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    Radioprotector compounds and methods
    1.
    发明授权
    Radioprotector compounds and methods 有权

    公开(公告)号：US08999993B2

    公开(公告)日：2015-04-07

    申请号：US13640188

    申请日：2011-04-06

    申请人： Roger Francis Martin ,  Jonathan White ,  Pavel Lobachevsky ,  David Winkler ,  Colin Skene ,  Sebastian Marcuccio

    发明人： Roger Francis Martin ,  Jonathan White ,  Pavel Lobachevsky ,  David Winkler ,  Colin Skene ,  Sebastian Marcuccio

    IPC分类号： A61K31/496 ,  C07D235/20 ,  C07D401/14 ,  C07D235/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14

    CPC分类号： C07D401/14 ,  C07D235/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14

    摘要： The invention relates to novel compounds, processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula II, as follows: wherein W represents —N(R1R2) where R1 and R2 are not both hydrogen and where they may together form a 5, 6 or 7 membered ring structure, —NHN(R1R2), —NHR3N(R1R2), —NHR3OR2, —N(R3)R3OR2, —N(R1)R3OR3OR3, —OR3NR1R2, —OR3 or W represents piperidyl, piperazinyl, morpholinyl, thiomorpholinyl or diazepanyl each of which may be optionally substituted by C1 to C4 alkyl, C2 to C4 alkenyl, —N(CO)N(R1R2), —N(CO)OR1, —N(CO)OR3OH, —(CO)NR1R2, —R3(CO)NR1R2, —R3OR1, —OR1, —N(R1R2) or —NH—; R1 and R2 are the same or different and are selected from hydrogen, C1 to C4 alkyl or C2 to C4 alkenyl; R3 is a C1 to C4 alkyl or C2 to C4 alkenyl group or chain; Z is the same or different and represents N or CH; Z′ is the same or different and represents N or C; X represents CH, N or NH, where is a double bond when X is CH or N and a single bond when X is NH; X′ represents N or NH, wherein when X is CH or NX′ is NH and wherein X and X′ are different and further where is a double bond when X′ is N and a single bond when X′ is NH; Q represents H, alkoxyl, —NR1R2, F or Cl; Q1 is absent when Z′ is N and when Z′ is C it represents H, alkoxyl, —NR1R2, F or Cl; A represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position, said ring including optional double bonds, substitutions and/or other heteroatoms and pharmaceutically acceptable derivatives thereof.

    RADIOPROTECTOR COMPOUNDS AND METHODS
    2.
    发明申请
    RADIOPROTECTOR COMPOUNDS AND METHODS 有权
    放射性化合物和方法

    公开(公告)号：US20130109678A1

    公开(公告)日：2013-05-02

    申请号：US13640188

    申请日：2011-04-06

    申请人： Roger Francis Martin ,  Jonathan White ,  Pavel Lobachevsky ,  David Winkler ,  Colin Skene ,  Sebastian Maruccio

    发明人： Roger Francis Martin ,  Jonathan White ,  Pavel Lobachevsky ,  David Winkler ,  Colin Skene ,  Sebastian Maruccio

    IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14

    CPC分类号： C07D401/14 ,  C07D235/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14

    摘要： The invention relates to novel compounds, processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula II, as follows: wherein W represents —N(R1R2) where R1 and R2 are not both hydrogen and where they may together form a 5, 6 or 7 membered ring structure, —NHN(R1R2), —NHR3N(R1R2), —NHR3OR2, —N(R3)R3OR2, —N(R1)R3OR3OR3, —OR3NR1R2, —OR3 or W represents piperidyl, piperazinyl, morpholinyl, thiomorpholinyl or diazepanyl each of which may be optionally substituted by C1 to C4 alkyl, C2 to C4 alkenyl, —N(CO)N(R1R2), —N(CO)OR1, —N(CO)OR3OH, —(CO)NR1R2, —R3(CO)NR1R2, —R3OR1, —OR1, —N(R1R2) or —NH—; R1 and R2 are the same or different and are selected from hydrogen, C1 to C4 alkyl or C2 to C4 alkenyl; R3 is a C1 to C4 alkyl or C2 to C4 alkenyl group or chain; Z is the same or different and represents N or CH; Z′ is the same or different and represents N or C; X represents CH, N or NH, where is a double bond when X is CH or N and a single bond when X is NH; X′ represents N or NH, wherein when X is CH or NX′ is NH and wherein X and X′ are different and further where is a double bond when X′ is N and a single bond when X′ is NH; Q represents H, alkoxyl, —NR1R2, F or Cl; Q1 is absent when Z′ is N and when Z′ is C it represents H, alkoxyl, —NR1R2, F or Cl; A represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position, said ring including optional double bonds, substitutions and/or other heteroatoms and pharmaceutically acceptable derivatives thereof.

