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公开(公告)号：US20120039855A1
公开(公告)日：2012-02-16
申请号：US13206715
申请日：2011-08-10
申请人： Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar , Charito Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj
发明人： Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar , Charito Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj
CPC分类号： A61L27/225 , A61L27/3834 , C12N2533/56
摘要： The invention relates to a fibrin-based scaffold suitable for supporting a population of cells comprising mesenchymal stem cells (MSC) and/or umbilical tissue derived cells (UTC) at the site of administration for a prolonged period of time. The scaffold is capable of supporting at least 1×106 cells/ml scaffold. The invention also relates to the preparation of the scaffold and to its use. Preparation of the scaffold is carried out with a fibrinogen component comprising fibrinogen having a final concentration of higher than 17.5 mg/ml scaffold. The scaffold and the embedded MSC and/or UTC can be used for increasing vascularization and/or wound healing at the site of administration.
摘要翻译： 本发明涉及一种适合于在给药部位长时间支持包含间充质干细胞（MSC）和/或脐带组织衍生细胞（UTC）的细胞群的基于纤维蛋白的支架。 支架能够支持至少1×10 6个细胞/ ml的支架。 本发明还涉及脚手架及其用途的制备。 用包含最终浓度高于17.5mg / ml支架的纤维蛋白原的纤维蛋白原组分进行支架的制备。 支架和嵌入式MSC和/或UTC可用于在给药部位增加血管形成和/或伤口愈合。
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2.发明授权Treatment of peripheral vascular disease using umbilical cord tissue-derived cells 有权使用脐带组织来源的细胞治疗外周血管疾病公开(公告)号：US09125906B2
公开(公告)日：2015-09-08
申请号：US13206913
申请日：2011-08-10
申请人： Charito S. Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj , Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar
发明人： Charito S. Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj , Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar
CPC分类号： A61K35/51 , A61K35/34 , A61K35/44 , A61K35/545 , A61K38/363 , A61K38/4833 , A61K45/06 , A61L27/3834 , A61L27/3839 , A61L27/3886 , A61L27/3895 , C12N5/0605 , C12N2510/00 , A61K2300/00 , A61K35/15
摘要： Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease with umbilical derived cells and fibrin glue are disclosed.
摘要翻译： 使用衍生自脐带组织的细胞刺激和支持血管生成，改善血流量，再生，修复和改善由外周缺血事件损伤的骨骼肌的组合物和方法，以及保护骨骼肌免受外周血管中的缺血性损伤 疾病患者被披露。 特别地，公开了用脐带血细胞和纤维蛋白胶治疗患有外周血管疾病的患者的方法。
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3.发明申请公开(公告)号：US20120213743A1
公开(公告)日：2012-08-23
申请号：US13206913
申请日：2011-08-10
申请人： Charito S. Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj , Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar
发明人： Charito S. Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj , Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar
CPC分类号： A61K35/51 , A61K35/34 , A61K35/44 , A61K35/545 , A61K38/363 , A61K38/4833 , A61K45/06 , A61L27/3834 , A61L27/3839 , A61L27/3886 , A61L27/3895 , C12N5/0605 , C12N2510/00 , A61K2300/00 , A61K35/15
摘要： Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease with umbilical derived cells and fibrin glue are disclosed.
摘要翻译： 使用衍生自脐带组织的细胞刺激和支持血管生成，改善血流量，再生，修复和改善由外周缺血事件损伤的骨骼肌的组合物和方法，以及保护骨骼肌免受外周血管中的缺血性损伤 疾病患者被披露。 特别地，公开了用脐带血细胞和纤维蛋白胶治疗患有外周血管疾病的患者的方法。
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公开(公告)号：US20120043347A1
公开(公告)日：2012-02-23
申请号：US13209650
申请日：2011-08-15
申请人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
发明人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/19 , A61M5/204 , A61M5/31586 , A61M35/003
摘要： The invention relates to a device for dispensing a fixed dose of fluid, the device comprising at least one barrel; at least one plunger at least partially enclosed within the barrel; a motion conversion mechanism for transferring actuated pressure force applied outside the barrel into movement of the at least one plunger in a dispensing direction, wherein the motion conversion mechanism comprises at least one rotating gear; and a releasing mechanism for disconnecting the plunger from the motion conversion mechanism, wherein at a released position the at least one plunger can move in a direction opposite to the dispensing direction, independent of a rotational movement of the at least one gear, and wherein the movement of the plunger in the opposite direction to the dispensing enables loading the fluid into the barrel.
