公开(公告)号：US20110028661A1

公开(公告)日：2011-02-03

申请号：US12809212

申请日：2008-12-18

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  Jim Yang

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  Jim Yang

IPC分类号： C08F283/12

CPC分类号： C08G18/3228 ,  C08G18/4812 ,  C08G18/61 ,  C08G18/6611

摘要： Block copolymers are formulated with multifunctional chain extenders. The block copolymers include a soft segment and a hard segment made from a diisocyanate, an alkylene diamine chain extender, and a multifunctional chain extender which provides delayed crosslinking. The multifunctional chain extenders have a functionality and typically have at least one OH group. The multifunctional chain extenders may be aliphatic or aromatic triols or polyols, or may have other configurations, as described. The resulting block copolymers have improved mechanical properties such as compression set. They may be used in medical applications, or in industrial applications such as seal and gasket applications, including O-rings, window seals, and automotive gaskets. The initially-formed polyurethane resin behaves as a thermoplastic processable material, while the configured end-use product is thermoset.

摘要翻译： 嵌段共聚物用多功能扩链剂配制。 嵌段共聚物包括软链段和由二异氰酸酯制成的硬链段，亚烷基二胺扩链剂和提供延迟交联的多官能扩链剂。 多功能扩链剂具有官能团并且通常具有至少一个OH基团。 多官能增链剂可以是脂族或芳族三醇或多元醇，或者可以具有如所述的其它构型。 所得的嵌段共聚物具有改进的机械性能，如压缩永久变形。 它们可用于医疗应用或工业应用中，例如密封和垫片应用，包括O型圈，窗户密封件和汽车垫圈。 初始形成的聚氨酯树脂表现为热塑性可加工材料，而配置的最终用途产品是热固性的。

公开(公告)号：US07884171B2

公开(公告)日：2011-02-08

申请号：US12638371

申请日：2009-12-15

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

IPC分类号： C08G18/00 ,  C08G77/04 ,  C08G77/22

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

公开(公告)号：US20110086077A1

公开(公告)日：2011-04-14

申请号：US12745509

申请日：2008-11-21

申请人： Keith R. McCrea ,  Robert S. Ward ,  Yuan Tian

发明人： Keith R. McCrea ,  Robert S. Ward ,  Yuan Tian

IPC分类号： A61L15/22 ,  A61K38/39 ,  A61P17/02

CPC分类号： A61L15/60 ,  A61L15/225 ,  A61L15/26 ,  A61L26/0019 ,  A61L26/0076 ,  A61L26/008 ,  C08L83/04

摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).

摘要翻译： 硅氧烷水凝胶制剂可以含有无规和/或嵌段共聚物或低聚物或大分子单体。 硅氧烷共聚物与其它聚合物或单体或大分子单体共聚或共混以获得最终配方。 硅氧烷水凝胶可以含有交联基团以提供完全或部分交联的最终结构。 硅氧烷水凝胶制剂可以预先形成为膜或其它结构，或者可以在使用时聚合，如在粘合剂制剂的情况下。 一种伤口敷料，其包含在施加到伤口之前或原位在伤口上形成的膜的硅酮水凝胶，该膜具有透气性，透湿性和高含水量，其中所述硅氧水凝胶由可聚合硅氧烷形成 例如甲基丙烯酸二官能聚二甲基硅氧烷和N，N-二甲基丙烯酰胺（DMA），甲基丙烯酸2-羟乙酯（HEMA）和三甲基甲硅烷氧基硅烷（TRIS）等交联剂。

公开(公告)号：US07671162B2

公开(公告)日：2010-03-02

申请号：US11211734

申请日：2005-08-26

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

IPC分类号： C08G18/00 ,  C08G77/04 ,  C08G77/22

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

公开(公告)号：US20100113711A1

公开(公告)日：2010-05-06

申请号：US12638371

申请日：2009-12-15

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

IPC分类号： C08G69/48 ,  C08G18/00 ,  C08G12/12 ,  C08G63/91 ,  C08G64/42 ,  C08G77/38

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

公开(公告)号：US20090258048A1

公开(公告)日：2009-10-15

申请号：US12083927

申请日：2006-12-07

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka ,  Shanger Wang

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka ,  Shanger Wang

IPC分类号： A61F2/02 ,  C08G63/91 ,  C12M3/00 ,  B65D71/00

CPC分类号： A61K31/785 ,  C08G18/0895 ,  C08G18/2875 ,  C08G18/288 ,  C08G18/44 ,  C08G18/6266

摘要： Polymers having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.

