公开(公告)号：US06799355B2

公开(公告)日：2004-10-05

申请号：US10221479

申请日：2002-09-13

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Gholamreza Javahery ,  William Ronald Stott

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Gholamreza Javahery ,  William Ronald Stott

IPC分类号： H01J4940

CPC分类号： H01J49/004 ,  G01N27/624

摘要： A method and an apparatus for selectively transmitting ions produced by an inductively coupled plasma ionization technique is disclosed. Ions produced within the plasma source are provided to a FAIMS analyzer within a low pressure chamber of a mass spectrometer and in fluid communication with the plasma source for receiving ions therefrom. The ions are separated in FAIMS and at least some of the ions are provided to the mass spectrometer after separation.

摘要翻译： 公开了一种用于选择性地传输由电感耦合等离子体电离技术产生的离子的方法和装置。 在等离子体源内产生的离子被提供给质谱仪的低压室内的FAIMS分析仪，并与等离子体源流体连通以接收离子。 离子在FAIMS中分离，分离后至少有一些离子被提供给质谱仪。

公开(公告)号：US20060060773A1

公开(公告)日：2006-03-23

申请号：US10503656

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Mark Weir

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Mark Weir

IPC分类号： B01D59/44

CPC分类号： H01J49/42

摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. The FAIMS also includes an outer electrode (104) having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween. The outer electrode has an ion inlet (114) for introducing ions from a source of ions into the analyzer region and an ion outlet (112) for extracting ions from the analyzer region, the ion inlet and the ion outlet being disposed on opposing sides of the outer electrode. The FAIMS is characterized in that at least one of the inner and outer electrodes is shaped such that a width of the analyzer region in the vicinity of the ion outlet is other than a width of the analyzer region in at least one other region.

摘要翻译： 公开了具有侧对电极几何形状的高场非对称波形离子迁移谱仪（FAIMS）。 FAIMS包括内部电极（102），其具有在与该长度方向横向的方向上弯曲的长度和外表面。 FAIMS还包括具有长度的外部电极（104），沿其长度的至少一部分延伸穿过的通道和弯曲的内表面，外部电极的长度的一部分与所述外部电极的长度的一部分重叠 内部电极，以便在其间提供分析器区域。 外部电极具有用于将离子从离子源引入分析器区域的离子入口（114）和用于从分析器区域提取离子的离子出口（112），离子入口和离子出口设置在离子入口 外电极。 FAIMS的特征在于，内电极和外电极中的至少一个被成形为使得离子出口附近的分析器区域的宽度不同于至少另一个区域中的分析器区域的宽度。

公开(公告)号：US06713758B2

公开(公告)日：2004-03-30

申请号：US10359644

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： H01J4900

CPC分类号： H01J49/00 ,  B01D59/46 ,  B01D59/48 ,  G01N21/3504 ,  G01N27/624

摘要： A high field asymmetric waveform ion mobility spectrometer (FAIMS) having spherical electrode geometry is disclosed. The spherical FAIMS includes an inner generally spherical electrode supported in a spaced-apart arrangement relative to an outer electrode. The outer electrode has a curved inner surface that maintains an approximately uniform spacing to the inner electrode. The space between the inner and outer electrodes defines an analyzer region, where an electric field is established by the application of an asymmetric waveform voltage and a direct current compensation voltage to at least one of the inner and outer electrodes. An ion inlet and an ion outlet are disposed within the curved inner surface of the outer electrode such that the shortest distance between the inlet and the outlet in any direction around the inner electrode is approximately a same distance.

摘要翻译： 公开了具有球形电极几何形状的高场非对称波形离子迁移谱仪（FAIMS）。 球形FAIMS包括相对于外部电极以间隔布置的方式支撑的内部大体上球形的电极。 外电极具有弯曲的内表面，其保持与内电极大致均匀的间隔。 内电极和外电极之间的空间限定分析器区域，其中通过对内电极和外电极中的至少一个施加非对称波形电压和直流补偿电压来建立电场。 离子入口和离子出口设置在外电极的弯曲内表面内，使得入口和出口之间在内电极周围的任何方向上的最短距离大致相同的距离。

公开(公告)号：US07034289B2

公开(公告)日：2006-04-25

申请号：US10503714

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： G01N27/624 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/65 ,  Y10T436/105831 ,  Y10T436/24

摘要： Provided is a side-to-side high field asymmetric waveform ion mobility spectrometer (FAIMS) including a generally cylindrically-shaped inner electrode having a length. Encircling the inner electrode is a generally cylindrically-shaped outer electrode assembly comprising at least first and second and third outer electrode segments. Each of the outer electrode segments has a channel extending therethrough and open at opposite ends thereof. In an assembled condition, the second outer electrode segment is disposed intermediate the first and third outer electrode segments in an end-to-end arrangement, each one of the first and second and third electrode segments overlapping a different portion of the length of the inner electrode. An electrical contact is provided on at least one of the inner electrode and the second outer electrode segment for receiving a first direct current voltage between the inner electrode and the second outer electrode segment, and for applying an asymmetric waveform voltage to the at least one of the inner electrode and the second outer electrode segment. The second outer electrode segment is maintained at a different potential relative to the first and third outer electrode segments, such that a potential gradient is formed in a direction along the length of the inner electrode.

