公开(公告)号：US4978622A

公开(公告)日：1990-12-18

申请号：US403899

申请日：1989-09-01

申请人： Robert Mishell ,  William Usinger

发明人： Robert Mishell ,  William Usinger

IPC分类号： A61K39/39 ,  C12P19/04

CPC分类号： C12P19/04 ,  A61K39/39 ,  A61K2039/55594

摘要： Substantially pigment-free gliding bacteria adjuvant (GBA) is isolated from medium in which Cytophaga strain GB-2 has been cultured by extraction with acetone to remove pigment, enzymatic digestion and filtration to remove residual protein and nucleic acids, and affinity chromatography to remove residual lipopolysaccharide. This pure form of GBA shows unexpectedly high specific immunopotentiating activity relative to crude GBA.

摘要翻译： 从培养基中分离出基本无色素的滑翔细菌佐剂（GBA），其中通过用丙酮萃取培养细胞质菌株GB-2以除去颜料，酶消化和过滤以除去残留的蛋白质和核酸，并进行亲和层析以除去残留物 脂多糖 这种纯形式的GBA相对于粗GBA显示出意想不到的高特异性免疫增强活性。

公开(公告)号：US20050214294A1

公开(公告)日：2005-09-29

申请号：US11057323

申请日：2005-02-11

申请人： Allan Flyvbjerg ,  Guangjie Guo ,  David Liu ,  Thomas Neff ,  Noelynn Oliver ,  William Usinger ,  Qingjian Wang

发明人： Allan Flyvbjerg ,  Guangjie Guo ,  David Liu ,  Thomas Neff ,  Noelynn Oliver ,  William Usinger ,  Qingjian Wang

IPC分类号： A61K31/00 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  C07K16/22

CPC分类号： A61K38/556 ,  A61K31/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/22 ,  A61K2300/00

摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.

摘要翻译： 本发明涉及用于治疗糖尿病肾病的特异性早期方面和晚期方面的方法和化合物。 还提供了用于治疗与早期和晚期糖尿病肾病相关的各种生理特征的方法和化合物。

公开(公告)号：US10676520B2

公开(公告)日：2020-06-09

申请号：US13163489

申请日：2011-06-17

申请人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

发明人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

IPC分类号： A61K39/42 ,  C12N5/10 ,  C07K16/10 ,  A61K39/00

摘要： Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

公开(公告)号：US20070020692A1

公开(公告)日：2007-01-25

申请号：US11525783

申请日：2006-09-22

申请人： Stephen Weitz ,  William Usinger

发明人： Stephen Weitz ,  William Usinger

IPC分类号： G01N33/53

CPC分类号： G01N33/6887 ,  G01N33/74

摘要： The present invention relates to methods of detection and quantitation of connective tissue growth factor (CTGF), and diagnosis and detection of various CTGF-associated diseases and disorders.

摘要翻译： 本发明涉及结缔组织生长因子（CTGF）的检测和定量方法，以及各种CTGF相关疾病和病症的诊断和检测。

公开(公告)号：US09017668B2

公开(公告)日：2015-04-28

申请号：US13162497

申请日：2011-06-16

申请人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

发明人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC分类号： A61K39/12 ,  A61K39/215 ,  C07K16/08 ,  C07K16/46

CPC分类号： C07K16/088 ,  A61K39/245 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

摘要翻译： 已从人B细胞中分离出人巨细胞病毒（CMV）gB蛋白的抗体。 这些抗体的亲和力高于先前报道的最佳抗体。 由于高亲和力对于预防跨越胎盘的病毒转移至关重要，本发明的抗体可用作预防或改善对怀孕期间CMV感染胎儿的影响的治疗和预防剂。

公开(公告)号：US20120020971A1

公开(公告)日：2012-01-26

申请号：US13163489

申请日：2011-06-17

申请人： Lawrence M. KAUVAR ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

发明人： Lawrence M. KAUVAR ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

IPC分类号： A61K39/42 ,  A61P31/00 ,  C12N5/10 ,  C12N15/85 ,  C12P21/08 ,  C07K16/10 ,  A61P31/16

摘要： Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

摘要翻译： 公开了与多个流感病毒进化枝交叉反应的单克隆抗体及其片段，包括第1组和第2组代表。 这些抗体可用于控制流行性感冒和大流行以及为季节性流感提供预防或治疗保护。