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    Microfluidic test carrier for apportioning a liquid quantity into subquantities
    2.
    发明授权
    Microfluidic test carrier for apportioning a liquid quantity into subquantities 有权
    用于将液体量分配到子量的微流体测试载体

    公开(公告)号：US09186671B2

    公开(公告)日：2015-11-17

    申请号：US13871720

    申请日：2013-04-26

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Manfred Augstein ,  Christoph Boehm ,  Susanne Wuerl

    IPC: B01L3/00 ,  B01J4/02

    CPC classification number: B01L3/50273 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0806 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0688

    Abstract: A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber.

    Abstract translation: 提供了一种在基板上形成的具有基板，覆盖层和毛细结构的微流体测试载体。 毛细管结构由衬底和覆盖层包围，并包括接收室，样品室和接收室和样品室之间的连接通道。 接收室具有两个边界面和侧壁，其中一个边界表面形成底部，另一个形成盖。 接收室具有周围的通风通道，并且在接收室和通风通道之间具有阻塞。 大坝和排气通道形成一个被设计为几何阀的毛细管阻塞，来自接收室的空气可以通过该几何阀排出到通风通道中。 排气通道出口和样品室流入之间的连接通道控制从接收室进入样品室的流体输送。 毛细管止动件被构造成防止自主流体从接收室输送。

    Method to perform a measurement of an analyte in a sample using an automatic analyzer
    3.
    发明授权
    Method to perform a measurement of an analyte in a sample using an automatic analyzer 有权

    公开(公告)号：US10241124B2

    公开(公告)日：2019-03-26

    申请号：US15092806

    申请日：2016-04-07

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Manfred Augstein ,  Nadine Losleben ,  Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

    IPC: C12M1/00 ,  G01N35/10 ,  B01L3/02 ,  G01F11/08 ,  B01L3/00 ,  G01N35/00

    Abstract: A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.

    Test Element Analysis System with Contact Surfaces Coated with Hard Material
    5.
    发明申请
    Test Element Analysis System with Contact Surfaces Coated with Hard Material 有权
    具有硬质材料接触面的测试元件分析系统

    公开(公告)号：US20140147913A1

    公开(公告)日：2014-05-29

    申请号：US14167344

    申请日：2014-01-29

    Applicant: Roche Diagnostics Operations, inc.

    Inventor： Manfred Augstein ,  Joerg Dreibholz ,  Stefan Riebel

    IPC: G01N27/26

    CPC classification number: G01N27/26 ,  G01N33/4875

    Abstract: The invention concerns a test element analytical system for the analytical examination of a sample, especially a body fluid, comprising at least one test element with one or more measuring zones and contact areas located on the test element, in particular electrodes or conductor paths, the sample to be examined being brought into the measuring zone to carry out an analysis in order to determine a characteristic measured quantity for the analysis, and an evaluation instrument with a test element holder for positioning the test element in a measuring position and a measuring device for measuring the characteristic change, the test element holder containing contact elements with contact areas which enable an electrical contact between the contact areas of the test element and the contact areas of the test element holder, characterized in that one of these contact areas is provided with an electrically conductive hard material surface.

    Abstract translation: 本发明涉及一种用于对样品，特别是体液的分析检查的测试元件分析系统，其包括至少一个具有一个或多个测量区域的测试元件和位于测试元件，特别是电极或导体路径上的接触区域， 要检查的样品进入测量区域进行分析，以确定用于分析的特征测量量，以及具有用于将测试元件定位在测量位置的测试元件保持器的评估仪器和用于 测量特性变化，所述测试元件保持器包含具有接触区域的接触元件，所述接触元件能够使所述测试元件的接触区域与所述测试元件保持器的接触区域之间的电接触，其特征在于，所述接触区域中的一个设置有 导电硬质材料表面。

    Test element analysis system with contact surfaces coated with hard material
    6.
    发明授权
    Test element analysis system with contact surfaces coated with hard material 有权

    公开(公告)号：US09638655B2

    公开(公告)日：2017-05-02

    申请号：US14167344

    申请日：2014-01-29

    Applicant: Roche Diagnostics Operations, inc.

    Inventor： Manfred Augstein ,  Joerg Dreibholz ,  Stefan Riebel

    IPC: G01N27/26 ,  G01N33/487

    CPC classification number: G01N27/26 ,  G01N33/4875

    Abstract: The invention concerns a test element analytical system for the analytical examination of a sample, especially a body fluid, comprising at least one test element with one or more measuring zones and contact areas located on the test element, in particular electrodes or conductor paths, the sample to be examined being brought into the measuring zone to carry out an analysis in order to determine a characteristic measured quantity for the analysis, and an evaluation instrument with a test element holder for positioning the test element in a measuring position and a measuring device for measuring the characteristic change, the test element holder containing contact elements with contact areas which enable an electrical contact between the contact areas of the test element and the contact areas of the test element holder, characterized in that one of these contact areas is provided with an electrically conductive hard material surface.

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