摘要翻译： 提供了一种包括具有长度的大致圆柱形的内部电极的侧对侧高场非对称波形离子迁移谱仪（FAIMS）。 围绕内部电极是大致圆柱形的外部电极组件，其包括至少第一和第二和第三外部电极段。 每个外部电极段具有穿过其延伸并在其相对端处开口的通道。 在组装状态下，第二外部电极段以端对端布置设置在第一和第三外部电极段的中间，第一和第二和第三电极段中的每一个与内部电极段的长度的不同部分重叠 电极。 在内部电极和第二外部电极段中的至少一个上提供电接触，​​用于接收内部电极和第二外部电极段之间的第一直流电压，并且将不对称波形电压施加到至少一个 内电极和第二外电极段。 第二外部电极段相对于第一和第三外部电极段保持在不同的电势，使得在沿着内部电极的长度的方向上形成电位梯度。

公开(公告)号：US07223967B2

公开(公告)日：2007-05-29

申请号：US10503656

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Mark Weir

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Mark Weir

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/42

摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. The FAIMS also includes an outer electrode (104) having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween. The outer electrode has an ion inlet (114) for introducing ions from a source of ions into the analyzer region and an ion outlet (112) for extracting ions from the analyzer region, the ion inlet and the ion outlet being disposed on opposing sides of the outer electrode. The FAIMS is characterized in that at least one of the inner and outer electrodes is shaped such that a width of the analyzer region in the vicinity of the ion outlet is other than a width of the analyzer region in at least one other region.

摘要翻译： 公开了具有侧对电极几何形状的高场非对称波形离子迁移谱仪（FAIMS）。 FAIMS包括内部电极（102），其具有在与该长度方向横向的方向上弯曲的长度和外表面。 FAIMS还包括具有长度的外部电极（104），沿其长度的至少一部分延伸穿过的通道和弯曲的内表面，外部电极的长度的一部分与所述外部电极的长度的一部分重叠 内部电极，以便在其间提供分析器区域。 外部电极具有用于将离子从离子源引入分析器区域的离子入口（114）和用于从分析器区域提取离子的离子出口（112），离子入口和离子出口设置在离子入口 外电极。 FAIMS的特征在于，内电极和外电极中的至少一个被成形为使得离子出口附近的分析器区域的宽度不同于至少另一个区域中的分析器区域的宽度。

公开(公告)号：US07026612B2

公开(公告)日：2006-04-11

申请号：US10503713

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Barbara Ells

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Barbara Ells

IPC分类号： H01J49/40

CPC分类号： G01N27/624 ,  H01J49/04

摘要： Disclosed is a method and apparatus for improving at least one of a peak separation and a signal intensity relating to an ion of interest being transmitted through an analyzer region of a FAIMS apparatus. A method according to the instant invention includes a step of introducing ions including an ion of interest into an analyzer region of a FAIMS. A flow of a doped carrier gas other than air is also provided through the analyzer region. The doped carrier gas includes a carrier gas and a trace amount of a predetermined dopant gas, the predetermined dopant gas selected for improving at least one of a peak separation and a signal intensity relating to the ion of interest relative to the peak separation and the signal intensity relating to the ion of interest in the presence of the carrier gas only. The ion of interest is selectively transmitted through the analyzer region in the presence of the doped carrier gas, and detected at a detector.

摘要翻译： 公开了一种用于改善通过FAIMS装置的分析器区域传输的与感兴趣的离子相关的峰值分离和信号强度中的至少一个的方法和装置。 根据本发明的方法包括将包含感兴趣的离子的离子引入到FAIMS的分析器区域中的步骤。 除了空气之外的掺杂载气的流动也通过分析器区域提供。 掺杂的载气包括载气和痕量的预定掺杂气体，所选择的预定掺杂剂气体相对于峰值分离和信号来改善峰值分离和与感兴趣的离子相关的信号强度中的至少一个 仅在载气存在下与感兴趣的离子有关的强度。 感兴趣的离子在掺杂的载气的存在下选择性地透过分析器区域，并在检测器处检测。

