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公开(公告)号：US20220003788A1
公开(公告)日：2022-01-06
申请号：US17304467
申请日：2021-06-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Jean-Pierre Bolliger , Rik Harbers , Rolf Knobel
Abstract: A method of determining a level of interference with a photometric in-vitro diagnostic assay and an in-vitro diagnostic analyzer for carrying out the method are described. The method comprises treating an aliquot of a sample with at least one reagent to obtain a sample/reagent mixture and subjecting the sample/reagent mixture to a photometric measurement in order to obtain a result of the in-vitro diagnostic assay, and during the same photometric measurement determining a preliminary level of interference by semi-quantitatively determining one or more interfering substances in the same sample/reaction mixture. The method further comprises triggering a separate photometric measurement of another aliquot of the same sample either undiluted or diluted with a liquid other than a reagent in order to determine an effective level of interference by quantitatively determining the one or more interfering substances, only upon determining a preliminary level of interference above a predetermined threshold.
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公开(公告)号：US11150256B2
公开(公告)日：2021-10-19
申请号：US16105121
申请日：2018-08-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Friedrich Ackermann , Andreas Calatzis , Rik Harbers , Roland Hutter , Jean-Pierre Bolliger , Theresa Kitcoff , Patrick Sascha Labud
Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.
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公开(公告)号：US20190004075A1
公开(公告)日：2019-01-03
申请号：US16105121
申请日：2018-08-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Friedrich Ackermann , Andreas Calatzis , Rik Harbers , Roland Hutter , Jean-Pierre Bolliger , Theresa Kitcoff , Patrick Sascha Labud
Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.
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公开(公告)号：US10082517B2
公开(公告)日：2018-09-25
申请号：US15084663
申请日：2016-03-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Friedrich Ackermann , Andreas Calatzis , Rik Harbers , Roland Hutter , Jean-Pierre Bolliger , Theresa Kitcoff , Patrick Sascha Labud
CPC classification number: G01N35/00663 , B01L9/00 , B01L2200/025 , G01N35/00693 , G01N35/00722 , G01N35/0092 , G01N35/04 , G01N35/1002 , G01N35/1009 , G01N35/1016 , G01N35/1079 , G01N2035/00425 , G01N2035/00673 , G01N2035/00891 , G01N2035/0094 , G01N2035/0406 , G01N2035/1025
Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.
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