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公开(公告)号：US20090022738A1
公开(公告)日：2009-01-22
申请号：US10572740
申请日：2004-10-15
申请人： Robert Hofmeister , Birgit Kohleisen , Ulla Lenkkeri-Schutz , Christian Itin , Patrick Bauerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
发明人： Robert Hofmeister , Birgit Kohleisen , Ulla Lenkkeri-Schutz , Christian Itin , Patrick Bauerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/63 , A61K35/12 , A61P39/00 , A61P37/02 , A61P35/00 , A61K31/7052 , C12N5/00 , C12P21/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmacutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.
摘要翻译： 本发明提供了细胞毒活性CD3特异性结合构建体，其包含与人CD3特异性结合的第一结构域和来自Ig的第二结合结构域。 此外，提供了编码本发明的CD3特异性结合构建体的核酸序列。 本发明的其它方面是包含所述核酸序列的载体和宿主细胞，用于生产本发明构建体的方法和包含所述构建体的组合物。 本发明还提供所述构建体用于制备用于治疗特定疾病的药物组合物，用于治疗特定疾病的方法和包含本发明的结合构建体的试剂盒的用途。
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公开(公告)号：US09102736B2
公开(公告)日：2015-08-11
申请号：US13323206
申请日：2011-12-12
申请人： Robert Hofmeister , Birgit Kohleisen , Ulla Lenkkeri-Schütz , Christian Itin , Patrick Bäuerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
发明人： Robert Hofmeister , Birgit Kohleisen , Ulla Lenkkeri-Schütz , Christian Itin , Patrick Bäuerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.
摘要翻译： 本发明提供了细胞毒活性CD3特异性结合构建体，其包含与人CD3特异性结合的第一结构域和来自Ig的第二结合结构域。 此外，提供了编码本发明的CD3特异性结合构建体的核酸序列。 本发明的其它方面是包含所述核酸序列的载体和宿主细胞，用于生产本发明构建体的方法和包含所述构建体的组合物。 本发明还提供所述构建体用于制备用于治疗特定疾病的药物组合物，用于治疗特定疾病的方法和包含本发明的结合构建体的试剂盒的用途。
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公开(公告)号：US08076459B2
公开(公告)日：2011-12-13
申请号：US10572740
申请日：2004-10-15
申请人： Robert Hofmeister , Birgit Kohleisen , Ulla Lenkkeri-Schütz , Christian Itin , Patrick Bäuerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
发明人： Robert Hofmeister , Birgit Kohleisen , Ulla Lenkkeri-Schütz , Christian Itin , Patrick Bäuerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an IG-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct is provided. Further aspects of the invention are vectors and host cells comprising the nucleic acid sequences, a process for the production of the construct and composition comprising the construct. The invention also provides the use of the constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.
摘要翻译： 本发明提供细胞毒活性的CD3特异性结合构建体，其包含与人CD3特异性结合的第一结构域和来自IG的第二结合结构域。 此外，提供编码CD3特异性结合构建体的核酸序列。 本发明的其它方面是包含核酸序列的载体和宿主细胞，用于生产构建体的方法和包含该构建体的组合物。 本发明还提供了用于制备用于治疗特定疾病的药物组合物的构建体的用途，用于治疗特定疾病的方法和包含本发明的结合构建体的试剂盒。
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公开(公告)号：US20130224205A1
公开(公告)日：2013-08-29
申请号：US13323206
申请日：2011-12-12
申请人： Robert HOFMEISTER , Birgit Kohleisen , Ulla Lenkkeri-Schütz , Christian Itin , Patrick Bäuerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
发明人： Robert HOFMEISTER , Birgit Kohleisen , Ulla Lenkkeri-Schütz , Christian Itin , Patrick Bäuerle , Francis J. Carr , Anita A. Hamilton , Stephen Williams
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.
