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公开(公告)号：US5612036A
公开(公告)日：1997-03-18
申请号：US519506
申请日：1995-08-25
申请人： Robert S. Hodges , William Paranchych , Kok K. Lee , Sastry A. Parimi , Randall T. Irvin , Peter C. Doig
发明人： Robert S. Hodges , William Paranchych , Kok K. Lee , Sastry A. Parimi , Randall T. Irvin , Peter C. Doig
IPC分类号： A61K39/00 , A61K31/00 , A61K38/00 , A61K39/104 , A61K39/395 , A61P31/00 , A61P31/04 , C07K7/08 , C07K14/195 , C07K14/21 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/46 , C12N15/09 , C12P21/02 , G01N33/569 , A61K39/02 , A61K38/10 , A61K39/108
CPC分类号： C07K16/461 , C07K14/21 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pillin protein. The pure polypeptide comprises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant cite of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such repeating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypeptides act an antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.
摘要翻译： 根据本发明通过发现小于天然存在的铜绿假单胞菌丸蛋白的多肽实现铜绿假单胞菌感染或定植的治疗和诊断。 纯多肽包含至少一个含有约十二个氨基酸残基和至多约二十个氨基酸残基的氨基酸残基，其限定能够免疫模拟铜绿假单胞菌菌素的抗原决定簇的序列。 该氨基酸残基序列可以在同一多肽分子中作为单元重复一次或多次。 多于一个这样的重复单元和多于一个相同类型的重复单元可以存在于单个多肽分子中。 多肽起抗原或免疫原的作用，抗体可以产生于免疫原和适于预防铜绿假单胞菌感染的疫苗。
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公开(公告)号：US5494672A
公开(公告)日：1996-02-27
申请号：US638492
申请日：1991-01-04
申请人： Robert S. Hodges , William Paranchych , Randall T. Irvin , Kok K. Lee , Sastry A. Parimi , Dick E. Zoutman , Peter C. Doig , Wah Y. Wong
发明人： Robert S. Hodges , William Paranchych , Randall T. Irvin , Kok K. Lee , Sastry A. Parimi , Dick E. Zoutman , Peter C. Doig , Wah Y. Wong
IPC分类号： A61K39/00 , A61K31/00 , A61K38/00 , A61K39/104 , A61K39/395 , A61P31/00 , A61P31/04 , C07K7/08 , C07K14/195 , C07K14/21 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/46 , C07K19/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/385 , G01N33/53 , G01N33/569 , A61K38/04 , A61K39/02
CPC分类号： C07K16/461 , C07K14/21 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： A peptide having a sequence corresponding to a C-terminal portion of the Pseudomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms. Also disclosed are methods of preparing peptides which are cross-reactive with the P. aeruginosa pilin peptide, and chimeric monoclonal antibodies immunoreactive with the pilin peptide.
摘要翻译： 公开了具有对应于铜绿假单胞菌毛林蛋白蛋白的C末端部分的序列的肽。 该肽与某些细菌和真菌微生物中存在的表面肽具有交叉反应性，并且有效抑制这些生物体与目标上皮细胞的结合。 肽也可以用于疫苗组合物中，用于产生针对这种交叉反应性微生物的免疫。 还公开了制备与铜绿假单胞菌菌素肽交叉反应的肽的方法和与肽素肽免疫反应的嵌合单克隆抗体。
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3.发明授权
公开(公告)号：US5445818A
公开(公告)日：1995-08-29
申请号：US927797
申请日：1992-08-10
申请人： Robert S. Hodges , William Paranchych , Kok K. Lee , Sastry A. Parimi , Randall T. Irvin , Peter C. Doig
发明人： Robert S. Hodges , William Paranchych , Kok K. Lee , Sastry A. Parimi , Randall T. Irvin , Peter C. Doig
IPC分类号： A61K39/00 , A61K31/00 , A61K38/00 , A61K39/104 , A61K39/395 , A61P31/00 , A61P31/04 , C07K7/08 , C07K14/195 , C07K14/21 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/46 , C12N15/09 , C12P21/02 , G01N33/569 , A61K39/02 , A61K38/10 , A61K39/38 , C07K1/00
CPC分类号： C07K16/461 , C07K14/21 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pillin protein. The pure polypeptide comprises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant cite of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such repeating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypeptides act an antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.
摘要翻译： 根据本发明通过发现小于天然存在的铜绿假单胞菌丸蛋白的多肽实现铜绿假单胞菌感染或定植的治疗和诊断。 纯多肽包含至少一个含有约十二个氨基酸残基和至多约二十个氨基酸残基的氨基酸残基，其限定能够免疫模拟铜绿假单胞菌菌素的抗原决定簇的序列。 该氨基酸残基序列可以在同一多肽分子中作为单元重复一次或多次。 多于一个这样的重复单元和多于一个相同类型的重复单元可以存在于单个多肽分子中。 多肽起抗原或免疫原的作用，抗体可以产生于免疫原和适于预防铜绿假单胞菌感染的疫苗。
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公开(公告)号：US5468484A
公开(公告)日：1995-11-21
申请号：US84739
申请日：1993-06-28
CPC分类号： C07K14/21 , C12N9/1077 , A61K39/00
摘要： The invention described includes methods and compositions useful in preventing infection by Pseudomonas aeruginosa and related organisms. Diclosed is a peptide having the sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseudomonas aeruginosa pilin protein. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against Pseudomonas aeruginosa as well as against such cross-reactive microorganisms.
