公开(公告)号：USRE35122E

公开(公告)日：1995-12-19

申请号：US840437

申请日：1992-02-24

申请人： James E. Corenman ,  Robert T. Stone ,  Andras Boross ,  Deborah A. Briggs ,  David E. Goodman

发明人： James E. Corenman ,  Robert T. Stone ,  Andras Boross ,  Deborah A. Briggs ,  David E. Goodman

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7257

摘要： A method and apparatus for improving the calculation of oxygen saturation and other blood constituents by non-invasive pulse oximeters. The method and apparatus permit more accurate determination of blood flow by collecting time-measures of the absorption signal at two or more wavelengths and processing the collected time-measure to obtain composite pulsatile flow data from which artifacts have been filtered. The processing may occur in the time domain or in the frequency domain. In the preferred time domain embodiment, successive portions of periodic information are weighted and added together in synchrony to obtain the composite pulse information. In the preferred frequency domain embodiment, the time-measure is Fourier transformed into its spectral components to form the composite information. A new method and apparatus for correlating the heartbeat and optical pulse is provided whereby a product of the ECG R-wave and optical pulse signals corresponding to the same heartbeat is obtained, and one signal is time shifted relative to the other until a maximum waveform product corresponding to the heartbeat is determined.

公开(公告)号：US4869254A

公开(公告)日：1989-09-26

申请号：US175115

申请日：1988-03-30

申请人： Robert T. Stone ,  Deborah A. Briggs

发明人： Robert T. Stone ,  Deborah A. Briggs

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1495

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： A method and apparatus for improving the calculation of oxygen saturation by non-invasive pulse oximeters during transient conditions. Transient conditions introduce artifactual errors into the detected optical signal because of changes in transmittance of the light with localized blood volume changes and as the average background oxygen saturation level of the patient's blood changes. The invention relates to correcting the detected optical pulses by linear interpolation and rate of change techniques or by selective frequency filtering and compensating the detected optical signal using the filtered signal to provide accurate estimates of oxygen saturation during transient conditions.

公开(公告)号：US4934372A

公开(公告)日：1990-06-19

申请号：US334694

申请日：1989-04-05

申请人： James E. Corenman ,  Robert T. Stone ,  Andras Boross ,  Deborah A. Briggs ,  David E. Goodman

发明人： James E. Corenman ,  Robert T. Stone ,  Andras Boross ,  Deborah A. Briggs ,  David E. Goodman

IPC分类号： A61B5/00 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/0428

CPC分类号： A61B5/04282 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/1455 ,  A61B5/7207 ,  A61B5/7225 ,  A61B5/7257

摘要： A method and apparatus for improving the calculation of oxygen saturation and other blood constituents by non-invasive pulse oximeters. The method and apparatus permit more accurate determination of blood flow by collecting time-measures of the absorption signal at two or more wavelengths and processing the collected time-measure to obtain composite pulsatile flow data from which artifacts have been filtered. The processing may occur in the time domain or in the frequency domain. In the preferred time domain embodiment, successive portions of periodic information are weighted and added together in synchrony to obtain the composite pulse information. In the preferred frequency domain embodiment, the time-measure in Fourier transformed into its spectral components to form the composite information. A new method and apparatus for correlating the heartbeat and optical pulse is provided whereby a product of the ECG R-wave and optical pulse signals corresponding to the same heartbeat is obtained, and one signal is time shifted relative to the other until a maximum waveform product corresponding to the heartbeat is determined.

摘要翻译： 一种用于通过非侵入式脉搏血氧计改善氧饱和度和其他血液成分计算的方法和装置。 所述方法和装置允许通过收集在两个或更多个波长处的吸收信号的时间测量值来对血流进行更准确的确定，并且处理所采集的时间量度以获得从其中过滤伪影的复合脉冲流数据。 该处理可以在时域或频域中发生。 在优选的时域实施例中，周期信息的连续部分被加权并且被同时加在一起以获得复合脉冲信息。 在优选频域实施例中，傅里叶变换成其频谱分量的时间测量以形成复合信息。 提供了一种用于使心跳和光脉冲相关的新方法和装置，由此获得对应于相同心跳的ECG R波和光脉冲信号的乘积，并且一个信号相对于另一个信号被时移，直到最大波形积 对应心跳确定。

