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1.发明申请Vascular Stent Which Elutes Amino Acid-Methyl-Ester Derivatives for the Treatment of Vulnerable Plaque and Vascular Disease 审中-公开用于治疗易发斑块和血管疾病的氨基酸 - 甲酯衍生物的血管支架公开(公告)号：US20110182964A1
公开(公告)日：2011-07-28
申请号：US13012374
申请日：2011-01-24
申请人： Robert J. Melder , Stefan Tunev
发明人： Robert J. Melder , Stefan Tunev
IPC分类号： A61K31/195 , A61K9/00 , A61K31/215 , A61K31/216 , A61K31/223 , A61P9/10 , A61P37/06
CPC分类号： A61K31/195 , A61K31/215 , A61K31/216 , A61K31/223 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/422
摘要： This invention provides implantable medical devices that include delivery systems containing amino acid derivatives, and related methods for making and using. More specifically, this invention provides vascular stents with coatings containing methyl ester derivatives of amino acids, and related methods for making and using.
摘要翻译： 本发明提供了包括含有氨基酸衍生物的递送系统的可植入医疗装置，以及制造和使用的相关方法。 更具体地，本发明提供血管支架，其具有包含氨基酸的甲酯衍生物的涂层，以及制备和使用的相关方法。
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公开(公告)号：US20110251663A1
公开(公告)日：2011-10-13
申请号：US12755585
申请日：2010-04-07
申请人： Robert J. Melder
发明人： Robert J. Melder
CPC分类号： A61F2/92 , A61F2/91 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61F2250/0068
摘要： The drug eluting rolled stent and a stent delivery system, which includes a catheter; a balloon operably attached to the catheter; and a stent disposed on the balloon. The stent includes a rectangular metal foil sheet having a first side and a second side, the rectangular metal foil sheet being rolled to form a cylindrical tube having a central axis and a spiral cross section perpendicular to the central axis; a polymer drug coating disposed between and adhering the first side and the second side; and at least one opening formed through the cylindrical tube generally perpendicular to the central axis, the at least one opening being shaped to form at least one strut having in cross section polymer drug layers between metal foil layers, polymer drug layer edges of the polymer drug layers being in communication with the at least one opening.
摘要翻译： 药物洗脱支架和支架输送系统，其包括导管; 可操作地附接到导管的球囊; 以及设置在气囊上的支架。 支架包括具有第一侧和第二侧的矩形金属箔片，矩形金属箔片被卷起以形成具有中心轴线和垂直于中心轴线的螺旋截面的圆柱形管子; 设置在第一面和第二面之间并粘附第一面和第二面的聚合物药物涂层; 以及至少一个通过所述圆柱形管形成的大致垂直于所述中心轴线的开口，所述至少一个开口被成形为形成至少一个支柱，所述至少一个支柱在金属箔层之间具有聚合物药物层的横截面，所述聚合物药物的聚合物药物层边缘 层与所述至少一个开口连通。
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3.发明授权Therapeutic use of bFGF to treat conditions involving adhesion of cytotoxic white cells to endothelium 失效治疗性使用bFGF来治疗涉及细胞毒性白细胞粘附于内皮的病症
公开(公告)号：US06010712A
公开(公告)日：2000-01-04
申请号：US921115
申请日：1997-08-29
CPC分类号： A61K38/1825 , A61K48/00
摘要： A method of treating a condition involving vascular adhesion of cytotoxic white cells by (a) identifying an animal suspected of having a condition involving vascular adhesion of cytotoxic white cells and (b) administering to the animal an amount of bFGF sufficient to decrease cell surface expression of ICAM-I or VCAM-I on endothelial cells, thereby reducing adhesion of cytotoxic white cells to vascular endothelium.
