利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.033 秒)

    Drug Eluting Rolled Stent and Stent Delivery System
    3.
    发明申请
    Drug Eluting Rolled Stent and Stent Delivery System 有权
    药物洗脱支架和支架递送系统

    公开(公告)号：US20110251663A1

    公开(公告)日：2011-10-13

    申请号：US12755585

    申请日：2010-04-07

    申请人： Robert J. Melder

    发明人： Robert J. Melder

    IPC分类号： A61F2/84 ,  B05D3/10 ,  A61F2/82

    CPC分类号： A61F2/92 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2250/0068

    摘要： The drug eluting rolled stent and a stent delivery system, which includes a catheter; a balloon operably attached to the catheter; and a stent disposed on the balloon. The stent includes a rectangular metal foil sheet having a first side and a second side, the rectangular metal foil sheet being rolled to form a cylindrical tube having a central axis and a spiral cross section perpendicular to the central axis; a polymer drug coating disposed between and adhering the first side and the second side; and at least one opening formed through the cylindrical tube generally perpendicular to the central axis, the at least one opening being shaped to form at least one strut having in cross section polymer drug layers between metal foil layers, polymer drug layer edges of the polymer drug layers being in communication with the at least one opening.

    摘要翻译： 药物洗脱支架和支架输送系统，其包括导管; 可操作地附接到导管的球囊; 以及设置在气囊上的支架。 支架包括具有第一侧和第二侧的矩形金属箔片，矩形金属箔片被卷起以形成具有中心轴线和垂直于中心轴线的螺旋截面的圆柱形管子; 设置在第一面和第二面之间并粘附第一面和第二面的聚合物药物涂层; 以及至少一个通过所述圆柱形管形成的大致垂直于所述中心轴线的开口，所述至少一个开口被成形为形成至少一个支柱，所述至少一个支柱在金属箔层之间具有聚合物药物层的横截面，所述聚合物药物的聚合物药物层边缘 层与所述至少一个开口连通。

    Drug Eluting Folded Stent and Stent Delivery System
    5.
    发明申请
    Drug Eluting Folded Stent and Stent Delivery System 有权
    药物洗脱折叠支架和支架递送系统

    公开(公告)号：US20110264187A1

    公开(公告)日：2011-10-27

    申请号：US12767099

    申请日：2010-04-26

    申请人： Robert J. Melder

    发明人： Robert J. Melder

    IPC分类号： A61F2/84 ,  B23P17/00 ,  A61F2/82

    CPC分类号： A61F2/91 ,  A61F2/958 ,  A61F2230/0054 ,  A61F2250/0068 ,  Y10T29/49982

    摘要： The drug eluting folded stent and a stent delivery system, which includes a stent having a plurality of struts interconnected to form a tubular body. At least one of the struts includes a U-shaped strut having in cross-section a first leg, a second leg, and a closed end connecting the first leg and the second leg, wherein the first leg, the second leg, and the closed end define a recess having a drug release opening opposite the closed end; and a drug coating disposed on the first leg, the second leg, and the closed end within the recess. The drug release opening is sized to release a drug from the drug coating at a predetermined drug elution rate.

    摘要翻译： 药物洗脱折叠的支架和支架输送系统，其包括具有互连以形成管状体的多个支柱的支架。 所述支柱中的至少一个包括具有横截面的U形支柱，第一腿部，第二腿部以及连接第一腿部和第二腿部的封闭端部，其中，第一腿部，第二腿部和闭合部 端部限定具有与封闭端相对的药物释放口的凹部; 以及药物涂层，其设置在所述凹部内的所述第一腿部，所述第二腿部和所述封闭端部上。 药物释放口的大小适于以预定药物洗脱速率从药物包衣中释放药物。

    Textured Medical Devices
    6.
    发明申请
    Textured Medical Devices 有权
    纹理医疗器械

    公开(公告)号：US20080183276A1

    公开(公告)日：2008-07-31

    申请号：US11668708

    申请日：2007-01-30

    申请人： Robert J. Melder

    发明人： Robert J. Melder

    IPC分类号： A61F2/82

    CPC分类号： A61L27/28 ,  A61L27/50 ,  A61L29/08 ,  A61L29/14 ,  A61L31/08 ,  A61L31/14 ,  A61L2400/18

    摘要： Disclosed are medical devices having textured surfaces and biocompatible coatings disposed thereon. The textured surfaces allow for durable coatings to be applied to the medical device without a previous pre-coating having been applied. The biocompatible coating can further comprise a bioactive agent.

