公开(公告)号：US09221051B2

公开(公告)日：2015-12-29

申请号：US13872686

申请日：2013-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Susanne Wuerl

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502723 ,  B01L3/502738 ,  B01L2200/0684 ,  B01L2200/12 ,  B01L2300/0803 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  F16K99/0017 ,  F16K99/0063 ,  F16K2099/0084

Abstract: A microfluidic element for analysis of a fluid sample having a substrate and a microfluidic transport system having a channel structure enclosed by the substrate and a covering layer. The channel structure comprises a channel with two side walls as well as a chamber that is in fluid communication with the channel. The chamber has a chamber wall with an inlet orifice. The channel comprises a channel section and a valve section adjoining the channel section, wherein the valve section is in fluid communication with the inlet orifice in the chamber wall in such a way that a fluid can flow from the channel through the valve section and into the chamber. The valve section has a fluid transport cross-section, which enlarges in flow direction. The fluid transport cross-section in the valve section is greater than the fluid transport cross-section in the preceding channel section.

Abstract translation: 用于分析具有基底的流体样品的微流体元件和具有由基底和覆盖层包围的通道结构的微流体输送系统。 通道结构包括具有两个侧壁的通道以及与通道流体连通的室。 该室具有一个具有入口孔的室壁。 通道包括通道部分和毗邻通道部分的阀部分，其中阀部分与腔室壁中的入口孔流体连通，使得流体可以从通道流过阀部分并进入 房间。 阀部分具有流体输送横截面，其在流动方向上扩大。 阀部分中的流体输送横截面大于前一通道部分中的流体输送横截面。

公开(公告)号：US09186671B2

公开(公告)日：2015-11-17

申请号：US13871720

申请日：2013-04-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Manfred Augstein ,  Christoph Boehm ,  Susanne Wuerl

IPC: B01L3/00 ,  B01J4/02

CPC classification number: B01L3/50273 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0806 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0688

Abstract: A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber.

Abstract translation: 提供了一种在基板上形成的具有基板，覆盖层和毛细结构的微流体测试载体。 毛细管结构由衬底和覆盖层包围，并包括接收室，样品室和接收室和样品室之间的连接通道。 接收室具有两个边界面和侧壁，其中一个边界表面形成底部，另一个形成盖。 接收室具有周围的通风通道，并且在接收室和通风通道之间具有阻塞。 大坝和排气通道形成一个被设计为几何阀的毛细管阻塞，来自接收室的空气可以通过该几何阀排出到通风通道中。 排气通道出口和样品室流入之间的连接通道控制从接收室进入样品室的流体输送。 毛细管止动件被构造成防止自主流体从接收室输送。