8-Phenyl-5,6,7,8-Hydroquinoline Tachykinin Receptor Antagonists
    3.
    发明申请
    8-Phenyl-5,6,7,8-Hydroquinoline Tachykinin Receptor Antagonists 审中-公开
    8-苯基-5,6,7,8-氢喹啉速激肽受体拮抗剂

    公开(公告)号:US20080039494A1

    公开(公告)日:2008-02-14

    申请号:US11667908

    申请日:2005-11-29

    摘要: The present invention is directed to certain 8-phenyl-5,6,7,8-hydroquinolinecompounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译: 本发明涉及可用作神经激肽-1(NK-1)受体拮抗剂的某些8-苯基-5,6,7,8-氢喹啉化合物,以及速激肽抑制剂,特别是物质P。本发明还涉及 其中包含这些化合物作为活性成分的药物制剂以及化合物及其制剂在治疗某些疾病(包括呕吐,尿失禁,抑郁和焦虑)中的用途。

    Hydroisoindoline tachykinin receptor antagonists
    4.
    发明申请
    Hydroisoindoline tachykinin receptor antagonists 有权
    羟基异吲哚啉速激肽受体拮抗剂

    公开(公告)号:US20050165083A1

    公开(公告)日:2005-07-28

    申请号:US11043213

    申请日:2005-01-26

    IPC分类号: C07D209/44 A61K31/4035

    CPC分类号: C07D209/44

    摘要: The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译: 本发明涉及可用作神经激肽-1(NK-1)受体拮抗剂,速激肽抑制剂,特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病,包括呕吐,尿失禁,抑郁和焦虑。

    Quinoline Tachykinin Receptor Antagonists
    5.
    发明申请
    Quinoline Tachykinin Receptor Antagonists 审中-公开
    喹啉速激肽受体拮抗剂

    公开(公告)号:US20070293492A1

    公开(公告)日:2007-12-20

    申请号:US11791241

    申请日:2005-11-29

    摘要: The present invention is directed to certain quinoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译: 本发明涉及可用作神经激肽-1(NK-1)受体拮抗剂,速激肽抑制剂,特别是物质P的某些喹啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病,包括呕吐,尿失禁,抑郁和焦虑。

    Anti-hypercholesterolemic compounds
    8.
    发明申请
    Anti-hypercholesterolemic compounds 失效
    抗高胆固醇血症化合物

    公开(公告)号:US20070078098A1

    公开(公告)日:2007-04-05

    申请号:US11542966

    申请日:2006-10-04

    CPC分类号: C07D205/08 C07D405/10

    摘要: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.

    摘要翻译: 本发明提供式I的胆固醇吸收抑制剂及其药学上可接受的盐和酯。 该化合物可用于降低血浆胆固醇水平,特别是低密度脂蛋白胆固醇,以及用于治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。

    Handheld circular sawing device
    10.
    发明授权

    公开(公告)号:US10033167B1

    公开(公告)日:2018-07-24

    申请号:US15480591

    申请日:2017-04-06

    IPC分类号: H02G1/12 B21F13/00

    摘要: A handheld circular sawing device for severing armored cable includes a housing. A first plate is coupled to and extends coplanarly with a first side of the housing. A second plate is positioned substantially perpendicular to the first plate along a lower edge of the first plate. The second plate is hingedly coupled by a first end to the first plate proximate to a rear of the housing. A second end of the second plate is positioned proximate to a front of the housing to define a channel. A power module and a motor are coupled to the housing. The motor is operationally coupled to the power module. A blade that is coupled to a shaft of the motor protrudes into the channel. The motor is positioned to rotate the blade coincident with the shaft to longitudinally cut a section of a tubular substrate that is positioned in the channel.