    摘要翻译： 本发明涉及新化合物，其制备方法及其在保护生物材料免受辐射损伤（放射防护）中的应用。 本发明优选的化合物是式II的化合物，其如下：其中W表示-N（R 1 R 2），其中R 1和R 2不是氢并且它们可以一起形成5,6或7元环结构，-NHN（R 1 R 2 ），-NHR3N（R1R2），-NHR3OR2，-N（R3）R3OR2，-N（R1）R3OR3OR3，-OR3NR1R2，-OR3或W表示哌啶基，哌嗪基，吗啉基，硫代吗啉基或二氮杂环丁基， C 1 -C 4烷基，C 2〜C 4烯基，-N（CO）N（R 1 R 2），-N（CO）OR 1，-N（CO）OR 3 OH， - （CO）NR 1 R 2，-R 3（CO）NR 1 R 2，-R 3 OR 1， -OR1，-N（R1R2）或-NH-; R 1和R 2相同或不同，并且选自氢，C 1至C 4烷基或C 2至C 4链烯基; R3是C1-C4烷基或C2-C4链烯基或链; Z相同或不同，代表N或CH; Z'相同或不同，表示N或C; X表示CH，N或NH，当X为CH或N时为双键，当X为NH时为单键; X'表示N或NH，其中当X是CH或NX'是NH并且其中X和X'不同，并且当X'是N时是双键，当X'是NH时，是单键; Q表示H，烷氧基，-NR1R2，F或Cl; 当Z'为N时，Q1不存在，当Z'为C时，它代表H，烷氧基，-NR1R2，F或Cl; A表示具有位于邻位的杂环N或O的五至十元单环或多环结构，所述环包括任选的双键，取代和/或其它杂原子及其药学上可接受的衍生物。

    Cell targeting conjugates
    3.
    发明申请
    Cell targeting conjugates 有权
    细胞靶向缀合物

    公开(公告)号：US20070140970A1

    公开(公告)日：2007-06-21

    申请号：US10590784

    申请日：2005-02-25

    申请人： Roger Martin ,  Jonathan White ,  Pavel Lobachevsky ,  Thomas Karagiannis

    发明人： Roger Martin ,  Jonathan White ,  Pavel Lobachevsky ,  Thomas Karagiannis

    IPC分类号： A61K49/00 ,  A61K39/395 ,  C07K16/46

    CPC分类号： A61K51/0459 ,  A61K31/4184 ,  C07C45/292 ,  C07D235/20 ,  C07C47/55

    摘要： The present invention relates to cell targeting conjugates and in particular, but not exclusively, to methods of their use in selectively eliminating and in selectively imaging target cells. The invention also relates to processes for production of the conjugates and to intermediate compounds that may be used in production of a specific class of cell targeting conjugates. In one embodiment there is provided a cell targeting conjugate comprising the following components that are covalently conjugated via a linker that is degradable within the target cells: i) a DNA minor groove binding ligand incorporating an effective Auger electron-emitting and/or gamma-emitting and/or positron-emitting atom or photoactive moiety; ii) a target cell specific protein or peptide that is capable of internalisation by target cells.

