公开(公告)号：US08541214B2

公开(公告)日：2013-09-24

申请号：US13084318

申请日：2011-04-11

申请人： Robert Hickey ,  Rahul Basu ,  Rathin Datta ,  Shih-Perng Tsai

发明人： Robert Hickey ,  Rahul Basu ,  Rathin Datta ,  Shih-Perng Tsai

IPC分类号： C12P7/06

CPC分类号： C12M29/16 ,  C12M21/12 ,  C12M25/10 ,  C12P7/04 ,  Y02E50/17

摘要： A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the microorganisms as a biolayer on the surface of the membrane facilitates cleaning of the membrane surface that retains the biofilm. In addition the shell gas space that surrounds the membranes may be flooded to reduce or remove the biofilm. Agitation of the liquid, by for example the bubbling of gas in the surrounding shell space, can fully or partially remove the biofilm from the membrane.

摘要翻译： 用于从合成气组分生产液体产物如乙醇，丁醇和其它化学品的稳定系统在厌氧条件下接触CO或亲水膜的CO或CO 2和H 2的混合物，并将这些组分转移到膜上作为生物膜的微生物接触。 将微生物作为生物层保持在膜的表面上有助于清洁保留生物膜的膜表面。 此外，围绕膜的壳体气体空间可能被淹没以减少或去除生物膜。 液体的搅拌，例如气体在周围的壳体空间中鼓泡，可以完全或部分地从膜中除去生物膜。

公开(公告)号：US07923227B2

公开(公告)日：2011-04-12

申请号：US12574499

申请日：2009-10-06

申请人： Robert Hickey ,  Rahul Basu ,  Rathin Datta ,  Shih-Perng Tsai

发明人： Robert Hickey ,  Rahul Basu ,  Rathin Datta ,  Shih-Perng Tsai

IPC分类号： C12P7/06

CPC分类号： C12M29/16 ,  C12M21/12 ,  C12M25/10 ,  C12P7/04 ,  Y02E50/17

摘要： A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the microorganisms as a biolayer on the surface of the membrane facilitates cleaning of the membrane surface that retains the biofilm. In addition the shell gas space that surrounds the membranes may be flooded to reduce or remove the biofilm. Agitation of the liquid, by for example the bubbling of gas in the surrounding shell space, can fully or partially remove the biofilm from the membrane.

摘要翻译： 用于从合成气组分生产液体产物如乙醇，丁醇和其它化学品的稳定系统在厌氧条件下接触CO或亲水膜的CO或CO 2和H 2的混合物，并将这些组分转移到膜上作为生物膜的微生物接触。 将微生物作为生物层保持在膜的表面上有助于清洁保留生物膜的膜表面。 此外，围绕膜的壳体气体空间可能被淹没以减少或去除生物膜。 液体的搅拌，例如气体在周围的壳体空间中鼓泡，可以完全或部分地从膜中除去生物膜。

公开(公告)号：US08828692B2

公开(公告)日：2014-09-09

申请号：US13101535

申请日：2011-05-05

申请人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

发明人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

IPC分类号： C12P7/54 ,  C12M1/00 ,  C12M1/12 ,  C12P7/04 ,  C12M1/34

CPC分类号： C12P7/065 ,  C12M21/12 ,  C12M23/58 ,  C12M25/10 ,  C12M29/16 ,  C12M41/28 ,  C12P7/04 ,  Y02E50/17

摘要： Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components into contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microorganisms that converted the syngas to desired liquid products. The system can sustain production with a variety of microorganisms and membrane configurations.

摘要翻译： 乙醇和其它液体产物是通过将合成气组分如CO或CO 2和H 2的混合物与膜的表面在厌氧条件下接触而生产的，并将这些组分与膜的相反侧的生物膜接触。 这些步骤为生产液体产品如乙醇，丁醇和其他化学品提供了稳定的系统。 供给在膜的气体接触侧的气体输送通过膜以形成将合成气转化为所需液体产物的厌氧微生物生物膜。 该系统可以通过各种微生物和膜结构来维持生产。

公开(公告)号：US20110256597A1

公开(公告)日：2011-10-20

申请号：US13101535

申请日：2011-05-05

申请人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

发明人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

IPC分类号： C12P7/54 ,  C12P7/14 ,  C12P7/16 ,  C12P7/04 ,  C12P7/52 ,  C12P7/06

CPC分类号： C12P7/065 ,  C12M21/12 ,  C12M23/58 ,  C12M25/10 ,  C12M29/16 ,  C12M41/28 ,  C12P7/04 ,  Y02E50/17

摘要： Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components into contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microorganisms that converted the syngas to desired liquid products. The system can sustain production with a variety of microorganisms and membrane configurations.