摘要翻译： 本发明涉及一种用于分配固定剂量的流体的装置，该装置包括至少一个桶; 至少一个柱塞至少部分地封闭在所述筒体内; 运动转换机构，用于将施加到所述筒外部的致动压力传递到所述至少一个柱塞在分配方向上的运动，其中所述运动转换机构包括至少一个旋转齿轮; 以及用于将活塞与运动转换机构分离的释放机构，其中在释放位置，所述至少一个柱塞可以在与所述分配方向相反的方向上移动，而与所述至少一个齿轮的旋转运动无关，并且其中 柱塞在与分配相反的方向上的运动使得能够将流体装载到筒中。
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公开(公告)号：US08640921B2
公开(公告)日：2014-02-04
申请号：US13209650
申请日：2011-08-15
申请人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
发明人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
IPC分类号： B67D7/70
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/19 , A61M5/204 , A61M5/31586 , A61M35/003
摘要： The invention relates to a device for dispensing a fixed dose of fluid, the device comprising at least one barrel; at least one plunger at least partially enclosed within the barrel; a motion conversion mechanism for transferring actuated pressure force applied outside the barrel into movement of the at least one plunger in a dispensing direction, wherein the motion conversion mechanism comprises at least one rotating gear; and a releasing mechanism for disconnecting the plunger from the motion conversion mechanism, wherein at a released position the at least one plunger can move in a direction opposite to the dispensing direction, independent of a rotational movement of the at least one gear, and wherein the movement of the plunger in the opposite direction to the dispensing enables loading the fluid into the barrel.
摘要翻译： 本发明涉及一种用于分配固定剂量的流体的装置，该装置包括至少一个桶; 至少一个柱塞至少部分地封闭在所述筒体内; 运动转换机构，用于将施加到所述筒外部的致动压力传递到所述至少一个柱塞在分配方向上的运动，其中所述运动转换机构包括至少一个旋转齿轮; 以及用于将活塞与运动转换机构分离的释放机构，其中在释放位置，所述至少一个柱塞可以在与所述分配方向相反的方向上移动，而与所述至少一个齿轮的旋转运动无关，并且其中 柱塞在与分配相反的方向上的运动使得能够将流体装载到筒中。
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公开(公告)号：US20110238009A1
公开(公告)日：2011-09-29
申请号：US13053448
申请日：2011-03-22
申请人： Moti Meron , Israel Nur , Roee Atlas
发明人： Moti Meron , Israel Nur , Roee Atlas
CPC分类号： A61M5/3294 , A61B17/00491 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31578 , A61M5/31581 , A61M5/31596 , A61M5/322 , A61M5/3257 , A61M5/326 , A61M5/3287 , A61M5/3293 , A61M5/46 , A61M2005/3128 , A61M2005/3206
摘要： A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position.
摘要翻译： 用于注射的装置包括具有上端的壳体，包括具有注射针开口的底表面的下端以及在所述上端和下端之间延伸的轴线。 该装置包括设置在壳体内用于在缩回位置和延伸位置之间移动的注射针。
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公开(公告)号：US09278181B2
公开(公告)日：2016-03-08
申请号：US13053448
申请日：2011-03-22
申请人： Moti Meron , Israel Nur , Roee Atlas
发明人： Moti Meron , Israel Nur , Roee Atlas
CPC分类号： A61M5/3294 , A61B17/00491 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31578 , A61M5/31581 , A61M5/31596 , A61M5/322 , A61M5/3257 , A61M5/326 , A61M5/3287 , A61M5/3293 , A61M5/46 , A61M2005/3128 , A61M2005/3206
摘要： A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position.