公开(公告)号：US4911167A

公开(公告)日：1990-03-27

申请号：US175152

申请日：1988-03-30

申请人： James E. Corenman ,  Robert T. Stone ,  Andras Boross ,  Deborah A. Briggs ,  David E. Goodman

发明人： James E. Corenman ,  Robert T. Stone ,  Andras Boross ,  Deborah A. Briggs ,  David E. Goodman

IPC分类号： A61B5/026 ,  A61B5/00 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1464

CPC分类号： A61B5/14551 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04282 ,  A61B5/7207 ,  A61B5/7225 ,  A61B5/7257

摘要： A method and apparatus for improving the calculation of oxygen saturation and other blood constituents by non-invasive pulse oximeters. The method and apparatus permit more accurate determination of blood flow by collecting time-measures of the absorption signal at two or more wavelengths and processing the collected time-measure to obtain composite pulsatile flow data from which artifacts have been filtered. The processing may occur in the time domain or in the frequency domain. In the preferred time domain embodiment, successive portions of periodic information are weighted and added together in synchrony to obtain the composite pulse information. In the preferred frequency domain embodiment, the time-measure is Fourier transformed into its spectral components to form the composite information. A new method and apparatus for correlating the heartbeat and optical pulse is provided whereby a product of the ECG R-wave and optical pulse signals corresponding to the same heartbeat is obtained, and one signal is time shifted relative to the other until a maximum waveform product corresponding to the heartbeat is determined.

摘要翻译： 一种用于通过非侵入式脉搏血氧计改善氧饱和度和其他血液成分计算的方法和装置。 所述方法和装置允许通过收集在两个或更多个波长处的吸收信号的时间测量值来对血流进行更准确的确定，并且处理所采集的时间量度以获得从其中过滤伪影的复合脉冲流数据。 该处理可以在时域或频域中发生。 在优选的时域实施例中，周期信息的连续部分被加权并且被同时加在一起以获得复合脉冲信息。 在优选频域实施例中，时间测量被傅里叶变换成其频谱分量以形成复合信息。 提供了一种用于使心跳和光脉冲相关的新方法和装置，由此获得对应于相同心跳的ECG R波和光脉冲信号的乘积，并且一个信号相对于另一个信号被时移，直到最大波形积 对应心跳确定。

公开(公告)号：US5078136A

公开(公告)日：1992-01-07

申请号：US389633

申请日：1989-08-04

申请人： Robert T. Stone ,  Deborah A. Briggs

发明人： Robert T. Stone ,  Deborah A. Briggs

IPC分类号： A61B5/00 ,  A61B5/0295

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： A method and apparatus for improving the calculation of oxygen saturation by non-invasive pulse oximeters during transient conditions. Transient conditions introduce artifactual errors into the detected optical signal because of changes in transmittance of the light with localized blood volume changes and as the average background oxygen saturation level of the patient's blood changes. The invention relates to correcting the detected optical pulses by linear interpolation and rate of change techniques or by selective frequency filtering and compensating the detected optical signal using the filtered signal to provide accurate estimates of oxygen saturation during transient conditions.

摘要翻译： 一种用于在瞬态条件下改善非侵入脉搏血氧仪计算氧饱和度的方法和装置。 由于随着局部血容量变化的光的透射率变化以及患者血液的平均背景氧饱和度水平改变，瞬态条件将人为误差引入检测到的光信号。 本发明涉及通过线性内插和变化率技术来校正检测到的光脉冲，或者通过选择性频率滤波来校正检测到的光脉冲，并且使用滤波信号来补偿检测到的光信号，从而在瞬态条件下提供准确的氧饱和度估

公开(公告)号：US20140296651A1

公开(公告)日：2014-10-02

申请号：US13854280

申请日：2013-04-01

申请人： Robert T. Stone

发明人： Robert T. Stone

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/08

CPC分类号： A61B5/6804 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/08 ,  A61B5/1135 ,  A61B5/6805 ,  A61B2562/227

摘要： A wearable physiological monitoring system comprising a garment that is configured to cover at least the chest region and the upper back of a wearer, a stretchable circumferential band that is attachable to the garment, the stretchable band including a respiration detection system that is configured to detect axial chest wall displacements of the wearer and integral signal transmission conductors, an electronics module that is releasably attachable to said garment and programmed to control the respiration detection system, process signals therefrom, and wirelessly transmit the processed signals, and a self-aligning magnetic connection system that is configured to removeably couple the electronics module to said band and, thereby, the signal transmission conductors.