摘要翻译： 一种通过（a）鉴定疑似具有涉及细胞毒性白细胞的血管粘附的病症的动物来治疗涉及细胞毒性白细胞的血管粘附的病症的方法，（b）向动物施用足以降低细胞表面表达的量的bFGF 的ICAM-1或VCAM-1在内皮细胞上，从而降低细胞毒性白细胞对血管内皮的粘附。
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公开(公告)号：US20110264187A1
公开(公告)日：2011-10-27
申请号：US12767099
申请日：2010-04-26
申请人： Robert J. Melder
发明人： Robert J. Melder
CPC分类号： A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0068 , Y10T29/49982
摘要： The drug eluting folded stent and a stent delivery system, which includes a stent having a plurality of struts interconnected to form a tubular body. At least one of the struts includes a U-shaped strut having in cross-section a first leg, a second leg, and a closed end connecting the first leg and the second leg, wherein the first leg, the second leg, and the closed end define a recess having a drug release opening opposite the closed end; and a drug coating disposed on the first leg, the second leg, and the closed end within the recess. The drug release opening is sized to release a drug from the drug coating at a predetermined drug elution rate.
摘要翻译： 药物洗脱折叠的支架和支架输送系统，其包括具有互连以形成管状体的多个支柱的支架。 所述支柱中的至少一个包括具有横截面的U形支柱，第一腿部，第二腿部以及连接第一腿部和第二腿部的封闭端部，其中，第一腿部，第二腿部和闭合部 端部限定具有与封闭端相对的药物释放口的凹部; 以及药物涂层，其设置在所述凹部内的所述第一腿部，所述第二腿部和所述封闭端部上。 药物释放口的大小适于以预定药物洗脱速率从药物包衣中释放药物。
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公开(公告)号：US06593112B1
公开(公告)日：2003-07-15
申请号：US09564829
申请日：2000-05-04
IPC分类号： C12N1518
CPC分类号： C07K16/22 , A61K38/00 , A61K48/00 , C07K14/50 , C12Q1/6876
摘要： The present invention relates to a novel human protein called Fibroblast Growth Factor 15, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein.
摘要翻译： 本发明涉及称为成纤维细胞生长因子15的新型人类蛋白质和编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。
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公开(公告)号：US20080183276A1
公开(公告)日：2008-07-31
申请号：US11668708
申请日：2007-01-30
申请人： Robert J. Melder
发明人： Robert J. Melder
IPC分类号： A61F2/82
摘要： Disclosed are medical devices having textured surfaces and biocompatible coatings disposed thereon. The textured surfaces allow for durable coatings to be applied to the medical device without a previous pre-coating having been applied. The biocompatible coating can further comprise a bioactive agent.
摘要翻译： 公开了具有纹理表面和设置在其上的生物相容性涂层的医疗装置。 纹理表面允许将耐用涂层施加到医疗装置，而不施加先前的预涂层。 生物相容性涂层还可包含生物活性剂。
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7.发明授权公开(公告)号：US06368858B1
公开(公告)日：2002-04-09
申请号：US09120136
申请日：1998-07-22
申请人： Gabriel Helmlinger , Paolo A. Netti , Robert J. Melder , Rakesh K. Jain , Hera Lichtenbeld-Dubois
发明人： Gabriel Helmlinger , Paolo A. Netti , Robert J. Melder , Rakesh K. Jain , Hera Lichtenbeld-Dubois
IPC分类号： C12N506
摘要： Cells in a matrix or in the matrix in a vessel are grown to form a multicellular aggregate. Pressure is exerted on the growing cells by the matrix or the matrix together with the vessel due to growing cellular mass displacing the matrix. A value representing pressure exerted on the cells is calculated and the pressure is modulated to control growth of the multicellular aggregate, or to produce a multicellular aggregate of a pre-selected size or a pre-selected size and shape. Matrices include agarose, alginate and collagen gels, and the pressure exerted on the cells can be non-isotropic. The cells may be tumor cells, or liver, pancreatic, brain, skin, bone or muscle cells, and cell growth can be in vitro or in vivo. When collagen forms the matrix, the matrix may contain glycosaminoglycan.