摘要翻译： 用于注射的装置包括具有上端的壳体，包括具有注射针开口的底表面的下端以及在所述上端和下端之间延伸的轴线。 该装置包括设置在壳体内用于在缩回位置和延伸位置之间移动的注射针。
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公开(公告)号：US09211555B2
公开(公告)日：2015-12-15
申请号：US13484616
申请日：2012-05-31
申请人： Moti Meron , Roee Atlas , Assaf Gershonovitch , Amatzia Gantz , John Goodman
发明人： Moti Meron , Roee Atlas , Assaf Gershonovitch , Amatzia Gantz , John Goodman
IPC分类号： B05B7/06 , B05B7/24 , A61B17/00 , B01F5/02 , B01F13/00 , B05B7/08 , A61M11/00 , A61M15/00 , A61M11/02 , A61M35/00
CPC分类号： B05B7/2472 , A61B17/00491 , A61B2017/00495 , A61B2017/00522 , A61M11/00 , A61M11/007 , A61M11/02 , A61M15/0003 , A61M35/003 , B01F5/0262 , B01F13/0023 , B05B7/061 , B05B7/08
摘要： The invention relates to an applicator tip for spraying and/or mixing at least two fluids that react together, the tip comprising: at least two fluid conduits for carrying the at least two fluids, each conduit having at least one outlet opening, the openings are positioned substantially on a same plane; at least two gas conduits for carrying a gas volume, each gas conduit comprises a proximal gas tube and a distal gas tube, each distal gas tube is bent as compared to the position of the proximal gas tube, and each distal gas tube has one gas opening positioned distal from the plane of the outlet openings; and a housing for accommodating the at least two fluid conduits and the at least two gas conduits. The device allows efficient spraying in close proximity to a surface.
摘要翻译： 本发明涉及一种用于喷射和/或混合至少两种反应在一起的流体的施用器尖端，所述尖端包括：用于承载至少两种流体的至少两个流体导管，每个导管具有至少一个出口开口，所述开口是 基本位于同一平面上; 用于承载气体体积的至少两个气体管道，每个气体导管包括近端气体管和远端气体管，每个远端气体管与近侧气体管的位置相比弯曲，并且每个远端气体管具有一个气体 开口位于远离出口开口的平面; 以及用于容纳所述至少两个流体导管和所述至少两个气体导管的壳体。 该装置允许在表面附近有效地喷涂。
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公开(公告)号：US20120305669A1
公开(公告)日：2012-12-06
申请号：US13484616
申请日：2012-05-31
申请人： Moti Meron , Roee Atlas , Assaf Gershonovitch , Amatzia Gantz , John Goodman
发明人： Moti Meron , Roee Atlas , Assaf Gershonovitch , Amatzia Gantz , John Goodman
IPC分类号： B05B7/06
CPC分类号： B05B7/2472 , A61B17/00491 , A61B2017/00495 , A61B2017/00522 , A61M11/00 , A61M11/007 , A61M11/02 , A61M15/0003 , A61M35/003 , B01F5/0262 , B01F13/0023 , B05B7/061 , B05B7/08
摘要： The invention relates to an applicator tip for spraying and/or mixing at least two fluids that react together, the tip comprising: at least two fluid conduits for carrying the at least two fluids, each conduit having at least one outlet opening, the openings are positioned substantially on a same plane; at least two gas conduits for carrying a gas volume, each gas conduit comprises a proximal gas tube and a distal gas tube, each distal gas tube is bent as compared to the position of the proximal gas tube, and each distal gas tube has one gas opening positioned distal from the plane of the outlet openings; and a housing for accommodating the at least two fluid conduits and the at least two gas conduits. The device allows efficient spraying in close proximity to a surface.
摘要翻译： 本发明涉及一种用于喷射和/或混合至少两种反应在一起的流体的施用器尖端，所述尖端包括：用于承载至少两种流体的至少两个流体导管，每个导管具有至少一个出口开口，所述开口是 基本位于同一平面上; 用于承载气体体积的至少两个气体管道，每个气体导管包括近端气体管和远端气体管，每个远端气体管与近侧气体管的位置相比弯曲，并且每个远端气体管具有一个气体 开口位于远离出口开口的平面; 以及用于容纳所述至少两个流体导管和所述至少两个气体导管的壳体。 该装置允许在表面附近有效地喷涂。
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