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    Aroylaminoacid disulfides
    6.
    发明授权
    Aroylaminoacid disulfides 失效
    芳酰胺酸二硫化物

    公开(公告)号：US4479950A

    公开(公告)日：1984-10-30

    申请号：US439525

    申请日：1982-11-05

    申请人： Paul R. Menard ,  Howard Jones ,  John T. Suh

    发明人： Paul R. Menard ,  Howard Jones ,  John T. Suh

    IPC分类号： A61K31/195 ,  A61K31/215 ,  C07D307/58 ,  C07D401/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07C149/40 ,  C07C149/41

    CPC分类号： C07C323/00 ,  C07C327/00

    摘要： Compounds of the structure ##STR1## wherein: P and Q are independently hydrogen, halo, CF.sub.3, OR.sub.1, SR.sub.1, sulfamoyl, alkyl and NR.sub.1 R.sub.2 ;R.sub.1, and R.sub.2 are independently hydrogen, alkyl, aminoalky, aryl, aralkyl, heteroaryl or cycloalkyl;Y is OH, OR.sub.1, NH.sub.2, or, N(R.sub.1 R.sub.2); andM is alkyl, cycloalkyl, aryl, aminoalkyl, aralkyl, heteroaryl or heterocyclicwherein:the alkyl groups and the alkyl moieties of aminoalkyl, alkoxy and thioalkyl contain from 1 to 6 carbon atoms; the cycloalkyl group contains from 3 to 8 carbon atoms; the aryl group contains from 6 to 10 carbon atoms; the aralkyl group contains from 7 to 16 carbon atoms; and the hetero group is selected from pyrrolidyl, piperidinyl, morpholinyl, pyridyl, quinolinyl, furyl, furfuryl and thienyl; and where Y is a hydroxy, their pharmaceutically acceptable, non-toxic alkali, alkaline earth and amine salts, have angiotensin converting enzyme inhibitory activity.

    摘要翻译： 其中：P和Q独立地是氢，卤素，CF 3，OR 1，SR 1，氨磺酰基，烷基和NR 1 R 2; R1和R2独立地是氢，烷基，氨基烷基，芳基，芳烷基，杂芳基或环烷基; Y是OH，OR1，NH2或N（R1R2）; 并且M是烷基，环烷基，芳基，氨基烷基，芳烷基，杂芳基或杂环，其中：烷基和氨基烷基，烷氧基和硫代烷基的烷基部分含有1至6个碳原子; 环烷基含有3至8个碳原子; 芳基含有6至10个碳原子; 芳烷基含有7至16个碳原子; 杂基选自吡咯烷基，哌啶基，吗啉基，吡啶基，喹啉基，呋喃基，糠基和噻吩基; 并且其中Y是羟基，其药学上可接受的，无毒的碱金属，碱土金属和胺盐具有血管紧张素转化酶抑制活性。