摘要翻译： 乙醇和其它液体产物是通过将合成气组分如CO或CO 2和H 2的混合物与膜的表面在厌氧条件下接触而生产的，并将这些组分与膜的相反侧的生物膜接触。 这些步骤为生产液体产品如乙醇，丁醇和其他化学品提供了稳定的系统。 供给在膜的气体接触侧的气体输送通过膜以形成将合成气转化为所需液体产物的厌氧微生物生物膜。 该系统可以通过各种微生物和膜结构来维持生产。

公开(公告)号：US20080305540A1

公开(公告)日：2008-12-11

申请号：US11972454

申请日：2008-01-10

申请人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

发明人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

IPC分类号： C12M1/12

CPC分类号： C12M23/44 ,  C12M21/12 ,  C12M25/10 ,  C12M29/16 ,  C12P7/04 ,  Y02E50/17

摘要： Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microoganisms that converted the syngas to desired liquid products. The system can sustain production with a variety of microorganisms and membrane configurations.

摘要翻译： 乙醇和其它液体产物通过将合成气组分如CO或CO 2和H 2的混合物与膜的表面在厌氧条件下接触而生产，并将这些组分与膜的相反侧上的生物膜接触。 这些步骤为生产液体产品如乙醇，丁醇和其他化学品提供了稳定的系统。 供应在膜的气体接触侧的气体输送通过膜以形成将合成气转化为所需液体产物的厌氧微生物的生物膜。 该系统可以通过各种微生物和膜结构来维持生产。

公开(公告)号：US20080305539A1

公开(公告)日：2008-12-11

申请号：US11781717

申请日：2007-07-23

申请人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

发明人： Robert Hickey ,  Rathin Datta ,  Shih-Perng Tsai ,  Rahul Basu

IPC分类号： C12M1/04

CPC分类号： C12P7/04 ,  C12M21/12 ,  C12M23/24 ,  C12M23/44 ,  C12M25/10 ,  C12M29/16

摘要： Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microorganisms that converted the syngas to desired liquid products. The system can sustain production with a variety of microorganisms and membrane configurations.

摘要翻译： 通过将合成气组分如CO或CO 2和H 2的混合物与膜的表面接触并将这些组分与膜的相对侧上的生物膜接触转移来生产乙醇和其它液体产物。 这些步骤为生产液体产品如乙醇，丁醇和其他化学品提供了稳定的系统。 供给在膜的气体接触侧的气体输送通过膜以形成将合成气转化为所需液体产物的厌氧微生物生物膜。 该系统可以通过各种微生物和膜结构来维持生产。

公开(公告)号：US20100047886A1

公开(公告)日：2010-02-25

申请号：US12574499

申请日：2009-10-06

申请人： Robert Hickey ,  Rahul Basu ,  Rathin Datta ,  Shih-Perng Tsai

发明人： Robert Hickey ,  Rahul Basu ,  Rathin Datta ,  Shih-Perng Tsai

IPC分类号： C12P7/54 ,  C12P1/00 ,  C12P7/06 ,  C12P7/16 ,  C12P7/04 ,  C12P7/52 ,  C12P1/04

CPC分类号： C12M29/16 ,  C12M21/12 ,  C12M25/10 ,  C12P7/04 ,  Y02E50/17

摘要： A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the microorganisms as a biolayer on the surface of the membrane facilitates cleaning of the membrane surface that retains the biofilm. In addition the shell gas space that surrounds the membranes may be flooded to reduce or remove the biofilm. Agitation of the liquid, by for example the bubbling of gas in the surrounding shell space, can fully or partially remove the biofilm from the membrane.

摘要翻译： 用于从合成气组分生产液体产物如乙醇，丁醇和其它化学品的稳定系统在厌氧条件下接触CO或亲水膜的CO或CO 2和H 2的混合物，并将这些组分转移到膜上作为生物膜的微生物接触。 将微生物作为生物层保持在膜的表面上有助于清洁保留生物膜的膜表面。 此外，围绕膜的壳体气体空间可能被淹没以减少或去除生物膜。 液体的搅拌，例如气体在周围的壳体空间中鼓泡，可以完全或部分地从膜中除去生物膜。

公开(公告)号：US08309348B2

公开(公告)日：2012-11-13

申请号：US13240848

申请日：2011-09-22

申请人： Shih-Perng Tsai ,  Rathin Datta ,  Rahul Basu ,  Seong-Hoon Yoon

发明人： Shih-Perng Tsai ,  Rathin Datta ,  Rahul Basu ,  Seong-Hoon Yoon

IPC分类号： C12P7/06 ,  C12P7/52 ,  C12P7/54 ,  C12P7/16 ,  C12P7/04

CPC分类号： C12M29/16 ,  C12M21/12 ,  C12M23/24 ,  C12M25/10 ,  C12P7/04 ,  Y02E50/17

摘要： A stable method for producing liquid products such as ethanol, propanol, butanol and other chemicals from syngas components that contacts CO or a mixture of CO2 and H2 with a highly porous side of an asymmetric membrane under anaerobic conditions and transfers these components into contact with microorganisms contained within bio-pores of the membrane. A liquid contacting side of the membrane utilizes a dense layer to control hydration of the bio-pores with a liquid phase. The gas feed directly contacts the microorganisms in the bio-pores and maximizes their utilization of the syngas. Metabolic products produced by the microorganisms leave the membrane through the side opposite the entering syngas. This method establishes a unitary direction across the membrane for the supply of the primary feed source to the microorganisms and the withdrawal of metabolically produced products. The feed and product flow improves productivity and performance of the microorganism and the membrane.

