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公开(公告)号：US20190110725A1
公开(公告)日：2019-04-18
申请号：US16157483
申请日：2018-10-11
申请人： Robert Wilkes , Gang Wang , Martin Mintchev , Orly Yadid-Pecht
发明人： Robert Wilkes , Gang Wang , Martin Mintchev , Orly Yadid-Pecht
摘要： The present invention provides method and apparatus for minimally-invasive capillary blood extraction comprising an apparatus capable of the harnessing the energy from frequent natural mammalian movements and then converting it into forces needed to execute skin lancing, specifically an insertion of a lancet in the body of the mammal. The apparatus consists of a rotational and a translational member which work together to effectively translate an angular displacement of the rotational element caused by mammalian movements to translational displacement of a sliding element at an angle to the plane which the force from the mammal was applied in. The ability of the invention to harness free energy and efficiently use that energy for actuating a lancet and facilitating blood extraction allows for the miniaturization of blood sampling technology into a wearable device.
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公开(公告)号：US20100215732A1
公开(公告)日：2010-08-26
申请号：US12294659
申请日：2007-03-29
IPC分类号： A61K9/48 , A61K38/43 , A61K31/722 , A61K31/717 , A61P3/04
CPC分类号： A61F5/0036 , A61J3/071 , A61K9/0065 , A61K9/009
摘要： An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, is provided for weight control. The implement includes: a fluid-permeable expandable container having a first dimension and a second dimension; and a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid; whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension.
摘要翻译： 提供用于在包括哺乳动物的动物的胃中扩张以填充胃中的空间的可口服施用的装置，用于重量控制。 所述工具包括：具有第一尺寸和第二尺寸的流体可渗透的可膨胀容器; 以及包括容纳在容器内并且当与流体接触时能够膨胀的可溶胀材料的多个簇; 从而当器具被摄取时，胃中的流体进入容器，导致其中的簇膨胀并且容器从第一尺寸膨胀到第二尺寸。
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3.发明申请Apparatuses and Methods for Endoscope and/or With Tool Actuated by Shape Memory Alloy Element 审中-公开用于内窥镜和/或具有由形状记忆合金元件驱动的工具的装置和方法公开(公告)号：US20150150544A1
公开(公告)日：2015-06-04
申请号：US14129853
申请日：2012-06-29
CPC分类号： A61B10/04 , A61B1/00158 , A61B1/0016 , A61B1/0058 , A61B1/041 , A61B5/150412 , A61B2010/0208 , A61B2010/045 , A61M5/158 , A61M2005/1585
摘要： Apparatuses and methods for capsule endoscopes with tools actuated by a combination of a shape memory alloy (SMA) element and a biasing element (e.g., spring). Apparatuses and methods for biopsies actuated by an SMA element.
摘要翻译： 具有由形状记忆合金（SMA）元件和偏置元件（例如弹簧）的组合致动的工具的胶囊内窥镜的装置和方法。 由SMA元件激活的活检的装置和方法。
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公开(公告)号：US20060178557A1
公开(公告)日：2006-08-10
申请号：US11347862
申请日：2006-02-06
申请人： Martin Mintchev , Orly Yadid-Pecht
发明人： Martin Mintchev , Orly Yadid-Pecht
IPC分类号： A61B1/00
CPC分类号： A61B1/041 , A61B1/00006 , A61B1/00016 , A61B1/00147 , A61B1/00177 , A61B1/0615
摘要： Wireless capsule endoscope technology has been used to image portions of the gastrointestinal (GI) tract, particularly the small bowel. However in other GI organs, especially those having larger-lumens, the capsule may become destabilized and tumble, precluding meaningful interpretation of the acquired images. The present invention describes a method and apparatus for permitting capsule imaging of organs having larger-lumens without tumbling, and includes an outer shell surrounding the capsule that targets the colon, as an example. Once the colon has been reached, the shell breaks or dissolves, and allows expansion of expandable materials attached to each end of the capsule, thereby stabilizing the capsule in the targeted organ, while permitting it to be moved by peristalsis and/or other means for locating the capsule. Imagers and light emitting diodes (LEDs) are activated during the expansion process, and enable overlapping of images. The capsule is moved through the colon, taking images at chosen frame rates with data being wirelessly transmitted by means of an RF transmitter, and is eventually expelled from the body.