摘要翻译： 具有式R（LE）x的聚合物，其中R是数均分子量为5000-7,000,000道尔顿且具有x个端基的聚合物芯，E是通过连接L与聚合物核心R共价连接的端基，L是二价 具有至少5个相同重复单元的低聚链，能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x可以彼此相同或不同。 单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面 修饰该聚合物的端基。 使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

公开(公告)号：US20110207897A1

公开(公告)日：2011-08-25

申请号：US12809217

申请日：2008-12-17

申请人： Keith R. Mccrba ,  Robert S. Ward ,  Yuan Tian ,  Jim Yang ,  Keith Kurczewski

发明人： Keith R. Mccrba ,  Robert S. Ward ,  Yuan Tian ,  Jim Yang ,  Keith Kurczewski

IPC分类号： C08G77/458 ,  C08G18/87

CPC分类号： C08G18/61 ,  C08G18/0828 ,  C08G18/288

摘要： Block copolymer having improved compression set comprising 40-98 wt-% soft segment, 1.9-20 wt-% hard segment, and 0.05-3 wt-% monofunctional ionic endgroups. The incorporation of ionomers into diisocyanate-based thermoplastic polyurethane materials greatly improves compression set with little impact on the overall TPU formulation. A typical formulation for making the block copolymer contains 84.2% polydimethylsiloxane, 12.9% diisocyanate, 2.9% diamine chain extender, 0.15% sodium 2-[bis(2-hydroxyethyl)amino]ethylsulfonate, and 0.05% isethionic acid. The polymeric material may be configured, for instance, as a contact lens, prosthetic spinal nucleus, orthopedic bearing surface, gasket, or sealant.

摘要翻译： 嵌段共聚物具有改进的压缩变形，其包含40-98重量％的软链段，1.9-20重量％的硬链段和0.05-3重量％的单官能离子端基。 将离子交联聚合到二异氰酸酯基热塑性聚氨酯材料中极大地改善了对整个TPU配方影响很小的压缩永久变形。 用于制备嵌段共聚物的典型制剂包含84.2％聚二甲基硅氧烷，12.9％二异氰酸酯，2.9％二胺增链剂，0.15％2- [双（2-羟乙基）氨基]乙基磺酸钠和0.05％羟乙磺酸。 聚合物材料可以被配置为例如隐形眼镜，假肢脊髓核，矫形支承表面，垫圈或密封剂。

公开(公告)号：US20110293522A1

公开(公告)日：2011-12-01

申请号：US13129438

申请日：2009-11-16

申请人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

发明人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

IPC分类号： A61K49/00 ,  B29C45/00 ,  A61P31/00 ,  A61P7/02 ,  C08G18/83 ,  A61K31/785

CPC分类号： C08G18/837 ,  A61K2800/61 ,  C08G18/08 ,  C08J7/12 ,  C08J7/14

摘要： Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.

摘要翻译： 聚合物表面改性方法包括以下步骤：在制品制造期间首先形成与聚合物链末端连接的主要反应性端基的表面，然后用生物活性分子，亲水和疏水单体，低聚物或聚合物改性活性表面 以获得特定的表面性质。 或者，多功能偶联剂可用于将主反应性基团与能够与与生物活性分子，亲水和疏水单体，低聚物和聚合物相关的官能团反应的第二反应性基团，以获得特定的表面性质。 本发明涉及将表面活性隔离物连接到聚合物链末端的反应性端基引入表面。 表面活性间隔物允许反应性端基在制造过程中迁移和富集到表面。 本发明提供具有抗血栓形成性质，润滑性，选择性吸附和抗微生物性质的生物界面的医疗装置。

公开(公告)号：US20100179284A1

公开(公告)日：2010-07-15

申请号：US12601787

申请日：2008-05-28

申请人： Robert S. Ward ,  Keith McCrea ,  Yuan Tian ,  Shanger Wang ,  Larry Jones ,  Anfeng Wang ,  James P. Parakka

发明人： Robert S. Ward ,  Keith McCrea ,  Yuan Tian ,  Shanger Wang ,  Larry Jones ,  Anfeng Wang ,  James P. Parakka

IPC分类号： C08B37/10

CPC分类号： A61K31/785 ,  C08G18/3228 ,  C08G18/3271 ,  C08G18/44 ,  C08G18/5024

摘要： Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.

摘要翻译： 由包含至少一种具有式R（LE）x的聚合物的聚合物主体组成的医疗装置，假体或包装组件，其中R是数均分子量为5000至70000道尔顿的聚合物芯，并且具有x个端基， x是整数≥1，E是通过连接L与聚合物核心R共价连接的端基，L是具有至少5个重复单元的二价低聚链，并且可以与L链相邻的分子自组装 聚合物和聚合物中的部分L和/或E可以在组成和/或分子量上彼此相同或不同。 聚合物主体包括位于体内内部的多个聚合物分子，其中至少一些内部聚合物分子具有形成身体表面的端基。 表面端基包括至少一个自组装部分。

公开(公告)号：US07368589B2

公开(公告)日：2008-05-06

申请号：US10699417

申请日：2003-10-31

申请人： Shivkumar Mahadevan ,  Frank Molock ,  Robert S. Ward ,  Yuan Tian ,  Shanger Wang ,  James M. Serpilio, Jr.

发明人： Shivkumar Mahadevan ,  Frank Molock ,  Robert S. Ward ,  Yuan Tian ,  Shanger Wang ,  James M. Serpilio, Jr.

IPC分类号： C07F7/00

CPC分类号： C08G77/34 ,  C07F7/20 ,  Y02P20/544

摘要： The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.

摘要翻译： 本发明涉及通过超临界流体萃取纯化含硅氧烷化合物的方法。 具体地说，本发明涉及一种方法，该方法包括以下步骤：使至少一种含硅氧烷的化合物与密度为约0.2至约0.8g / ml的超临界流体接触，降低所述密度，使得两相形成第一相 包括所述至少一种含硅氧烷化合物和包含至少一种杂质的第二相，并将所述第二相与所述第一相分离。