Poly (ester-anhydrides) and intermediates therefor
    10.
    发明授权
    Poly (ester-anhydrides) and intermediates therefor 失效
    聚(酯 - 酸酐)及其中间体

    公开(公告)号:US5756652A

    公开(公告)日:1998-05-26

    申请号:US609099

    申请日:1996-02-29

    摘要: Biodegradable poly(ester-anhydrides) designed to display two-stage degradation profiles are described. The presence of the anhydride linkages allows a relatively rapid decrease in molecular weight, the extent of which is governed by the concentration of the anhydride linkages along the chain, followed by possible dissolution and a slower degradation of the remaining oligomers, the rate of which is governed by the composition of the polyester prepolymers. Methods for the preparation of the poly(ester-anhydrides) and their polyester precursors are also described.

    摘要翻译: 描述了设计用于显示两阶段降解曲线的可生物降解的聚(酯 - 酸酐)。 酸酐键的存在允许分子量的相对快速降低,其程度由沿着链的酸酐键的浓度决定,随后可能的溶解和残留的低聚物的较慢降解,其速率是 由聚酯预聚物的组成决定。 还描述了制备聚(酯 - 酸酐)及其聚酯前体的方法。