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14 条记录 (耗时 0.04 秒)

    HETEROCYCLIC COMPOUNDS AS S1P1 AGONISTS FOR THE TREATMENT OF AUTOIMMUNE AND VASCULAR DISEASES
    3.
    发明申请
    HETEROCYCLIC COMPOUNDS AS S1P1 AGONISTS FOR THE TREATMENT OF AUTOIMMUNE AND VASCULAR DISEASES 有权
    作为S1P1治疗自身免疫性疾病和血管疾病的药物的异种化合物

    公开(公告)号：US20130237566A1

    公开(公告)日：2013-09-12

    申请号：US13883358

    申请日：2011-11-02

    申请人： Robert J. Cherney ,  Zhongyu Wang

    发明人： Robert J. Cherney ,  Zhongyu Wang

    IPC分类号： C07D413/14 ,  C07D413/04

    CPC分类号： C07D413/14 ,  C07D413/04

    摘要： Disclosed are compounds of Formula (I) or stereoisomers, salts, or prodrugs thereof, wherein: W is CH2 or O; Q is Formula (II), Formula (III) or Formula (IV); and R1, R2, R3, R4, n, and G are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

    摘要翻译： 公开了式（I）的化合物或其立体异构体，盐或前药，其中：W是CH 2或O; Q是式（II），式（III）或式（IV）; 并且R1，R2，R3，R4，n和G如本文所定义。 还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

    Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases
    4.
    发明授权
    Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases 有权
    杂环化合物作为S1P1激动剂用于治疗自身免疫性和血管性疾病

    公开(公告)号：US08629282B2

    公开(公告)日：2014-01-14

    申请号：US13883358

    申请日：2011-11-02

    申请人： Robert J. Cherney ,  Zhongyu Wang

    发明人： Robert J. Cherney ,  Zhongyu Wang

    IPC分类号： C07D271/06

    CPC分类号： C07D413/14 ,  C07D413/04

    摘要： Disclosed are compounds of Formula (I) or stereoisomers, salts, or prodrugs thereof, wherein: W is CH2 or O; Q is Formula (II), Formula (III) or Formula (IV); and R1, R2, R3, R4, n, and G are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

    摘要翻译： 公开了式（I）的化合物或其立体异构体，盐或前药，其中：W是CH 2或O; Q是式（II），式（III）或式（IV）; 并且R1，R2，R3，R4，n和G如本文所定义。 还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

    Safe quick disconnect leakage protector
    6.
    发明授权
    Safe quick disconnect leakage protector 有权
    安全快速断开漏电保护器

    公开(公告)号：US09219360B2

    公开(公告)日：2015-12-22

    申请号：US14235798

    申请日：2011-08-09

    申请人： Zhongyu Wang

    发明人： Zhongyu Wang

    IPC分类号： H02H3/00 ,  H02H3/16 ,  H02H3/05 ,  H02H3/33 ,  H02H5/10 ,  H02H1/06

    CPC分类号： H02H3/162 ,  H02H1/066 ,  H02H3/05 ,  H02H3/16 ,  H02H3/334 ,  H02H5/105

    摘要： The present disclosure provides a safe quick disconnect leakage protector, including a power supply circuit, a sampling circuit, a couple of single-pole single-throws, an on and off control circuit, and a testing circuit. The sampling circuit collects the leakage current signal between the live wire and the neutral wire and outputting the leakage current signal; the main control circuit receives the leakage current signal outputted from the sampling circuit, amplifies the leakage current signal, and outputs a grounding failure control signal when the leakage current reaches the predetermined value; the on and off control circuit receives the grounding failure control signal outputted from the main control circuit and controls the single-pole single-throw switches to disconnect the load from the external power supply according to the grounding failure control signal, thereby protecting the load and improves the safety of the leakage protection of an electrical appliance.

    摘要翻译： 本公开提供了一种安全的快速断开泄漏保护器，包括电源电路，采样电路，一对单极单掷，开关控制电路和测试电路。 采样电路收集有线和中线之间的漏电流信号，并输出漏电流信号; 主控电路接收从采样电路输出的泄漏电流信号，放大漏电流信号，并在泄漏电流达到预定值时输出接地故障控制信号; 接通和断开控制电路接收从主控电路输出的接地故障控制信号，并控制单刀单掷开关根据接地故障控制信号从外部电源断开负载，从而保护负载和 提高电器的漏电保护的安全性。