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    SYSTEM AND METHOD FOR MEASURING SOLID STRESS IN TISSUES
    3.
    发明申请
    SYSTEM AND METHOD FOR MEASURING SOLID STRESS IN TISSUES 审中-公开
    用于测量组织中固体应力的系统和方法

    公开(公告)号：US20160089043A1

    公开(公告)日：2016-03-31

    申请号：US14892380

    申请日：2014-05-21

    申请人： Gabriel GRUIONU ,  Lucian GRUIONU ,  Lance L. MUNN ,  Rakesh K. JAIN

    发明人： Gabriel Gruionu ,  Lucian Gruionu ,  Lance L. Munn ,  Rakesh K. Jain

    IPC分类号： A61B5/03 ,  A61B10/02 ,  A61B1/00

    CPC分类号： A61B5/03 ,  A61B1/0008 ,  A61B5/0093 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/4494 ,  A61B10/0233 ,  A61B2010/045 ,  A61B2562/0247

    摘要： A system and method is configured for use with an endoscope, a biopsy needle, and a data acquisition system. The system includes a sensor tip and a pressure sensor coupled to the sensor tip and having at least one piezo-resistor component with an internal-facing side and an external-facing side, and an opening adjacent to the at least one piezo-resistor component to allow fluid access to the internal-facing side and the external-facing side. The system also includes a tubing member with a distal end and a proximal end, the sensor tip coupled to the distal end, the sensor tip and the tubing member configured to be routed through the biopsy needle and connection elements coupled to the proximal end of the tubing member, the connection elements configured to mount the tubing member relative to the biopsy needle and to couple the pressure sensor to the data acquisition system.

    摘要翻译： 系统和方法被配置为与内窥镜，活检针和数据采集系统一起使用。 该系统包括耦合到传感器端头的传感器端头和压力传感器，并且具有至少一个具有面向内侧和面向外侧的压电电阻部件，以及与至少一个压电电阻部件相邻的开口 以允许流体进入内向侧和面向外侧。 该系统还包括具有远端和近端的管道构件，传感器顶端联接到远端，传感器尖端和管构件被配置成穿过活检针和连接元件，该连接元件连接到 管状构件，所述连接元件被配置成相对于活检针安装管道构件并且将压力传感器耦合到数据采集系统。

    System and method for measuring solid stress in tissues
    4.
    发明授权
    System and method for measuring solid stress in tissues 有权

    公开(公告)号：US11259714B2

    公开(公告)日：2022-03-01

    申请号：US14892380

    申请日：2014-05-21

    申请人： Gabriel Gruionu ,  Lucian Gruionu ,  Lance L. Munn ,  Rakesh K. Jain

    发明人： Gabriel Gruionu ,  Lucian Gruionu ,  Lance L. Munn ,  Rakesh K. Jain

    IPC分类号： A61B5/03 ,  A61B1/00 ,  A61B10/02 ,  A61B5/00 ,  A61B8/00 ,  A61B8/12 ,  A61B8/08 ,  A61B10/04

    摘要： A system and method is configured for use with an endoscope, a biopsy needle, and a data acquisition system. The system includes a sensor tip and a pressure sensor coupled to the sensor tip and having at least one piezo-resistor component with an internal-facing side and an external-facing side, and an opening adjacent to the at least one piezo-resistor component to allow fluid access to the internal-facing side and the external-facing side. The system also includes a tubing member with a distal end and a proximal end, the sensor tip coupled to the distal end, the sensor tip and the tubing member configured to be routed through the biopsy needle and connection elements coupled to the proximal end of the tubing member, the connection elements configured to mount the tubing member relative to the biopsy needle and to couple the pressure sensor to the data acquisition system.

    Modulation of multicellular aggregates by pressure from growth in a matrix
    5.
    发明授权
    Modulation of multicellular aggregates by pressure from growth in a matrix 失效
    通过基质中生长的压力调节多细胞聚集体

    公开(公告)号：US06368858B1

    公开(公告)日：2002-04-09

    申请号：US09120136

    申请日：1998-07-22

    申请人： Gabriel Helmlinger ,  Paolo A. Netti ,  Robert J. Melder ,  Rakesh K. Jain ,  Hera Lichtenbeld-Dubois

    发明人： Gabriel Helmlinger ,  Paolo A. Netti ,  Robert J. Melder ,  Rakesh K. Jain ,  Hera Lichtenbeld-Dubois

    IPC分类号： C12N506

    CPC分类号： C12M25/14 ,  C12M35/04

    摘要： Cells in a matrix or in the matrix in a vessel are grown to form a multicellular aggregate. Pressure is exerted on the growing cells by the matrix or the matrix together with the vessel due to growing cellular mass displacing the matrix. A value representing pressure exerted on the cells is calculated and the pressure is modulated to control growth of the multicellular aggregate, or to produce a multicellular aggregate of a pre-selected size or a pre-selected size and shape. Matrices include agarose, alginate and collagen gels, and the pressure exerted on the cells can be non-isotropic. The cells may be tumor cells, or liver, pancreatic, brain, skin, bone or muscle cells, and cell growth can be in vitro or in vivo. When collagen forms the matrix, the matrix may contain glycosaminoglycan.