摘要翻译： 无线胶囊内窥镜技术已经被用于成像胃肠道（GI）部分，特别是小肠。 然而，在其他GI器官，特别是具有较大流明的GI器官中，胶囊可能变得不稳定和翻滚，从而排除所获得的图像的有意义的解释。 本发明描述了一种用于允许具有较大流明而不翻滚的器官的胶囊成像的方法和装置，并且包括以胶囊为靶标的外壳，作为示例。 一旦达到结肠，壳就会破裂或溶解，并允许膨胀附着在胶囊每个端部的可膨胀材料，从而使胶囊在目标器官中稳定，同时允许其通过蠕动和/或其它手段移动 定位胶囊。 成像器和发光二极管（LED）在扩展过程中被激活，并使图像重叠。 将胶囊移动通过结肠，以所选择的帧速率拍摄图像，数据通过RF发射器无线传输，并且最终从身体排出。
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公开(公告)号：US09579227B2
公开(公告)日：2017-02-28
申请号：US13687153
申请日：2012-11-28
CPC分类号： A61F5/0073
摘要： An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, is provided for weight control. The implement includes: a fluid-permeable expandable container having a first dimension and a second dimension; and a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid; whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension.
摘要翻译： 提供用于在包括哺乳动物的动物的胃中扩张以填充胃中的空间的可口服施用的装置，用于重量控制。 所述工具包括：具有第一尺寸和第二尺寸的流体可渗透的可膨胀容器; 以及包括容纳在容器内并且当与流体接触时能够膨胀的可溶胀材料的多个簇; 从而当器具被摄取时，胃中的流体进入容器，导致其中的簇膨胀并且容器从第一尺寸膨胀到第二尺寸。
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公开(公告)号：US20160206200A1
公开(公告)日：2016-07-21
申请号：US14914397
申请日：2014-08-22
申请人： Michael POSCENTE , Orly YADID-PECHT , Christopher ANDREWS , Martin MINTCHEV , UTI LIMITED PARTNERSHIP
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , A61B5/0028 , A61B5/0538 , A61B5/4233 , A61B5/4238 , A61B5/4244 , A61B5/4255 , A61B5/6852 , A61B5/6861
摘要： The present invention provides a method and an apparatus for minimally-invasive diagnosis of conditions within the body of an animal. In one particular embodiment, the present invention provides a method and an apparatus for utilizing intraluminally-generated signals to diagnose disorders or monitor the function of internal organ of an animal by assessing the signal transcutaneously. The signals can be electrical, magnetic, electromagnetic, acoustic, ultrasonic, optical, etc.
摘要翻译： 本发明提供了用于对动物身体内的病症进行微创诊断的方法和装置。 在一个具体实施方案中，本发明提供了一种利用经内腔产生的信号通过经皮评估信号来诊断疾病或监测动物内脏功能的方法和装置。 信号可以是电，磁，电磁，声，超声波，光学等
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公开(公告)号：US20060116564A1
公开(公告)日：2006-06-01
申请号：US11163342
申请日：2005-10-14
申请人： Martin Mintchev , Karan Kaler , Orly Yadid-Pecht
发明人： Martin Mintchev , Karan Kaler , Orly Yadid-Pecht
CPC分类号： A61B5/053 , A61B5/037 , A61B5/0538 , A61B5/14539 , A61B5/4233 , A61B5/6885
摘要： Disclosed is an esophageal catheter that is capable of simultaneously measuring impedance, hydrostatic pressure and contact pressure in an esophagus from peristaltic waves, esophageal fluid and the transit bolus in a single test episode. Circumferential impedance sensors include sensing electrodes that are oppositely disposed on the circumferential impedance sensor, and reference electrodes that are also oppositely disposed on the circumferential impedance sensor and interspersed between the sensing electrodes. Accurate impedance measurements can be made in this fashion in a transverse direction in the esophagus. A hydrostatic pressure sensor is disposed at the distal tip of the esophageal probe that has a rigid cover to protect the hydrostatic pressure sensor from contact pressures of the esophagus. In this manner, the hydrostatic pressure sensor can provide purely hydrostatic pressure data from the fluids in the esophagus. Disposed above the hydrostatic pressure sensor, at the distal end of the probe, is an optical contraction sensor that detects both hydrostatic and contact pressure, by detecting the occlusion created by a flexible membrane disposed between an optical source and an optical detector mounted longitudinally in the probe, in response to contractions at the esophagus. The output of the hydrostatic pressure sensor and the optical contraction sensor permits estimations to be made of the contact pressures created by the esophagus.
