公开(公告)号：US20150099954A1

公开(公告)日：2015-04-09

申请号：US14566033

申请日：2014-12-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sabine Achmann ,  Holger Kotzan ,  Ulrich Mueller ,  Monika Strasser ,  Herbert Wieder

IPC: A61B5/1473 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468

Abstract: Sensor elements are provided for determining at least one analyte concentration in a body fluid. The sensor elements are at least partially implantable into a body tissue and have a substrate and at least two electrodes. One electrode is a working electrode having at least one conductive pad applied to the substrate and at least one electrically conductive sensor material is applied to the conductive pad that includes at least one detector substance adapted to perform an electrically detectable electrochemical detection reaction with the analyte. Another electrode is a counter electrode having at least one counter electrode conductive pad applied to the substrate. The sensor elements also include at least one electrically insulating material that surrounds at least the counter electrode on all sides, where a height of the electrically insulating material at least equals a height of the counter electrode conductive pad.

Abstract translation: 提供传感器元件用于确定体液中的至少一种分析物浓度。 传感器元件至少部分可植入体内组织并具有基底和至少两个电极。 一个电极是具有施加到衬底的至少一个导电焊盘的至少一个导电焊盘的工作电极，并且至少一个导电传感器材料被施加到导电焊盘，该导电焊盘包括适于与被分析物进行电可检测的电化学检测反应的至少一个检测器物质。 另一电极是具有施加到基板的至少一个对电极导电垫的对电极。 传感器元件还包括至少一个电绝缘材料，其至少围绕所有侧面的对电极，其中电绝缘材料的高度至少等于对电极导电焊盘的高度。

公开(公告)号：US08997330B2

公开(公告)日：2015-04-07

申请号：US13664757

申请日：2012-10-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Holger Kotzan ,  Gregor Bainczyk

IPC: H01S4/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  C12Q1/00

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/6848 ,  C12Q1/006 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T156/1052

Abstract: An implantable sensor is provide which can be used for determining a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid. The implantable sensor has a layered construction with at least one insulating carrier substrate and at least two electrodes which are arranged in at least two different layer planes of the implantable sensor and are electrically isolated from one another by the at least one insulating carrier substrate. The electrodes have electrode areas which face the medium when the sensor has been implanted, and are in contact with the medium over a large area and substantially uniformly, directly or via a generally analyte-permeable membrane layer.

Abstract translation: 可提供可植入式传感器，其可用于确定介质，特别是身体组织和/或体液中的至少一种分析物的浓度。 所述可植入传感器具有分层结构，其具有至少一个绝缘载体衬底和至少两个电极，所述至少两个电极被布置在所述可植入传感器的至少两个不同的层平面中并且通过所述至少一个绝缘载体衬底彼此电隔离。 电极具有当传感器被植入时面向介质的电极区域，并且在大面积上并且基本上均匀地直接地或经由大致分析物可渗透的膜层与介质接触。

公开(公告)号：US20130056144A1

公开(公告)日：2013-03-07

申请号：US13664757

申请日：2012-10-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Holger Kotzan ,  Gregor Bainczyk

IPC: B05D5/12 ,  B32B38/04 ,  B32B37/14

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/6848 ,  C12Q1/006 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T156/1052

Abstract: An implantable sensor is provide which can, be used for determining a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid. The implantable sensor has a layered construction with at least one insulating carrier substrate and at least two electrodes which are arranged in at least two different layer planes of the implantable sensor and are electrically isolated from one another by the at least one insulating carrier substrate. The electrodes have electrode areas which face the medium when the sensor has been implanted, and are in contact with the medium over a large area and substantially uniformly, directly or via a generally analyte-permeable membrane layer.

Abstract translation: 提供了一种可植入传感器，其可用于确定介质，特别是身体组织和/或体液中的至少一种分析物的浓度。 所述可植入传感器具有分层结构，其具有至少一个绝缘载体衬底和至少两个电极，所述至少两个电极被布置在所述可植入传感器的至少两个不同的层平面中并且通过所述至少一个绝缘载体衬底彼此电隔离。 电极具有当传感器被植入时面向介质的电极区域，并且在大面积上并且基本上均匀地直接地或经由大致分析物可渗透的膜层与介质接触。