公开(公告)号：US06940421B2

公开(公告)日：2005-09-06

申请号：US09730170

申请日：2000-12-05

申请人： Roger D. Chamberlain ,  John C. Bell

发明人： Roger D. Chamberlain ,  John C. Bell

IPC分类号： H04L12/26 ,  G08C15/00

CPC分类号： H04L43/06

摘要： A remote telemetry system utilizing dual communication pathways comprising low-cost remote communications devices operating on existing wire-based communications systems, wireless communications systems, and/or a combination thereof, to provide real-time reading and control of the remote telemetry units. A central controller directs the operation of the remote telemetry units and receives data from the remote telemetry units. The central controller is configured to utilize a conventional broadcast communications channel to transmit commands to individual remote telemetry units, each of which is assigned a unique identification code. Signals broadcast from the central controller are received at receivers associated with each remote telemetry unit, which performs a directed operation if a unique identification code included in the broadcast signal matches the identification code assigned to the remote telemetry unit. Each remote telemetry unit is provided with access to a conventional shared two-way communication pathway for return communication to the central controller. The shared two-way communication pathway is inactive unless specifically activated by a remote telemetry unit upon receipt of a signal from the central controller. In this manner, a large number of remote telemetry units may be provided with regulated access to a single shared two-way communications channel.

摘要翻译： 一种使用双通信路径的远程遥测系统，包括在现有有线通信系统，无线通信系统和/或其组合上操作的低成本远程通信设备，以提供远程遥测单元的实时读取和控制。 中央控制器引导远程遥测单元的操作并从远程遥测单元接收数据。 中央控制器被配置为利用常规广播通信信道将命令发送到各个远程遥测单元，每个远程遥测单元被分配唯一的识别码。 在与每个远程遥测单元相关联的接收机处接收从中央控制器广播的信号，如果包括在广播信号中的唯一识别码与分配给远程遥测单元的识别码匹配，则执行定向操作。 每个远程遥测单元都具有访问常规的共享双向通信路径，用于返回到中央控制器的通信。 共享双向通信路径是无效的，除非在远程遥测单元接收到来自中央控制器的信号时特别激活。 以这种方式，可以向大量的远程遥测单元提供对单个共享双向通信信道的受控访问。

公开(公告)号：US08147822B1

公开(公告)日：2012-04-03

申请号：US09664444

申请日：2000-09-18

申请人： John C. Bell ,  Nahum Sonenberg ,  David F. Stojdl ,  Earl G. Brown ,  Harold L. Atkins ,  Ricardo M. Marius ,  Brian D. Lichty ,  Shane B. Knowles

发明人： John C. Bell ,  Nahum Sonenberg ,  David F. Stojdl ,  Earl G. Brown ,  Harold L. Atkins ,  Ricardo M. Marius ,  Brian D. Lichty ,  Shane B. Knowles

IPC分类号： A61K35/76

CPC分类号： A61K35/766 ,  A61K38/21 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20251 ,  C12N2810/6081 ,  A61K2300/00

摘要： The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterized by having low levels, or no, PKR activity, or as being PKR−/−, STAT1−/− or both PKR−/− and STAT1−/−. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.

摘要翻译： 本发明涉及一种降低肿瘤细胞活力的方法，该方法涉及向肿瘤细胞施用不是常见的人类病原体的病毒。 优选地，病毒表现出差异的易感性，因为正常细胞不受病毒的影响。 这种差异敏感性在干扰素存在下更显着。 肿瘤细胞的特征在于具有低水平或无PKR活性，或PKR - / - ，STAT1 - /或PKR - / - 和STAT1 - / - 两者。 病毒选自由弹状病毒和小RNA病毒组成的组，优选为水泡性口炎病毒（VSV）或其衍生物。

公开(公告)号：US07731974B2

公开(公告)日：2010-06-08

申请号：US10551103

申请日：2004-03-29

申请人： John C. Bell ,  Brian D. Lichty ,  David F. Stojdl

发明人： John C. Bell ,  Brian D. Lichty ,  David F. Stojdl

IPC分类号： A61K39/205 ,  A61K35/76 ,  C12N7/00 ,  C12N7/01 ,  C12N15/47 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/522 ,  A61K2039/5254 ,  A61K2039/572 ,  A61K2039/585 ,  C07K14/005 ,  C07K2319/07 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20234 ,  C12N2760/20261

摘要： The present invention provides mutant viruses with a decreased ability to block nuclear transport of mRNA or protein in an infected cell which are attenuated in vivo. The mutant viruses of the present invention may also be capable of triggering the anti-viral systems of normal host cells while remaining sensitive to the effects of these systems. The present invention further provides for the use of the mutant viruses in a range of applications including, but not limited to, as therapeutics for the treatment of cancer and infections, as vaccines and adjuvants, as viral vectors, and as oncolytic and cytolytic agents for the selective lysis of malignant or infected cells.