摘要翻译： 一种穿戴式生理监测系统，包括被配置为至少覆盖佩戴者的胸部区域和上背部的衣服，可附接到衣服的可伸缩周边带，所述可拉伸带包括呼吸检测系统，所述呼吸检测系统被配置为检测 佩戴者和整体信号传输导体的轴向胸壁位移，电子模块，其可释放地附接到所述衣服并被编程为控制呼吸检测系统，处理来自其的信号，以及无线传送经处理的信号，以及自对准磁连接 系统，其被配置为可移除地将电子模块耦合到所述频带，从而将信号传输导体耦合。

公开(公告)号：US20110288436A1

公开(公告)日：2011-11-24

申请号：US13067000

申请日：2011-04-28

申请人： Robert T. Stone

发明人： Robert T. Stone

IPC分类号： A61B5/00 ,  B05D5/12

CPC分类号： A61B5/03 ,  A61B5/0215 ,  A61B5/036 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14542 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/18

摘要： A method for insulating an electronic component, comprising encapsulating the electronic component with an electrically insulating pouch having a first protective layer and a second electrically insulating layer, the first protective layer comprising a flexible polymeric material, the second electrically insulating layer comprising the parylene layer.

摘要翻译： 一种用于绝缘电子部件的方法，包括用具有第一保护层和第二电绝缘层的电绝缘袋密封所述电子部件，所述第一保护层包括柔性聚合物材料，所述第二电绝缘层包含所述聚对二甲苯层。

公开(公告)号：US5357971A

公开(公告)日：1994-10-25

申请号：US207892

申请日：1994-03-07

申请人： Neil J. Sheehan ,  Scott R. Rouw ,  Robert T. Stone

发明人： Neil J. Sheehan ,  Scott R. Rouw ,  Robert T. Stone

IPC分类号： A61B5/08 ,  A61B5/083 ,  A61B5/097 ,  G01N33/00 ,  G01N33/497 ,  B01D13/00

CPC分类号： A61B5/0836 ,  G01N33/497 ,  G01N33/004

摘要： A noninvasive device and methods for measuring the end-tidal carbon monoxide concentration in a patient's breath, particularly newborn and premature infants. The patient's breath is monitored. An average carbon monoxide concentration is determined based on an average of discrete samples in a given time period. The ratio of the end-tidal portion of the breath flow sample is separately determined, preferably based on monitoring the level of carbon dioxide in the gas sample and identifying the carbon dioxide concentration levels corresponding to the end-tidal portion of the breath sample. The sensed carbon monoxide level is converted to the end-tidal carbon monoxide level by subtracting the ambient carbon monoxide level and dividing the remainder by the ratio of end-tidal breath to breath in the breath sample. An easy to use microcontroller-based device containing a carbon dioxide detector, a carbon monoxide detect and a pump for use in a hospital, home, physician's office or clinic by persons not requiring high skill and training is described. A replaceable filter unit made of a single tri-lumen PVC extrusion and a tube segment inter-connecting two of the lumens used to provide the consumable filtration material. The filtration material is interposed between the carbon dioxide sensor and the carbon monoxide sensor which are mounted inside the monitor housing. The filter unit also interfaces the canula for receiving the patient's breath sample and a hydrophobic filter between the patient and the carbon dioxide monitor. The filter unit is replaceable when the filtration medium is no longer effective or for use with different patients and may be disposable.