摘要翻译： 所描述的发明包括可用于预防铜绿假单胞菌和相关生物体感染的方法和组合物。 被分离的是具有与蛋白质外切酶S中的抗原位点相对应的序列的肽，其与铜绿假单胞菌皮林蛋白质的C末端部分具有抗原性。 该肽与某些细菌和真菌微生物中存在的表面肽具有交叉反应性，并且有效抑制这些生物体与目标上皮细胞的结合。 肽也可以用于疫苗组合物中，用于产生针对铜绿假单胞菌的免疫以及针对这种交叉反应性微生物。
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5.发明授权Pseudomonas exoenzyme S peptide composition and method 失效PSEUDOMONAS EXOENZYME S PEPTIDE COMPOSITION AND METHOD
公开(公告)号：US5223604A
公开(公告)日：1993-06-29
申请号：US721759
申请日：1991-06-25
CPC分类号： C07K14/21 , C12N9/1077 , A61K39/00
摘要： A peptide having a sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseusdomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms.
摘要翻译： 公开了具有对应于蛋白质外切酶S中抗原性位点的序列的肽，其与铜绿假单胞菌菌毛蛋白质的C末端部分具有抗原性。 该肽与某些细菌和真菌微生物中存在的表面肽具有交叉反应性，并且有效抑制这些生物体与目标上皮细胞的结合。 肽也可以用于疫苗组合物中，用于产生针对这种交叉反应性微生物的免疫。
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公开(公告)号：US06767545B2
公开(公告)日：2004-07-27
申请号：US09865159
申请日：2001-05-24
申请人： Randall T. Irvin , Randy J. Read , Bart Hazes , Wah Y. Wong , Sastry A. Parimi , Linda M. G. Glasier
发明人： Randall T. Irvin , Randy J. Read , Bart Hazes , Wah Y. Wong , Sastry A. Parimi , Linda M. G. Glasier
IPC分类号： A61K3902
CPC分类号： A61K38/164 , C07K14/21 , C07K2319/00
摘要： A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.
摘要翻译： 公开了一种用于治疗或预防铜绿假单胞菌感染的组合物和方法。 该组合物包括经改良的铜绿假单胞菌肽蛋白肽，以防止皮林的低聚。 该方法包括将组合物给予感染了假单胞菌的人患有这种感染的风险。
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公开(公告)号：US06342233B1
公开(公告)日：2002-01-29
申请号：US09329884
申请日：1999-06-11
申请人： Randall T. Irvin , Randy J. Read , Bart Hazes , Wah Y. Wong , Sastry A. Parimi , Linda M. G. Glasier
发明人： Randall T. Irvin , Randy J. Read , Bart Hazes , Wah Y. Wong , Sastry A. Parimi , Linda M. G. Glasier
IPC分类号： A61K39108
CPC分类号： A61K38/164 , C07K14/21 , C07K2319/00
摘要： A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.
摘要翻译： 公开了一种用于治疗或预防铜绿假单胞菌感染的组合物和方法。 该组合物包括经改良的铜绿假单胞菌肽蛋白肽，以防止皮林的低聚。 该方法包括将组合物给予感染了假单胞菌的人患有这种感染的风险。
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公开(公告)号：US20120016102A1
公开(公告)日：2012-01-19
申请号：US13179058
申请日：2011-07-08
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译： 本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物，装置和方法。 组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与 表面。 本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。 本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。
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公开(公告)号：US20080287367A1
公开(公告)日：2008-11-20
申请号：US11996379
申请日：2006-07-21
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译： 本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物和方法。 组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与 表面。 本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。 本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。
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公开(公告)号：US5641760A
公开(公告)日：1997-06-24
申请号：US261487
申请日：1994-06-17
申请人： Lei Yu , Kok Kheong Lee , Hasmukh B. Sheth , Randall T. Irvin , Robert S. Hodges
发明人： Lei Yu , Kok Kheong Lee , Hasmukh B. Sheth , Randall T. Irvin , Robert S. Hodges
IPC分类号： C12N15/02 , A61K31/70 , A61K31/7024 , A61K31/7028 , A61K38/00 , A61K39/395 , A61K47/48 , A61P31/04 , C07H13/06 , C07H15/04 , C07K16/12 , C07K16/14 , C12P21/08 , C12R1/91 , A61K31/715
CPC分类号： A61K31/70 , A61K47/48861 , C07K16/14 , A61K38/00
摘要： A method of treating Candida albicans infection is disclosed. In one embodiment, for treatment of oral or vaginal infection, the treatment is by topical application of a composition of conjugates that are each composed of a carrier structure and multiple .beta.GalNac(1-4).beta.Gal moieties attached to the structure. In another embodiment, for treatment of systemic infection, the treatment is by parenteral administration of a humanized form of a mouse monoclonal antibody produced by mouse hybridoma cell line Fm16 or cell line PK99H.
摘要翻译： 公开了治疗白色念珠菌感染的方法。 在一个实施方案中，为了治疗口腔或阴道感染，治疗是通过局部施用结合物的组合物，其各自由载体结构和连接到该结构的多个βGalNac（1-4）βGal部分组成。 在另一个实施方案中，为了治疗全身感染，治疗是通过胃肠外施用小鼠杂交瘤细胞系Fm16或细胞系PK99H产生的小鼠单克隆抗体的人源化形式。
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