摘要翻译： 培养基质或容器中的基质中的细胞以形成多细胞骨架。 由于基质或基体与容器一起由于细胞质量逐渐增大而使生长的细胞产生压力。 计算表示施加在细胞上的压力的值，并且调节压力以控制多细胞骨架的生长，或产生预选尺寸或预选尺寸和形状的多细胞聚集体。 基质包括琼脂糖，藻酸盐和胶原凝胶，并且施加在细胞上的压力可以是非各向同性的。 细胞可以是肿瘤细胞，也可以是肝脏，胰腺，脑，皮肤，骨骼或肌肉细胞，细胞可以在体外或体内生长。 当胶原形成基质时，基质可能含有糖胺聚糖。
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公开(公告)号：US08764777B2
公开(公告)日：2014-07-01
申请号：US12421309
申请日：2009-04-09
申请人： Robert J. Melder
发明人： Robert J. Melder
IPC分类号： A61B17/08
CPC分类号： A61B17/064 , A61B17/068 , A61B2017/00243 , A61F2/2487
摘要： An endoventricular device includes a backbone and a plurality of segments having a plurality of anchors that are delivered to the treatment site in an inverted delivery configuration within a delivery catheter and when deployed moves from the inverted delivery configuration to a tissue penetrating implantation configuration.
摘要翻译： 内室装置包括骨架和多个段，其具有多个锚，其以递送导管内的反向递送构型递送到治疗部位，并且当部署时，从反向递送构型移动到组织穿透植入构型。
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公开(公告)号：US08636811B2
公开(公告)日：2014-01-28
申请号：US12755585
申请日：2010-04-07
申请人： Robert J. Melder
发明人： Robert J. Melder
IPC分类号： A61F2/02
CPC分类号： A61F2/92 , A61F2/91 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61F2250/0068
摘要： The drug eluting rolled stent and a stent delivery system, which includes a catheter; a balloon operably attached to the catheter; and a stent disposed on the balloon. The stent includes a rectangular metal foil sheet having a first side and a second side, the rectangular metal foil sheet being rolled to form a cylindrical tube having a central axis and a spiral cross section perpendicular to the central axis; a polymer drug coating disposed between and adhering the first side and the second side; and at least one opening formed through the cylindrical tube generally perpendicular to the central axis, the at least one opening being shaped to form at least one strut having in cross section polymer drug layers between metal foil layers, polymer drug layer edges of the polymer drug layers being in communication with the at least one opening.
摘要翻译： 药物洗脱支架和支架输送系统，其包括导管; 可操作地附接到导管的球囊; 以及设置在气囊上的支架。 支架包括具有第一侧和第二侧的矩形金属箔片，矩形金属箔片被卷起以形成具有中心轴线和垂直于中心轴线的螺旋截面的圆柱形管子; 设置在第一面和第二面之间并粘附第一面和第二面的聚合物药物涂层; 以及至少一个通过所述圆柱形管形成的大致垂直于所述中心轴线的开口，所述至少一个开口被成形为形成至少一个支柱，所述至少一个支柱在金属箔层之间具有聚合物药物层的横截面，所述聚合物药物的聚合物药物层边缘 层与所述至少一个开口连通。
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公开(公告)号：US20100262156A1
公开(公告)日：2010-10-14
申请号：US12421309
申请日：2009-04-09
申请人： Robert J. Melder
发明人： Robert J. Melder
CPC分类号： A61B17/064 , A61B17/068 , A61B2017/00243 , A61F2/2487
摘要： An endoventricular device includes a backbone and a plurality of segments having a plurality of anchors that are delivered to the treatment site in an inverted delivery configuration within a delivery catheter and when deployed moves from the inverted delivery configuration to a tissue penetrating implantation configuration.
摘要翻译： 内室装置包括骨架和多个段，其具有多个锚，其以递送导管内的反向递送构型递送到治疗部位，并且当部署时从反向递送构型移动到组织穿透植入构型。
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