    摘要翻译： 本发明涉及细胞靶向缀合物，特别是但不排他地涉及它们用于选择性地消除和选择性地成像靶细胞的方法。 本发明还涉及可用于生产特定类别的细胞靶向缀合物的缀合物和中间体化合物的制备方法。 在一个实施方案中，提供了细胞靶向缀合物，其包含通过可在靶细胞内可降解的接头共价共轭的以下成分：i）掺入有效俄歇电子发射和/或γ发射的DNA小沟结合配体 和/或正电子发射原子或光活性部分; ii）能够靶细胞内化的靶细胞特异性蛋白质或肽。

    Variable focus lens and spectacles
    4.
    发明授权
    Variable focus lens and spectacles 失效
    可变焦距镜头和眼镜

    公开(公告)号：US08441737B2

    公开(公告)日：2013-05-14

    申请号：US12937136

    申请日：2009-04-08

    申请人： Justin Buch ,  William Johnson ,  Miranda Newbery ,  Andrew Roberston ,  Richard Taylor ,  Jonathan White

    发明人： Justin Buch ,  William Johnson ,  Miranda Newbery ,  Andrew Roberston ,  Richard Taylor ,  Jonathan White

    IPC分类号： G02B3/12

    CPC分类号： G02B3/14 ,  G02C7/085

    摘要： The invention provides a variable focus lens formed from a ring with a front surface and a rear surface, a flexible membrane is attached to a radially inner part of the front surface, and a front cover is attached to a radially outer part of the front surface, a rear cover is provided on the rear surface of the ring, preferably integral with the ring, so that a variable volume cavity is defined between the flexible membrane, the ring and the rear cover, second flexible membrane can be provided between the ring and the rear cover, where the invention also provides a method of filling a variable focus lens, and an adjustment mechanism for varying the focus of the lens.

    摘要翻译： 本发明提供一种由具有前表面和后表面的环形成的可变焦距透镜，柔性膜附接到前表面的径向内部，并且前盖附接到前表面的径向外部部分 在所述环的后表面上设置有后盖，优选地与所述环一体形成，使得在所述柔性膜，所述环和所述后盖之间限定可变容积腔，所述第二柔性膜可以设置在所述环与所述环之间， 后盖，其中本发明还提供了一种填充可变焦距透镜的方法，以及用于改变透镜焦点的调节机构。

    Donated Blood Collection Kit
    5.
    发明申请
    Donated Blood Collection Kit 有权
    捐赠血液收集套件

    公开(公告)号：US20110281346A1

    公开(公告)日：2011-11-17

    申请号：US12778710

    申请日：2010-05-12

    申请人： Lise N. Halpern ,  Tim Costello ,  Jonathan White

    发明人： Lise N. Halpern ,  Tim Costello ,  Jonathan White

    IPC分类号： C12M1/00 ,  B65B5/00

    CPC分类号： A61M1/02 ,  A61M2205/6054 ,  A61M2205/6063 ,  A61M2205/6072 ,  A61M2209/06 ,  B01L3/5453 ,  B01L9/54

    摘要： A donated blood collection kit includes an easy-to-open closed container. Stored within the container are items necessary or useful for collecting donated blood, such as an antiseptic scrub, an antiseptic swab, test tubes, a blood collection container, a gauze pad and a sheet of pre-printed adhesive barcode labels. Each kit is assigned a unique identification when the kit is manufactured. The identification may eventually be used as the unique donor identification for a unit of donated blood that is collected using the items in the kit. The container is pre-labeled with the unique identification, such as by a barcode or an RF-ID tag. The test tubes and, if included, the blood collection container are pre-labeled with the same unique donor identification. The adhesive barcode labels in the container are pre-printed with the same unique donor identification and may be affixed to items that are not provided in the kit but, nonetheless, should be associated with the unit of blood that may be collected using the kit. Information about lot numbers and expiration dates for the items in the kit may be encoded in the kit's unique identification and/or stored in a database in association with the kit's identification.