摘要翻译： 本发明提供了在体内减毒的受感染细胞中阻断mRNA或蛋白质的核转运能力降低的突变病毒。 本发明的突变病毒还可能能够触发正常宿主细胞的抗病毒系统，同时对这些系统的作用保持敏感。 本发明还提供了在一系列应用中使用突变病毒，包括但不限于作为治疗癌症和感染的治疗剂，作为疫苗和佐剂，作为病毒载体，以及作为溶瘤和细胞溶解剂 选择性裂解恶性或感染细胞。

公开(公告)号：US4311354A

公开(公告)日：1982-01-19

申请号：US129571

申请日：1980-03-12

申请人： Darrell Robinson ,  John C. Bell

发明人： Darrell Robinson ,  John C. Bell

IPC分类号： H02B1/03 ,  H01R13/44 ,  G01R11/04 ,  H01R13/60

CPC分类号： H02B1/03

摘要： A meter disconnect adaptor for assembly into a residential electric meter socket. The adaptor has a base with a peripheral configuration which allows it to be used with either a ringless type of meter box, or in a ring type of mounting, and has blade simulating members extending from one side of the base and resilient fingers extending from the other side of the base for receiving contact blades of the electric meter. In one embodiment of the invention the adaptor has a group of resilient fingers arranged to allow assembly of the meter therein in any one of a number of orientations.

摘要翻译： 一个仪表断开适配器，用于组装到住宅电表插座中。 适配器具有具有外围结构的基座，其允许其与无环式仪表箱或环形安装件一起使用，并且具有从基座的一侧延伸的刀片模拟构件和从该基座的一侧延伸的弹性指 用于接收电表接触片的基座的另一侧。 在本发明的一个实施例中，适配器具有一组弹性指状物，其布置成允许将仪表组装在多个取向中的任何一个中。

公开(公告)号：US08282917B2

公开(公告)日：2012-10-09

申请号：US12750410

申请日：2010-03-30

申请人： John C. Bell ,  Brian D. Lichty ,  David F. Stodjl

发明人： John C. Bell ,  Brian D. Lichty ,  David F. Stodjl

IPC分类号： A61K35/76

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/522 ,  A61K2039/5254 ,  A61K2039/572 ,  A61K2039/585 ,  C07K14/005 ,  C07K2319/07 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20234 ,  C12N2760/20261

摘要： The present invention provides mutant viruses with a decreased ability to block nuclear transport of mRNA or protein in an infected cell which are attenuated in vivo. The mutant viruses of the present invention may also be capable of triggering the anti-viral systems of normal host cells while remaining sensitive to the effects of these systems. The present invention further provides for the use of the mutant viruses in a range of applications including, but not limited to, as therapeutics for the treatment of cancer and infections, as vaccines and adjuvants, as viral vectors, and as oncolytic and cytolytic agents for the selective lysis of malignant or infected cells.

摘要翻译： 本发明提供了在体内减毒的受感染细胞中阻断mRNA或蛋白质的核转运能力降低的突变病毒。 本发明的突变病毒还可能能够触发正常宿主细胞的抗病毒系统，同时对这些系统的作用保持敏感。 本发明还提供了在一系列应用中使用突变病毒，包括但不限于作为治疗癌症和感染的治疗剂，作为疫苗和佐剂，作为病毒载体，以及作为溶瘤和细胞溶解剂 选择性裂解恶性或感染细胞。

公开(公告)号：US20110206640A1

公开(公告)日：2011-08-25

申请号：US13060028

申请日：2009-08-20

申请人： John C. Bell ,  Fabrice Le Boeuf

发明人： John C. Bell ,  Fabrice Le Boeuf

IPC分类号： A61K35/76 ,  A61P35/00

CPC分类号： A61K38/162 ,  A61K35/76 ,  A61K35/766 ,  A61K38/193 ,  C12N2710/24132 ,  C12N2760/20232 ,  A61K2300/00

摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.

摘要翻译： 一方面，本发明提供了通过用两种或多种病毒株感染宿主组织来优先杀死宿主例如癌细胞中的靶增殖细胞的方法。 可以选择病毒株以提供协同和共生作用，其涉及目标增殖细胞中的同时溶解感染。 在选择的实施方案中，选择病毒使得第一毒力因子在被第一病毒感染的增殖细胞中的表达增加了第二病毒的溶解作用; 并且第二种毒力因子在用第二种病毒感染的增殖细胞中的表达增加了第一种病毒的溶解作用。 可以选择第一和第二病毒的基因组，使得它们与宿主细胞中的病毒基因组之间的重组不相容。

公开(公告)号：US08227440B2

公开(公告)日：2012-07-24

申请号：US12549939

申请日：2009-08-28

申请人： Grant McFadden ,  John C. Bell

发明人： Grant McFadden ,  John C. Bell

IPC分类号： A61K48/00 ,  A01N65/00

CPC分类号： A61K35/768 ,  C12N2710/24032

摘要： The present invention relates to therapeutic use of Myxoma virus. Myxomas virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.