摘要翻译： 从厌氧条件下接触CO或CO 2和H 2的混合物的合成气成分的液体产物如乙醇，丙醇，丁醇和其它化学品的稳定方法与非对称膜的高度多孔侧接触并将这些成分转移到微生物 包含在膜的生物孔内。 膜的液体接触侧利用致密层来控制具有液相的生物孔的水合作用。 气体进料直接接触生物孔中的微生物并最大限度地利用合成气。 由微生物产生的代谢产物通过与进入合成气相反的一侧离开膜。 该方法建立了跨膜的单一方向，用于向微生物供应初级进料源和代谢产物的抽出。 饲料和产品流动提高了微生物和膜的生产力和性能。

公开(公告)号：US20090215153A1

公开(公告)日：2009-08-27

申请号：US12258180

申请日：2008-10-24

申请人： Shih-Perng Tsai ,  Rathin Datta ,  Rahul Basu ,  Seong-Hoon Yoon

发明人： Shih-Perng Tsai ,  Rathin Datta ,  Rahul Basu ,  Seong-Hoon Yoon

IPC分类号： C12N1/20 ,  C12M3/00

CPC分类号： C12P7/04 ,  C12M21/12 ,  C12M23/24 ,  C12M25/10 ,  C12M29/16 ,  Y02E50/17

摘要： A membrane supported bioreactor arrangement and method for anaerobic conversion of gas into liquid products including membrane modules having hollow fibers packed across a cross sectional area of the membrane module, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for retaining a porous biolayer about the outer surface of the membrane wall and a less permeable hydration layer around the hollow fiber lumen; a membrane vessel for surrounding the outside of the hollow fibers with a process gas from a gas supply conduit; and a liquid supply conduit operably connected to the hollow fibers for supplying a process liquid to the hollow fiber lumens. The gas supply conduit enables the formation of a biolayer on the outer surface of the hollow fiber wall by interaction of microorganisms with the process gas and the production of a liquid product.

摘要翻译： 一种膜支持的生物反应器装置和用于将气体厌氧转化成液体产物的方法，包括膜组件的膜组件，膜组件横跨膜组件的横截面区域填充，每个中空纤维由具有限定生物孔的多孔外层的不对称膜壁 用于保持围绕所述膜壁的外表面的多孔生物层和围绕所述中空纤维腔的较不透水的水合层; 用于利用来自气体供应管道的处理气体围绕中空纤维外部的膜容器; 以及可操作地连接到中空纤维上的液体供应管道，用于将处理液体供应到中空纤维内腔。 气体供应导管能够通过微生物与工艺气体的相互作用和液体产物的生产在中空纤维壁的外表面上形成生物层。

公开(公告)号：US08329456B2

公开(公告)日：2012-12-11

申请号：US12036007

申请日：2008-02-22

申请人： Shih-Perng Tsai ,  Rathin Datta ,  Rahul Basu ,  Seong-Hoon Yoon

发明人： Shih-Perng Tsai ,  Rathin Datta ,  Rahul Basu ,  Seong-Hoon Yoon

IPC分类号： C12M1/12 ,  C12N5/00 ,  C12N5/02

CPC分类号： C12P7/04 ,  C12M21/12 ,  C12M23/24 ,  C12M25/10 ,  C12M29/16 ,  Y02E50/17

摘要： A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a highly porous side of an asymmetric membrane under anaerobic conditions and transferring these components into contact with microorganisms contained within bio-pores of the membrane. The membrane side of the membrane utilizes a dense layer to control hydration of the bio-pores with a liquid phase. The gas feed directly contacts the microorganisms in the bio-pores and maximizes their utilization of the syngas. Metabolic products produced by the microorganisms leave the membrane through the side opposite the entering syngas. This system and method establishes a unitary direction across the membrane for the supply of the primary feed source to the microorganisms and the withdrawal of metabolically produced products. The feed and product flow improves productivity and performance of the microorganism and the membrane.

摘要翻译： 用于从合成气组分生产液体产物如乙醇，丁醇和其他化学品的稳定系统在厌氧条件下将CO或CO 2和H 2的混合物与非对称膜的高度多孔侧接触并将这些组分转移到与生物体内所含的微生物接触 膜的孔。 膜的膜侧利用致密层来控制具有液相的生物孔的水合。 气体进料直接接触生物孔中的微生物并最大限度地利用合成气。 由微生物产生的代谢产物通过与进入合成气相反的一侧离开膜。 该系统和方法建立了跨膜的单一方向，用于向微生物供应初级进料源并提取代谢产物。 饲料和产品流动提高了微生物和膜的生产力和性能。