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公开(公告)号：US20120115819A1
公开(公告)日：2012-05-10
申请号：US13319513
申请日：2010-05-13
申请人： Roger B. Clark , Diana Katharine Hunt , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus P. Rönn
发明人： Roger B. Clark , Diana Katharine Hunt , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号： A61K31/65 , C07C275/24 , C07D211/14 , C07D205/04 , C07D295/155 , C07C311/05 , C07D403/12 , A61P31/04 , C07D207/14 , C07D207/12 , C07D207/09 , C07D207/10 , C07C237/26 , C07D213/56
CPC分类号： C07C237/26 , C07C271/22 , C07C271/44 , C07C275/24 , C07C311/13 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2603/52 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D211/14 , C07D261/20 , C07D295/155 , C07D413/06
摘要： The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。
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公开(公告)号：US08501716B2
公开(公告)日：2013-08-06
申请号：US13570837
申请日：2012-08-09
申请人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其药学上可接受的盐。 结构式（A）的变量在本文中定义。 还描述了包含结构式（A）的化合物及其治疗用途的药物组合物。
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公开(公告)号：US20130109657A1
公开(公告)日：2013-05-02
申请号：US13718909
申请日：2012-12-18
申请人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号： A61K31/65 , C07D207/09 , A61K45/06
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其药学上可接受的盐。 结构式（A）的变量在本文中定义。 还描述了包含结构式（A）化合物及其治疗用途的药物组合物。
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公开(公告)号：US08906887B2
公开(公告)日：2014-12-09
申请号：US12462795
申请日：2009-08-07
申请人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号： A61K31/65 , C07C237/26 , C07D233/61 , C07D207/34 , C07D295/088 , C07D211/60 , C07D257/04 , C07D295/15 , C07D209/94 , C07D231/14 , A61K45/06 , C07D207/14 , C07D333/34 , C07C311/08 , C07D231/56 , C07C311/21 , C07D207/10 , C07D413/12 , C07D213/81 , C07D249/04 , C07D261/20 , C07D207/09 , C07D239/42 , C07D333/38 , C07D277/56 , C07D207/08 , C07D231/12 , C07D207/12 , C07D213/82 , C07D205/04 , C07D295/26 , C07D207/16 , C07D261/18 , C07D211/76 , C07D213/74
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
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公开(公告)号：US20100105671A1
公开(公告)日：2010-04-29
申请号：US12462795
申请日：2009-08-07
申请人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号： A61K31/535 , C07D261/20 , C07D265/30 , C07D207/04 , A61K31/42 , A61K31/40 , A61P31/04
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其药学上可接受的盐。 结构式（A）的变量在本文中定义。 还描述了包含结构式（A）化合物及其治疗用途的药物组合物。
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公开(公告)号：US08796245B2
公开(公告)日：2014-08-05
申请号：US13718909
申请日：2012-12-18
申请人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号： A61K31/65 , C07C237/26 , C07D205/04 , C07D231/14 , C07D207/12 , C07D213/82 , C07D295/088 , C07D249/04 , C07D261/20 , C07D311/08 , C07D213/74 , C07D209/94 , C07D207/09 , C07D413/12 , C07D295/26 , C07D207/10 , C07D211/60 , C07D231/56 , C07D207/34 , C07D211/76 , C07D207/16 , C07D207/14 , C07D295/15 , A61K45/06 , C07D333/34 , C07D233/61 , C07D333/38 , C07D277/56 , C07D213/81 , C07D239/42 , C07D207/08 , C07D231/12 , C07D261/18 , C07D257/04
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其药学上可接受的盐。 结构式（A）的变量在本文中定义。 还描述了包含结构式（A）的化合物及其治疗用途的药物组合物。
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公开(公告)号：US20120302527A1
公开(公告)日：2012-11-29
申请号：US13570837
申请日：2012-08-09
申请人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人： Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其可药用盐。 结构式（A）的变量在本文中定义。 还描述了包含结构式（A）的化合物及其治疗用途的药物组合物。
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公开(公告)号：US20120108569A1
公开(公告)日：2012-05-03
申请号：US13319307
申请日：2010-05-07
申请人： Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
发明人： Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号： A61K31/497 , A61P31/04 , A61K31/435 , C07D221/18 , C07D401/04
CPC分类号： C07D221/18
摘要： The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号：US08828988B2
公开(公告)日：2014-09-09
申请号：US13731753
申请日：2012-12-31
申请人： Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
发明人： Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号： A61K31/397 , A61K31/497 , A61K31/435
CPC分类号： C07D221/18
摘要： The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号：US08367654B2
公开(公告)日：2013-02-05
申请号：US13319307
申请日：2010-05-07
申请人： Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
发明人： Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号： A61K31/397 , A61K31/497 , A61K31/435 , C07D403/02 , C07D221/18 , C07D205/04
CPC分类号： C07D221/18
摘要： The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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