公开(公告)号：US20190004075A1

公开(公告)日：2019-01-03

申请号：US16105121

申请日：2018-08-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Friedrich Ackermann ,  Andreas Calatzis ,  Rik Harbers ,  Roland Hutter ,  Jean-Pierre Bolliger ,  Theresa Kitcoff ,  Patrick Sascha Labud

IPC: G01N35/00 ,  B01L9/00 ,  G01N35/04 ,  G01N35/10

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

公开(公告)号：US10082517B2

公开(公告)日：2018-09-25

申请号：US15084663

申请日：2016-03-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Friedrich Ackermann ,  Andreas Calatzis ,  Rik Harbers ,  Roland Hutter ,  Jean-Pierre Bolliger ,  Theresa Kitcoff ,  Patrick Sascha Labud

IPC: G01N35/00 ,  B01L9/00 ,  G01N35/10 ,  G01N35/04

CPC classification number: G01N35/00663 ,  B01L9/00 ,  B01L2200/025 ,  G01N35/00693 ,  G01N35/00722 ,  G01N35/0092 ,  G01N35/04 ,  G01N35/1002 ,  G01N35/1009 ,  G01N35/1016 ,  G01N35/1079 ,  G01N2035/00425 ,  G01N2035/00673 ,  G01N2035/00891 ,  G01N2035/0094 ,  G01N2035/0406 ,  G01N2035/1025

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

公开(公告)号：US11150256B2

公开(公告)日：2021-10-19

申请号：US16105121

申请日：2018-08-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Friedrich Ackermann ,  Andreas Calatzis ,  Rik Harbers ,  Roland Hutter ,  Jean-Pierre Bolliger ,  Theresa Kitcoff ,  Patrick Sascha Labud

IPC: G01N35/00 ,  G01N35/10 ,  G01N35/04

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

公开(公告)号：US09878322B2

公开(公告)日：2018-01-30

申请号：US14047230

申请日：2013-10-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Roland Hutter ,  Roland Stoeckli

IPC: B01L3/00 ,  B01L3/02 ,  G01N35/10

CPC classification number: B01L3/021 ,  B01L2200/0615 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2200/146 ,  B01L2400/0487 ,  G01N35/1004 ,  G01N35/1016 ,  G01N2035/1018 ,  Y10T436/2575

Abstract: A pipetting unit and a method of using the pipetting unit for pipetting a volume V1 of test liquid for carrying out an in vitro diagnostic test are presented. The method comprises dipping a nozzle of a pipetting unit into a test liquid and aspirating a volume V4 of the test liquid larger than the volume V1 required for carrying out the test. The method further comprises dipping the pipetting unit into a wash liquid and dispensing a volume V2 equal or smaller than V4 minus V1 of the test liquid into the wash liquid. The method further comprises dipping the pipetting unit into a reaction liquid and dispensing the volume V1 of test liquid required for the test.