摘要翻译： 用于测量患者呼吸中的终端一氧化碳浓度的非侵入性装置和方法，特别是新生儿和早产儿。 监测患者的呼吸。 平均一氧化碳浓度基于给定时间段内的离散样品的平均值来确定。 优选基于监测气体样品中的二氧化碳水平并识别对应于呼吸样品的末端潮气部分的二氧化碳浓度水平，分别测定呼气流量样品的潮气部分的比例。 感测到的一氧化碳水平通过减去环境一氧化碳水平并将其余部分除以呼吸样本中的呼吸末端呼吸与呼吸的比例而转化为终潮一氧化碳水平。 描述了一种易于使用的基于微控制器的装置，其包含二氧化碳检测器，一氧化碳检测器和用于在医院，家庭，医生办公室或诊所中由不需要高技能和训练的人员使用的泵。 由单个三腔PVC挤出机制成的可替换的过滤器单元和用于提供消耗性过滤材料的两个腔室之间的管段相互连接。 过滤材料介于安装在监视器壳体内部的二氧化碳传感器和一氧化碳传感器之间。 过滤器单元还将套管接合以接收患者的呼吸样本和患者和二氧化碳监测器之间的疏水过滤器。 当过滤介质不再有效或与不同的患者一起使用时，过滤器单元是可更换的，并且可以是一次性的。

公开(公告)号：US20110160560A1

公开(公告)日：2011-06-30

申请号：US12655405

申请日：2009-12-29

申请人： Robert T. Stone

发明人： Robert T. Stone

IPC分类号： A61B3/16 ,  G01L19/04 ,  G01L9/12 ,  A61B5/00

CPC分类号： A61B5/031 ,  A61B3/16 ,  A61B2560/0252 ,  A61B2562/028 ,  G01L9/125 ,  G01L27/002

摘要： An implantable pressure sensor system having a sensor assembly configured and adapted to measure pressure in a volume, the sensor assembly including at least a first MEMS pressure sensor, an application-specific integrated circuit (ASIC) having memory means, temperature compensation system, drift compensation system, and power supply means for powering the sensor assembly, the first MEMS pressure sensor having a pressure sensing element that is responsive to exposed pressure, the pressure sensing element being adapted to generate a pressure sensor signal representative of the exposed pressure, the temperature compensation system being adapted to correct for temperature induced variations in the pressure sensor signal, the drift compensation system being adapted to correct for pressure and temperature induced pressure sensor signal drift.

摘要翻译： 一种植入式压力传感器系统，其具有构造并适于测量体积中的压力的​​传感器组件，所述传感器组件至少包括第一MEMS压力传感器，具有存储装置的专用集成电路（ASIC），温度补偿系统，漂移补偿 系统和用于为传感器组件供电的电源装置，第一MEMS压力传感器具有响应于暴露的压力的压力感测元件，压力感测元件适于产生代表暴露的压力的压力传感器信号，温度补偿 系统适于校正压力传感器信号中温度引起的变化，漂移补偿系统适于校正压力和温度引起的压力传感器信号漂移。

公开(公告)号：US06594511B2

公开(公告)日：2003-07-15

申请号：US09815827

申请日：2001-03-23

申请人： Robert T. Stone ,  Alex K. Mills

发明人： Robert T. Stone ,  Alex K. Mills

IPC分类号： A61B500

CPC分类号： A61B5/14551 ,  A61B5/0006 ,  A61B5/0245 ,  A61B5/0456 ,  A61B5/7214

摘要： A method for determining physiological characteristics comprising the steps of (a) acquiring a first blood oxygen signal from a subject, the blood oxygen signal having an undesirable artifact signal component; (b) acquiring an additional physiological signal having a heart rate component using an acquisition technique that is different and independent from the first acquiring step; (c) processing the first blood oxygen signal and the physiological signal to provide a first waveform having a reduced level of the artifact signal component therein; (d) processing the first waveform and the physiological signal to provide a reference waveform; and (e) processing the reference waveform and the physiological signal to provide a second blood oxygen saturation signal corresponding to the blood oxygen saturation level of said subject.

摘要翻译： 一种用于确定生理特征的方法，包括以下步骤：（a）从对象获取第一血氧信号，所述血氧信号具有不期望的伪像信号分量; （b）使用与第一获取步骤不同且独立的获取技术来获取具有心率分量的附加生理信号; （c）处理所述第一血氧信号和所述生理信号以提供具有降低的所述伪影信号分量水平的第一波形; （d）处理第一波形和生理信号以提供参考波形; 以及（e）处理参考波形和生理信号以提供对应于所述对象的血氧饱和度水平的第二血氧饱和度信号。