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1.发明授权Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US08364258B2
公开(公告)日：2013-01-29
申请号：US12802812
申请日：2010-06-14
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/18
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： An apparatus for enhancing an immune response in a vertebrate subject is described. The apparatus includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种用于增强脊椎动物受试者的免疫应答的装置。 该装置包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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公开(公告)号：US20100137844A1
公开(公告)日：2010-06-03
申请号：US12315510
申请日：2008-12-02
IPC分类号： A61K9/22
CPC分类号： A61K31/497 , A61K9/0019 , A61K9/19 , A61K9/2018 , A61K31/00 , A61K31/145 , A61K31/4725 , A61K31/506 , A61K45/06 , A61M5/14276 , A61M5/16827 , A61M5/1723 , A61M2205/0244 , A61M2205/50 , A61M2205/52 , G06F19/3468 , Y02A50/411 , Y02A90/26 , A61K2300/00
摘要： Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.
摘要翻译： 所公开的某些实施方案涉及调节至少一种炎性反应或反应的组合物，包括治疗组合物，方法，装置和系统。 根据各种实施方案，组合物，方法，装置和系统涉及调节Toll样受体，Src家族激酶，NF-kB分子，蛋白酶或蛋白酶体中的一种或多种。
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公开(公告)号：US20100137787A1
公开(公告)日：2010-06-03
申请号：US12315512
申请日：2008-12-02
CPC分类号： A61K31/497 , A61K9/0019 , A61K9/19 , A61K9/2018 , A61K31/00 , A61K31/145 , A61K31/4725 , A61K31/506 , A61K45/06 , A61M5/14276 , A61M5/16827 , A61M5/1723 , A61M2205/0244 , A61M2205/50 , A61M2205/52 , G06F19/3468 , Y02A50/411 , Y02A90/26 , A61K2300/00
摘要： Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.
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公开(公告)号：US20100136096A1
公开(公告)日：2010-06-03
申请号：US12315513
申请日：2008-12-02
IPC分类号： A61K9/127 , A61K31/439 , A61K31/506 , A61K31/4706 , A61K31/145 , A61K31/69 , A61K31/7088 , A61K38/02 , A61K31/739 , A61K31/70
CPC分类号： A61K31/145 , A61K9/0019 , A61K9/19 , A61K9/20 , A61K9/4825 , A61K31/439 , A61K31/4706 , A61K31/506 , A61K31/69 , A61K31/70 , A61K31/7088 , A61K31/739 , A61K38/02 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.
摘要翻译： 所公开的某些实施方案涉及调节至少一种炎性反应或反应的组合物，包括治疗组合物，方法，装置和系统。 根据各种实施方案，组合物，方法，装置和系统涉及调节Toll样受体，Src家族激酶，NF-kB分子，蛋白酶或蛋白酶体中的一种或多种。
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公开(公告)号：US09358350B2
公开(公告)日：2016-06-07
申请号：US13568033
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Systems and methods for wearable injection guides are described, which include: acquiring one or more digital images of a body region of an individual with at least one image capture device; creating a digitally rendered model of a wearable injection guide from the one or more digital images of the body region of the individual; adding one or more digitally rendered fiducials indicative of at least one treatment parameter to the digitally rendered model of the wearable injection guide; and forming the wearable injection guide from the digitally rendered model of the wearable injection guide, the formed wearable injection guide including one or more fiducials corresponding to the one or more digitally rendered fiducials on the digitally rendered model of the wearable injection guide.
