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    Combination comprising a CDK inhibitor and doxorubicin
    3.
    发明申请
    Combination comprising a CDK inhibitor and doxorubicin 审中-公开
    包含CDK抑制剂和多柔比星的组合

    公开(公告)号：US20050222054A1

    公开(公告)日：2005-10-06

    申请号：US10952575

    申请日：2004-09-27

    申请人： Roger Sleigh ,  Anton Berns ,  Helen Coley ,  Scott Lyons

    发明人： Roger Sleigh ,  Anton Berns ,  Helen Coley ,  Scott Lyons

    IPC分类号： A61K31/522 ,  A61K31/704

    CPC分类号： A61K45/06 ,  A61K31/522 ,  A61K31/704 ,  A61K2300/00

    摘要： A first aspect of the invention relates to a combination comprising a CDK inhibitor and doxorubicin. A second aspect of the invention relates to a pharmaceutical product comprising a CDK inhibitor and doxorubicin as a combined preparation for simultaneous, sequential or separate use in therapy. A third aspect of the invention relates to a method of treating a proliferative disorder, said method comprising simultaneously, sequentially or separately administering a CDK inhibitor and doxorubicin to a subject.

    摘要翻译： 本发明的第一方面涉及包含CDK抑制剂和多柔比星的组合。 本发明的第二方面涉及包含CDK抑制剂和多柔比星作为用于在治疗中同时，连续或分别使用的组合制剂的药物产品。 本发明的第三个方面涉及一种治疗增殖性疾病的方法，所述方法包括同时依次或分别给受试者施用CDK抑制剂和多柔比星。

    High efficiency gene targeting in mouse embryonic stem cells
    4.
    发明授权
    High efficiency gene targeting in mouse embryonic stem cells 失效
    高效基因靶向小鼠胚胎干细胞

    公开(公告)号：US06653113B1

    公开(公告)日：2003-11-25

    申请号：US09253818

    申请日：1999-02-19

    申请人： Anton Berns ,  Els Robanus Maandag ,  Hein te Riele

    发明人： Anton Berns ,  Els Robanus Maandag ,  Hein te Riele

    IPC分类号： C12N1300

    CPC分类号： C12N15/85 ,  C12N15/902

    摘要： The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a “targeting DNA”) that is substantially isogenic with a DNA in the cell genome (a “target DNA”); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.

    摘要翻译： 本发明提供用于修饰动物细胞基因组的新方法，其通常包括以下步骤：构建DNA分子，其中所需的序列修饰包含在基本上同基因的DNA片段中（“靶向DNA”），其中 细胞基因组DNA（“靶DNA”）; 将靶向DNA构建体引入细胞（例如通过显微注射，电穿孔，转染或磷酸钙沉淀）; 并且通过同源重组选择其中所需的序列修饰已导入基因组的细胞。

    Gene targeting in animal cells using isogenic DNA constructs
    5.
    发明授权
    Gene targeting in animal cells using isogenic DNA constructs 失效
    使用同基因DNA构建体在动物细胞中进行基因靶向

    公开(公告)号：US5789215A

    公开(公告)日：1998-08-04

    申请号：US908348

    申请日：1997-08-07

    申请人： Anton Berns ,  Els Robanus Maandag ,  Hein te Riele

    发明人： Anton Berns ,  Els Robanus Maandag ,  Hein te Riele

    IPC分类号： C12N15/85 ,  C12N15/90 ,  C12N5/06 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11

    CPC分类号： C12N15/85 ,  C12N15/902

    摘要： The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA") that is substantially isogenic with a DNA in the cell genome (a."target DNA"); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.

    摘要翻译： 本发明提供用于修饰动物细胞基因组的新方法，其通常包括以下步骤：构建DNA分子，其中所需的序列修饰包含在基本上同基因的DNA片段中（“靶向DNA”），其中 细胞基因组DNA（a。“靶DNA”）; 将靶向DNA构建体引入细胞（例如通过显微注射，电穿孔，转染或磷酸钙沉淀）; 并且通过同源重组选择其中所需的序列修饰已导入基因组的细胞。