摘要翻译： 公开了一种食管导管，其能够在单次测试发作中同时测量来自蠕动波，食道液和转运丸的食管中的阻抗，静水压力和接触压力。 环绕阻抗传感器包括相对设置在周向阻抗传感器上的感测电极，以及也相对设置在周向阻抗传感器上并散布在感测电极之间的参考电极。 这种方式可以在食道的横向上进行准确的阻抗测量。 静水压力传感器设置在食管探针的远端，其具有刚性盖以保护静水压力传感器免受食管接触压力的影响。 以这种方式，静水压力传感器可以提供来自食道中的流体的纯静水压力数据。 位于探头前端的静水压力传感器上方，是一个光学收缩传感器，通过检测由位于光源和光学探测器之间纵向安装的光学探测器之间的柔性膜产生的闭塞，从而检测静水压力和接触压力。 探测，以应对食道的收缩。 静水压力传感器和光学收缩传感器的输出允许估计由食道产生的接触压力。
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公开(公告)号：US09066877B2
公开(公告)日：2015-06-30
申请号：US12936558
申请日：2009-04-28
CPC分类号： A61K9/4866
摘要： Bezoar-forming units for forming at least one temporary bezoar in a gastrointestinal organ of an animal, including a mammal, to fill a space in the said organ, are provided for weight control. The units include biodegradable fiber-based configurations of various length and shape having a first dimension and a second dimension; whereby when the bezoar-forming units are located in the given gastrointestinal organ, at least one temporary, permeable bezoar is formed.
摘要翻译： 提供用于在动物的包括哺乳动物的胃肠器官中形成至少一个临时牛黄以填充所述器官中的空间的贝类形成单元用于体重控制。 这些单元包括具有第一尺寸和第二尺寸的各种长度和形状的可生物降解的基于纤维的构造; 由此当形成牛黄的单元位于给定的胃肠器官中时，形成至少一个临时的可渗透的牛黄。
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公开(公告)号：US20110082419A1
公开(公告)日：2011-04-07
申请号：US12936558
申请日：2009-04-28
IPC分类号： A61M31/00
CPC分类号： A61K9/4866
摘要： Bezoar-forming units for forming at least one temporary bezoar in a gastrointestinal organ of an animal, including a mammal, to fill a space in the said organ, are provided for weight control. The units include biodegradable fiber-based configurations of various length and shape having a first dimension and a second dimension; whereby when the bezoar-forming units are located in the given gastrointestinal organ, at least one temporary, permeable bezoar is formed.
摘要翻译： 提供用于在动物的包括哺乳动物的胃肠器官中形成至少一个临时牛黄以填充所述器官中的空间的贝类形成单元用于体重控制。 这些单元包括具有第一尺寸和第二尺寸的各种长度和形状的可生物降解的纤维基构造; 由此当形成牛黄的单元位于给定的胃肠器官中时，形成至少一个临时的可渗透的牛黄。
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公开(公告)号：US20100145316A1
公开(公告)日：2010-06-10
申请号：US12517752
申请日：2007-12-18
IPC分类号： A61M31/00
CPC分类号： A61K9/0065 , A61K9/009 , A61L31/146 , A61M29/02 , A61M31/00 , A61M31/002
摘要： A device for delivering a substance in situ in a body comprising at least one permeable expandable container having a first dimension and a second dimension and having contained therein the substance to be delivered; and at least one expandable particle comprising a swellable material contained within the container and capable of expanding when contacted with a fluid; whereby when the device is positioned in situ, bodily fluid permeates the container causing the at least one expandable particle contained therein to swell and the container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance is provided.
摘要翻译： 一种用于在物体中原位输送物质的装置，包括至少一个具有第一尺寸和第二尺寸的渗透性可扩张容器，并且其中容纳有待输送物质; 以及至少一个可膨胀颗粒，其包含容纳在容器内的可膨胀材料，并且当与流体接触时能够膨胀; 由此当装置位于原位时，体液渗透容器，导致容纳在其中的至少一个可膨胀颗粒膨胀，并且容器从第一维度膨胀到第二维度，使得装置保持原位一段时间 提供了足以实现物质所需的输送。
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