摘要翻译： 本发明涉及粘液瘤病毒的治疗用途。 粘液瘤病毒可以选择性感染具有缺陷先天性抗病毒反应的细胞，包括对干扰素无反应的细胞，可用于治疗特征在于存在这种细胞（包括癌症）的疾病。

公开(公告)号：US20100086522A1

公开(公告)日：2010-04-08

申请号：US12374277

申请日：2007-07-18

申请人： John C. Bell ,  Anthony T. Power

发明人： John C. Bell ,  Anthony T. Power

IPC分类号： A61K35/76 ,  C12N5/00

CPC分类号： A61K35/766 ,  A61K47/6901 ,  A61K2039/515 ,  C12N2760/20232

摘要： The invention provides compositions and methods for treating neoplastic disease, such as cancer, with an oncolytic virus, such as VSV. A carrier cell is used to target a diseased tissue, and to cloak the oncolytic virus from surveillance by the subject's immune system during a targeting interval. Following delivery of the virus to the target tissue, the lysis of the carrier cell, and of the target cell, by the oncolytic virus, promotes an adaptive tumouricidal immune response. A wide variety of disparate carrier cells may be used, in conjunction with a promiscuous oncolytic virus having broad tropism, in an approach which facilitates successive treatments in which a new carrier will not be susceptible to an adaptive immune response mounted against previously used carriers. The promiscuity of the virus also facilitates lysis of carrier cells and target cells that are allogenic or xenogenic. The lytic phase of the carrier cell infection is staged so that the carrier is administered in an eclipse phase, and lysis follows the conclusion of the therapeutic targeting interval.

摘要翻译： 本发明提供了用溶瘤病毒如VSV治疗肿瘤疾病如癌症的组合物和方法。 载体细胞用于靶向患病组织，并且在靶向间隔期间通过受试者的免疫系统对溶瘤病毒进行遮盖。 在将病毒递送至靶组织后，溶瘤病毒对载体细胞和靶细胞的裂解促进适应性的免疫反应。 可以使用多种不同的载体细胞，与具有广泛趋向性的混杂溶瘤病毒联合使用，其有利于连续治疗，其中新载体不会对针对先前使用的载体安装的适应性免疫应答敏感。 病毒的混杂也有助于溶解同种异体或异种的载体细胞和靶细胞。 载体细胞感染的裂解期分期进行，使得载体在日食阶段施用，并且裂解遵循治疗靶向间隔的结论。

公开(公告)号：US06137282A

公开(公告)日：2000-10-24

申请号：US104817

申请日：1998-06-25

申请人： David C. Macke, Sr. ,  Theodore James Eckert ,  John C. Bell ,  Timothy L. Bell

发明人： David C. Macke, Sr. ,  Theodore James Eckert ,  John C. Bell ,  Timothy L. Bell

IPC分类号： G01R31/11 ,  H03K17/94 ,  H03K17/96 ,  G01R27/04 ,  H03M11/00

CPC分类号： H03K17/96 ,  G01R31/11 ,  H03K17/94 ,  H03K2217/96066

摘要： A user input device is disclosed adapting the electronic components of a time-domain reflectometry material level sensor to replace traditional user input devices such as push-buttons, control knobs, and variable sliders. An electrical conductor is arrayed beneath an input panel, such that when a high permittivity or high conductivity material is placed in proximity to the conductor, the characteristic impedance of the conductor is altered at that point, reflecting electronic pulses transmitted through the conductor. The reflected electronic pulse is received by the associated electronics, and the position of the material along the conductor subsequently determined. By segmenting the conductor into virtual regions, each corresponding to an individual "button", discrete input may be received by the device based upon the placement of the material within specific virtual regions. Alternatively, the conductor may function as an infinitely variable "slider" control, with movement of the material along the conductor producing a proportionally varying output signal.

摘要翻译： 公开了一种用户输入设备，其适配时域反射测量材料水平传感器的电子部件以取代诸如按钮，控制旋钮和可变滑块的传统用户输入设备。 电导体排列在输入面板的下面，使得当高介电常数或高导电性材料放置在导体附近时，导体的特性阻抗在该点被改变，反映了透过导体的电子脉冲。 反射的电子脉冲由相关联的电子元件接收，随后确定材料沿着导体的位置。 通过将导体分割为虚拟区域，每个对应于单个“按钮”，离散输入可以由设备基于材料在特定虚拟区域内的放置而被接收。 或者，导体可以用作无级可变“滑块”控制，材料沿着导体的移动产生按比例变化的输出信号。

公开(公告)号：US10603351B2

公开(公告)日：2020-03-31

申请号：US13060028

申请日：2009-08-20

申请人： John C. Bell ,  Fabrice Le Boeuf

发明人： John C. Bell ,  Fabrice Le Boeuf

IPC分类号： A61K38/16 ,  A61K35/766 ,  A61K35/768 ,  A61K38/19 ,  A61K35/76

摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.