    摘要翻译： 捐赠的血液收集套件包括一个易于打开的密闭容器。 储存在容器内的是用于收集捐赠血液的必需或有用的物品，例如消毒洗涤剂，防腐拭剂，试管，采血容器，纱布垫和预先印刷的粘合剂条形码标签片。 当套件被制造时，每个套件被分配一个唯一的标识。 该鉴定可能最终被用作使用试剂盒中的物品收集的捐赠血液单位的唯一捐赠者身份。 容器被预先标记有唯一标识，例如通过条形码或RF-ID标签。 试管和（如果包括的话）采血容器用相同的独特供体标识物进行预标记。 容器中的粘合剂条形码标签被预先印有相同的独特的供体标识，并且可以粘贴在试剂盒中未提供的物品上，但仍应与使用试剂盒收集的血液单位相关。 关于套件中项目的批号和有效期的信息可以编码成套件的唯一标识和/或与套件标识相关联的数据库中。

    Funeral service apparatus
    7.
    发明授权
    Funeral service apparatus 有权
    殡仪服务器具

    公开(公告)号：US08613121B1

    公开(公告)日：2013-12-24

    申请号：US12956404

    申请日：2010-11-30

    申请人： Jonathan White

    发明人： Jonathan White

    IPC分类号： B25F1/04 ,  B26B11/00

    CPC分类号： B25F1/04 ,  B26B11/00

    摘要： A funeral service apparatus and method for implementing the funeral service apparatus is provided and includes an apparatus body having a hex wrench, a knife blade, a Phillips head screwdriver, a flat head screwdriver, a holy water containment vial, a committal sand containment vial, scissors, a tape measure having a measuring tape, a pen and a flashlight. The hex wrench, knife, Phillips head screwdriver, flat head screwdriver, scissors and measuring tape are rotatably associated with the funeral service apparatus to be configurable between an extended configuration and a stored configuration. Moreover, the holy water containment vial, the committal sand containment vial and the pen are slidably associated with the funeral service apparatus to be configurable between an extended configuration and a stored configuration.

    摘要翻译： 提供了一种用于实施殡仪服务装置的殡仪服务装置和方法，包括具有六角扳手，刀片，十字头螺丝刀，平头螺丝刀，圣水容纳小瓶，防沙容器小瓶， 剪刀，带有卷尺的卷尺，笔和手电筒。 十六角扳手，刀，十字头螺丝刀，平头螺丝刀，剪刀和卷尺与殡仪服务装置可旋转地相关联，以在扩展配置和存储配置之间进行配置。 此外，圣水容器小瓶，落沙容器小瓶和笔可与殡仪服务设备可滑动地相关联，以在扩展配置和存储配置之间进行配置。

    VARIABLE FOCUS LENS AND SPECTACLES
    8.
    发明申请
    VARIABLE FOCUS LENS AND SPECTACLES 失效
    可变焦距镜头和镜头

    公开(公告)号：US20110261466A1

    公开(公告)日：2011-10-27

    申请号：US12937136

    申请日：2009-04-08

    申请人： Justin Buch ,  William Johnson ,  Miranda Newbery ,  Andrew Roberston ,  Richard Taylor ,  Jonathan White

    发明人： Justin Buch ,  William Johnson ,  Miranda Newbery ,  Andrew Roberston ,  Richard Taylor ,  Jonathan White

    IPC分类号： G02B3/14 ,  G02B15/14

    CPC分类号： G02B3/14 ,  G02C7/085

    摘要： The invention provides a variable focus lens formed from a ring with a front surface and a rear surface, a flexible membrane is attached to a radially inner part of the front surface, and a front cover is attached to a radially outer part of the front surface, a rear cover is provided on the rear surface of the ring, preferably integral with the ring, so that a variable volume cavity is defined between the flexible membrane, the ring and the rear cover, second flexible membrane can be provided between the ring and the rear cover, where the invention also provides a method of filling a variable focus lens, and an adjustment mechanism for varying the focus of the lens.

    摘要翻译： 本发明提供一种由具有前表面和后表面的环形成的可变焦距透镜，柔性膜附接到前表面的径向内部，并且前盖附接到前表面的径向外部部分 在所述环的后表面上设置有后盖，优选地与所述环一体形成，使得在所述柔性膜，所述环和所述后盖之间限定可变容积腔，所述第二柔性膜可以设置在所述环与所述环之间， 后盖，其中本发明还提供了一种填充可变焦距透镜的方法，以及用于改变透镜焦点的调节机构。