    摘要翻译： 公开了具有纹理表面和设置在其上的生物相容性涂层的医疗装置。 纹理表面允许将耐用涂层施加到医疗装置，而不施加先前的预涂层。 生物相容性涂层还可包含生物活性剂。

    Modulation of multicellular aggregates by pressure from growth in a matrix
    7.
    发明授权
    Modulation of multicellular aggregates by pressure from growth in a matrix 失效
    通过基质中生长的压力调节多细胞聚集体

    公开(公告)号：US06368858B1

    公开(公告)日：2002-04-09

    申请号：US09120136

    申请日：1998-07-22

    申请人： Gabriel Helmlinger ,  Paolo A. Netti ,  Robert J. Melder ,  Rakesh K. Jain ,  Hera Lichtenbeld-Dubois

    发明人： Gabriel Helmlinger ,  Paolo A. Netti ,  Robert J. Melder ,  Rakesh K. Jain ,  Hera Lichtenbeld-Dubois

    IPC分类号： C12N506

    CPC分类号： C12M25/14 ,  C12M35/04

    摘要： Cells in a matrix or in the matrix in a vessel are grown to form a multicellular aggregate. Pressure is exerted on the growing cells by the matrix or the matrix together with the vessel due to growing cellular mass displacing the matrix. A value representing pressure exerted on the cells is calculated and the pressure is modulated to control growth of the multicellular aggregate, or to produce a multicellular aggregate of a pre-selected size or a pre-selected size and shape. Matrices include agarose, alginate and collagen gels, and the pressure exerted on the cells can be non-isotropic. The cells may be tumor cells, or liver, pancreatic, brain, skin, bone or muscle cells, and cell growth can be in vitro or in vivo. When collagen forms the matrix, the matrix may contain glycosaminoglycan.

    摘要翻译： 培养基质或容器中的基质中的细胞以形成多细胞骨架。 由于基质或基体与容器一起由于细胞质量逐渐增大而使生长的细胞产生压力。 计算表示施加在细胞上的压力的值，并且调节压力以控制多细胞骨架的生长，或产生预选尺寸或预选尺寸和形状的多细胞聚集体。 基质包括琼脂糖，藻酸盐和胶原凝胶，并且施加在细胞上的压力可以是非各向同性的。 细胞可以是肿瘤细胞，也可以是肝脏，胰腺，脑，皮肤，骨骼或肌肉细胞，细胞可以在体外或体内生长。 当胶原形成基质时，基质可能含有糖胺聚糖。

    Endoventricular stay and delivery system
    8.
    发明授权
    Endoventricular stay and delivery system 有权
    室内停留和分娩系统

    公开(公告)号：US08764777B2

    公开(公告)日：2014-07-01

    申请号：US12421309

    申请日：2009-04-09

    申请人： Robert J. Melder

    发明人： Robert J. Melder

    IPC分类号： A61B17/08

    CPC分类号： A61B17/064 ,  A61B17/068 ,  A61B2017/00243 ,  A61F2/2487

    摘要： An endoventricular device includes a backbone and a plurality of segments having a plurality of anchors that are delivered to the treatment site in an inverted delivery configuration within a delivery catheter and when deployed moves from the inverted delivery configuration to a tissue penetrating implantation configuration.

    摘要翻译： 内室装置包括骨架和多个段，其具有多个锚，其以递送导管内的反向递送构型递送到治疗部位，并且当部署时，从反向递送构型移动到组织穿透植入构型。

    Drug eluting rolled stent and stent delivery system
    9.
    发明授权
    Drug eluting rolled stent and stent delivery system 有权
    药物洗脱支架和支架输送系统

    公开(公告)号：US08636811B2

    公开(公告)日：2014-01-28

    申请号：US12755585

    申请日：2010-04-07

    申请人： Robert J. Melder

    发明人： Robert J. Melder

    IPC分类号： A61F2/02

    CPC分类号： A61F2/92 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2250/0068

    摘要： The drug eluting rolled stent and a stent delivery system, which includes a catheter; a balloon operably attached to the catheter; and a stent disposed on the balloon. The stent includes a rectangular metal foil sheet having a first side and a second side, the rectangular metal foil sheet being rolled to form a cylindrical tube having a central axis and a spiral cross section perpendicular to the central axis; a polymer drug coating disposed between and adhering the first side and the second side; and at least one opening formed through the cylindrical tube generally perpendicular to the central axis, the at least one opening being shaped to form at least one strut having in cross section polymer drug layers between metal foil layers, polymer drug layer edges of the polymer drug layers being in communication with the at least one opening.

    摘要翻译： 药物洗脱支架和支架输送系统，其包括导管; 可操作地附接到导管的球囊; 以及设置在气囊上的支架。 支架包括具有第一侧和第二侧的矩形金属箔片，矩形金属箔片被卷起以形成具有中心轴线和垂直于中心轴线的螺旋截面的圆柱形管子; 设置在第一面和第二面之间并粘附第一面和第二面的聚合物药物涂层; 以及至少一个通过所述圆柱形管形成的大致垂直于所述中心轴线的开口，所述至少一个开口被成形为形成至少一个支柱，所述至少一个支柱在金属箔层之间具有聚合物药物层的横截面，所述聚合物药物的聚合物药物层边缘 层与所述至少一个开口连通。