公开(公告)号：US07005633B2

公开(公告)日：2006-02-28

申请号：US10503659

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： H01J49/40

CPC分类号： G01N27/624 ,  G01N21/3504

摘要： Disclosed are an apparatus and a method for separating ions produced at an electrospray ionization source, based upon the high field mobility properties of the ions. An apparatus according to the instant invention includes a high field asymmetric waveform ion mobility spectrometer (FAIMS) having an analyzer region defined by a space between an inner electrode (32) and an outer electrode (34). In particular, the outer electrode includes an ion inlet (38) for introducing ions into a first portion of analyzer region and an ion outlet (56) for extracting ions from a second portion of the analyzer region. The FAIMS is characterized in that a gas-directing conduit (48) is provided through at least a portion of the inner electrode. In particular, the gas-directing conduit includes an opening at a first end thereof for supporting fluid communication between the gas-directing conduit and the first portion of the analyzer region. The gas-directing conduit is adapted at a second end thereof opposite the first end for supporting fluid communication between a gas source and the gas-directing conduit. The opening is orientated relative to the ion inlet such that gas provided through the gas-directing conduit flows partially outwardly from the analyzer region through the ion inlet, so as to desolvate the ions produced at an ionization source (42, 45) as they are introduced into the analyzer region.

摘要翻译： 公开了基于离子的高场迁移率特性分离在电喷雾离子源产生的离子的装置和方法。 根据本发明的装置包括具有由内电极（32）和外电极（34）之间的空间限定的分析器区域的高场不对称波形离子迁移谱仪（FAIMS）。 特别地，外部电极包括用于将离子引入分析器区域的第一部分的离子入口（38）和用于从分析器区域的第二部分提取离子的离子出口（56）。 FAIMS的特征在于，通过内部电极的至少一部分提供导气导管（48）。 特别地，导气导管包括在其第一端处的开口，用于支撑气体导向导管和分析器区域的第一部分之间的流体连通。 气体导向管道在其与第一端相对的第二端处适配，以支撑气体源和气体导向管道之间的流体连通。 开口相对于离子入口定向，使得通过导气导管提供的气体通过离子入口部分地从分析器区域向外流动，从而使离子化物质（42,45）产生的离子原样脱水 引入分析仪区域。

公开(公告)号：US06998608B2

公开(公告)日：2006-02-14

申请号：US10338858

申请日：2003-01-09

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： B01D59/44 ,  H01J49/00 ,  H01J49/40

CPC分类号： G01N27/624 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/65 ,  Y10T436/105831 ,  Y10T436/24

摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) with optical based detection of selectively transmitted ions. Light from a light source is directed through an optical port in an electrode of the FAIMS. A light detector is provided for receiving light that is one of transmitted and scattered by the selectively transmitted ions within the FAIMS.

公开(公告)号：US20050161596A1

公开(公告)日：2005-07-28

申请号：US10503713

申请日：2003-02-07

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Barbara Ells

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Barbara Ells

IPC分类号： G01N27/64 ,  H01J49/04 ,  H01J49/28

CPC分类号： G01N27/624 ,  H01J49/04

摘要： Disclosed is a method and apparatus for improving at least one of a peak separation and a signal intensity relating to an ion of interest being transmitted through an analyzer region of a FAIMS apparatus. A method according to the instant invention includes a step of introducing ions including an ion of interest into an analyzer region of a FAIMS. A flow of a doped carrier gas other than air is also provided through the analyzer region. The doped carrier gas includes a carrier gas and a trace amount of a predetermined dopant gas, the predetermined dopant gas selected for improving at least one of a peak separation and a signal intensity relating to the ion of interest relative to the peak separation and the signal intensity relating to the ion of interest in the presence of the carrier gas only. The ion of interest is selectively transmitted through the analyzer region in the presence of the doped carrier gas, and detected at a detector.

摘要翻译： 公开了一种用于改善通过FAIMS装置的分析器区域传输的与感兴趣的离子相关的峰值分离和信号强度中的至少一个的方法和装置。 根据本发明的方法包括将包含感兴趣的离子的离子引入到FAIMS的分析器区域中的步骤。 除了空气之外的掺杂载气的流动也通过分析器区域提供。 掺杂的载气包括载气和痕量的预定掺杂气体，所选择的预定掺杂剂气体相对于峰值分离和信号来改善峰值分离和与感兴趣的离子相关的信号强度中的至少一个 仅在载气存在下与感兴趣的离子有关的强度。 感兴趣的离子在掺杂的载气的存在下选择性地透过分析器区域，并在检测器处检测。

公开(公告)号：US06917036B2

公开(公告)日：2005-07-12

申请号：US10338859

申请日：2003-01-09

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： B01D59/44 ,  G01N27/64 ,  H01J49/00 ,  H01J49/04 ,  H01J49/40 ,  H01J49/42

CPC分类号： G01N27/624 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/65 ,  Y10T436/105831 ,  Y10T436/24

摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) with optical based detection of selectively transmitted ions. Light from a light source is directed through an optical port in an electrode of the FAIMS. A light detector is provided for receiving light that is one of transmitted and scattered by the selectively transmitted ions within the FAIMS.

摘要翻译： 公开了一种具有光学检测选择性透射离子的高场非对称波形离子迁移谱仪（FAIMS）。 来自光源的光被引导通过FAIMS的电极中的光学端口。 提供光检测器，用于接收由FAIMS内的选择性透射离子传播和散射的光。