin (6) and a freeze-drying bin (5) located in the microwave bin (6), wherein the freeze-drying bin (5) comprises an upper bin opening, a left bin wall, a right bin wall and a bottom bin wall, and the left, right and bottom bin walls are all made from nonmetal wave transmitting materials, such as polyfluortetraethylene, polyethylene, polypropylene or quartz glass. The device solves the technical problem of freeze-drying failure caused by glow discharge of microwave under freeze-drying environment.

摘要翻译： 连续微波冷冻干燥装置包括位于微波炉（6）中的真空吸水系统（1），微波屏蔽板（2），微波炉（6）和冷冻干燥箱（5） 其特征在于，所述冷冻干燥箱（5）包括上部箱体开口，左侧箱壁，右侧箱壁和底部箱体壁，左侧和右侧箱体壁全部由非金属波浪传输材料制成，例如 聚四氟乙烯，聚乙烯，聚丙烯或石英玻璃。 该装置解决了冷冻干燥环境下微波辉光放电引起的冷冻干燥故障的技术问题。

公开(公告)号：US20120087940A1

公开(公告)日：2012-04-12

申请号：US13126293

申请日：2009-10-30

申请人： Makoto Inoue ,  Koichi Saeki ,  Jun You ,  Toshiaki Tabata ,  Hitoshi Iwasaki ,  Tsugumine Shu ,  Mamoru Hasegawa

发明人： Makoto Inoue ,  Koichi Saeki ,  Jun You ,  Toshiaki Tabata ,  Hitoshi Iwasaki ,  Tsugumine Shu ,  Mamoru Hasegawa

IPC分类号： A61K31/7105 ,  A61P25/28 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/0007 ,  A61K38/00 ,  A61K2039/53 ,  A61K2039/545 ,  C07K14/4711 ,  C07K2319/55 ,  C12N2760/18843 ,  C12N2799/021 ,  C12N2799/04

摘要： The present invention provides methods for efficiently inducing anti-Aβ antibody and methods for preventing and treating Alzheimer's disease. The present inventors successfully induced anti-Aβ antibody in a highly efficient manner by administering an RNA viral vector that expresses a fusion protein between an AB5 toxin B subunit and an Aβ antigen peptide. Administration of the vector resulted in a significant increase of anti-Aβ antibody in plasma, and decrease in the Aβ level in brain tissues and decrease in the anti-Aβ antibody-positive area. The present invention enables more efficient vaccine gene therapy for preventing and treating Alzheimer's disease.

摘要翻译： 本发明提供了有效诱导抗Aβ的方法。 抗体和预防和治疗阿尔茨海默病的方法。 本发明人成功地诱导了抗A＆Bgr; 抗体，通过施用在AB5毒素B亚基和A＆bgr之间表达融合蛋白的RNA病毒载体以高效的方式; 抗原肽。 载体的施用导致抗A和Bgr的显着增加; 血浆中的抗体，A和Bgr的减少; 脑组织中的水平和抗A和Bgr的降低; 抗体阳性区。 本发明使得能够更有效地预防和治疗阿尔茨海默病的疫苗基因治疗。