公开(公告)号：US20140041443A1

公开(公告)日：2014-02-13

申请号：US14038805

申请日：2013-09-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Heino Eikmeier ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn ,  Ewald Rieger

IPC: G01N33/49

CPC classification number: G01N33/49 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1468 ,  A61B2560/04 ,  A61B2560/0406 ,  A61B2560/0418 ,  A61B2560/0425

Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

Abstract translation: 本文公开了用于确定体液的至少一个分析参数的便携式诊断测量装置，特别是用于确定在血糖测定中可能发生的体液中的分析物浓度。 还公开了包括测量装置和至少一个一次性测试元件的分析系统。 测试元件可以被设计为载体带，并且可以至少部分地以平坦的方式接触测量装置的接收表面，其中接收表面布置在测量装置的壳体的窄侧上。

公开(公告)号：US20140238118A9

公开(公告)日：2014-08-28

申请号：US14038805

申请日：2013-09-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Heino Eikmeier ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn ,  Ewald Rieger

IPC: G01N33/49

CPC classification number: G01N33/49 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1468 ,  A61B2560/04 ,  A61B2560/0406 ,  A61B2560/0418 ,  A61B2560/0425

Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

公开(公告)号：US20140206024A1

公开(公告)日：2014-07-24

申请号：US14222645

申请日：2014-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Joachim Hoenes ,  Carina Horn ,  Claudia Gaessler-Dietsche

IPC: C12Q1/32

CPC classification number: C12Q1/32

Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

Abstract translation: 本发明提供式（I）的稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生物化学检测方法和试剂盒中的用途。

公开(公告)号：US20160090398A1

公开(公告)日：2016-03-31

申请号：US14959280

申请日：2015-12-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Joachim Hoenes ,  Carina Horn ,  Thomas Meier ,  Wolfgang Petrich

IPC: C07H19/207 ,  G01N21/64 ,  C12Q1/26

CPC classification number: C07H19/207 ,  C12Q1/26 ,  G01N21/6428 ,  G01N33/533 ,  G01N33/535 ,  G01N33/542 ,  G01N33/5735 ,  G01N33/581 ,  G01N33/582 ,  G01N2201/062 ,  G01N2333/90248

Abstract: The invention also relates to compounds, which are useful for intra-molecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.

Abstract translation: 本发明还涉及可用于分子内荧光共振能量转移（FRET）的化合物，其包含基于carbaNADH的第一荧光团的氧化形式和可在波长445至540之间激发的第二荧光团 nm，其发射最大值大于560nm，以及与其相关的方法，试剂盒和组合物。

公开(公告)号：US09796746B2

公开(公告)日：2017-10-24

申请号：US14959280

申请日：2015-12-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Joachim Hoenes ,  Carina Horn ,  Thomas Meier ,  Wolfgang Petrich

IPC: C07H19/207 ,  G01N33/533 ,  G01N33/535 ,  G01N33/542 ,  G01N33/573 ,  G01N33/58 ,  C12Q1/26 ,  G01N21/64

CPC classification number: C07H19/207 ,  C12Q1/26 ,  G01N21/6428 ,  G01N33/533 ,  G01N33/535 ,  G01N33/542 ,  G01N33/5735 ,  G01N33/581 ,  G01N33/582 ,  G01N2201/062 ,  G01N2333/90248

Abstract: The invention also relates to compounds, which are useful for intra-molecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.