摘要翻译： 本发明提供了细胞毒活性的CD3特异性结合构建体，其包含与人CD3特异性结合的第一结构域和来自Ig的第二结合结构域。 此外，提供了编码本发明的CD3特异性结合构建体的核酸序列。 本发明的其它方面是包含所述核酸序列的载体和宿主细胞，用于生产本发明构建体的方法和包含所述构建体的组合物。 本发明还提供所述构建体用于制备用于治疗特定疾病的药物组合物，用于治疗特定疾病的方法和包含本发明的结合构建体的试剂盒的用途。
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公开(公告)号：US07264806B2
公开(公告)日：2007-09-04
申请号：US10977369
申请日：2004-10-29
申请人： Francis J. Carr , Anita A. Hamilton
发明人： Francis J. Carr , Anita A. Hamilton
IPC分类号： C07H21/00 , C07K16/00 , C12N5/06 , A61K39/395 , C12P21/06
CPC分类号： C07K16/467 , A61K2039/505 , C07K16/2893 , C07K2317/24 , C07K2317/56 , C07K2319/00
摘要： The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity.
摘要翻译： 本发明提供了抗CD52抗体的修饰形式，其具有减少的潜在T细胞表位的数量，预期显示降低的免疫原性。
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公开(公告)号：US07087724B2
公开(公告)日：2006-08-08
申请号：US10184300
申请日：2002-06-26
申请人： Francis J. Carr , Anita A. Hamilton
发明人： Francis J. Carr , Anita A. Hamilton
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.
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公开(公告)号：US20090092546A1
公开(公告)日：2009-04-09
申请号：US12231381
申请日：2008-09-02
申请人： Francis J. Carr , Anita A. Hamilton
发明人： Francis J. Carr , Anita A. Hamilton
IPC分类号： A61K51/10 , C07K16/18 , A61K101/02 , A61K103/10 , A61K103/20 , A61K101/00 , A61K103/34
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.
摘要翻译： 本发明一般涉及一种衍生自一种动物或禽类物种或菌株的载体分子，当从另一种动物或禽类生物的物种或毒株暴露于免疫系统时，它们基本上是非免疫原性的。 更具体地，本发明提供了用于诊断和治疗应用的去免疫化免疫相互作用分子和甚至更特定的去免疫化抗体。
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公开(公告)号：US20100286375A1
公开(公告)日：2010-11-11
申请号：US12657255
申请日：2010-01-15
申请人： Francis J. Carr , Anita A. Hamilton
发明人： Francis J. Carr , Anita A. Hamilton
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.
摘要翻译： 本发明一般涉及一种衍生自一种动物或禽类物种或菌株的载体分子，当从另一种动物或禽类生物的物种或毒株暴露于免疫系统时，它们基本上是非免疫原性的。 更具体地，本发明提供了用于诊断和治疗应用的去免疫化免疫相互作用分子和甚至更特定的去免疫化抗体。
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公开(公告)号：US07910104B2
公开(公告)日：2011-03-22
申请号：US11833818
申请日：2007-08-03
申请人： Francis J. Carr , Anita A. Hamilton
发明人： Francis J. Carr , Anita A. Hamilton
IPC分类号： A61K39/395 , A61P43/00 , C07K16/18
CPC分类号： C07K16/467 , A61K2039/505 , C07K16/2893 , C07K2317/24 , C07K2317/56 , C07K2319/00
摘要： The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity.
摘要翻译： 本发明提供了抗CD52抗体的修饰形式，其具有减少的潜在T细胞表位的数量，预期显示降低的免疫原性。
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公开(公告)号：US07459143B2
公开(公告)日：2008-12-02
申请号：US11432223
申请日：2006-05-10
申请人： Francis J. Carr , Anita A. Hamilton
发明人： Francis J. Carr , Anita A. Hamilton
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.
摘要翻译： 本发明一般涉及一种衍生自一种动物或禽类物种或菌株的载体分子，当从另一种动物或禽类生物的物种或毒株暴露于免疫系统时，它们基本上是非免疫原性的。 更具体地，本发明提供了用于诊断和治疗应用的去免疫化免疫相互作用分子和甚至更特定的去免疫化抗体。
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