    摘要翻译： 培养基质或容器中的基质中的细胞以形成多细胞骨架。 由于基质或基体与容器一起由于细胞质量逐渐增大而使生长的细胞产生压力。 计算表示施加在细胞上的压力的值，并且调节压力以控制多细胞骨架的生长，或产生预选尺寸或预选尺寸和形状的多细胞聚集体。 基质包括琼脂糖，藻酸盐和胶原凝胶，并且施加在细胞上的压力可以是非各向同性的。 细胞可以是肿瘤细胞，也可以是肝脏，胰腺，脑，皮肤，骨骼或肌肉细胞，细胞可以在体外或体内生长。 当胶原形成基质时，基质可能含有糖胺聚糖。

    Method for locating tumors prior to needle biopsy
    8.
    发明授权
    Method for locating tumors prior to needle biopsy 失效
    针刺活检前定位肿瘤的方法

    公开(公告)号：US5396897A

    公开(公告)日：1995-03-14

    申请号：US058682

    申请日：1993-05-03

    申请人： Rakesh K. Jain ,  Adam Stacy-Clear ,  Yves Boucher ,  Richard Moore ,  Daniel B. Kopans

    发明人： Rakesh K. Jain ,  Adam Stacy-Clear ,  Yves Boucher ,  Richard Moore ,  Daniel B. Kopans

    IPC分类号： A61B5/03 ,  A61B19/00 ,  A61B5/00

    CPC分类号： A61B5/03 ,  A61B2090/3904

    摘要： A method for locating a lesion within a tissue mass, includes steps of measuring a selected parameter at two or more points in at least one path through the tissue mass, the measure of the selected parameter in a lesion being different from that in normal tissue. Also, apparatus for measuring a tissue parameter at two or more points in at least one path through the tissue mass includes an insertion needle, distally sharpened and made sufficiently rigid so that it can be inserted distal end foremost into the tissue mass along the path, and, insertible with the needle, a sensor capable of prodding a measure of the tissue parameter at a point in the tissue mass along the path. Where the parameter is selected as one that has a measure different in a lesion type, the apparatus can be used in carrying out the method, whereby a measure at a point in the tissue mass of the selected tissue parameter provided by the sensor indicates that the point is within a lesion. In an embodiment for measuring interstitial fluid pressure in the tissue mass, the sensor includes a tube slidably engageable within the lumen of the insertion needle; the sensor tube is closed at a distal end, and the walls of the sensor tube and the insertion needle are prodded distally with ports, positioned in relation to the respective distal ends such that when the sensor tube is engaged within the insertion tube lumen the ports can be substantially aligned to provide fluid communication between the lumen of the sensor tube and the tissue adjacent the ports; the sensor tube lumen contains a plurality of filaments, and is operationally connected to a pressure measurement deuce such that the pressure measurement deuce is responsive to fluid pressure within the sensor tube lumen.

    摘要翻译： 一种用于定位组织块内的损伤的方法，包括以下步骤：在至少一个穿过组织块的路径中的两个或多个点处测量所选择的参数，所述病变中所选参数的测量与正常组织中的不同。 此外，在穿过组织块的至少一条路径中的两个或更多个点处测量组织参数的装置包括：远端切削并制成足够刚性的插入针，使得其可以沿着路径最前端插入组织块， 并且能够与针一起插入能够沿着路径刺激组织块中的一点处的组织参数的测量的传感器。 如果参数被选择为具有在病变类型中不同的度量的参数，则可以使用该装置来执行该方法，由此由传感器提供的所选择的组织参数的组织块中的点处的度量指示： 点在病变内。 在用于测量组织块中的组织液压的实施例中，传感器包括可滑动地接合在插入针的内腔内的管; 传感器管在远端封闭，并且传感器管和插入针的壁通过端口向远端方向延伸，其位置相对于相应的远端，使得当传感器管接合在插入管腔内时，端口 可以基本上对准以提供传感器管的内腔和邻近端口的组织之间的流体连通; 传感器管腔包含多个细丝，并且可操作地连接到压力测量装置，使得压力测量装置响应于传感器管腔内的流体压力。

    TREATMENT OF ANGIOGENIC- OR VASCULAR-ASSOCIATED DISEASES
    9.
    发明申请
    TREATMENT OF ANGIOGENIC- OR VASCULAR-ASSOCIATED DISEASES 审中-公开
    治疗血管生成或血管相关疾病

    公开(公告)号：US20140161720A1

    公开(公告)日：2014-06-12

    申请号：US14119532

    申请日：2012-05-25

    申请人： Igor Garkavtsev ,  Rakesh K. Jain

    发明人： Igor Garkavtsev ,  Rakesh K. Jain

    IPC分类号： C07D311/92 ,  A61K36/185 ,  A61K31/352 ,  A61K45/06 ,  A61K47/30

    CPC分类号： C07D311/92 ,  A61K31/337 ,  A61K31/352 ,  A61K36/185 ,  A61K45/06 ,  A61K47/30 ,  A61K2300/00

    摘要： Described herein are methods and compositions comprising a compound of formula (I), e.g., dehydro-alpha-lapachone, or an analog, derivative, isomer, prodrug, or pharmaceutically acceptable salt thereof, for treatment and/or prevention of angiogenic- or vascular-associated diseases or disorders. The compound has anti-vascular activity. In some embodiments, the compound has anti-vascular activity that targets pathways other than VEGF pathways. In some embodiments, the compound or the composition further comprises anti-tumor activity. In some embodiments, the compound or the composition can decrease adhesion or motility of at least one cell (e.g., endothelial cells or cancer cells).

    摘要翻译： 本文描述了包含式（I）化合物的方法和组合物，例如脱氢-α-拉帕酮或其类似物，衍生物，异构体，前药或药学上可接受的盐，用于治疗和/或预防血管生成或血管 相关的疾病或病症。 该化合物具有抗血管活性。 在一些实施方案中，化合物具有靶向除VEGF途径之外的途径的抗血管活性。 在一些实施方案中，化合物或组合物还包含抗肿瘤活性。 在一些实施方案中，化合物或组合物可降低至少一种细胞（例如内皮细胞或癌细胞）的粘附或运动性。