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公开(公告)号:US06596097B1
公开(公告)日:2003-07-22
申请号:US09577441
申请日:2000-05-24
申请人: Robert Snow , Gregory McIntire , Edward Bacon , Evan Gustow
发明人: Robert Snow , Gregory McIntire , Edward Bacon , Evan Gustow
IPC分类号: C23C1816
CPC分类号: A61N5/1001 , A61N2005/1019 , C23C22/68 , G21G4/06 , G21G4/08
摘要: A method for the immobilization of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidizing agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is 125I− and the binding agent comprises bromide ions.
摘要翻译: 一种在金属基材表面上固定放射性阴离子的方法,所述方法包括在与所述金属的离子形成不溶性盐的放射性阴离子的溶液的存在下用氧化剂处理底物。 优选地,还将存在粘合剂。 优选地,金属是银,放射性阴离子是125I-,并且结合剂包括溴离子。
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公开(公告)号:US20060199991A1
公开(公告)日:2006-09-07
申请号:US11363844
申请日:2006-02-28
申请人: Dewi Lewis , Lucinda Dollimore , Nigel Powell , Gregory McIntire , Evan Gustow , Robert Snow
发明人: Dewi Lewis , Lucinda Dollimore , Nigel Powell , Gregory McIntire , Evan Gustow , Robert Snow
IPC分类号: A61N5/00
CPC分类号: A61N5/1027 , A61N2005/1023 , A61N2005/1025 , G21G4/08
摘要: The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.
摘要翻译: 本发明提供了一种辐射源的使用,该辐射源是低能X射线发射器,例如, 主要光子的发射能量在20至100keV,优选20至40keV的范围内,半衰期为10至100天,优选为15至70天,用于治疗再狭窄。 合适的放射性同位素包括钯-103,镝-159,钐-145,镉-109,镱-169,优选碘-125。 还公开了高活性放射性体和包含这种放射性同位素的来源,以及制造这种来源的方法。
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公开(公告)号:US07390505B2
公开(公告)日:2008-06-24
申请号:US10766960
申请日:2004-01-30
申请人: Evan Gustow , Tuula Ryde , Eugene R. Cooper
发明人: Evan Gustow , Tuula Ryde , Eugene R. Cooper
IPC分类号: A61K9/14 , A61K31/335 , A01N43/02
CPC分类号: A61K31/7048 , A61K9/145 , A61K9/146
摘要: The present invention is directed to nanoparticulate compositions comprising topiramate. The topiramate particles of the composition have an effective average particle size of less than about 2 microns.
摘要翻译: 本发明涉及包含托吡酯的纳米颗粒组合物。 组合物的托吡酯颗粒具有小于约2微米的有效平均粒度。
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公开(公告)号:US20070298115A1
公开(公告)日:2007-12-27
申请号:US11802542
申请日:2007-05-23
申请人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号: A61K31/235 , A61K9/50 , A61P3/04 , A61P43/00 , A61P9/00 , C07C69/767 , C13K13/00
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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公开(公告)号:US07011619B1
公开(公告)日:2006-03-14
申请号:US09763006
申请日:1999-08-13
申请人: Dewi M. Lewis , Lucinda A. Dollimore , Nigel Powell , Gregory L. McIntire , Evan Gustow , Robert A. Snow
发明人: Dewi M. Lewis , Lucinda A. Dollimore , Nigel Powell , Gregory L. McIntire , Evan Gustow , Robert A. Snow
IPC分类号: A61N5/00
CPC分类号: A61N5/1027 , A61N2005/1023 , A61N2005/1025 , G21G4/08
摘要: The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.
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公开(公告)号:US20080095851A1
公开(公告)日:2008-04-24
申请号:US11802567
申请日:2007-05-23
申请人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号: A61K9/14 , A61K31/216 , A61P3/00
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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公开(公告)号:US20070264348A1
公开(公告)日:2007-11-15
申请号:US11710607
申请日:2007-02-26
申请人: Tuula Ryde , Evan Gustow , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号: A61K31/19
CPC分类号: A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/19 , A61K45/06 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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公开(公告)号:US20050276974A1
公开(公告)日:2005-12-15
申请号:US10444066
申请日:2003-05-23
申请人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译: 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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公开(公告)号:US5518187A
公开(公告)日:1996-05-21
申请号:US180827
申请日:1994-01-12
申请人: Joseph A. Bruno , Brian D. Doty , Evan Gustow , Kathleen J. Illig , Nats Rajagopalan , Pramod Sarpotdar
发明人: Joseph A. Bruno , Brian D. Doty , Evan Gustow , Kathleen J. Illig , Nats Rajagopalan , Pramod Sarpotdar
IPC分类号: A61J3/02 , A61K9/14 , A61K9/16 , A61K9/26 , A61K31/19 , A61K31/192 , A61K49/00 , A61K49/04 , A61K51/00 , B02C17/00 , B02C17/20 , B02C19/00 , G03C1/005 , B02C23/18
CPC分类号: A61K9/146 , A61K9/14 , A61K9/1688 , G03C1/005 , Y10S977/775 , Y10S977/788 , Y10S977/90 , Y10S977/928
摘要: A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
摘要翻译: 一种制备药物或诊断显像剂的颗粒的方法,其包括在包含聚合物树脂的研磨介质的存在下研磨药物或显像剂。 该方法提供表现出减少污染的颗粒。
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