摘要翻译： 描述了可穿戴式注射引导件的系统和方法，其包括：用至少一个图像捕获装置获取个体的身体区域的一个或多个数字图像; 从个体的身体区域的一个或多个数字图像创建可戴式注射引导件的数字渲染模型; 将指示至少一个治疗参数的一个或多个数字呈现的基准添加到所述可佩戴注射引导件的数字渲染模型; 以及从所述可穿戴式注射导向器的数字渲染模型形成所述可穿戴式注射导向器，所述可穿戴式注射引导件包括与所述可穿戴式注射导向器的数字渲染模型上的所述一个或多个数字呈现的基准相对应的一个或多个基准。
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6.发明授权Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject 有权用于调节脊椎动物受试者中棕色脂肪组织活性的方法，装置和系统公开(公告)号：US08968377B2
公开(公告)日：2015-03-03
申请号：US13068421
申请日：2011-05-09
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
CPC分类号： A61F7/02 , A61F7/007 , A61F7/106 , A61F7/12 , A61F2007/0002 , A61F2007/0011 , A61F2007/0056 , A61F2007/0075 , A61F2007/009 , A61F2007/0093 , A61F2007/0226 , A61F2007/0233 , A61F2007/029 , A61F2007/101 , A61F2007/126 , A61N1/0534 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/36053 , A61N1/3606 , A61N1/36135 , A61N2/002 , A61N2/004 , A61N5/025 , A61N5/04 , A61N7/00 , A61N2007/0008
摘要： Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.
摘要翻译： 本文公开了用于治疗脊椎动物受试者中的疾病，病症或病症的装置，系统和方法。 提供了一种装置，其包括配置成施加到脊椎动物的一个或多个组织的一个或多个冷却元件，所述脊椎动物受到调节脊椎动物受试者的棕色脂肪组织的至少一种活动，以及可编程控制器，其被配置为向该脊椎动物 或更多个冷却元件，以响应关于脊椎动物对象的一个或多个生理状况的信息。
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公开(公告)号：US20140039451A1
公开(公告)日：2014-02-06
申请号：US13567921
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
IPC分类号： A61M5/42
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Wearable injection guides and manufacture and use thereof are described, which include: a rigid material formed to substantially conform in shape to a topography of a body region of an individual, the rigid material substantially impenetrable to an injection needle, and the rigid material including one or more injection needle access regions arranged in a treatment pattern.
摘要翻译： 描述了可穿戴的注射引导件及其制造和使用，其包括：刚性材料，形成为基本上符合个体的身体区域的形状，基本上不能穿透到注射针的刚性材料，并且刚性材料包括一个 或更多的注射针入口区域以治疗图案排列。
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8.发明授权Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US08321012B2
公开(公告)日：2012-11-27
申请号：US12655195
申请日：2009-12-22
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/18
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种增强脊椎动物受试者免疫应答的方法。 该方法包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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公开(公告)号：US20100137247A1
公开(公告)日：2010-06-03
申请号：US12315509
申请日：2008-12-02
IPC分类号： A61K31/47 , A61K31/439 , A61K31/496 , A61K31/397 , A61K31/69 , A61P29/00 , A61P33/06
CPC分类号： A61K31/497 , A61K9/0019 , A61K9/19 , A61K9/2018 , A61K31/00 , A61K31/145 , A61K31/4725 , A61K31/506 , A61K45/06 , A61M5/14276 , A61M5/16827 , A61M5/1723 , A61M2205/0244 , A61M2205/50 , A61M2205/52 , G06F19/3468 , Y02A50/411 , Y02A90/26 , A61K2300/00
摘要： Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.
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公开(公告)号：US20100137246A1
公开(公告)日：2010-06-03
申请号：US12315504
申请日：2008-12-02
IPC分类号： A61K31/69 , A61K31/439 , A61K31/4706 , A61K31/506 , A61K31/428 , A61K31/5415 , A61P29/00 , A61P35/00 , A61P33/06 , A61K31/497 , A61K31/145 , C12N5/06
CPC分类号： A61K31/145 , A61K31/428 , A61K31/439 , A61K31/4706 , A61K31/497 , A61K31/506 , A61K31/5415 , A61K31/69 , Y02A50/411
摘要： Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.
摘要翻译： 所公开的某些实施方案涉及调节至少一种炎性反应或反应的组合物，包括治疗组合物，方法，装置和系统。 根据各种实施方案，组合物，方法，装置和系统涉及调节Toll样受体，Src家族激酶，NF-kB分子，蛋白酶或蛋白酶体中的一种或多种。
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